• A new compliant scaffold suitable for small-diameter vascular grafts has been developed that promotes strong attachment of endothelial cells. (strath.ac.uk)
  • Additive manufacturing has a great potential for creating hard tissue substitutes, such as bone and cartilage, or soft tissues, such as vascular and skin grafts. (desktopmetal.com)
  • Her works also included development of hybrid scaffold using biodegradable polymer and biomimetic fibrin composite for small diameter vascular grafts and tissue engineered skin substitutes. (drmoopensmc.ac.in)
  • This technology uses the three-dimensional model as the "blueprint" and 3D printer and bio materials to produce customized grafts, auxilliary grafts, scaffolds, tissues and organs, and other products from the biological ink containing cells and biological materials, so as to realize the tissue functionalization. (runyoung.tech)
  • Moreover, the harvest of vessels prolongs the surgical procedure and it may lead to the morbidity of donor site in elder patients: therefore, it seems that the use of tissue-engineered vessels would be an attractive and less invasive substitute for autologous vascular grafts. (biomedcentral.com)
  • Conclusions-Our novel bioresorbable vascular grafts showed well-organized neointimal formation in the high pressure arterial circulation environment. (docksci.com)
  • If the patient has viable tissue, they must be subjected to additional surgical procedures for harvesting and preparing the tissue grafts. (docksci.com)
  • To alleviate these issues, prosthetic arterial grafts have arisen as a viable alternative to autologous arterial or venous substitutes required for patients with cardiovascular diseases. (docksci.com)
  • Current commercialized prosthetic grafts composed of expanded-polytetrafluoroethylene or polyethylene terephthalate have arisen as a substitute and have shown promise in large blood vessels (>6mm). (docksci.com)
  • Several types of grafts can be used for vascular reconstruction. (medscape.com)
  • These can be divided into autologous tissue grafts, allografts, xenografts, alloplastic prostheses/artificial grafts, and tissue-engineered vascular grafts. (medscape.com)
  • Tissue engineering of native vessels is an alternative approach for patients with vascular disease who lack sufficient saphenous vein or other suitable conduits for autologous vascular graft. (biomedcentral.com)
  • He is also designing a small diameter tissue engineered vascular graft to treat cardiovascular diseases. (pitt.edu)
  • Novel Bioresorbable Vascular Graft With Sponge-Type Scaffold as a Small-Diameter Arterial Graft. (docksci.com)
  • The purpose of the present study is to evaluate the feasibility of arterial bioresorbable vascular graft, which has a porous sponge type scaffold, as a small-diameter arterial conduit. (docksci.com)
  • The ideal vascular graft has yet to be developed, and all materials have advantages and disadvantages. (medscape.com)
  • These data confirm the potential of this novel composite scaffold in vascular tissue engineering. (strath.ac.uk)
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
  • SEM images and characterization methods were also used to evaluate the effect of apelin-13 attachment to the acellular scaffold on tissue recellularization. (biomedcentral.com)
  • The researchers evaluated the effects of daily injection of a C3a receptor antagonist (C3aRa), SB290157, beginning eight hours after the SARS-CoV-2 S1 infusion in hACE2-expressing animals to establish that complement activation is critical in potentiating the S1-induced endothelial damage in the pulmonary tissues. (crunchtime-records.com)
  • Ed and vascular disease.27 18 in a tissue that may persist endothelial cells express cx27 in addition to diseases that affect .Gov.Uk/docs/facts and figures 2-6.Pdf. (ben.edu)
  • The incubation of DSS fibroblasts with a synthetic cannabinoid receptor agonist (WIN55, 212- 2) decreased their expression in a dose-dependent manner, together with a parallel reduction in collagen production and pro- fibrotic cytokines, including transforming growth factor-beta (TGF-beta), connective tissue growth factor and interleukin-6 (IL-6). (aad.org)
  • Also, those with other diseases that include glaucoma, cataract, and other related conditions can obtain great benefits to strengthen their vascular and connective tissues, cells, and nerves around the eyeballs. (dhmreviews.com)
  • Specifically, a bilateral hypoplasia of the medial clavicular portion of the pectoralis major muscle was noticed along with the coexistence of total right pectoralis minor aplasia, substituted by loose connective and fatty tissue. (edu.au)
