AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Cyclin D1Cyclin-Dependent KinasesCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase 2Protein SubunitsCyclin D2Molecular Sequence DataAmino Acid SequenceCyclin DCyclinsMacromolecular SubstancesCDC2-CDC28 KinasesCyclin D3Cyclin-Dependent Kinase 6Base SequenceCell CycleCDC2 Protein KinasePhosphorylationMutationProtein BindingCell Cycle ProteinsProtein-Serine-Threonine KinasesBinding SitesCyclin-Dependent Kinase 9RNA, MessengerGenes, bcl-1G1 PhaseCell LineCloning, MolecularGene AmplificationEscherichia coliChromosomes, Human, Pair 11KineticsSequence Homology, Amino AcidCyclin ECyclin-Dependent Kinase Inhibitor p27Protein ConformationProtein Structure, TertiaryRecombinant ProteinsProton-Translocating ATPasesMolecular WeightElectrophoresis, Polyacrylamide GelModels, MolecularSaccharomyces cerevisiaeCell Line, TumorLymphoma, Mantle-CellCyclin-Dependent Kinase 8S PhaseTranscription, GeneticRecombinant Fusion ProteinsKinetinTransfectionDiagnostic Techniques, RadioisotopeMutagenesis, Site-DirectedSignal TransductionDNA PrimersCells, CulturedProto-Oncogene ProteinsProtein KinasesDNA-Binding ProteinsEnzyme ActivationSaccharomyces cerevisiae ProteinsBlotting, WesternVaccines, SubunitIn Situ Hybridization, FluorescenceNuclear ProteinsOncogene ProteinsSequence AlignmentCell ProliferationVacuolar Proton-Translocating ATPasesGene Expression Regulation, NeoplasticGene Expression RegulationHeLa CellsCyclin HCyclin-Dependent Kinase Inhibitor p21Transcription FactorsCyclin-Dependent Kinase Inhibitor p16PurinesTumor Suppressor ProteinsMitosisGlycoprotein Hormones, alpha SubunitProtein Phosphatase 2Cyclin BPromoter Regions, GeneticPeptide FragmentsReverse Transcriptase Polymerase Chain ReactionCarrier ProteinsDNACell NucleusGene ExpressionPhosphoprotein PhosphatasesPrecipitin TestsPolymerase Chain ReactionCattleEnzyme InhibitorsDNA, ComplementaryDown-RegulationDimerizationStructure-Activity Relationship
CyclinCatalyticRegulatoryProteinCDK4Protein subunitLungChromosome 11RegulateTargetsComplexExpressionCell cycleHumanCancerCells
Cyclin6
  • Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. (wikipedia.org)
  • The CCND1 gene encodes the cyclin D1 protein. (wikipedia.org)
  • This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (wikipedia.org)
  • Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
  • Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)
  • Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. (affbiotech.cn)
Catalytic2
Regulatory2
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). (thermofisher.com)
Protein1
  • system_update_alt데이터시트system_update_alt안전 데이터시트Overview 개요Product Name:Human TIP49A ELISA KitProduct Code:HUFI01923Size:96 AssaysAlias:RUVBL1, TIP49a, Pontin 52, Nuclear matrix protein 238, NMP 238, INO80 complex subunit H, TIP60-associated protein. (assaygenie.kr)
CDK49
  • CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (nih.gov)
  • Cyclin D1 is a regulatory subunit of cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
  • NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun. (omicsdi.org)
  • Furthermore, HDGF could interact with c-Jun, an oncogenic transcription factor, which eventually induced the expressions of cell cycle promoters, CCND1/CDK4/CDK6. (omicsdi.org)
  • This finding suggested that NAP1L1 could interact with HDGF, and the latter recruited c-Jun, a key oncogenic transcription factor, that further induced CCND1/CDK4/CDK6 expression, thereby promoting proliferation and chemoresistance in glioma cells. (omicsdi.org)
  • Cell Cycle Protein Expression in Neuroendocrine Tumors: Association of CDK4/CDK6, CCND1, and Phosphorylated Retinoblastoma Protein With Proliferative Index. (omicsdi.org)
  • Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. (thermofisher.com)
  • Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. (thermofisher.com)
  • Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. (nih.gov)
Protein subunit1
  • 15. AFAP1 antisense RNA 1 promotes retinoblastoma progression by sponging microRNA miR-545-3p that targets G protein subunit beta 1. (nih.gov)
Lung1
  • The effects of p27, CDK6, and CCND1 on the proliferation of lung cancer cells were examined by the MTT assay, and flow cytometry was used to investigate the mechanism by which p27 affected cell proliferation. (omicsdi.org)
Chromosome 111
  • The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). (wikipedia.org)
Regulate2
  • Immunofluorescence, co-immunoprecipitation, and Western blotting were used to determine if p27 interacted with CDK and CCND1 to regulate the cell cycle. (omicsdi.org)
  • Moreover, CCND1 did not regulate the cell cycle alone, but rather, functioned together with CDK6. (omicsdi.org)
Targets1
  • MA5-15650 targets CCND1 in indirect ELISA, WB applications and shows reactivity with Human samples. (thermofisher.com)
Complex2
Expression3
  • Quantitative PCR and immunohistochemistry were used to detect the expression of p27, CDK6, and CCND1 in the tissues of cancer patients. (omicsdi.org)
  • Transcriptional regulator which enhances expression of CCND1. (nih.gov)
  • 17. LncRNA FOXD2-AS1 regulates chondrocyte proliferation in osteoarthritis by acting as a sponge of miR-206 to modulate CCND1 expression. (nih.gov)
Cell cycle1
  • The results showed that p27, CDK6, and CCND1 played different roles in tumorigenesis and development, which are in accordance with CDK6 and CCND1 in affecting the cell cycle and cell proliferation. (omicsdi.org)
Human2
  • Purified recombinant fragment of human CCND1 expressed in E. Coli. (thermofisher.com)
  • The MA5-15650 immunogen is purified recombinant fragment of human CCND1 expressed in E. Coli. (thermofisher.com)
Cancer1
  • CCND1/CyclinD1 status in metastasizing bladder cancer: a prognosticator and predictor of chemotherapeutic response. (cornell.edu)
Cells1
  • 14. Silence of FOXD2-AS1 inhibited the proliferation and invasion of esophagus cells by regulating miR-145-5p/CDK6 axis. (nih.gov)