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  • mRNA
  • The mRNA expression of the different subunits that compose the K ATP channels was evaluated in MDA-MB-231 cells by reverse transcriptase-polymerase chain reaction. (biomedcentral.com)
  • mitotic
  • Here, we show that Notch inhibition in KS tumor cells using γ-secretase inhibitors or Notch-1 small interfering RNA resulted in G 2 -M cell cycle arrest and mitotic catastrophe characterized by the presence of micronucleated cells and an increased mitotic index. (aacrjournals.org)
  • Taken together, these studies suggest that Notch inhibition can initiate aberrant mitosis by inducing NF-κB activity that inappropriately increases cyclin B1 resulting in cell death via mitotic catastrophe. (aacrjournals.org)
  • specificity
  • The specificity of SCF CDC4 is thought to be governed by ySKP1 and the F-box-containing subunit CDC4, which together form a substrate receptor that tethers SIC1 to the complex. (pnas.org)
  • LY294002
  • In the following experiments, we found that CDCA2 regulated CCND1 expression through activating the PI3K/AKT pathway, and confirmed this using a specific PI3K inhibitor (LY294002). (springer.com)
  • Treatment of cells with phosphoinositidyl 3-kinase inhibitor (LY294002) and constitutively activator (insulin-like growth factor I) had significant effects on the anoikis of SKP2 RNA interference cells. (aacrjournals.org)
  • ubiquitin ligase
  • Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCFFBXO31 ubiquitin ligase. (uchc.edu)
  • It is a member of the F-box family and constitutes the substrate recognition subunit of the SCF SKP2 ubiquitin ligase complex. (aacrjournals.org)
  • homolog
  • Other frequent abnormalities included whole-chromosome uniparental isodisomies ( wUPIDs) 9 and 11, gain of 17q not associated with isochromosome formation, extra gain of part of 21q, deletions of ETS variant 6 (ETV6), cyclin-dependent kinase inhibitor 2A (CKDN2A) and paired box 5 (PAX5), and PAN3 poly(A) specific ribonuclease subunit homolog (PAN3) microdeletions. (diva-portal.org)
  • palbociclib
  • The development of a new generation of selective CDK 4/6 inhibitors, including palbociclib, abemaciclib and ribociclib has ability to target CDK 4/6 with fewer adverse effects and improved effectiveness, as they have a vital role in the G1 to S phase cell-cycle transition. (psmarketresearch.com)
  • Favorable results with palbociclib and its recent U.S. Food and Drug Administration approval demonstrate that CDK inhibitors with narrow selectivity profiles can have clinical utility for therapy based on individual tumor genetics. (aspetjournals.org)
  • A brief overview of results obtained with ATP-competitive inhibitors such as palbociclib and dinaciclib is presented, followed by a compilation of new avenues that have been pursued toward the development of novel, non-ATP-competitive CDK inhibitors. (aspetjournals.org)
  • proliferation
  • Clinical application of first-generation, non-selective CDK inhibitors are designed to inhibit proliferation of cells, that was initially hindered by the lack of efficacy and high risk of toxicity observed with these agents. (psmarketresearch.com)
  • Deregulation of the cyclins and CKIs can cause aberrant proliferation and genomic instability. (uchc.edu)
  • Gli inhibited cell proliferation assessed by a clonogenic method in a dose dependent manner, with an increment in the population doubling time. (biomedcentral.com)
  • ribosomal
  • Decreased expression or modification was observed for complexin 1 (CPLX1), alpha-synuclein, parvalbumin, ribosomal protein large P2, prohibitin, nerve growth factor, beta subunit (NGFB), peroxiredoxin 6 (PRDX6), 1-acylglycerol-3-phosphate O-acyltransferase 2_predicted, cystatin B (CYTB) and lysosomal membrane glycoprotein 1. (hud.ac.uk)
  • Human
  • Indirubin, an indigoid active ingredient of a traditional Chinese recipe, was the first example of a CDK inhibitor used to treat human chronic myelogenous leukemia (CML). (aacrjournals.org)
  • Elevated hormonal levels of chromogranin A, pancreastatin, human chorionic gonadotropin subunits (HCG), neuron specific enolase (NSE), neurokinin A (NKA or Substance K) and pancreatic polypeptide may be present and assist with NET diagnosis. (infectiousdiseaseadvisor.com)