Loading...
  • prognosis
  • These results emphasise the importance of taking morphological subtype into account in biomarker studies related to periampullary cancer, and indicate that therapies targeting dendritic cells may be of value in the treatment of PB-type tumours, which are associated with the worst prognosis. (lu.se)
  • Focusing on the poor prognosis subtype, our 3rd objective is to dissect tumor-intrinsic regulatory mechanism based on network inference from deconvolved gene expression profiles, and subsequently to prioritize master regulators for experimental validation by our collaborators at the University of Amsterdam. (edu.hk)
  • Lung adenocarcinoma has a complex variety of different hystopathologic subtypes with distinct epidemiology, pathology and prognosis. (edoriumjournals.com)
  • Each one of these subtypes has a distinct epidemiology, pathology and prognosis . (edoriumjournals.com)
  • NSCLC
  • Additionally, a multivariate analysis also showed a significant correlation between strong TGase 2 expression and shorter disease-free survival (DFS) in NSCLC (p = 0.029 and HR = 1.554) and in the non-adenocarcinoma subtype (p = 0.030 and HR = 2.184). (biomedcentral.com)
  • Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide and adenocarcinoma subtype is the responsible for at least half of these cases . (edoriumjournals.com)
  • classification
  • We also applied our classification system on validation datasets and observed much similar molecular and clinical characteristics between subtypes. (biomedcentral.com)
  • The 160 subtype-specific markers and a deep learning based classification system may be used to better stratify PDAC patients for personalized treatments. (biomedcentral.com)
  • As currently available clinicopathological classification systems and treatment modalities fail to tailor patient management or improve survival substantially, molecular subtyping of PDAC may help unravel its mechanisms of carcinogenesis and progression, and help discover efficient therapeutic molecules. (biomedcentral.com)
  • Mucinous and non-mucinous subtypes are now on the lung cancer classification list. (icnet.uk)
  • International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. (nih.gov)
  • The American Thoracic Society is a cosponsor of a newly published lung adenocarcinoma classification. (nih.gov)
  • In 2011, the new lung adenocarcinoma classification was published and supported by the International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS): PEAC was first reconized as a rare variant of LAC. (edoriumjournals.com)
  • There are other classification systems that have been proposed for lung cancers, including BACs and other forms of adenocarcinoma. (wikipedia.org)
  • The Noguchi classification system for small adenocarcinomas has received considerable attention, particularly in Japan, but has not been nearly as widely applied and recognized as the WHO system. (wikipedia.org)
  • PDAC
  • Six molecular and clinical distinct subtypes of PDAC: L1-L6, are identified and grouped into tumor-specific (L1, L2 and L6) and stroma-specific subtypes (L3, L4 and L5). (biomedcentral.com)
  • In the meantime, we identified 160 subtype-specific markers and built a deep learning-based classifier for PDAC. (biomedcentral.com)
  • We identified six molecular and clinical distinct subtypes to describe a more complete picture of the PDAC heterogeneity. (biomedcentral.com)
  • In order to better understand the biology of PDAC we used iRegulon to identify transcription factors (TFs) as master regulators of PDAC and its subtypes. (biomedcentral.com)
  • PDAC can be classified in molecular subtypes that independently predict survival. (biomedcentral.com)
  • Recently, based on 27 microdissected surgical samples, three subtypes of PDAC (classical, quasimesenchymal, and exocrine-like) were identified and their gene signatures defined as PDAssign . (biomedcentral.com)
  • Our recent work on in-house-generated RNA-Seq data for 90 stage II PDAC patients also identified 4 molecularly distinct subtypes (PDACS1-4). (edu.hk)
  • Of utmost importance is to elucidate the interrelations between the five PDAC taxonomies, including ours, and define common disease patterns (or consensus molecular subtypes, CMSs) in a principled, unbiased manner, which is our 1st objective in the proposal. (edu.hk)
