Subunit amino acids carrier proteins. Medical search. Frequent questions

The partial proteolysis of the [ 125 I]AzQ-labeled 49 kDa subunit by V8-protease and N-terminal sequencing of the resulting peptides revealed that the amino acid residue cross-linked by [ 125 I]AzQ is within the sequence region Thr25-Glu143 (118 amino acids). (elsevierpure.com)
Grisemycin, salinipeptin, and cypemycin belong to the linaridin class of ribosomally synthesized and posttranslationally modified peptides that contain multiple dehydrobutyrine and D-amino acid residues. (hokudai.ac.jp)
Furthermore, we demonstrated that GrmH/GrmL complex accepted salinipeptin and cypemycin precursor peptides, which possess three additional amino acids. (hokudai.ac.jp)
2014) reviewed data on the bioavailability of selected peptides and proteins in relation to inhalation exposure. (europa.eu)
Water 2H and 17O spin relaxation is used to study water dynamics in the hydration layers of two small peptides, two globular proteins and in living cells of two microorganisms. (lu.se)
This distribution comprises a small fraction of protein-specific hydration sites, where water rotation is strongly retarded, and a dominant fraction of generic hydration sites, where water rotation is as fast as in the hydration shells of small peptides. (lu.se)

PTP4A2 protein interacts with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), therefore has a role as a regulator of GGT II activity. (glpbio.cn)

This leads to an almost complete arrest of protein synthesis in the cell and its death. (org.ua)
The information contained in the ribonucleic acid is used for the synthesis of Proteins. (biotionary.com)
1) The messenger RNA (mRNA, messenger RNA) reaches the ribosomes after its synthesis and serves there as a template for protein biosynthesis. (biotionary.com)
Overall, this work defines human telomerase DNA binding and synthesis properties at single-molecule level and establishes conserved telomerase subunit architecture from single-celled organisms to humans. (elifesciences.org)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) CD98 light subunit protein encoded by the SLC7A5 gene SLC3A2 has been shown to interact with SLC7A7. (wikipedia.org)
One basic problem is how a decrease in tRNA levels, by downregulating Pol III efficiency, influences the expression pattern of protein-coding genes. (mdpi.com)
the team and its collaborators have shown that the products of HPS-associated genes in skin melanocytes regulate two pathways of membrane protein transport from endosomes to newly forming melanosomes and a retrograde pathway from melanosomes. (chop.edu)
HPS types 7, 8 and 9 are due to mutations in genes encoding subunits of BLOC-1, a complex required for the generation of tubular cargo carriers destined for melanosomes. (chop.edu)
HPS types 3, 5 and 6 are due to mutations in genes encoding subunits of BLOC-2, a complex that directs BLOC-1-dependent cargo carriers with melanosomes. (chop.edu)
The ribonucleic acid is a copy of the one found in the cell nucleus Deoxyribonucleic acid, which in the sequence of nucleotides (genetic code) the information for the differentHas stored genes. (biotionary.com)
The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)
Subsequent investigations have identified six other stargazin-like genes which are currently classified as cacng3 - cacng8 (encoding proteins γ 3 - γ 8 ), in a continuation of the VDCC γ subunit nomenclature [ 12 - 17 ]. (biomedcentral.com)
In the majority of cases, Rf genes produce proteins that act directly on the CMS conferring mitochondrial transcripts by binding them specifically and promoting processing events. (frontiersin.org)
In the majority of cases, Rf genes produce proteins that bind specifically to the CMS conferring transcripts in the mitochondria and promote processing events leading to a strong reduction in the production of mitochondrial CMS-inducing proteins (reviewed in Chen and Liu, 2014 ). (frontiersin.org)

