• The translocation t(11;14)(q13;q32) is considered the precipitating oncogenic event that induces cell cycle deregulation in mantle cell lymphoma due to overexpression of cyclin D1 . (wikidoc.org)
  • This translocation juxtaposes the CCDN1 gene encoding cyclin D1 to the immunoglobulin heavy chain (IgH) leading to its overexpression. (wikidoc.org)
  • The phenotype and genetic abnormalities of DLBCL with cyclin D1 overexpression can be complex and may be difficult to differentiate from blastoid and pleomorphic variants of mantle cell lymphoma. (biomedcentral.com)
  • Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphoma characterized by the t(11;14) (q13;q32) translocation leading to the overexpression of cyclin D1. (elsevierpure.com)
  • Mantle cell lymphoma (MCL) is a type of peripheral B-cell non-Hodgkin's lymphoma characterized by constitutive cyclin D1 overexpression leading to cell-cycle dysregulation and disruption of DNA damage repair. (bloodjournal.ru)
  • However, compared to normal ovarian tissues, overexpression of cyclin D1 and c-Myc was observed in 42.6% (20/47) and 65.9% (31/47) of tumors examined, respectively. (bmj.com)
  • There was no significant difference of overexpression of cyclin D1 or c-Myc gene products between these four histologic subtypes of ovarian adenocarcinomas. (bmj.com)
  • Finally, we discuss the effects of CCN5 expression on yet another aggressive breast cancer subtype, characterized by HER2 overexpression. (ku.edu)
  • They showed the upregulation of p63 target genes, the enrichment for TP53 and RB1 mutations, and overexpression of CD49, Cyclin B1, and EGFR. (johnshopkins.edu)
  • Previously, Slamon and researchers at the Jonsson Cancer Center demonstrated that adding ribociclib, a cyclin-dependent kinase inhibitor, to the standard hormone therapy improves overall survival in both premenopausal and postmenopausal women with metastatic HR positive/HER2 negative breast cancer. (nepalnews.com)
  • Background: p16 is a cyclin-dependent kinase inhibitor and a cardinal regulator of the cell cycle. (bvsalud.org)
  • P27 is a cyclin-dependent kinase inhibitor that negatively regulates cell proliferation. (springeropen.com)
  • P27 is a cyclin-dependent kinase inhibitor (CKI) that controls protein synthesis during the cell cycle. (springeropen.com)
  • This leads to stabilization and nuclear localization of FOXO3A resulting in transcriptional activation of the cyclin-dependent kinase inhibitor P27KIP1. (ku.edu)
  • Using antisense RNA, Dr. Pestell's group was the first to show that cyclin D1 drives mammary tumor growth in vivo. (sciencedaily.com)
  • Well differentiated (WDLPS), also known as atypical lipomatous tumor (ALT), and dedifferentiated liposarcomas (DDLPS) are the most common subtypes. (sarcomahelp.org)
  • Moreover, the relationship between p16 expression and age, tumor size, carcinoma subtype, tumor grade, and lymph node involvement was investigated in the tumor group. (bvsalud.org)
  • Overall, our consensus hierarchical clustering approach identified robust tumor expression subtypes, and our subsequent integrative analysis of genomics, proteomics, and CRISPR screening data revealed subtype-specific biology and vulnerabilities. (getzlab.org)
  • Methods We analyzed genomic expression profiles of bladder cancer in three cohorts of fresh frozen tumor samples: MD Anderson (n = 132), Lund (n = 308), and The Cancer Genome Atlas (TCGA) (n = 408) to validate the expression signatures of luminal and basal subtypes and relate them to clinical follow-up data. (johnshopkins.edu)
  • In this cohort study with 1575 Black female breast cancer survivors aged 20 to 75 years at diagnosis, African genetic ancestry was more strongly associated with tumor subtype than mortality. (cdc.gov)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • Slamon also led the discovery program that found that cyclin-dependent kinase inhibitors are effective in treating hormone receptor positive breast cancer. (nepalnews.com)
  • These lung adenocarcinoma expression subtypes and their biomarkers could help identify patients likely to respond to CDK4/6, MET, or PD-L1 inhibitors, potentially improving patient outcome. (getzlab.org)
  • 1 Although endocrine therapies are typically used to treat the disease, many patients develop resistance to first-line cyclin-dependent kinase 4/6 inhibitors and estrogen receptor-targeting treatments, which emphasizes the need for superior endocrine therapy-based options. (pharmaceuticalcommerce.com)
  • Compared to lower subtype selectivity of CDK2 ATP-competitive inhibitors, CDK2 allosteric inhibitor with higher subtype selectivity has been used to treat CDK2-related diseases. (mdpi.com)
  • In ER+ cancer cells, PIP5K1α acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of target genes including cyclin D1 and CDK1. (lu.se)
