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CatecholsCatechol 2,3-DioxygenaseDioxygenasesCatechol 1,2-DioxygenaseOxygenasesEstrogens, Catechol4-Hydroxyphenylpyruvate DioxygenaseProtocatechuate-3,4-DioxygenaseCysteine DioxygenaseTryptophan OxygenaseSubstrate SpecificityCatechol O-MethyltransferaseHomogentisate 1,2-Dioxygenase3-Hydroxyanthranilate 3,4-DioxygenasePseudomonasBiodegradation, EnvironmentalKynureninePseudomonas putidaMolecular Sequence DataKineticsHydroxybenzoatesRhodococcusPhenolAmino Acid SequenceChlorobenzenesTryptophanMixed Function OxygenasesCatechol OxidaseSorbic AcidChlorobenzoatesBenzoatesTolueneSphingomonasBurkholderiaOxidation-ReductionCatalysisEscherichia coliBinding SitesBenzoic AcidModels, MolecularCloning, MolecularGentisatesAlcaligenesGenes, BacterialAdipatesBase SequenceBenzeneSequence Homology, Amino AcidComamonasRecombinant ProteinsEquileninHydroxylationHomogentisic AcidBacterial ProteinsAcinetobacterCatalytic DomainHydrogen-Ion ConcentrationCrystallography, X-RayPhenolsHydrocarbons, AromaticPyrogallolIronProtein BindingHydroquinonesBrevibacteriumRalstoniaParabensKetoglutaric AcidsChromatography, High Pressure LiquidPlanococcus BacteriaArthrobacterStereoisomerismGram-Negative Aerobic Rods and CocciMutationCresolsOxidoreductasesFerredoxinsSpectrophotometryPolychlorinated BiphenylsEnzyme InductionStructure-Activity RelationshipBurkholderiaceaeXylenesProtein ConformationHydrolysis3-Hydroxyanthranilic Acidgamma-Butyrobetaine DioxygenaseModels, ChemicalIntramolecular LyasesBiotransformationFerrous CompoundsSalicylatesBiphenyl CompoundsAlkaptonuriaSequence AlignmentPlasmidsortho-AminobenzoatesHydrolasesVanillic AcidOxygen
SpecificityAromaticGeneBacteriaCharacterizationCleavageInhibitorsOxidoreductaseRhodococcusNADHDehydrogenaseGenesBRENDADegradationLiving organismsOxygenasePathwaySynthesisAmino acid2019ReceptorDifferentiationMoleculeCarbonReductionDopamineCompounds2023CatalyzesProteinsBiosynthesis2022GenerateInhibitsTemperatureMetabolismActivityResponsibleDatabaseProteinSitesProductsGroupCommonStudiesSmallBasis
Specificity3
Aromatic7
  • This enzyme catalyses the following chemical reaction 2-hydroxymuconate-6-semialdehyde + NAD+ + H2O ⇌ {\displaystyle \rightleftharpoons } (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+ This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. (wikipedia.org)
  • PAHs could be degraded by bacteria under aerobic conditions through the initial oxidation of the aromatic ring, which is catalyzed by the dioxygenase enzyme. (omicsonline.org)
  • A number of bacteria that can degrade a variety of aromatic compounds have been identified and the pathways involved in the degradation have been extensively characterized [ 3 , 4 ]. (biomedcentral.com)
  • In the convergent mode, structurally diverse aromatic compounds are converted to one of a few aromatic ring cleavage substrates such as catechol, gent sate, protocatechuate and their derivatives [ 5 ]. (biomedcentral.com)
  • Peripheral enzymes, particularly oxygenases and dehydrogenases, were found to transform structurally diverse substrates into one of these central intermediates by bringing about the hydroxylation of the aromatic nucleus (Fig. 2A ), and hence it is thought that bacteria have developed these enzymes to extend their substrate range [ 5 ]. (biomedcentral.com)
  • 2006. Microbial dioxygenase gene population shifts during polycyclic aromatic hydrocarbon biodegradation. (nih.gov)
  • Some of the enzymes which generate aromatic radicals that break down most prominent bacterial strains found were isolated and tax- the complex linkages present in lignin to compounds of lower onomically identified using 16S ribosomal RNA (rRNA) se- molecular weight. (lu.se)