MRRF attaches to the large ribosomal subunit in the cleft which has a peptidyl transferase center. (prospecbio.com)
It functions as a structural component and is phosphorylated by RIBOSOMAL PROTEIN S6 KINASES, integrating signals for cell growth and proliferation, especially during embryonic development. (bvsalud.org)

and lysosomal proteins, such as the transporter MFSD12, that impact melanogenesis indirectly. (chop.edu)
In summary, depletion of multiple soluble lysosomal proteins suggest a critical role of CLN7 for lysosomal function, which may contribute to the pathogenesis and progression of CLN7 disease. (kentlandsinitiative.org)
encodes the lysosomal polytopic CLN7 membrane protein of unknown function which contains sequence similarities with the drug: H+ antiporter family DHA1 of the major facilitator superfamily (MFS) (4,12). (kentlandsinitiative.org)
Lysosomal localization of the endogenous CLN7 protein has been demonstrated by proteomic analyses using purified human and rat tritosomes, by immunoblotting of mouse liver tritosomes and by immunohistochemical localization in cultured hippocampal neurons (15C18). (kentlandsinitiative.org)
In these mice, loss of Cln7 leads to (i) autofluorescence and lysosomal storage of subunit c of mitochondrial ATP synthase and saposin D in the brain and retina, (ii) neurodegeneration in the olfactory bulb, cerebellum, cortex and retina, (iii) neuroinflammation, as well as (iv) reduced lifespan of mutant mice (19). (kentlandsinitiative.org)
Furthermore, dysregulated expression of several soluble lysosomal proteins and impaired macroautophagy in the Cln7 ko mice suggest that loss of Cln7 results in lysosomal dysfunction in the brain (19). (kentlandsinitiative.org)
In CLN3 disease, which is caused by defects in the lysosomal membrane protein CLN3, alterations in the amounts of TPP1 (27), lysosomal acid phosphatase (28) and mannose 6-phosphate-containing glycoproteins (29) in the brain have been reported. (kentlandsinitiative.org)
We found that the loss of Cln7 results in alterations in lysosomal soluble proteins under steady state conditions. (kentlandsinitiative.org)
GSD type II, also known as alpha glucosidase deficiency (GAA, acid maltase deficiency) or Pompe disease, is a prototypic lysosomal disease. (medscape.com)

POLR2K Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 81 amino acids (1-58 a.a) and having a molecular mass of 9.4kDa. (prospecbio.com)
MRRF Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 228 amino acids (56-262 a.a.) and having a molecular mass of 25.1kDa.MRRF is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. (prospecbio.com)

The natural receptor of DT, proHB-EGF is a single chain transmembrane glycoprotein of 208 amino acid residues. (org.ua)
The BSA structure is a single polypeptide chain consisting of about 583 amino acid residues and no carbohydrates. (scienceoxygen.com)
Bovine serum albumin structure and biological functions The BSA molecule consists of 583 amino acids, bound in a single chain cross-linked with 17 cystine residues (eight disulfide bonds and one free thiol group), and has a molecular mass of 66400 Da [1]. (scienceoxygen.com)

Most of our recombinant proteins are fluorescent derivatives of various DT and proHB-EGF. (org.ua)
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)

LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine, phenylalanine) amino acids. (wikipedia.org)
PTP4A2 is part of a small class of the protein tyrosine phosphatase (PTP) family. (glpbio.cn)

Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism. (medlineplus.gov)
This battery of measurements are used in the diagnosis and treatment of certain liver, heart, and kidney diseases, acid-base imbalance in the respiratory and metabolic systems, other diseases involving lipid metabolism and various endocrine disorders as well as other metabolic or nutritional disorders. (cdc.gov)

Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)
The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)
These unusual ORFs are maternally inherited, and effectively translated into novel mitochondrial proteins, with the resulting failure to produce functional pollen as the sole observed phenotype ( Chen and Liu, 2014 ). (frontiersin.org)

