Loading...
  • Function
  • After two weeks, function was measured in isolated working hearts along with substrate fractional contributions to the citric acid cycle by using perfusate with 13C labeled mixed fatty acids, lactate, ketone bodies and unlabeled glucose and insulin. (osti.gov)
  • Hypertrophy
  • 12 13 Although valuable information regarding mechanotransduction and hypertrophy has been learned from the study of neonatal cardiomyocytes, there is little information regarding the mechanisms wherein this process occurs in the adult left ventricle. (ahajournals.org)
  • fatty
  • Increased availability of the metabolic substrates glucose and pyruvate has been found to improve recovery following ischaemia and reperfusion, while the presence of fatty acids upon reperfusion is detrimental. (le.ac.uk)
  • This growth factor, by activating EC Notch signaling, is responsible for facilitating GPIHBP1-mediated translocation of LPL across EC and regulating LPL-derived fatty acid delivery to the cardiomyocytes. (ahajournals.org)
  • molds
  • Abadi and her coauthors have created three-dimensional substrates--essentially, molds--that recreate the environment in which heart cells grow inside the human body. (eurekalert.org)
  • expression
  • The decrease in coronary flow and concomitant reduction in oxygen delivery triggers specific and coordinated responses in gene expression, including activation of hypoxia-inducible factor 1-alpha ( 12 ) and the reactivation of the fetal gene program ( 13 ), both of which improve the cardiomyocytes' tolerance to ischemia. (onlinejacc.org)
  • In the present study, we screened GBP expression in cardiomyocytes and tried the developed a novel DDS targeting the injured myocardium. (ahajournals.org)
  • acute
  • Central to achievement of this goal is metabolic flexibility, wherein the heart shifts reliance from one substrate to another, in response to acute perturbations in workload and/or substrate availability (including feeding-fasting and sleep-wake cycles, which occur on a daily basis). (onlinejacc.org)
  • metabolic
  • Metabolic preconditioning and postconditioning with elevated concentrations of metabolic substrates also improved contractile recovery. (le.ac.uk)
  • The importance of metabolic flexibility is underscored by appreciation for the fact that various substrates are more than just a fuel for the heart, serving also as building blocks for numerous cellular components (e.g., membranes, proteins), cofactors, and signaling molecules. (onlinejacc.org)
  • cells
  • Soluble components of the culture system such as growth factors within serum and insoluble components such as the substrate on which cells adhere to are important variables controlling the biological activity of cells. (imperial.ac.uk)
  • Growing the cells in a three-dimensional substrate that mimics the natural heart environment produces better cells. (medgadget.com)
  • They laid the mesh on a glass substrate to test whether cardiomyocytes would colonize the surface and grow more cells. (nanotech-now.com)
  • It's because of these properties and the carbon nanofibers that cardiomyocytes and neurons congregate on the scaffold and spawn new cells, in effect regenerating the area. (nanotech-now.com)
  • If heart muscle cells--cardiomyocytes--could be repaired by cells taken from one's own body, the patient's recovery improves. (eurekalert.org)
  • On day one we start seeing the effect of the substrate on the morphology of the cells," Abadi says. (eurekalert.org)
  • As cardiomyocytes need to communicate with each other during their growth, Abadi also plans to stimulate electrical conductivity between cells. (eurekalert.org)
  • Compared with recombinant CYP2J2, terfenadine was hydroxylated in cardiomyocytes at a similar K m value of 1.5 μ M. The V max of terfenadine hydroxylation in recombinant enzyme was found to be 29.4 pmol/pmol P450 per minute and in the cells 6.0 pmol/pmol P450 per minute. (aspetjournals.org)
  • subsequent
  • UPS-mediated proteolysis generally involves 2 steps: targeting of the substrate protein by ubiquitination and the subsequent degradation of the ubiquitinated protein by the 26S proteasome. (ahajournals.org)
  • study
  • hPSC-CMs cultured on stiff substrates like glass or polystyrene do not have the ability to shorten during contraction, making them less suitable for the study of hPSC-CM contractile function. (readbyqxmd.com)
  • production
  • Further, the production of nitric oxide in interleukin-1β-stimulated cardiomyocytes was enhanced by incorporation of GlcNAc-Ls containing pravastatin, but not the treatment of the unmodified pravastatin. (ahajournals.org)
  • delivery
  • Further analyses reveal that the impairment is likely attributable to insufficient delivery of substrate proteins into the 20S proteasomes, and depletion of key components of the 19S subcomplex may be responsible. (ahajournals.org)
  • signal
  • Our findings imply that sarcolemmal outward and inward rectifier potassium channels are substrates for IGF-1/PI3K/Akt signal transduction molecules. (hindawi.com)