  • Genetic causes of MCPH subtypes 1-7 include mutations in genes encoding microcephalin, cyclin-dependent kinase 5 regulatory associated protein 2 (CDK5RAP2), abnormal spindle-like, microcephaly associated protein (ASPM), centromeric protein J (CENPJ), and SCL/TAL1-interrupting locus (STIL) as well as linkage to the two loci 19q13.1-13.2 and 15q15-q21. (nih.gov)
  • To promote progression towards DNA replication, CDK/cyclin complexes phosphorylate proteins required for the activation of genes involved in DNA synthesis, as well as components of the DNA replication machinery. (unibas.ch)
  • Delas A, Sophie D, Brousset P, Laurent C. Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature. (bloodjournal.ru)
  • 1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest" . (wikidoc.org)
  • SOX11 , a SOX family transcription factor , has recently been identified as an important molecular feature of MCL regardless of cyclin D1 status. (wikidoc.org)
  • Based on these clinical observations there is a crucial need to better understand the underlying molecular mechanisms driving these two distinct LPS subtypes. (sarcomahelp.org)
  • Identification of specific molecular subtypes can lead to better drug design and improved patient outcomes by predicting optimal therapeutic strategies. (fredhutch.org)
  • Diffuse large B-cell lymphoma, NOS (DLBCL), is a heterogeneous group of lymphomas with many morphologic and immunophenotypic variants and molecular subtypes. (biomedcentral.com)
  • Background It has been suggested that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to chemotherapy. (johnshopkins.edu)
  • Findings Bladder cancers could be assigned to two candidate intrinsic molecular subtypes referred to here as luminal and basal in all of the datasets analyzed. (johnshopkins.edu)
  • The immunohistochemical expressions of only two markers, luminal (GATA3) and basal (KRT5/6), were sufficient to identify the molecular subtypes of bladder cancer with over 90% accuracy. (johnshopkins.edu)
  • Interpretation The molecular subtypes of bladder cancer have distinct clinical behaviors and sensitivities to chemotherapy, and a simple two-marker immunohistochemical classifier can be used for prognostic and therapeutic stratification. (johnshopkins.edu)
  • The National Cancer Institute (Bethesda, MD) has outlined four molecular subtypes of the disease. (biotechprimer.com)
  • SOX11 over-expression is reported in over 90% of mantle cell lymphomas (MCL), including the rare cyclin D1 negative cases. (nordiqc.org)
  • Currently the only diagnostic application is verification of mantle cell lymphomas, particularly the rare cyclin D1 negative cases. (nordiqc.org)
  • SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. (nordiqc.org)
  • A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. (biomedcentral.com)
  • Our data indicate that the subtype 2 receptor-mediated antiproliferative effect of SRIH on TT cell proliferation may be exerted through a decrease in cyclin D1 levels. (unife.it)
  • These events were associated with a decrease in cyclin D1 and Bcl-X L , and an increase in accumulation of acetylated histone H3, acetylated α-tubulin, and Noxa in cell lines. (elsevierpure.com)
  • Dr. Pestell and colleagues developed transgenic mice that could induce cyclin D1 expression in the breast and examined cells with cyclin D1 gene deleted. (sciencedaily.com)
  • Because the cyclin D1 gene has been implicated in a variety of other human cancers these findings may have broad implications for processing of non coding RNA in human tumorigenesis. (sciencedaily.com)
  • Duplication of CCND1 gene was attributed to some of the cases with cyclin D1 expression. (biomedcentral.com)
  • The underlying mechanism for cyclin D1 expression was due to an abnormal gene rearrangement involving BCL-6 and CCND1, which was different from most reported cases. (biomedcentral.com)
  • Subtype 4 (S4)-associated cell lines exhibited specific vulnerability to loss of CDK6 and CDK6-cyclin D3 complex gene (CCND3). (getzlab.org)
  • Each subtype is categorized by cancer's hormone receptor (HR) status and the level of expression from the HER2 gene. (biotechprimer.com)
  • These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)
  • In this study we aimed to investigate the association of FLT3 -ITD gene mutation with bone marrow blast cell count, CD34 expression as malignant cell burden, cyclin D1 and Bcl-xL expressions as indexes of cell proliferation and anti-apoptosis and human equilibrative nucleoside transporter 1 (hENT1) expression as cytarabine transporter during AML treatment. (iranpath.org)
  • A significant association was found between FLT3 -ITD gene mutations in AML patients with bone marrow blast cell count, CD34, cyclin D1 and hENT1 expressions, however no association was obtained with Bcl-xL expression. (iranpath.org)
  • In a recent study using a microarray approach, 27 STS of seven different histological subtypes were profiled for miRNA expression. (sarcomahelp.org)
  • Bladder cancer (BC) is the tenth most common cancer worldwide with urothelial carcinoma (UC) being the main histologic subtype. (springeropen.com)