Proteins must be folded correctly to fulfill their molecular functions in cells. (mpg.de)
Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. (mpg.de)
Newly-synthesized proteins at the ribosomes are not yet able to fulfill their molecular functions in the cell. (mpg.de)
Nascent proteins are protected from intermolecular interactions that would hamper their folding by chaperones, molecular folding assistants. (mpg.de)
On the other hand, DT represents a very interesting molecular machine which allows using this protein in different bioengineering applications, such as ablation of certain cell types in transgenic mice, development of immunotoxins targeted for specific cell markers and also for delivery of certain proteins into the cytosol. (org.ua)
The RNA has a lower molecular mass than the DNA (deoxyribonucleic acid). (biotionary.com)
Since proteins can vary in size, the molecular mass of the mRNA also varies considerably. (biotionary.com)
Probing molecular identity of native single potassium channels by overexpression of dominant negative subunits. (ucdenver.edu)
The 678 amino acid recombinant protein has a predicted molecular mass of approximately 76 kD. (biolegend.com)

ATP synthase, alpha subunit, C-terminal [Interproscan]. (ntu.edu.sg)

These proteins take part in the fusion pathway in two consecutive steps. (centrodinoferrari.com)
Maple syrup urine disease (MSUD) is an aminoacidopathy secondary to an enzyme defect in the catabolic pathway of the branched-chain amino acids leucine, isoleucine, and valine. (medscape.com)

DT molecule is composed of two subunits: subunit A and subunit B. The A-subunit of DT is represented by a single domain - the catalytic or C-domain which modifies eEF-2. (org.ua)
English R ibo n ucleic a cid ) denotes an fromGiant molecule made up of nucleic acids. (biotionary.com)
In this study, we describe new approaches of subunit labeling for single-molecule imaging, applied to determine the TERT content of complexes assembled in cells or cell extract. (elifesciences.org)
In cell culture, it acts as a small molecule carrier. (scienceoxygen.com)
This manuscript reports the fundamental finding that an oligomeric protein kinase, CaMKII, can be phosphorylated by another molecule of the holoenzyme in a manner that does not involve subunit exchange. (elifesciences.org)

Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. (ucdenver.edu)
Receptor-like protein kinase. (or.jp)
The dodecameric protein kinase CaMKII is expressed throughout the body. (elifesciences.org)

Thus, DP-4 forms a heterodimer with E2F subunits, binds to the E2F site and associates with pocket proteins including pRb. (ox.ac.uk)
Analysis of the photo-cross-linked proteins by peptide mass fingerprinting and immunoblotting revealed that [ 125 I]AzQ specifically binds to the 49 kDa and ND1 subunits with a frequency of ∼4:1. (elsevierpure.com)
AMPA receptor variants were identified with a polyclonal antibody recognizing the conserved extracellular loop region of all four AMPA receptor subunits (GluR1-4, both flip and flop ), whereas NMDA receptors were immunolabeled with a polyclonal antibody that binds to an extracellular N-terminal epitope of the NR1 subunit, common to all splice variants. (jneurosci.org)
Because of its negative charge, Bovine Serum Albumin: Binds water, salts, fatty acids, vitamins and hormones and carries these bound components between tissues and cells. (scienceoxygen.com)
BSA stabilizes Streptococcus thermophilus beta-galactosidase against thermal inactivation and binds to the active enzyme subunits formed on heating. (scienceoxygen.com)

CATs and HATs: the SLC7 family of amino acid transporters" (PDF). (wikipedia.org)
The members of the MFS are secondary active, ion-coupled transporters of sugars, amino acids, drugs, nucleosides as well as organic and inorganic cations and anions (13). (kentlandsinitiative.org)

protein_coding" "AGT24181","N559_2495","Klebsiella pneumoniae","cytochrome C biogenesis protein transmembrane region [Ensembl]. (ntu.edu.sg)

These results highlight an emerging complexity in the DP family of E2F subunits, and suggest that DP-4 may endow E2F heterodimers with distinct transcription properties. (ox.ac.uk)