  • Tumour
  • Tumour associated macrophages (TAM) can roughly be divided into two subtypes, M1 and M2, whereof M1 are associated with pro-inflammatory properties and M2 anti-inflammatory properties. (biomedcentral.com)
  • Both such subtypes are associated with mutations in the short-arm of chromosome 3, with the implicated genes being either tumour suppressor genes (VHL and TSC) or oncogenes (like c-Met). (wikipedia.org)
  • histology
  • Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer of adenocarcinoma histology: a network meta-analysis vs new therapeutic options. (icr.ac.uk)
  • PATIENTS & METHODS: We provide an update to a network meta-analysis evaluating the relative efficacy of nintedanib + docetaxel versus other second-line agents in adenocarcinoma histology non-small-cell lung cancer. (icr.ac.uk)
  • smokers
  • however, among people who have smoked fewer than 100 cigarettes in their lifetimes ("never-smokers"), adenocarcinoma is the most common form of lung cancer. (wikipedia.org)
  • According to the Nurses' Health Study, the risk of adenocarcinoma of the lung increases substantially after a long duration of previous tobacco smoking, with a previous smoking duration of 30 to 40 years giving a relative risk of approximately 2.4 compared to never-smokers, and a duration of more than 40 years giving a relative risk of approximately 5. (wikipedia.org)
  • The adenocarcinoma has an increased incidence in smokers, and is the most common type of lung cancer seen in non-smokers and women. (wikipedia.org)
  • Inhibitor of EML4-ALK crizotinib shows benefit in a subset of non-small cell lung cancer that is characterized by the EML4-ALK fusion oncogene, found in some relatively young, never or light smokers with adenocarcinoma. (wikipedia.org)
  • distinct
  • These results show that the two subtypes of adenocarcinoma of the AOV exhibit significant differences in tumoral PD-L1 expression and intratumoral CD8 + T lymphocyte density, which might contribute to their distinct clinical features. (springer.com)
  • clinical
  • Here, we evaluated the clinical implications of PD-L1 expression and CD8 + T lymphocyte density in adenocarcinomas of the AOV and their potential association with Yes-associated protein (YAP). (springer.com)
  • We used the gene set enrichment analysis (GSEA) and survival analysis to conduct the molecular and clinical characterization of the identified subtypes, respectively. (biomedcentral.com)
  • It has been divided into numerous subtypes on the basis of clinical and histological characteristics. (thefreedictionary.com)
  • Conclusions
  • Conclusions: The results from this study demonstrate that high infiltration of tolerogenic immature DCs independently predicts a shorter survival in patients with PB-type periampullary adenocarcinoma, and that high density of the MARCO + subtype of TAMs predicts a shorter survival in patients with I-type tumours. (lu.se)
  • molecular
  • We found molecular subtypes, but not clinicopathological factors, as independent predictors of survival. (biomedcentral.com)
  • Despite these various molecular subtyping effort, its translational potential is hampered by discrepant results, which are probably due to differences in bioinformatic algorithms, diverse discovery cohorts, sample preparation methods and gene expression platforms. (edu.hk)
  • periampullary
  • Methods: The density of tolerogenic immature CD1a + dendritic cells (DC), and MARCO + , CD68 + and CD163 + tissue-associated macrophages (TAM) was analysed by immunohistochemistry in tissue micro arrays with tumours from 175 consecutive cases of periampullary adenocarcinoma who had undergone pancreaticoduodenectomy, 110 with pancreatobiliary type (PB-type) and 65 with intestinal type (I-type) morphology. (lu.se)
  • types
  • Although these new therapies have had little impact on the treatment of SCLC, some very promising results have been obtained in certain histiological types and subtypes of NSCLC's. (wikipedia.org)
  • long
  • 2017) Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: discovery, mechanisms, and therapeutic applications . (lncrnablog.com)
  • While each gland may not be secreting the same substance, as long as there is an exocrine function to the cell, it is considered glandular and its malignant form is therefore named adenocarcinoma. (wikipedia.org)