Amino Acid SubstitutionMolecular Sequence DataAmino Acid SequenceMutationBase SequenceMutagenesis, Site-DirectedPoint MutationStructure-Activity RelationshipModels, MolecularEvolution, MolecularBinding SitesKineticsPhylogenyEscherichia coliSequence AlignmentMutation, MissenseProtein ConformationSequence Homology, Amino AcidMutagenesisGenetic VariationDNA Mutational AnalysisProtein Structure, TertiarySequence Analysis, DNACell LineRaynaud DiseaseCodonAlanineProtein BindingModels, GeneticRecombinant ProteinsDNAPhenotypePolymerase Chain ReactionCloning, MolecularAllelesProtein Structure, SecondaryDNA PrimersSubstrate SpecificityConserved SequenceSelection, GeneticSpecies SpecificityGlycinePlasmidsBacterial ProteinsCysteineAmino AcidsTime FactorsCatalysisBiological EvolutionDrug SubstitutionArginineAspartic AcidExonsTransfectionPedigreeModels, BiologicalSerinePolymorphism, GeneticCricetinaeComputer SimulationNo-Reflow PhenomenonTemperatureMutant ProteinsSequence Homology, Nucleic AcidMolecular StructureRecombinant Fusion ProteinsNucleic Acid ConformationFreeze SubstitutionHistidineProlineHydrogen-Ion ConcentrationLysineTranscription, GeneticGenotypeSequence DeletionCells, CulturedPeptidesAsparagineEscherichia coli ProteinsAmino Acid MotifsThermodynamicsSaccharomyces cerevisiaeBase CompositionCircular DichroismViral ProteinsLikelihood FunctionsVirus ReplicationProteinsCell MembraneCOS CellsPeptide FragmentsValineMagnetic Resonance SpectroscopyCrystallography, X-RayDNA-Binding ProteinsPhenylalanineEnzyme StabilityCatalytic DomainOligodeoxyribonucleotidesDNA, Complementary