Stargazin (γ 2 ) and the closely related γ 3 , and γ 4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4-isoxazoleproponinc (AMPA) receptor regulatory proteins (TARPs). (biomedcentral.com)
When co-expressed in Xenopus oocytes with a Ca V 2.1/β 4 VDCC complex, either in the absence or presence of an α2δ 2 subunit, neither γ 2 nor γ 4 significantly modulated the VDCC peak current amplitude, voltage-dependence of activation or voltage-dependence of steady-state inactivation. (biomedcentral.com)
Whilst the fact that neither γ 2 nor γ 4 modulated the properties of a VDCC complex with which they could associate in vivo in Purkinje cells adds weight to the hypothesis that the principal role of these proteins is not as auxiliary subunits of VDCCs, it does not exclude the possibility that they play another role in VDCC function. (biomedcentral.com)

In this study, we confirmed that both GrmH and GrmL, which were shown to constitute a protein complex by a co-purification experiment, were required to catalyze the dehydration, epimerization, and proteolytic cleavage of a precursor peptide GrmA by in vivo experiments. (hokudai.ac.jp)
The S glycoprotein is synthesized as a precursor protein consisting of ~1,300 amino acids that is then cleaved into an amino (N)-terminal S1 subunit (~700 amino acids) and a carboxyl (C)-terminal S2 subunit (~600 amino acids). (biolegend.com)

MRRF controls the release of ribosome from messenger RNA at the termination of protein biosynthesis. (prospecbio.com)
a Transverse section of the cryo-EM map density (gray) of the large (60S) subunit of the yeast G2400A mutant ribosome with TEL (salmon) bound within the NPET. (ciisb.org)

This is much more complex than the chaperone-assisted protein folding that was known so far. (mpg.de)
When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. (jefferson.edu)
A mouse model of HPS bears a point mutation altering a single amino acid within the VPS33A subunit of the HOPS/CORVET endolysosomal tethering complex. (chop.edu)
The present study has revealed, for the first time, the inhibitor binding site in complex I at the sub-subunit level. (elsevierpure.com)
The IFNG signaling complex is formed by 2 IFNGR1 subunits binding one IFNG dimer directly, and then 2 IFNGR2 molecules further stabilizing the receptor complex. (rndsystems.com)
However, it is not known how many copies of the TERT protein are present in each complex. (elifesciences.org)
They can self-splice without the help of any proteins, whereas nuclear introns are spliced by the spliceosome, an RNA and protein-containing enzyme complex. (jove.com)
It is believed that BP3 is the main IGF-I binding protein, forming a ternary complex of 140,000 daltons with IGF-I and an acid-labile subunit. (scopeheal.com)
[ 5 ] The branched-chain alpha-keto acid dehydrogenase (BCKD) complex was purified and characterized in 1978. (medscape.com)
MSUD is caused by a deficiency of the BCKD complex, which catalyses the decarboxylation of the alpha-keto acids of leucine, isoleucine, and valine to their respective branched-chain acyl-CoAs. (medscape.com)
An adaptor protein subunit of MTORC2 COMPLEX. (bvsalud.org)

The anticodon, which consists of three nucleic acid bases and is complementary to the codon on the mRNA, is located in a loop of the complicated three-dimensional structure of the tRNA. (biotionary.com)
The naturally available ribozymes are known to catalyze a narrow range of reactions such as phosphoryl transfer in nucleic acids and peptide bond formation in proteins. (jove.com)

In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
The alpha isoform is responsible for synaptic plasticity and participates in memory through its phosphorylation of synaptic proteins. (elifesciences.org)

Nowadays, growing scientific interest to DT is associated with possibility of its use in medicine as a carrier protein in conjugate vaccines, a component of immunotoxin drugs, and in anticancer therapy. (org.ua)