  • Commonly, an analogy is drawn between the vascular system and sap of plants and the blood vessels and blood of the human body . (newworldencyclopedia.org)
  • They cause weakness in the blood vessels, particularly the arteries, that can lead to vascular problems such as aneurysms, aortic dissections, and ruptures. (vascular.org)
  • When 3D bioprinting technology was first applied in biomedicine, only 3D scaffolds including bone, cartilage, blood vessels, nerves, tendons, teeth and skin tissues could be printed. (runyoung.tech)
  • The treatment of osteoarthritis (OA)-related cartilage defects is a great clinical challenge due to the complex pathogenesis of OA and poor self-repair ability of cartilage tissue. (bvsalud.org)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
  • Rafie Hamidpour, Abdulmajeed A.Hammadi, Luay Rashan: A new novel technique for isolation of stromal vascular fraction from adipose tissue using acoustic waves for clinical applications. (edu.om)
  • These disadvantages can result in complications and the development of a bone substitute materials offers a potential alternative to overcome these shortcomings. (frontiersin.org)
  • If you have diabetes, it is common to develop foot ulcers as a result of vascular complications. (hcavirginia.com)
  • Smoking cessation should be encouraged to reduce the risk of vascular disease complications. (diabetesjournals.org)
  • The key factor during the smart hydrogel design is on accurately identifying the characteristics of natural tissues and faithfully replicating the composition, structure, and biological functions of these tissues at the molecular level. (bvsalud.org)
  • Such hydrogels can accurately sense distinct physiological and external factors such as temperature and biologically active molecules, so they may in turn actively and promptly adjust their response, by regulating their own biological effects, thereby promoting damaged tissue repair. (bvsalud.org)
  • Generally speaking, 3D bioprinting means to print biocompatible materials containing living cells into three-dimensional functional living tissues through 3D printing technology, and realize functions similar to, identical with, or even superior to target tissues or biological organs. (runyoung.tech)
  • Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. (routledge.com)
  • Our wound healing specialists employ moist wound care principles and use advanced technologies, such as the negative pressure device, biological skin substitutes and multilayer compression wraps. (hcavirginia.com)
  • She is also director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering at the university. (routledge.com)
  • He also serves as a Director of the Center for Vascular Remodeling and Regeneration, the Co-Director of the Center for Medical Innovation, the Acting Director of the University's GRID Institute, as well as the Director of the Vascular Bioengineering Laboratory. (pitt.edu)
  • Her In vivo animal model preclinical evaluations include Burn & Diabetic animal wound model for skin substitutes, Spinal cord injury model for fibrin aided neural progenitor transplantation, Myocardial infarction model for cardiac progenitor transplantation, Rabbit knee joint inflammation model for the anti-inflammatory function of HSA-Curcumin and Lung cancer (xenograft) model in SCID mice for anticancer property of Curcumin-HSA. (drmoopensmc.ac.in)
  • Physicians only need to use the cells of the patients as raw materials in order to cultivate tissues and organs that are completely suitable for patients. (runyoung.tech)
  • The research in Dr. Vorp's lab focuses on the biomechanics, "mechanopathobiology," regenerative medicine, and tissue engineering of tubular tissues and organs, predominantly the vasculature. (pitt.edu)
  • Systemic Sclerosis Systemic sclerosis is a rare chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin, joints, and internal organs (especially the esophagus. (msdmanuals.com)
  • 3.They lack tissue differentiation and vascular tissues. (rbsesolutions.com)
  • The EPCs plays critical role in postnatal vasculogenesis through pivotal bioactivities of mobilization, homing, migration, differentiation, and proliferation in angiovasculogenic tissues [ 6 ]. (hindawi.com)
  • The vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. (bvsalud.org)
  • Broadband intense pulsed lights for vascular malformations -- 33. (edu.au)
  • Porcine small-intestinal submucosa has been used to construct vascular conduits. (medscape.com)
  • Bovine pericardium has been used to fabricate conduits for vascular reconstruction. (medscape.com)