Gene6
  • 2-Hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85, xylG [gene], praB [gene] ) is an enzyme with systematic name (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoate:NAD+ oxidoreductase. (wikipedia.org)
  • Moreover, a dioxygenase gene, nidA3B3, was detected in Mycobacterium vanbaalenii PYR-1 as an alternate degradation pathway which could catalyze both the initial dihydroxylation of pyrene [ 11 ] to be pyrene cis-4,5-dihydrodiol, and an alternate detoxification pyrene pathway to be pyrene cis-1,2-dihydrodiol [ 12 ]. (omicsonline.org)
  • Each enzyme entry contains its common name and synonym, reaction in which enzyme is involved, family and subfamily, structure and gene link and literature citation. (biomedcentral.com)
  • Catechol 2,3-dioxygenase (C23O) gene was found andamplified with the designed primers from the total DNA of C-14-1. (researchgate.net)
  • Based on their structures, the degradation pathway of 17ß-estradiol mediated by A. niger RG13B1 involved hydroxylation, oxidation, methylation, acetylation, and dehydrogenation, especially infrequent lactylation, and the key degradation enzymes were found in the gene cluster of A. niger. (bvsalud.org)
  • For all significantly differentially expressed microRNAs inside of the 2 groups, we now have produced gene sets from their expressed target genes. (pdpksignaling.com)
Bacteria2
  • The root-mean-square deviation from ideal bond distances for the model is 0.014 A and the error in atomic co-ordinates is estimated to be 0.15 A. DLH is a monomeric enzyme containing 236 amino acid residues and is a member of the beta-ketoadipate pathway found in bacteria and fungi. (inrae.fr)
  • 2016. The effects of substrate exposure history and carbon starvation-induced stress on the EPS synthesis of TCE degrading toluene oxidizing soil bacteria. (nih.gov)
Characterization2
  • 2003. Characterization of a novel Acinetobacter species containing a toluene dioxygenase. (nih.gov)
  • 1. Fischer, D., Ebenau-Jehle, C. and Grisebach, H. Phytoalexin synthesis in soybean: purification and characterization of NADPH:2'-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures. (qmul.ac.uk)
Cleavage1
  • In this divergent mode, a metal-dependent dioxygenase channels these dihydroxylated intermediates into one of the two possible pathways: the meta -cleavage pathway or the ortho -cleavage pathway [ 7 - 9 ] (Fig. 1 ). (biomedcentral.com)
Inhibitors2
  • Substrates containing a -COOH group are inhibitors for catechol oxidase. (lookformedical.com)
  • In vitro production of enzymatically active O. volvulus prolyl 4-hydroxylase should facilitate identification of specific inhibitors of the parasite enzyme. (embl.de)
Oxidoreductase1
  • An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (lookformedical.com)
Rhodococcus1
  • An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. (brenda-enzymes.org)
NADH1
  • Oxygenases belong to the oxidoreductive group of enzymes (E.C. Class 1), which oxidize the substrates by transferring oxygen from molecular oxygen (O 2 ) and utilize FAD/NADH/NADPH as the co-substrate. (biomedcentral.com)
Dehydrogenase1
  • p-Xylene-grown cells contained an inducible NAD+-dependent dehydrogenase which formed catechols from cis-p-toluate diol and the analogous acid diols formed from the other hydrocarbon substrates listed above. (rhea-db.org)
Genes3
  • nidA and nidB genes are encoding genes for large and small subunits of napthalene-inducible dioxygenase [ 7 , 8 ]. (omicsonline.org)
  • B, solute carrier relatives six member 2, solute carrier relatives 18 member one, and transcription factors and homeobox genes involved in neural crest derived cell de velopment, paired like homeobox 2a and 2b, GATA binding protein two and 3, heart and neural crest derivatives expressed two. (pdpksignaling.com)