Some enzymes are made of just one component protein that works on its own, but others are made of multiple proteins that are all required for the enzyme to work properly. (elifesciences.org)
However, many enzymes can bind to different combinations of proteins to form groups (or 'complexes') with a variety of three-dimensional shapes, so there may be a variety of enzyme complexes in the solution. (elifesciences.org)
Further experiments used a mutant form of the TERT protein that cannot interact with other TERT molecules and found that complexes that contain this mutant protein still have normal enzyme activity. (elifesciences.org)
The S1 subunit contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells. (biolegend.com)

Some neuroactive compounds are amino acids, which also have metabolic functions in the presynaptic cell. (org.es)
In the following years, Dancis et al identified the pathogenetic compounds as branched-chain amino acids and their corresponding alpha-keto acids. (medscape.com)

A functionally distinct member of the DP family of E2F subunits. (ox.ac.uk)
[8] The Tm HydS has a hydrogenase domain with distinct amino acid modifications in the active site pocket, including the presence of a Per-Arnt-Sim (PAS) domain . (eol.org)
In addition, the E1 component consists of 2 distinct subunits (ie, E1 alpha, E1 beta) that form an alpha-2 beta-2 heterotetramer. (medscape.com)

In comparison with similar proteins that build the cytoskeleton of bacteria, which are evolutionary older and simpler cells, the researchers found fundamental differences in the protein folding. (mpg.de)

The ECD of human IFNGR1 shares 50% amino acid sequence identity with mouse IFNGR1. (rndsystems.com)
Mature mouse IL-22BP consists of two tandem Fibronectin type-III domains and shares 85% and 68% amino acid sequence identity with rat IL-22BP and the short isoform of human IL-22BP, respectively (6, 14). (rndsystems.com)

Bovine Serum Albumin (BSA) is used in a variety of laboratory applications including its function as a protein concentration standard, its function as a cell nutrient and its ability to stabilize enzymes during restriction digest. (scienceoxygen.com)
The Bovine Serum Albumin Standard Bovine serum albumin (BSA) is a globular protein that is often used as a protein concentration standard in lab experiments as well as in numerous other biochemical applications. (scienceoxygen.com)
Bovine serum albumin (BSA) is a globular protein (~66 kDa MW) that is used in numerous biochemical applications due to its stability and lack of interference with biological reactions. (scienceoxygen.com)
Bovine Serum Albumin, also known as "BSA" or "Fraction V", is a protein derived from bovine blood plasma. (scienceoxygen.com)
Bovine Serum Albumin (BSA) is the standard reference for total protein quantitation by colorimetric assays. (scienceoxygen.com)
Bovine serum albumin (BSA) blocking buffer is ideal for saturating excess protein-binding sites on membranes and microplates for Western blotting and ELISA applications, respectively. (scienceoxygen.com)

Most MTTP gene mutations lead to the production of microsomal triglyceride transfer protein with reduced or absent function, preventing the formation of beta-lipoproteins. (medlineplus.gov)
Gunduz M, Ozaydin E, Atar MB, Koc N, Kirsaclioglu C, Kose G, Cefalu AB, Averna M, Tarugi P. Microsomal triglyceride transfer protein gene mutations in Turkish children: A novel mutation and clinical follow up. (medlineplus.gov)
Walsh MT, Di Leo E, Okur I, Tarugi P, Hussain MM. Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects. (medlineplus.gov)

Its elaborate subunit organization and propensity for autophosphorylation allow it to preserve neuronal plasticity across space and time. (elifesciences.org)

We found an asymmetric motion of the chaperone that is coordinated by the binding and lysis of ATP, energy-carrier molecules. (mpg.de)
Skin is generally considered as a very effective barrier for larger molecules such as polypeptides and proteins. (europa.eu)
This protein helps produce beta-lipoproteins, which are molecules that are made up of proteins (including one called apolipoprotein B), cholesterol, and particular types of fats called phospholipids and triglycerides. (medlineplus.gov)

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. (wikipedia.org)
SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. (wikipedia.org)
CLN7 belongs to a group of atypical solute carriers of MFS type which are located at the plasma membrane and/or in intracellular compartments (14). (kentlandsinitiative.org)