  • Urothelial carcinoma (UC) is considered the most common histologic subtype of BC [ 3 ]. (springeropen.com)
  • The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
  • They found that patients with the luminal A subtype of breast cancer had increased levels of expression of both cyclin D1 and Dicer. (sciencedaily.com)
  • Luminal A subtype of breast cancer is the most common type and also has the best prognosis. (sciencedaily.com)
  • Patients with triple negative breast cancer (TNBC), where the cancer cells do not express nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to the patients with luminal subtypes of cancer. (ku.edu)
  • To date, data on the relationship of expression of these proteins and histologic subtype of epithelial ovarian cancer are still scarce and discordant. (bmj.com)
  • This study shows that cyclin D1 and c-Myc are frequently overexpressed in epithelial ovarian carcinomas, but they are not correlated with a particular histologic subtype. (bmj.com)
  • The work supports the idea that cancer-causing proteins like cyclin D1 may drive cancer progression in part via miRNA biogenesis. (sciencedaily.com)
  • Subsequently, a different set of CDK/cyclin complexes triggers the phosphorylation of numerous proteins to promote the profound structural reorganizations that accompany the entry of cells into mitosis. (unibas.ch)
  • Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTRs) activating several pathways in many tissues. (unife.it)
  • Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. (biomedcentral.com)
  • Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer. (lu.se)
  • Hence, it seems reasonable that research and potential therapeutic strategies for these two subtypes of DIPG should be tailored specifically, focused on the now-known differential impacts of the H3.1K27M versus H3.3K27M mutations on cancer epigenomes. (nature.com)
  • We investigated FLT3 -ITD mutations, bone marrow blast cell count, CD34, cyclin D1, Bcl-xL and hENT1 expression in bone marrow aspirates from 22 de novo AML patients in a cross sectional study. (iranpath.org)
  • In patients with FLT3 -ITD mutations, CD34 and cyclin D1 expressions were higher (MFI 328.80 vs 25.78, p =0.003 and MFI 74.51 vs 57.15 p =0.005) than the patients without mutations. (iranpath.org)
  • HR-positive/HER2-negative breast cancer is the most common subtype of the disease and accounts for nearly 70% of breast cancer cases in the Unites States. (nepalnews.com)
  • HR-positive breast cancer is the most common subtype of the disease, as more than 65% of tumors are considered HR-positive and HER2-low or HER2-negative. (pharmaceuticalcommerce.com)
  • Although our preliminary results need to be validated in a larger number of tumors, the abnormal expression of cyclin D1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis and deserve further study. (bmj.com)
  • We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. (lu.se)
  • These enzymes are controlled by transient associations with cyclin regulatory subunits, binding of inhibitory polypeptides and reversible phosphorylation reactions. (unibas.ch)
  • These drugs work by blocking the activity of cyclin-dependent kinase 4/6 enzymes, which promote cell division and cancer growth. (nepalnews.com)
  • Herein, we report a case of DLBCL with cyclin D1 expression and unusual genetic rearrangement involving CCND1 and BCL-6. (biomedcentral.com)
  • In recent years, two transcriptional subtypes of pancreatic ductal adenocarcinoma (PDAC), the most aggressive form of pancreatic cancer, have been identified: classical and basal. (fredhutch.org)
  • In prior work, they showed that cyclin D1 regulates the non coding genome, and that the non-coding genome, in turn, regulates expression of cyclin D1. (sciencedaily.com)
  • There is no expression of Cyclin D1 or CD5 within the malignant population. (radiopaedia.org)
  • We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and assessed proteomic changes associated with ARID1A mutation/BAF250a expression in EC and CCC. (biomedcentral.com)
  • SAM (Significance Analysis of Microarrays) was performed to determine differential protein expression by histological subtype and ARID1A mutation status. (biomedcentral.com)
  • We report a case of diffuse large B-cell lymphoma with cyclin D1 expression. (biomedcentral.com)
  • However, rare DLBCLs may show cyclin D1 expression in absence of t (11,14)(q13;q23) or SOX11 expression. (biomedcentral.com)
  • Here we utilized a consensus hierarchical clustering approach on 509 LUAD cases from The Cancer Genome Atlas (TCGA) to identify five robust LUAD expression subtypes. (getzlab.org)
  • No abnormal expression of cyclin D1 or c-Myc was demonstrated in any of the 12 normal ovarian specimens. (bmj.com)
  • Epstein-Barr virus latent membrane protein expression and cyclin DI cell cyase protein expression in malignant and normal oesophageal tissues to see whether any variation in their expression in these tissues could be of diagnostic or prognostic value. (bvsalud.org)