  • This article addresses the options and rationale behind choosing vascular reconstruction conduits in the pediatric population, as related to the most common circumstances requiring intervention. (medscape.com)
  • The other type of transport tissue in plants, xylem , transports water. (newworldencyclopedia.org)
  • Similar to the network of veins and arteries, the phloem and xylem of a vascular plant comprises an extensive network of tubes that transport essential fluids from one part of a plant to another area. (newworldencyclopedia.org)
  • Sap, the watery fluid with dissolved substances that travels through vascular tissues (both xylem and phloem), is transported through phloem in elongated tubes, called sieve tubes , formed by chains of living cells called sieve tube members . (newworldencyclopedia.org)
  • In leaves, the sugar source, the xylem, and the phloem are located close to the photosynthetic tissue, which takes water from the xylem and, through active transport, loads sugar (and other products of photosynthesis) into the phloem for transport to the sink. (newworldencyclopedia.org)
  • Xylem tissues of the radial vascular bundles are composed of small groups of pitted and reticulate vessels embedded in parenchyma. (thepharmacognosy.com)
  • The identification of constitutive mechanical models of vascular tissue is essential for quantifying the local environment of mechanosensitive vascular cells in normal and disease states, understanding mechanically-mediated vascular tissue remodeling, and providing a basis for the engineering of vascular tissue substitutes. (sc.edu)
  • Are they of value in immunologically-mediated collagen vascular disease? (aad.org)
  • The most pressing limitation in using autografts for cardiovascular surgeries is insufficient availability of viable tissue in patients, especially patients with widespread atherosclerotic vascular disease. (docksci.com)
  • Cigarette smoke (CS) is well known to be a risk factor for pulmonary diseases including chronic obstructive pulmonary disease (COPD), lung cancer, asthma, pulmonary hypertension, and vascular diseases such as atherosclerosis [ 1 ]. (hindawi.com)
  • Initial screening for peripheral vascular disease should include a history for claudication and an assessment of the pedal pulses. (diabetesjournals.org)
  • The vast majority of data regarding vascular reconstructive surgery in pediatric patients come from experience with right ventricular outflow obstruction, midaortic syndrome, renal-artery occlusive disease and hypertension, iatrogenic vascular trauma, and access for hemodialysis. (medscape.com)
  • This examination should include assessment of protective sensation, foot structure and biomechanics, vascular status, and skin integrity. (diabetesjournals.org)
  • C3 deposits in the pulmonary tissues were assessed to study the deleterious function of complement activation in the onset of pulmonary vascular damage in hACE2-expressing mice infused with S1. (crunchtime-records.com)
  • They also investigated the potential activities of the C3a/C3a receptor (C3aR) axis in SARS-CoV-2 S1-induced damage to pulmonary tissue by examining the levels of certain C3aR at various time points across several pulmonary compartments. (crunchtime-records.com)
  • To determine if S1 infusion caused pulmonary vascular cell injury in hACE2-expressing mice, the team quantified the number of biomarkers associated with thrombo-inflammatory processes, such as thrombomodulin (TM). (crunchtime-records.com)
  • Transmission electron microscopy (TEM) was used to examine the pulmonary tissues of hACE2-expressing animals a week after the S1 injection. (crunchtime-records.com)
  • C3aRa treatment inhibited C3a/C3aR activation and pulmonary C3 deposition, reducing vascular thrombi inflammation and fibrosis. (crunchtime-records.com)
  • Histopathological evaluation of the pulmonary tissues at seven days showed diffuse alveolar damage, thickening of the alveolar septa, and hypercellularity in the pulmonary tissues. (crunchtime-records.com)
  • In the pulmonary tissues a week after the SARS-CoV-2 S1 infusion, significant deposition of GR1-positive neutrophils and MAC2-positive macrophages was observed, indicative of early complement activation was crucial in the recruitment of inflammatory cells into the pulmonary tissues. (crunchtime-records.com)
  • Cigarette smoke is a major public health problem associated with multitude of diseases, including pulmonary and vascular diseases. (hindawi.com)
