Subtype receptors adrenergic alpha 1. Medical search. Frequent questions

Other effects on smooth muscle are contraction in: Ureter Uterus (when pregnant): this is minor compared to the relaxing effects of the β2 receptor, agonists of which-notably albuterol/salbutamol-were formerly[citation needed] used to inhibit premature labor. (wikipedia.org)
These include agonists capable of selectively activating β1-, β2- or β3-adrenoceptors, as well as antagonists selective for each of the three subtypes. (sigmaaldrich.com)
beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. (duke.edu)
The regional and subtype selectivity are compatible with primary deficits in the development of noradrenergic projections to the cerebellum identified in previous studies and provide further evidence that therapeutic use of beta-adrenergic agonists may produce neurobehavioral teratology. (duke.edu)
These observations suggest that LSD and other indole hallucinogens may act as 5-HT2 agonists at postsynaptic 5-HT2 receptors. (erowid.org)
Alpha-2 agonists often have a sedating effect and are commonly used as anesthesia enhancers in surgery, as well as in treatment of drug or alcohol dependence . (wikipedia.org)
alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines. (nih.gov)
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds. (nih.gov)
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. (rndsystems.com)
Interrelationship between alpha- and beta-adrenergic agonists and histamine in canine airways. (uchicago.edu)

284 AB - Alpha-1 adrenergic stimulation modulates ventricular automaticity via an alpha-1 adrenoceptor (AR) subtype blocked by the alpha-1B antagonist chloroethylclonidine (CEC) and alters repolarization via receptor subtype(s) (alpha-1A and alpha-1D) blocked by WB4101. (aspetjournals.org)
Indoramin is an alpha-1 selective antagonist of adrenergic receptor, sold under trade names Baratol and Doralese, and now available as a generic. (ncats.io)
Prokinetic effect of indoramin, an alpha-adrenergic antagonist, on human gall-bladder. (ncats.io)
Specially, Flomax is a selective antagonist of alpha-1 adrenergic receptors, particularly the alpha-1A subtype. (hellopharmacist.com)
RAPAFLO is the brand name for silodosin, a selective antagonist of alpha-1 adrenoreceptors. (globalrph.com)
Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. (globalrph.com)
RAPAFLO, an alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). (globalrph.com)
The properties of four aryl piperazine compounds (RWJ-38063, RWJ-68141, RWJ-68157, and RWJ-69736) are described in this report and compared with the properties of tamsulosin, an alpha(1)-AR antagonist that is used in the treatment of BPH. (bvsalud.org)
The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. (research.com)

β-Adrenoceptor antagonists, either non subtype-selective or selective for the β1-adrenoceptor, are widely used as antihypertensives, although the mechanism for this action is still not clearly understood. (sigmaaldrich.com)
Alpha antagonists and intraoperative floppy iris syndrome: A spectrum. (ncats.io)
Competitive neuromuscular blocking drugs act as antagonists at acetylcholine receptors, reducing the effectiveness of acetylcholine in generating an end-plate potential . (britannica.com)
Scholars@Duke publication: In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia. (duke.edu)
alpha(1) Adrenergic receptors mediate both vascular and lower urinary tract tone, and alpha(1) receptor antagonists such as terazosin (1b) are used to treat both hypertension and benign prostatic hyperplasia (BPH). (duke.edu)
This paper explores 4-aryldihydropyrimidinones attached to an aminopropyl-4-arylpiperidine via a C-5 amide as selective alpha(1A) receptor subtype antagonists. (duke.edu)
The development of alpha(1a)-adrenergic receptor (AR) subtype-selective antagonists is likely to result in uroselective agents that effectively treat benign prostatic hyperplasia (BPH) symptoms without causing undesirable side effects that may be due to vascular alpha(1)-AR blockade. (bvsalud.org)

Most β-adrenoceptor mediated actions involve stimulation of adenylyl cyclase via interaction of the agonist-receptor complex with G s . (sigmaaldrich.com)
Three β-adrenoceptor proteins have been cloned, and the characteristics of these recombinant receptors correspond with those of the three well characterized β-adrenoceptors on native tissues, designated as β1, β2 and β3. (sigmaaldrich.com)
While it was initially thought that cardiac stimulation involved primarily the β1-adrenoceptor, it now appears that all of the receptor subtypes may be involved. (sigmaaldrich.com)
Carvedilol, a molecule combining nonselective β-adrenoceptor blockade with α 1 -adrenoceptor blockade, has recently been shown to produce a dramatic reduction in the mortality/morbidity associated with congestive heart failure. (sigmaaldrich.com)
Effect of cyproterone acetate on alpha1-adrenoceptor subtypes in rat vas deferens. (ncats.io)
The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it. (meltingpointathens.com)
Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines. (nih.gov)