  • EBV-LMPI protein expression and cyclin DI expression were studied immunohisto chemically in these tissue sections. (bvsalud.org)
  • Cyclin D1 and c-Myc are key participants in the cell-cycle pathway, in which aberrancies have been associated with malignant transformation. (bmj.com)
  • The study aimed to assess whether the incidence of these malignant histopathological subtypes has changed in this setting. (bvsalud.org)
  • Moreover, our data show an increase in glycogen synthase kinase-3beta activity, which triggers phosphorylation-dependent cyclin D1 degradation. (unife.it)
  • Genomic features in S3 and S4 were further identified as biomarkers for enabling clinical diagnosis of these subtypes. (getzlab.org)
  • Conclusion: Thoracic mass - classic Hodgkin lymphoma: likely nodular sclerosing subtype. (radiopaedia.org)
  • We have generated isogenic paclitaxel resistant cell lines from their corresponding native cell lines which reflect the 3 most common ovarian histologic subtypes, these include serous, clear cell and endometrioid subtypes [ 2 ]. (biomedcentral.com)
  • The more aggressive basal-like subtype of breast cancers, however, exhibited lower levels of cyclin D1 and Dicer, which would in turn globally reduce the level of mature miRNA. (sciencedaily.com)
  • The most lethal subtype of diffuse intrinsic pontine glioma (DIPG) is H3K27M. (nature.com)
  • Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. (lu.se)
  • The most common mutation in HR-positive breast cancer is a mutation in phosphoinositide (PI) 3 kinase, which occurs in about 40% of this breast cancer subtype, Rugo said. (medpagetoday.com)
  • Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network vat recente ontwikkelingen samen en beschrijft hoe het Preagnant netwerk een professionele infrastructuur creeërt voor patiënten en professionals, artsen en onderzoekers. (kanker-actueel.nl)
  • Although early-stage TNBC responds well to treatment, the advanced disease is worse overall survival when compares with other breast cancer subtypes. (cancer-research-network.com)
  • The GCB and ABC subtypes of DLBCL can be predicted using a panel of only 3 immunohistochemical stains (CD10, bcl-6, and MUM1). (biomedcentral.com)
  • this is a heterogeneous group of tumors composed of several histologic subtypes. (sarcomahelp.org)
  • In addition to its role in regulating the cell cycle, cyclin D1 induces Dicer and thereby promotes the maturation of miRNA," says lead researcher Richard Pestell, M.D., Ph.D., Director of the Kimmel Cancer Center at Thomas Jefferson University and Chair of the Department of Cancer Biology. (sciencedaily.com)
  • At present, much research is focused on elucidating the links between CDK/cyclin complexes and signal transduction pathways controlling cell growth, differentiation and death. (unibas.ch)
  • A widely-expressed cyclin A subtype that functions during the G1/S and G2/M transitions of the CELL CYCLE. (uams.edu)
  • At the cellular level, several processes are highly controlled, including the establishment and maintenance of apico-basal polarity, the control of the cell cycle and cell cycle exit, and the acquisition of cell subtype identities. (biologists.com)
  • We aimed to validate these subtypes in several clinical cohorts and identify signature immunohistochemical markers that would permit simple and cost-effective classification of the disease in primary care centers. (johnshopkins.edu)
  • In the current study, the group sought to investigate the mechanism by which cyclin D1 regulates the biogenesis of non coding miRNA. (sciencedaily.com)
  • Pancreatic ductal adenocarcinoma subtypes: what your type means? (fredhutch.org)
  • Pancreatic ductal adenocarcinoma (PDAC) has two predominant subtypes: classical and basal. (fredhutch.org)
  • The researchers noticed that cells lacking cyclin D1 produced less of the miRNA-processing protein, Dicer, and therefore had reduced levels of mature miRNA. (sciencedaily.com)
  • The group also examined cells lacking Dicer, and noted many similarities between Dicer-lacking and cyclin D1-lacking cells, in addition to failure of miRNA processing, suggesting a deeper connection between these two processes. (sciencedaily.com)
  • The research attention given to the role of BMP signaling in DIPG has so far strongly emphasized the ACVR1 mutation DIPG subtype. (nature.com)
  • Thus, our study delineates context-dependent features of the BMP signaling pathway in a DIPG subtype. (nature.com)
  • A recent study led by Jessica Gianopulos, a graduate student in Dr. Sita Kugel's lab, an Assistant Professor in the Human Biology Division, identified sirtuin 6 (SIRT6) as a differential marker for PDAC subtypes. (fredhutch.org)
  • The National Comprehensive Cancer Network (NCCN) guidelines for NHL provide general recommendations on classification, differential diagnosis and supportive care, as well as specific guidance for the management of the most common subtypes. (medscape.com)
  • Cyclin A2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)