Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene. (wikipedia.org)
MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. (eu.org)
The eukaryotic translation initiation factor EIF-2B is a complex made up of five different subunits, alpha, beta, gamma, delta and epsilon, and catalyses the exchange of EIF-2-bound GDP for GTP. (embl.de)
EIF2B6
The EIF2B5 gene provides instructions for making one of five parts of a protein called eIF2B, specifically the epsilon subunit of this protein. (medlineplus.gov)
Under some conditions, eIF2B increases protein synthesis by helping to recycle molecules called GTP, which carry energy to the initiation factor. (medlineplus.gov)
Under other conditions, it slows protein synthesis by binding tightly to the initiation factor, which converts the eIF2B protein into an inactive form and prevents recycling of GTP. (medlineplus.gov)
Childhood ataxia with central nervous system hypomyelination (CACH), or vanishing white matter leukoencephalopathy (VWM), is a fatal brain disorder caused by mutations in eukaryotic initiation factor 2B (eIF2B). (yeastgenome.org)
Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D) (human eIF2B(betaV316D)), forms complexes with reduced stability and lower eIF2B activity. (yeastgenome.org)
Mutations affecting the eukaryotic initiation factor 2B (eIF2B) cause one of the most common leukodystrophies, the autosomal recessive childhood ataxia with central nervous system hypomyelination (CACH), or vanishing white matter disease (VWM). (medlink.com)
Catalytic subunit3
Pol δ is anchored to one of the three PCNA monomers through the C-terminal domain of the catalytic subunit. (nature.com)
Mammalian Pol δ consists of a catalytic subunit and three regulatory subunits (Fig. 1a ). (nature.com)
The catalytic subunit (p125) harbours the polymerase and exonuclease activities, and a metal-binding C-terminal domain (CTD). (nature.com)
In humans there exist five isoforms of the B56 type regulatory subunit and they bind to their interacting proteins through a conserved LxxIxE motif. (eu.org)
The motif is conserved in essential proteins throughout the eukaryotic domain of life and also in human viruses, suggesting that the motifs are required for basic cellular function. (eu.org)
Protein dephosphorylation by the PP2A phosphatase is mainly achieved through the interaction of its regulatory subunit with the associated proteins. (eu.org)
Many of these proteins were initially annotated as putative translation initiation factors despite the fact that there is no evidence for the requirement of an IF2 recycling factor in prokaryotic translation initiation. (embl.de)
The catalytic core sits on top of PCNA in an open configuration while the regulatory subunits project laterally. (nature.com)
Complex4
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways. (medlineplus.gov)
2004) Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity. (yeastgenome.org)
Complement C3a receptor 1 is the receptor for complement factor C3a, a component of the alternative complement cascade. (guidetomalariapharmacology.org)
Mutations1
We performed mutagenesis to introduce changes equivalent to 12 human CACH/VWM mutations in three subunits of the equivalent factor from yeast (Saccharomyces cerevisiae) and analyzed effects on cell growth, translation, and gene expression in response to stresses. (yeastgenome.org)
a Domain organization of the four subunits of human Pol δ and amino acid sequence of PCNA-interacting (PIP-box) motifs. (nature.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myogenic Factor 5 (MYF5) in Tissue homogenates and other biological fluids. (1elisakits.com)
Description: A sandwich ELISA kit for detection of Myogenic Factor 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
Description: Quantitative sandwich ELISA for measuring Human Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates or other biological fluids. (1elisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in serum, plasma, tissue homogenates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
PP2A-mediated protein dephosphorylation is involved in a broad range of cellular processes including cell-cycle progression, cytoskeletal dynamics, and growth factor signalling. (eu.org)
Cell1
Description: Quantitative sandwich ELISA for measuring Mouse Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Unknown1
However, how eukaryotic Pol δ achieves processive DNA synthesis and how it cooperates with PCNA and other factors during Okazaki fragment processing remains unknown. (nature.com)