There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. (nih.gov)
Recently, three different subtypes of this receptor have been identified, with the alpha(1A) receptor being most prevalent in lower urinary tract tissue. (duke.edu)

A pharmacological profile of the methylenedioxy-substituted amphetamine derivatives indicates that MDMA and MDA exhibited highest affinity for serotonin uptake sites, 5-HT2 serotonin, alpha 2-adrenergic and M-1 muscarinic receptors. (erowid.org)
Acetylcholine released from cholinergic nerve endings, contracts the smooth muscle of bladder body via activation of muscarinic receptors to cause voiding. (scirp.org)
Salivary seromucous glands are regulated predominantly by parasympathetic activation of muscarinic receptors, resulting in exocrine secretion of mucins and macroglobulin responsible by lubrication and protection of oral mucosa 3-4 . (bvsalud.org)

Unlike 2,5-DMA derivatives, MDMA and MDA demonstrated little selectivity for 5-HT2 versus 5-HT1 subtypes of receptors. (erowid.org)
Due to its selectivity for the alpha(1a) over the alpha(1b) and alpha(1d) receptors as well as its favorable pharmacokinetic profile, 48 has the potential to relieve the symptoms of BPH without eliciting effects on the cardiovascular system. (duke.edu)
Radioligand binding studies show that all four RWJ compounds have significantly higher affinity for the alpha(1a)-AR subtype than for the alpha(1b) or alpha(1d) subtype and display a higher level of receptor subtype selectivity than tamsulosin. (bvsalud.org)

α1-receptors primarily mediate smooth muscle contraction, but have important functions elsewhere as well. (wikipedia.org)
Forray , C et al "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (aspetjournals.org)
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. (ncats.io)
When activated, the α1 receptor triggers smooth muscle contraction in blood vessels in the skin, gastrointestinal tract, kidney, and brain, among other areas. (meltingpointathens.com)
The α 1 adrenergic receptor stimulates phosphatidylinositol turnover and increased diacylglycerol activates protein kinase C, while increased inositoltrisphosphate mobilize Ca 2+ to cause smooth muscle contraction. (scirp.org)

To avoid confusion, naming was continued with the letter D. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α1-adrenergic receptors in the central and peripheral nervous systems. (wikipedia.org)
The neurotransmitter norepinephrine has higher affinity for the α1 receptor than does the hormone adrenaline. (wikipedia.org)
In particular, norepinephrine decreases glutamatergic excitatory postsynaptic potentials by the activation of α1-adrenergic receptors. (wikipedia.org)
Norepinephrine also stimulates serotonin release by binding α1-adrenergic receptors located on serotonergic neurons in the raphe. (wikipedia.org)
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. (thermofisher.com)
Regardless of how and where it is released, norepinephrine acts on target cells by binding to and activating adrenergic receptors located on the cell surface. (wikipedia.org)
What receptor does norepinephrine bind to? (meltingpointathens.com)
Norepinephrine can then go on to bind three main receptors: alpha1 (alpha-1), alpha-2, and beta receptors. (meltingpointathens.com)
These receptors classify as G-protein coupled receptors with either inhibitory or excitatory effects and different binding affinities to norepinephrine. (meltingpointathens.com)
Norepinephrine released from adrenergic nerve endings, relaxes bladder body by increasing intracellular cAMP via β-adrenergic receptors widely expressed in the bladder body, and contracts bladder base and proximal urethra via α-adrenergic receptors to prevent premature bladder emptying. (scirp.org)

Alpha1 adrenergic receptors are a type of adrenergic receptors that play a central role in the sympathetic nervous system-the part of the nervous system that increases heart rate, blood pressure, breathing rate, and eye pupil size. (meltingpointathens.com)

294(1): 224-9, 2000 Jul. (bvsalud.org)
200(1): 16-26, 2000 Feb 25. (bvsalud.org)

In smooth muscle cells of blood vessels the principal effect of activation of these receptors is vasoconstriction. (wikipedia.org)
In contrast to α2-adrenergic receptors, α1-adrenergic-receptors in the arterial vasculature of skeletal muscle are more resistant to inhibition, and attenuation of α1-adrenergic-receptor-mediated vasoconstriction only occurs during heavy exercise. (wikipedia.org)
Do beta-1 receptors cause vasoconstriction? (meltingpointathens.com)
Epinephrine binds both α and β adrenergic receptors to cause vasoconstriction and vasodilation. (meltingpointathens.com)