Expression analyses showed that the mRNA expression, biosynthesis, intracellular sorting and proteolytic processing of Cln5 were not affected, whereas the depletion of mature Cln5 protein was due to increased proteolytic degradation by cysteine proteases in Cln7 ko lysosomes. (kentlandsinitiative.org)
protein_coding" "Cz12g19130.t1","No alias","Chromochloris zofingiensis","Clp protease proteolytic subunit /Translocation-enhancing protein TepA [Interproscan]. (ntu.edu.sg)

2001). Thus, under normal conditions, systemic uptake from dermal exposure to insulin and similar proteins/ polypetides is considered to be very low / insignificant. (europa.eu)

All children are at increased risk for metabolic decompensation during periods of increased protein catabolism (eg, intercurrent illness, trauma, surgery). (medscape.com)

B-subunit is composed of two domains: receptor domain or R-domain, which is responsible for binding to cell DT receptor, and transmembrane or T-domain, which is involved in the process of C-domain transfer in the cytosol across endosomal membrane. (org.ua)

Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
c TEL bound within the NPET with the surrounding nucleotides of the 25S rRNA (gray) and His133 residue of uL22 protein (purple). (ciisb.org)

VDCCs are intrinsically involved in the regulation of a multiplicity of Ca 2+ dependent processes in many different cell types where they are inserted into the plasma membrane as hetero-oligomeric complexes of a pore-forming α 1 subunit with auxiliary β, α2δ and possibly γ subunits [ 2 ]. (biomedcentral.com)

Xenopus embryonic spinal neurons express potassium channel Kvbeta subunits. (ucdenver.edu)

TIM barrel domain, Glyoxalase/fosfomycin resistance/dioxygenase domain, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily [InterProScan]. (ntu.edu.sg)
Glycine-tRNA ligase, alpha subunit [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz05g31090.t1","No alias","Chromochloris zofingiensis","Pterin 4 alpha carbinolamine dehydratase [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz06g21140.t1","No alias","Chromochloris zofingiensis","Aldose 1-/Glucose-6-phosphate 1-epimerase [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz10g14210.t1","No alias","Chromochloris zofingiensis","DEAD/DEAH box helicase domain [Interproscan]. (ntu.edu.sg)

SARS-CoV-2 B.1.1.7 Spike Protein S1, amino acid Val16-Arg685 (Accession # QHD43416.1), with (HV69-70del, Y144del, N501Y, A570D, P681H) and a C-terminal 8-His tag was expressed in CHO cells. (biolegend.com)
Accession H0086 Systematic name Allele 1 and 2: g.1030T>A, c.2T>A, r.2u>a, p.Met1Lys Description Allele 1 and 2: A point mutation in the exon 1 leading to Description an amino acid change Date 17-Aug-2010 (Rel. (lu.se)

The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. (wikipedia.org)

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle contractions. (mpg.de)
Like all proteins, actin is "born" at the ribosomes, the protein factories of the cell, which string together amino acids into a long chain. (mpg.de)
Pigment cell-specific transmembrane proteins SLC45A2 and OCA2 are a transporter and channel, respectively, that modulate melanosome pH at different stages of melanosome maturation and that are targets of mutation in different forms of oculocutaneous albinism. (chop.edu)
Each protein in a cell is encoded by a special mRNA. (biotionary.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
In the present study, we provide quantitative proteomic data that have been obtained by mass spectrometric analysis of isolated lysosomes from Cln7 ko mouse fibroblasts by means of Stable Isotope Labelling by Amino acids in Cell culture (SILAC). (kentlandsinitiative.org)
Using subunit-specific antibodies, however, it is not possible to distinguish between the absence of AMPA receptors and the lack of a particular subunit on the cell surface. (jneurosci.org)
Somatomedins are a group of proteins that promote growth and cell division in response to stimulation by growth hormone (GH), also known as somatotropin (STH). (scopeheal.com)
The coronavirus spike (S) glycoprotein is a class I viral fusion protein on the outer envelope of the virion that plays a critical role in viral infection by recognizing host cell receptors and mediating fusion of the viral and cellular membranes. (biolegend.com)
The human γ 2 , γ 3 and γ 4 stargazin-like proteins are detected only in the CNS and display differential distributions among brain regions and several cell types in found in the cerebellum and hippocampus. (biomedcentral.com)

