• Daubner, S.C., Hillas, P. J., Fitzpatrick, P.F. Characterization of chimeric pterin dependent hydroxylases: Contributions of the regulatory domains of tyrosine and phenylalanine hydroxylase to substrate specificity. (springer.com)
  • Additionally, we have characterized the kinetics governing the specificity and discrimination of several widely administered Nucleotide Reverse Transcriptase Inhibitors (NRTI's) used to combat HIV infection including 3TC (Lamivudine), FTC (Emtricitabine), and AZT (Zidovudine) for the wild-type polymerase and mutants with clinical resistance to these compounds. (utexas.edu)
  • Enzymatic properties and substrate sp. (ugent.be)
  • Van der Borght J, Chen C, Hoflack L, Van Renterghem L, Desmet T, Soetaert W. Enzymatic properties and substrate specificity of the trehalose phosphorylase from Caldanaerobacter subterraneus. (ugent.be)
  • 1-3 AmDHs take ammonia, ketone, and NADH as substrates and release an (R)-amine, NAD + , and water as products as seen in the reaction scheme below. (aiche.org)
  • In enzymology, a mannitol dehydrogenase (EC 1.1.1.255) is an enzyme that catalyzes the chemical reaction D-mannitol + NAD+ ⇌ {\displaystyle \rightleftharpoons } D-mannose + NADH + H+ Thus, the two substrates of this enzyme are D-mannitol and NAD+, whereas its 3 products are D-mannose, NADH, and H+. (wikipedia.org)
  • Kinetic analysis reveals that the major source of the substrate specificity lies in changes in K(m) for the various substrates. (nih.gov)
  • HeLa cells expressing double- and triple-haplotype mutants also revealed results similar to those for the single mutants ( Fig. 1, A to C ). However, the P-gp inhibitors cyclosporin A (CsA) and verapamil (fig. S1) were less effective against all the substrates in cells expressing the double or triple haplotypes carrying C3435T relative to the wild type, the SNPs, or the haplotype that does not carry C3435T. (sciencemag.org)
  • With the objective of improving the differentiation of enzyme specificities in a knowledge-based context, and to obtain new evolutionary insights, we present here a new, robust subfamily classification of family GH5. (diva-portal.org)
  • This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better! (wikigenes.org)
  • To assess the origin of specificity of Escherichia coli leucyl-tRNA synthetase (LeuRS) against the cognate aminoacylation product in editing, we followed binding and catalysis independently using cognate leucyl- and non-cognate norvalyl-tRNA Leu and their non-hydrolyzable analogues. (elsevier.com)
  • Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin. (semanticscholar.org)
  • Mutants containing alanine at position 226 exhibited an altered conformation that may be converted to a trypsin-like structure upon binding of a substrate analog. (nih.gov)
  • We hypothesize that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites. (sciencemag.org)
  • We further established the critical role for the A76 3′-OH group of the tRNA Leu in post-transfer editing, which supports the substrate-assisted deacylation mechanism. (elsevier.com)
  • In doing so, we define the role of induced-fit in nucleotide specificity and mismatch discrimination. (utexas.edu)
  • As the variety of substrates accepted by AmDHs increases, so too does their utility for the production of pharmaceuticals and fine chemicals. (aiche.org)