During exercise, α1-adrenergic receptors in active muscles are attenuated in an exercise intensity-dependent manner, allowing the β2-adrenergic receptors which mediate vasodilation to dominate. (wikipedia.org)
These studies demonstrate that beta(1)-adrenergic receptors play a dominant role in the murine vascular system to mediate vasodilation. (meltingpointathens.com)

Are beta receptors G-protein? (meltingpointathens.com)
Do beta receptors cause vasodilation? (meltingpointathens.com)

Cardiac alpha (α)1-ARs have received less attention, however data from cell and animal studies indicate that they protect against the development of HF. (unc.edu)
Dr. Beak discovered that the orphan nuclear receptor, RORα, is expressed in the mouse and human heart and mediates cardiac hypertrophy in response to angiotensin II. (unc.edu)
It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue. (meltingpointathens.com)

Derivatives of 2,5-DMA exhibited preferential high affinity at 5-HT2 serotonin receptors when compared to their relative affinities at 5-HT1 serotonin receptors. (erowid.org)
Furthermore, 2,5-DMA derivatives exhibited agonist-like binding characteristics at 5-HT2 serotonin receptors with the R(-) isomer being the more potent isomer. (erowid.org)
There were significant correlations between the in vitro affinities of 2,5-DMA derivatives at 5-HT2 serotonin receptors and their human hallucinogenic potencies as well as with their potencies in behavioral generalization studies, suggesting the importance of 5-HT2 serotonin receptors in mediating the hallucinogenic effects of the various 2,5-DMA derivatives. (erowid.org)
The methylenedioxy amphetamine derivatives exhibited an inverse stereospecificity with respect to serotonin uptake sites versus postsynaptic 5-HT receptors with the S(+) isomer being more potent at the presynaptic recognition site, while the R(-) isomer was more potent at the postsynaptic recognition sites. (erowid.org)
Similar to the 2,5-DMA derivatives, MDMA and MDA exhibited agonist-like binding characteristics at 5-HT2 serotonin receptors. (erowid.org)
The relatively weak hallucinogenic effects of the methylenedioxy-substituted amphetamine derivatives (when compared to the 2,5-DMA derivatives) may be mediated through actions at 5-HT2 serotonin receptors. (erowid.org)
In addition, the neurotoxic, psychotomimetic, analgesic, temperature regulation, and mood-altering effects of MDMA and other methylenedioxy-substituted derivatives may be mediated, in part, through their actions at other serotonin recognition sites in brain, including serotonin uptake sites and 5-HT1A serotonin receptors. (erowid.org)

Urethral sphincter Bronchioles (although minor to the relaxing effect of β2 receptor on bronchioles) Iris dilator muscle Seminal tract, resulting in ejaculation Activation of α1-adrenergic receptors produces anorexia and partially mediates the efficacy of appetite suppressants like phenylpropanolamine and amphetamine in the treatment of obesity. (wikipedia.org)

It binds to these receptors, which are found on the smooth muscle cells of the prostate, bladder neck, and urethra. (hellopharmacist.com)
The results of the study demonstrated that silodosin binds with high affinity to the alpha-1A subtype. (globalrph.com)

Prazosin (1-100 nM) did not change either the inhibitory effect of UK-14,304 or the facilitatory effect of CEC. (unesp.br)
Alternatively, one can admit that CEC is able to inhibit alpha-2 autoreceptors, which causes an increase of the transmitter release, and to activate a nonadrenergic inhibitory receptor thus causing a reduction of the transmitter release. (unesp.br)
EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. (research.com)
Depending on the receptor, the response may be excitatory or inhibitory. (msdmanuals.com)

It also induces contraction of the internal urethral sphincter of the urinary bladder, although this effect is minor compared to the relaxing effect of β2-adrenergic receptors. (wikipedia.org)
When beta-1 receptors are stimulated they increase the heart rate and increase the heart's strength of contraction or contractility. (meltingpointathens.com)
Because this mechanism is relatively insensitive to drug action, the most important group of drugs that affect the neuromuscular junction act on (1) acetylcholine release, (2) acetylcholine receptors, or (3) the enzyme acetylcholinesterase (which normally inactivates acetylcholine to terminate muscle fibre contraction). (britannica.com)
The muscarinic receptor-mediated contraction of smooth muscle is induced by activation of protein kinase C and by increased intracellular Ca 2+ . (scirp.org)