GTP-Binding Protein alpha Subunits" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems. (jefferson.edu)
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "GTP-Binding Protein alpha Subunits" by people in Profiles. (jefferson.edu)
Defects in the SCN2A gene which codes for the alpha subunit of this sodium channel are associated with benign familial infantile seizures type 3, and early infantile epileptic encephalopathy type 11. (rush.edu)
Defects in the SCN9A gene, which codes for the alpha subunit of this sodium channel, are associated with several pain sensation-related disorders. (ucdenver.edu)
The alpha-1 subunit is the binding site for calcium-based antagonists. (uams.edu)
The ATP1B2 protein is composed of 3 subunits: alpha (catalytic), beta and gamma. (neuromics.com)

AMPA receptors are composed of four subunits, GluR1-4. (jneurosci.org)

Neither lactic acid nor H2O2 production by Lj 62B was responsible for this effect. (bvsalud.org)
The purpose of the research paper was firstly to identify bacteriocin-producing lactic acid bacteria characterizing strains with anti-listeria activity and, secondly, to characterize bacteriocin evaluating its in vitro efficiency as a natural preservative and, thirdly, to evaluate the anti-listeria effect of the bacteriocinogenic strain of Lactiplantibacillus plantarum in cheeses and produce an edible film with anti-listerial effect. (bvsalud.org)
Of 355 lactic acid bacteria strains tested, two were able to produce bacteriocin against Listeria monocytogenes and were identified as Lactiplantibacillus plantarum and Lactiplantibacillus pentosus. (bvsalud.org)
When oxygen is limited, as in muscles that have undergone prolonged exercise, pyruvate is not consumed in the TCA cycle but is rather converted into lactic acid by lactate dehydrogenase (LDH) in a process termed anaerobic glycolysis. (hindawi.com)

The increase in TMEM106B levels with ageing was specific to carriers of the rs1990622-A allele in the TMEM106B gene that increases risk for frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and hippocampal sclerosis with ageing. (biomedcentral.com)
The MTTP gene provides instructions for making a protein called microsomal triglyceride transfer protein. (medlineplus.gov)

Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. (mpg.de)
The actin amino acid chain (center) gets folded into the mature 3D-structure inside the cavity of the chaperonin TRiC. (mpg.de)
Researchers from the department "Cellular Biochemistry" of MPIB director F.-Ulrich Hartl have now revealed the unique non-folding properties of the universal protein actin. (mpg.de)
Unlike all previously studied proteins, actin cannot acquire its fold in absence of the chaperonin TRiC. (mpg.de)
Actin has many more protein interaction partners than the bacterial cytoskeletal proteins, but it has lost the ability to fold independently. (mpg.de)
The co-evolution of TRiC and actin has allowed actin to "out-source" the responsibility for protein folding to the chaperonin. (mpg.de)
The researchers solved the protein structure of TRiC to study its function and found that it has a special mode of action for actin folding. (mpg.de)
These subunits form a cavity inside which actin gets folded. (mpg.de)
The study of actin is the first description of a non-folder protein. (mpg.de)
Hartl further adds, "Actin is just one example of a protein that gets folded by TRiC, albeit a very prominent one. (mpg.de)
Mechanical forces driving the constriction are attributed to myosin motor proteins, which slide actin filaments along each other. (ciisb.org)

NMDA receptors comprise the essential NR1 subunit and one or more of the modulatory NR2 subunits, NR2A-D ( Hollmann and Heinemann 1994 ). (jneurosci.org)