  • Composite scaffolds were produced by wet spinning polycaprolactone (PCL) fibres which form the luminal surface, then electrospinning porous polyurethane (PU) onto the back of the PCL fibres to form the vessel wall substitute. (strath.ac.uk)
  • In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
  • She is a manuscript reviewer for several journals on Biomaterials, Stem Cell & Tissue Engineering and an expert project reviewer for funding agencies like TIFAC-DST, ICMR, DSIR, DBT, and KSCSTE- Kerala. (drmoopensmc.ac.in)
  • This study is a pilot study for 3D printing of a new material mixture potentially used as a tubular substitute for urethra replacement. (desktopmetal.com)
  • Could companies eventually print functional cancerous tissue in the lab to hasten the development of oncology drugs? (advfn.com)
  • Angiosarcoma is a vascular tumor, the cells of which manifest many of the morphologic and functional properties of normal epithelium. (medscape.com)
  • Mostajeran M, Wetterling F, W Blixt F, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)
  • [ 1 ] Initial results with his techniques were disappointing because of the high rate of degeneration and vascular failure due to poor preservation methods, immunologic rejection, and inflammatory reactions that produced fibrosis, calcification, and aneurysms. (medscape.com)
  • Her research expertise also includes Adult Stem Cell-based Tissue Engineering & Regenerative medicine. (drmoopensmc.ac.in)
  • Since the development of the first bioprinter at the beginning of the 21st century, bioprinting has entered many fields including pathological model production, tissue design for drug screening, medical research and regenerative medicine. (runyoung.tech)
  • My early work was focused on understanding soft tissue-material interactions for the purpose of optimizing surgical sealant performance. (sc.edu)
  • Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. (wjgnet.com)
  • For patients with viable tissue, there is often a lack of harvestable vessels due to previous cardiovascular surgical procedures [1]. (docksci.com)
  • As eyes are into cavities connected to many nerves, veins, and tissues it is crucial to offer a full approach to guarantee they receive the nutrients they need. (dhmreviews.com)
  • The more significant difference lies in identifying the thermal changes due to changes in vascular network to support the growth of the tumor/lesion. (wikipedia.org)
  • The more detailed map of the vascular network contains information pointing to the location where the breast has changed to accommodate the tumor. (wikipedia.org)
  • In addition to typical phloem elements, fibers , sclereids (small bundles of supporting tissue in plants that form durable layers), and albuminous cells (similar in function to companion cells and found in gymnosperms ) can also be found in phloem. (newworldencyclopedia.org)
  • As your wound improves, Mirragen is absorbed into the surrounding tissue so there's no need to have it removed. (engineeredtissue.com)
  • We work with you and your referring doctor, as well as collaborate with other specialized physicians, such as vascular surgeons, when necessary, to promote proper, complete wound healing. (hcavirginia.com)
  • Therefore, it can be a suitable substitute for the common oral industrial antibiotics. (bvsalud.org)
  • Publications in these areas have been impactful in terms of providing data and models for previously understudied yet critical regions of the circulatory system, applying continuum-mechanical principles to explain intra-vessel variations in geometry, properties, and composition, and introducing tissue-engineered constructs which exhibit enhanced matrix elaboration and thus potential as vascular substitutes. (sc.edu)
  • Testometric tensile testing machine was also used for the assessment of mechanical properties and uniaxial tensile strength of decellularized and recellularized vessels compared to that of native tissues. (biomedcentral.com)
  • This sugar concentration gradient causes cells to actively transport solutes out of the sieve-tube elements into sink tissue. (newworldencyclopedia.org)
  • A meristem is a tissue in plants consisting of undifferentiated cells (meristematic cells) and found in zones of the plant where growth can take place: the roots and shoots. (newworldencyclopedia.org)
  • Mature cork cells are plant cells that form the protective water-resistant tissue in the outer covering of stems or trunks. (answerlib.org)
  • What tissue produces cork cells? (answerlib.org)
  • No, cork cells are not produced by the vascular cambium . (answerlib.org)