Other behavioral, cardiovascular, and toxic effects of MDMA and related derivatives may be mediated by actions at other central and/or peripheral recognition sites, including muscarinic cholinergic receptors and alpha 2-adrenergic receptors, for which these compounds exhibit relatively high affinity. (erowid.org)

The IUPHAR compendium of receptor characterization and classification. (sigmaaldrich.com)
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)

The beta 1 receptor is vital for the normal physiological function of the sympathetic nervous system. (meltingpointathens.com)
Briefly, following receptor stimulation, activated Gs leads to stimulation of adenylyl cyclase and the generation of intracellular cAMP which induces further downstream signaling responsible for the physiological actions of beta1 receptor activation. (meltingpointathens.com)
Physiological antagonism caused by adrenergic stimulation of canine tracheal muscle. (uchicago.edu)

To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)
In such cases, the dendrites (a neuron's receiving branches) on the postsynaptic neurons release neurotransmitters that affect receptors on the presynaptic neurons. (msdmanuals.com)
1. Lindvall, O., Björklund, A.: The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons. (lu.se)

α1-Adrenergic receptors are members of the G protein-coupled receptor superfamily. (wikipedia.org)
His study of G protein-coupled receptor is a part of Receptor. (research.com)
His G protein-coupled receptor research is multidisciplinary, incorporating perspectives in PELP-1 and Immune receptor. (research.com)

radioligand binding to various subtypes of serotonergic (5-HT 1A , 5-HT 2A , 5HT 6 , 5HT 7 ), adrenergic (alpha 1 and alpha 2 ), and dopaminergic (D 1 and D 2 ) receptors. (medchem-ippas.eu)

alpha-1 (α1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the Gq heterotrimeric G protein. (wikipedia.org)

Through various cellular signaling mechanisms, hormones and medications activate the beta-1 receptor. (meltingpointathens.com)
A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. (rndsystems.com)

A-61603, a potent α 1 -adrenergic receptor agonist, selective for the α 1A receptor subtype. (rndsystems.com)

A dosage regimen of lysergic acid diethylamide (LSD) that reliably produces behavioral tolerance in rats was evaluated for effects on neurotransmitter receptor binding in rat brain using a variety of radioligands selective for amine receptor subtypes. (erowid.org)
The signal may stimulate or inhibit the receiving cell, depending on the neurotransmitter and receptor involved. (msdmanuals.com)

Despite the absence of body or brain growth impairment, selective increases were seen postnatally in cerebellar alpha 1- and alpha 2-receptor subtypes, whereas the same receptor populations were decreased by small amounts in cerebral cortex and midbrain + brainstem. (duke.edu)
Binding of indoramin to alpha1 receptors was studied using rat cerebral cortex membranes with [3H]prazosin to label alpha1 adrenoreceptors. (ncats.io)

At present, he and his group are investigating the distribution of adrenergic, muscarinic and endothelin receptors in the lower urinary tract of rats and rabbits. (yale.edu)

However, in contrast to the prejunctional α 2 -adrenoceptors, these prejunctional receptors do not appear to have major physiologic significance. (sigmaaldrich.com)
The present study was undertaken to look for the effect of chloroethylclonidine (CEC) on prejunctional alpha-2 autoreceptors of the canine saphenous vein. (unesp.br)

The contractile mechanism of skeletal muscles entails the binding of acetylcholine to nicotinic receptors on the membranes of muscle fibres. (britannica.com)
This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)

The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)
On the other hand, adrenergic activity is inhibited in this phase, leading to relax proximal urethra for voiding. (scirp.org)

Heart failure (HF) is characterized by markedly elevated levels of catecholamines that bind to adrenergic receptors (ARs) in the heart. (unc.edu)
Neurotransmitters that are released bind to receptors on another neuron. (msdmanuals.com)
Neurotransmitters diffuse across the synaptic cleft and bind briefly to specific receptors on the adjoining neuron or effector cell. (msdmanuals.com)

In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regions of the offspring. (duke.edu)
In contrast, a selective α-adrenergic agonist phenylephrine, elicited greater contractions both in the aged body and trigone than those in young rats. (scirp.org)
Methods: Healthy rats (n=32) were divided into 4 groups: untreated-control, astaxanthin-treated (1 mg/kg body weight- BW), fish oil-treated (10 mg EPA/kg BW and 7 mg DHA/kg BW), and fish oil plus astaxanthin-treated. (bvsalud.org)