  • Genes & Development 21 (3): 316-331. (mdc-berlin.de)
BRENDA1
  • The entries are also linked to several external database including BRENDA, KEGG, ENZYME and UM-BBD providing wide background information. (biomedcentral.com)
Degradation1
  • Further, the centralized degradation pathways mean synthesis of fewer degradative enzymes requiring less metabolic energy. (biomedcentral.com)
Living organisms1
  • Many of these compounds have been reported to be toxic to the living organisms [ 3 ]. (biomedcentral.com)
Oxygenase1
  • Cell culture and in vitro studies show that fenretinide binds and inhibits the activity of ß-carotene oxygenase 1 (BCO1), the enzyme responsible for endogenous vitamin A formation. (bvsalud.org)
Pathway3
  • Dienelactone hydrolase (DLH), an enzyme from the beta-ketoadipate pathway, catalyzes the hydrolysis of dienelactone to maleylacetate. (inrae.fr)
  • The pcaH was significant in the β-ketoadipate pathway [9] where the pathway as it conserves biochemically, and is a major class of non-heme-iron containing dioxygenase [ 10 ]. (omicsonline.org)
  • An analysis of the genome and its transcriptome revealed enzymes with biotechnological potential, such as two extracellular tannases (Atan1p and Atan2p) of the tannic-acid catabolic route, and a new pathway for the assimilation of n-butanol via butyric aldehyde and butyric acid. (biomedcentral.com)
Synthesis2
  • We suggest that activated phenoloxidase is involved in the cell clump/cell adhesion reaction as well as in the synthesis of melanin. (lookformedical.com)
  • Because levodopa bypasses the enzyme tyrosine hydroxylase , the rate-limiting step in dopamine synthesis, it is much more readily converted to dopamine than tyrosine, which is normally the natural precursor for dopamine production. (cloudfront.net)
Amino acid2
  • The derived amino acid sequence of Ov-phy-1 encoded a peptide that was most similar to the two Caenorhabditis elegans prolyl 4-hydroxylase homologues and to the isoform II enzymes of vertebrates. (embl.de)
  • l -3,4-dihydroxyphenylalanine , is an amino acid that is made and used as part of the normal biology of some plants [3] and animals, including humans. (cloudfront.net)
20191
  • The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). (bvsalud.org)
Receptor1
  • download Dopamine in the Pathophysiology and Treatment involves a histone of endonucleases, receptor effects catalyzed in solar enzymes. (evakoch.com)
Differentiation2
  • A survey of agricultural technologies influencing the biosynthesis and accumulation of phenolic compounds in crop plants is presented, including observations on the effects of light, temperature, mineral nutrition, water management, grafting, elevated atmospheric CO 2 , growth and differentiation of the plant and application of elicitors, stimulating agents and plant activators. (mdpi.com)
  • Ran GTP benefits with differentiation, acquiring its enzyme. (evakoch.com)
Molecule1
  • Search chemical reactions in Rhea for this molecule. (rhea-db.org)
Carbon1
  • As the thiolate anion is not energetically favoured in the hydrophobic interior of the enzyme, it swings into the active site where it can be stabilized by the His202 imidazolium and the dipole of helix C. The Cys123 thiolate which now lies adjacent to the acyl carbon of the substrate, is thus generated only in the presence of substrate. (inrae.fr)
Reduction2
  • this has seen reduction in SO 2 emissions across Europe by more than 60% between 1990 and 2004 (Vestreng et al. (springer.com)
  • reproductive enthusiastic feed 's the Common reduction of 1,3-diaminobenzenes from entirely gradual risks. (xn--drpverein-rahe-vpb.de)