The lab is using a number of approaches to define the SNAREs involved in fusion of BLOC-1-dependent carriers with maturing melanosomes and to understand how their localization and activity are regulated. (chop.edu)

The sequence encoded a novel protein rich in alanine (25%) and proline (20%), which contained regions similar to proteins of comparable amino acid composition such as extracellular matrix components or the membrane-cytoskeletal linker synapsin. (lookformedical.com)

The fundamental question of whether human telomerase catalytic activity requires cooperation across two TERT subunits remains under debate. (elifesciences.org)

In prokaryotes there is a special feature insofar as a single, so-called polycistronic mRNA, can serve as a template for several proteins. (biotionary.com)

Polymerase (RNA) II (DNA directed) Polypeptide K, also known as POLR2K is am ember of the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (prospecbio.com)
Somatomedin-C (SM-C), or insulin-like growth factor I (IGF-I), is a simple 70-amino acid basic chain polypeptide similar to proinsulin (50% sequence homology) and the other member Well-characterized of the somatomedin family: IGF II (67AA, 70% sequence homology with IGF-I). (scopeheal.com)
Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22 RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). (rndsystems.com)
This protein family is largely expanded in land plant genomes. (frontiersin.org)
The PPR protein family is consequently divided in subfamilies depending on the number and type of repeats present in their sequence as well as optional C-terminal domains. (frontiersin.org)

The subunits of the ribosomes contain four different types of RNA as structural components, which differ in size and were originally divided according to their sedimentation behavior (their sinking speed in the ultracentrifuge): In eukaryotes these are 28 S, 18 S, 5.8 S and 5 S rRNA (S = Svedberg unit of sedimentation). (biotionary.com)

The tRNA serves as a carrier of the amino acids on the growing protein chain during protein biosynthesis on the ribosomes. (biotionary.com)

95%) of serum IGF-I circulates bound to specific growth factor binding proteins, of which six classes are now recognized (IGF-BPs 1-6). (scopeheal.com)

Various flavoproteins and iron-sulphur proteins have been identified as potential electron carriers for use during cellular respiration. (eol.org)

A serum albumin test measures the amount of this protein in the clear liquid portion of the blood. (scienceoxygen.com)
The "self"-protein albumin in mouse airway fluid was uniquely modified by GSH-MDI at position 414K, a preferred site of MDI reactivity on human albumin. (cdc.gov)

Neuroactive glutamate is classified as an excitatory amino acid (EAA) because glutamate binding onto postsynaptic receptors typically stimulates, or depolarizes, the postsynaptic cells. (org.es)

Author Manuscript not ) subunit. (cdc.gov)

Anatomy5

Organisms7

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes46

Information Science4

Health Care2

Peptides6

Beta subunit1

Synthesis5

Genes10

Ribosomal2

Lysosomal9

Human Recombinant2

Residues3

Recombinant proteins2

Tyrosine2

Metabolism2

Mitochondrial4

Molecular9

Synthase1

Pathway2

Molecule5

Kinase3

Binds5

Transporters2

Cytochrome1

Heterodimers1

VDCC3

Precursor2

Ribosome2

Complex11

Nucleic2

Phosphorylation2

Drugs1

Enzyme4

Compounds2

Distinct3

Cytoskeleton1

Sequence identity2

Bovine Serum A6

Mutations3

Neuronal1

Molecules3

Solute3

Proteolytic2

Similar proteins1

Increased protein catabolism1

Cytosol1

Nucleotides2

Auxiliary1

Neurons1

InterProScan5

Accession2

Heterodimer1

Cell10

Alpha8

AMPA1

Lactic acid4

Gene2

Actin11

Comprise1

Localization1

Extracellular1

Catalytic activity1

MRNA1

Family5

RRNA1

TRNA1

Bound1

Electron1

Albumin2

Glutamate1

Manuscript1