The Beta1 Receptor is a generally excitatory GPCR connected to the Gs G-protein. (meltingpointathens.com)

Prostaglandin E 1 also dilates blood vessels, and it is sometimes administered by intravenous infusion to treat peripheral vascular disease . (britannica.com)
Neuropathological changes shared by aged dogs and humans: Changes in brain pathology that aged dogs share with aged humans with a diagnosis of one form of human dementia (Alzheimer's disease) include (1) thickening of the meninges and dilation of the ventricles, (2) age-related gliosis, (3) vascular changed, (4) diffuse plaques, and (5) amyloid deposition. (vin.com)

An in vitro study examining binding affinity of silodosin to the three subtypes of the alpha-1 adrenoreceptors (alpha-1A, alpha-1B, and alpha-1D) was conducted. (globalrph.com)

Evidence for two subtypes of alpha adrenergic receptors in canine airway smooth muscle. (uchicago.edu)

Anti-sialogue (anticholinergic) - reduces salivary and GIT secretions (pre-operative prep) due to widespread location of autonomic receptors side effects are common which both the clinician and patient should be aware of. (emedsa.org.au)

Pretreatment with chlorethylclonidine, which selectively alkylates the alpha-1B subtype, did not affect the Emax value of phenylephrine-induced contractions, but significantly shifted the curve to the right. (aspetjournals.org)
In order to elucidate the mechanism of functional changes in aged rat urinary bladder, we studied the influence of senescence on, 1) the α-adrenergic contractile response to phenylephrine in the urinary bladder body and trigone, 2) the muscarinic contractile response to carbachol in the body and trigone. (scirp.org)

In conclusion, in the setting of betaadrenergic blockade, an alpha-1B receptor appears responsible for the alpha-1 adrenergic decrease in heart rate and facilitation of vagal responsiveness. (aspetjournals.org)
Blockade of these alpha-1 adrenoreceptors can cause smooth muscle in these tissues to relax, resulting in an improvement in urine flow and a reduction in BPH symptoms. (globalrph.com)

Receptor-activated G proteins are bound to the inner surface of the cell membrane. (meltingpointathens.com)

These antibodies target beta-1 Adrenergic Receptor in Human, Mouse, Rat and Non-human primate samples. (thermofisher.com)

The beta-2 receptors are located in the bronchioles of the lungs and the arteries of the skeletal muscles. (meltingpointathens.com)

In order to elucidate the mechanisms of age-related changes in urinary bladder function, we studied the influence of aging on the contractile response to muscarinic and α-adrenergic stimulation, and on the binding characteristics of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB) to muscarinic cholinoceptors, in addition to histological examination in rat urinary bladder. (scirp.org)

"Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain" Neuropsychopharmacology . (erowid.org)

Functional characterisation of alpha(1)-adrenoceptors in denervated rat vas deferens. (ncats.io)

Beta blockers , which counter some of the effects of noradrenaline by blocking their receptors, are frequently used to treat glaucoma , migraine , and a range of cardiovascular problems. (wikipedia.org)
Alpha blockers , which counter a different set of noradrenaline effects, are used to treat several cardiovascular and psychiatric conditions. (wikipedia.org)

How does beta-1-adrenergic dysfunction affect the G-protein receptor? (meltingpointathens.com)

Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. (thermofisher.com)

Agonists10

Antagonist9

Antagonists7

Adrenoceptor7

Different subtypes2

Muscarinic receptors3

Selectivity3

Smooth muscle contraction5

Norepinephrine10

Alpha1 adrenergic1

20002

Vasoconstriction4

Mediate vasodilation2

Beta receptors2

Cardiac3

Serotonin7

Mediates1

Binds2

Inhibitory4

Contraction4

Compounds1

Characterization2

Physiological3

Neurons3

Protein-coupled receptor3

Serotonergic1

GPCRs1

Signaling2

Potent1

Neurotransmitter2

Cerebral cortex2

Lower urinary tract1

Prejunctional2

Membranes2

Urethra2

Bind3

Rats3

Excitatory1

Vascular2

Affinity1

Canine1

Autonomic1

Phenylephrine2

Blockade2

Proteins1

Human1

Skeletal1

Characteristics1

Selectively1

Functional1

Noradrenaline2

Dysfunction1

Pharmacological1