UbiquitinUbiquitin-Protein LigasesUbiquitinsUbiquitin ThiolesteraseSubstrate SpecificityUbiquitinationUbiquitin-Conjugating EnzymesProteasome Endopeptidase ComplexCullin ProteinsMolecular Sequence DataPolyubiquitinAmino Acid SequenceLigasesSKP Cullin F-Box Protein LigasesProtein BindingKineticsUbiquitin-Protein Ligase ComplexesProtein Structure, TertiaryUbiquitin-Activating EnzymesF-Box ProteinsEndosomal Sorting Complexes Required for TransportUbiquitin CBinding SitesModels, MolecularProteolysisMutationCatalysisRING Finger DomainsCysteine EndopeptidasesAnaphase-Promoting Complex-CyclosomeCell LineSequence Homology, Amino AcidLysineSaccharomyces cerevisiae ProteinsHydrolysisSaccharomyces cerevisiaeEndopeptidasesRecombinant ProteinsCarrier ProteinsUbiquitinated ProteinsCatalytic DomainCrystallography, X-RayProtein ConformationPhosphorylationAmino Acid MotifsBase SequenceProtein Processing, Post-TranslationalEscherichia coliS-Phase Kinase-Associated ProteinsHeLa CellsHEK293 CellsUbiquitin-Specific ProteasesSignal TransductionCell Cycle ProteinsProto-Oncogene Proteins c-cblMutagenesis, Site-DirectedRecombinant Fusion ProteinsModels, BiologicalPeptide HydrolasesHydrogen-Ion ConcentrationMultienzyme ComplexesCarbon-Nitrogen LyasesProtein TransportSequence Alignmentbeta-Transducin Repeat-Containing ProteinsProteinsNuclear ProteinsCloning, MolecularStructure-Activity RelationshipProteasome InhibitorsSUMO-1 ProteinLeupeptinsAdenosine TriphosphateMultiprotein ComplexesProtein StabilityDNA-Binding ProteinsProtein FoldingEnzyme ActivationElectrophoresis, Polyacrylamide GelImmunoprecipitationPeptide SynthasesSmall Ubiquitin-Related Modifier ProteinsTwo-Hybrid System TechniquesTransfectionMembrane ProteinsOxidation-ReductionCells, CulturedAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesMolecular WeightPeptidesBlotting, WesternCattleBacterial ProteinsProtein Structure, SecondaryProtein Interaction Domains and MotifsAmino Acid SubstitutionEnzyme StabilityModels, ChemicalIntracellular Signaling Peptides and Proteins