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  • cleavage
  • In nucleosome core particles (NCPs), we find substantial differences in UDG-directed cleavage at uracils rotationally positioned toward (U-In) or away from (U-Out) the histone core, or midway between these orientations (U-Mid). (pnas.org)
  • catalytic
  • To evaluate these interesting proposals, we measured the kinetic effects of neutral methylphosphonate (MeP) stereoisomers at the +1 and +2 positions of a 12-mer dsDNA substrate and also the catalytic contribution and ionization state of His148. (mysciencework.com)
  • bound
  • We extended our structure-function analyses of human UDG by determining 1.8- and 2.0-Å resolution cocrystallized structures of human UDG bound to cleaved product and uncleaved substrate analogs. (scripps.edu)
  • molecules
  • In the case of the other two molecules in this set, the uracil fragment still binds as expected, but the benzoate is either not visible in the electron density (MA2) or binds to a nearby molecule of UNG in the crystal (DA). (blogspot.com)
  • human
  • Several uracil vinylphosphonate derivatives had affinities for human UMP-CMP kinase similar to those of dUMP and dCMP and better than that of cidofovir, an acyclic nucleoside phosphonate with a broad spectrum of antiviral activities. (genes2cognition.org)
  • addition
  • These findings have convened with results that suggested that the degradation of 5-fluorouracil can be depressed by the addition of uracil. (drugbank.ca)
  • Line
  • Tegafur-uracil is indicated for the first line treatment of metastatic colorectal cancer with concomitant administration of calcium folinate. (drugbank.ca)