Dopamine1
  • This reactions in high download Dopamine in the Pathophysiology and of overall Phosphorylation that is particular( Gustafsson et al. (evakoch.com)
Compounds2
  • low-molecular-weight (LMW) compounds consist of two or three rings, and high-molecular-weight (HMW) compounds, more than three rings [ 3 ]. (omicsonline.org)
  • Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)
20234
  • 2023, 43(3): 297-309. (tea-science.com)
  • Analysis of Codon Usage Bias and Phylogenesis in the Chloroplast Genome of Ancient Tea Tree Camellia taliensis in Forest-tea Garden[J]. Journal of Tea Science, 2023, 43(3): 297-309. (tea-science.com)
  • 2023, 43(3): 310-324. (tea-science.com)
  • Thea bohea L.) Based on GBS-SNP[J]. Journal of Tea Science, 2023, 43(3): 310-324. (tea-science.com)
Catalyzes1
  • The enzyme catalyzes the oxidation of o-diphenols to o-quinones without hydroxylating monophenols, the additional activity of tyrosinase. (lookformedical.com)
Proteins2
  • It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. (lookformedical.com)
  • To characterize the proteins involved in cell clump/cell adhesion of insect cellular defense reactions, we induced the cell clump/cell adhesion reaction in vitro with the hemolymph of larvae of the coleopteran insect, Tenebrio molitor. (lookformedical.com)
Biosynthesis1
  • The enzyme responsible for collagen maturation is prolyl 4-hydroxylase, making this enzyme a central activity in cuticle biosynthesis and a potentially important chemotherapeutic target. (embl.de)
20221
Generate1
  • Specifically, less than half of the United Nations' member states have the resources to generate water quality data robust enough to drive governance 3 . (nature.com)
Inhibits1
  • Coumaran (2,3-dihydrobenzofuran), a secondary metabolite of Cyperus nipponicus , inhibits the feeding of polyphagous insects. (go.jp)
Temperature1
Metabolism2
Activity1
Responsible1
  • The enzymes responsible for growth on these substrates are encoded by a large plasmid with properties similar to those of TOL plasmids isolated from other strains of Pseudomonas. (rhea-db.org)
Database1
Protein2
  • This competitive enzyme-linked immunosorbent assay-like method, used competitive binding of free hyaluronan in the sample and biotin-labeled standard hyaluronan to hyaluronan binding protein in solid phase. (go.jp)
  • Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)
Sites2
Products1
  • The catechols were converted to meta ring fission products by an inducible catechol-2,3-dioxygenase which was partially purified from p-xylene-grown cells of P. putida BG1. (rhea-db.org)
Group2
  • Unlike the proteases, DLH seems to protonate the incipient leaving group only after the collapse of the first tetrahedral intermediate, rendering DLH incapable of hydrolyzing amide analogues of its ester substrate. (inrae.fr)
  • A group of 1,2-benzenediols that contain the general formula R-C6H5O2. (lookformedical.com)
Common1
  • The 2,3-dihydrobenzofuran derivative, 7-acetyl-4,6-dimethoxy-2-isopropenyl-2,3-dihydrobenzofuran, had an ED 50 value of 1.3 μg (5.4×10 -9 mol)/cm 2 against the common cutworm. (go.jp)
Studies2
  • Our inhibitor binding studies suggest that its substrate, dienelactone, is held in the active site by hydrophobic interactions around the lactone ring and by the ion pairs between its carboxylate and Arg-81 and Arg-206. (inrae.fr)
  • Expressed sequence tag (EST) analysis and developmental polymerase chain reaction (PCR) studies demonstrated that Ov-phy-1 was expressed in L3 and adult parasites. (embl.de)
Small1
  • Also acts on 2'-hydroxyformononetin and to a small extent on 2'-hydroxygenistein. (qmul.ac.uk)
Basis1