  • As growth proceeds, the cork cambium forms in living cells of the epidermis, cortex, or, in some plants, phloem and produces a secondary protective tissue, the periderm . (answerlib.org)
  • The outer ground tissue consists of subcrised parenchymatous cells. (thepharmacognosy.com)
  • These cells dam up the vascular tissue, and it is these clogged pores that prevent an oak cask from leaking. (whiskyadvocate.com)
  • Plants expressing this construct conferred a vascular cell-specific expression pattern for the reporter gene. (molcells.org)
  • Reconstructions with free and pedicled flaps usually involve highly complex technical procedures, with considerable failure rates (12%) and the risk of amputation (18%)3,7, which are related to the patient's condition (instability, hemodynamic imbalance), the small percentage of surrounding viable tissue, and rarity of receptor areas for transfer. (rbcp.org.br)
  • Vascular reconstruction in pediatric patients requires a substantially different approach from that used in adults. (medscape.com)
  • The angiothermography is not a test that substitutes for other tests, but stands in relation to them as a technique that gives additional information to clarify the clinical picture and improve the quality of diagnosis. (wikipedia.org)
  • First, we provided the initial demonstration that adhesion is a tissue-specific phenomenon that can be exploited in advanced material design. (sc.edu)
  • During SC administration, a needle is inserted through the epidermal and dermal layers of the skin and into the fatty subcutaneous tissue. (pharmtech.com)
  • Cork cambium is the lateral meristem that is accountable for secondary growth substituting the epidermis in the roots and stems. (answerlib.org)
  • Cork cambium is a plant tissue that is part of a plant's outer covering, or periderm. (answerlib.org)
  • 3D printing has been used to create vascular tissue, low-cost prosthesis, proprietary, patient plaster, bone substitute etc. (pcbcart.com)
  • If you smoke, ask your vascular surgeon to help you find a smoking cessation program that will work for you. (vascular.org)
  • This technology, once implemented in large scale, will bring a new life to numerous patients needing organ transplatation and tissue repair. (runyoung.tech)
  • The EPCs seem to be impaired and thus lead to the repair of capacity of the lung tissue reduced in patients with COPD. (hindawi.com)
  • Patients should be educated on the implications of sensory loss and the ways to substitute other sensory modalities (hand palpation, visual inspection) for surveillance of early problems. (diabetesjournals.org)
  • La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
  • Infection is a risk with any parenteral injection because of the risk of bacteria being introduced into the tissue (2, 4-6), which in turn can lead to abscesses and infections in the skin or soft tissue. (pharmtech.com)
  • Angiosarcoma is rare, accounting for less than 2% of all soft-tissue sarcomas, and may vary from highly differentiated tumors to those with significant anaplasia, often making these tumors difficult to differentiate from melanoma or carcinoma. (medscape.com)
  • While it can occur in any location in the body, angiosarcoma is most commonly found in the skin and soft tissues. (medscape.com)
  • [ 3 , 4 ] In contrast to the deep location of most soft-tissue sarcomas, angiosarcoma has a predilection for skin and superficial soft tissue on the scalps of elderly people, constituting less than 1% of all head and neck malignancies. (medscape.com)
  • Deletion analyses of the promoter region indicated that regulatory elements determining vascular cell-specific expression are present in the 200-bp region between -245 bp and -45 bp from the transcription initiation site. (molcells.org)
  • He is interested inbetter understanding substitutes integration with native tissue, in particular vascular integration that is vital for cell survival. (uthscsa.edu)
  • The formation of the cork tissue is the end result of the meristematic activity of a specialized phellogen tissue, or cork cambium, followed by cell expansion and an extensive cell wall deposition of suberin and waxes and, ultimately, an irreversible program of senescence ending in cell death (Soler et al. (answerlib.org)
  • As daily nutrition may lack enough nutrients, this supplement is an excellent choice to complement and substitute those nutrients. (dhmreviews.com)
  • Smart hydrogels can autonomously sense and respond to the physiological/pathological changes of the tissue microenvironment and continuously adapt the response according to the dynamic spatiotemporal shifts in conditions. (bvsalud.org)