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AnaphaseAnaphase-Promoting Complex-CyclosomeUbiquitin-Protein Ligase ComplexesCdc20 ProteinsCdh1 ProteinsMitosisApc3 Subunit, Anaphase-Promoting Complex-CyclosomeCell Cycle ProteinsApc1 Subunit, Anaphase-Promoting Complex-CyclosomeSpindle ApparatusSecurinCyclin BF-Box ProteinsGenes, APCMetaphaseLigasesM Phase Cell Cycle CheckpointsCyclin A2Apc5 Subunit, Anaphase-Promoting Complex-CyclosomeUbiquitin-Protein LigasesCyclin B1Mad2 ProteinsChromosome SegregationSubstrate SpecificityCell CycleMolecular Sequence DataPrometaphaseHeLa CellsAmino Acid SequenceCDC2 Protein KinaseUbiquitinationMeiosisSaccharomyces cerevisiae ProteinsGemininSchizosaccharomyces pombe ProteinsMutationProtein-Serine-Threonine KinasesProtein BindingCyclin AApc2 Subunit, Anaphase-Promoting Complex-CyclosomeFungal ProteinsSchizosaccharomycesApc8 Subunit, Anaphase-Promoting Complex-CyclosomeSeparaseNocodazoleNuclear ProteinsAurora KinasesTelophaseProto-Oncogene Proteins c-mosChromatidsXenopus ProteinsPhosphorylationSaccharomyces cerevisiaeProtein SubunitsG1 PhaseOocytesUbiquitinGenes, cdcUbiquitin-Conjugating EnzymesKineticsMicrotubulesXenopusSKP Cullin F-Box Protein LigasesUbiquitinsProteasome Endopeptidase ComplexRecombinant Fusion ProteinsApc6 Subunit, Anaphase-Promoting Complex-CyclosomeAmino Acid MotifsModels, BiologicalKinetochoresProtein KinasesRNA InterferenceS PhaseCarrier ProteinsChromosomesCalcium-Binding ProteinsCytokinesisDrosophila ProteinsBase SequenceCell LineBinding SitesProtein Processing, Post-TranslationalSequence Homology, Amino AcidG2 PhaseCentromereRepressor ProteinsApc11 Subunit, Anaphase-Promoting Complex-CyclosomeCadherinsDrosophilaRNA, Small InterferingCyclinsAdenomatous Polyposis Coli ProteinMacromolecular SubstancesProtein Structure, TertiaryProtein StabilityModels, MolecularChromosomal Proteins, Non-HistoneEscherichia coliCyclin-Dependent KinasesEndopeptidases

MitosisActivatorSpecificityCdh1ProteinsMetaphase to anaphaseUbiquitinationInhibitorsCatalyticLigaseTetratricopeptideAmino acidProteinConsistsSpecific

Mitosis4

• The APC/C also targets the mitotic cyclins for degradation, resulting in the inactivation of M-CDK (mitotic cyclin-dependent kinase) complexes, promoting exit from mitosis and cytokinesis Unlike the SCF, activator subunits control the APC/C. Cdc20 and Cdh1 are the two activators of particular importance to the cell cycle. (wikipedia.org)
• The subunit, CDC20 allows APC to degrade substrates such as anaphase inhibitors (Pdsp1) at the beginning of anaphase, on the other hand when CDC20 is substituted for specificity factor Hct1, APC degrades a different set of substrates, particularly mitosis cyclins in late anaphase. (wikipedia.org)
• It is also suggested that variations in these WD40 domains result in varying substrate specificity, which is confirmed by recent results suggesting that different APC substrates can directly and specifically bind to Cdc20 and Cdh1/Hct1 Ultimately, the specificity differences are responsible for the timing of the destruction of several APC targets during mitosis. (wikipedia.org)
• It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication. (jefferson.edu)

Activator2

• Activator subunits bind to APC at varying stages of the cell cycle to control its ubiquitination activity, often by directing APC to target substrates destined for ubiquitination. (wikipedia.org)
• Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. (jefferson.edu)

Specificity1

• The specificity of APC ligases is proposed to be controlled by the incorporation of specificity factors into the ligase complex, instead of substrate phosphorylation. (wikipedia.org)

Cdh12

• Activators CDC20 and Cdh1 are of particular significance and are the most widely studied and familiar of the APC/C subunits. (wikipedia.org)
• C-termini regions of CDC20 and Cdh1 have a WD40 domain that is suggested to form a binding platform that binds APC substrates, thus contributing to APCs ability to target these substrates, although the exact mechanism through which they increase APC activity is unknown. (wikipedia.org)

Proteins4

• Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. (wikipedia.org)
• The APC/C is a large complex of 11-13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. (wikipedia.org)
• The APC/C's main function is to trigger the transition from metaphase to anaphase by tagging specific proteins for degradation. (wikipedia.org)
• These proteins target the APC/C to specific sets of substrates at different times in the cell cycle, thus driving it forward. (wikipedia.org)

Metaphase to anaphase2

• The APC/C's main function is to trigger the transition from metaphase to anaphase by tagging specific proteins for degradation. (wikipedia.org)
• HN - 2014 FX - Ammonia MH - Anaphase-Promoting Complex-Cyclosome UI - D064173 MN - D8.811.464.938.750.92 MN - D12.776.167.24 MS - An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. (nih.gov)

Ubiquitination3

• When securin undergoes ubiquitination by the APC/C and releases separase, which degrades cohesin, sister chromatids become free to move to opposite poles for anaphase. (wikipedia.org)
• Activator subunits bind to APC at varying stages of the cell cycle to control its ubiquitination activity, often by directing APC to target substrates destined for ubiquitination. (wikipedia.org)
• These two subunits catalyze ubiquitination of substrates when the C-terminal domain of Apc2 forms a tight complex with Apc11. (wikipedia.org)

Inhibitors1

• These domains, also found in Apc3, Apc7, and Apc8, have been shown to mediate protein-protein interactions, suggesting that Apc6 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors. (nih.gov)

Catalytic1

• The catalytic core of the APC/C consists of the cullin subunit Apc2 and RING H2 domain subunit Apc11. (wikipedia.org)

Ligase2

• Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. (wikipedia.org)
• The specificity of APC ligases is proposed to be controlled by the incorporation of specificity factors into the ligase complex, instead of substrate phosphorylation. (wikipedia.org)

Tetratricopeptide2

• The major motifs in APC subunits include tetratricopeptide (TPR) motifs and WD40 repeats 1. (wikipedia.org)
• A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34 amino acid tetratricopeptide repeats. (nih.gov)

Amino acid1

• These include Apc1, the largest subunit which contains 11 tandem repeats of 35-40 amino acid sequences, and Apc2, which contains three cullin repeats of approximately 130 amino acids total. (wikipedia.org)

Protein1

• Separase then triggers the cleavage of cohesin, the protein complex that binds sister chromatids together. (wikipedia.org)

Consists1

• It consists entirely of pentameric α7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen. (nih.gov)

Specific1

• These proteins target the APC/C to specific sets of substrates at different times in the cell cycle, thus driving it forward. (wikipedia.org)