Substantial reactivity. Medical search. Frequent questions

Neutralizing antibody cross-reactivity occurs between Zika virus and related flaviviruses, but the degree to which this confounds diagnosis is uncertain. (cdc.gov)
Prolonged detection of IgM and neutralizing antibody cross-reactivity make it difficult to determine the timing of Zika virus infection and differentiate between related flaviviruses. (cdc.gov)
Cross-reactivity between Zika virus and other flaviviruses occurs both with IgM and neutralizing antibodies and makes distinguishing Zika virus from dengue virus infections especially challenging. (cdc.gov)
Whereas primary Zika virus infections typically generate highly specific neutralizing antibodies, secondary flavivirus infections show a high degree of cross-reactivity ( 6 , 15 , 16 ). (cdc.gov)
Screening the array with sera and ileal fluid samples from immunized pigs suggested cross-reactivity among homologous proteins and a general activation of immunity. (frontiersin.org)
For patients with a diagnosis of gonorrhea and a concomitant reported allergy to penicillin, ceftriaxone is often avoided, even though the cross-reactivity between penicillin allergy and third-generation cephalosporins is low ( 652 - 654 ). (cdc.gov)
This structural similarity has led to considerable confusion regarding cross-reactivity of these drugs and the risks for allergic reactions from cephalosporins among penicillin-allergic patients. (cdc.gov)
This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
While, naturally, the search for a successful vaccine and efficient treatment protocols are paramount, immunologists who focus on autoimmunity have been concerned whether the infection or even a newly developed vaccine itself can trigger autoimmunity via cross-reactivity. (frontiersin.org)
Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
There are three important questions regarding the role of cross-reactivity with SARS-CoV-2. (frontiersin.org)
First, does cross-reactivity play a role in the multi-system disorders associated with SARS-CoV-2 infection? (frontiersin.org)
Second, how does cross-reactivity contribute to the pathophysiology of SARS-CoV-2-induced autoimmunity? (frontiersin.org)
We will begin with the first question of whether cross-reactivity can be involved in the multi-system response of COVID-19 infection. (frontiersin.org)
Lower SARS-CoV-2 cross-reactivity was seen in countries and cohorts of high HIV seroprevalence. (medrxiv.org)
More sparse individual-level data showed associations of higher SARS-CoV-2 cross-reactivity with Plasmodium parasitemia and lower SARS-CoV-2 cross-reactivity with HIV seropositivity. (medrxiv.org)
Levels of cross-reactivity tracks especially with malaria prevalence. (medrxiv.org)
In two independent antibody purification/depletion experiments with permutated order of VAR2CSA variants, IgG purified on the first VAR2CSA antigen displayed broad cross-reactivity to both recombinant and native VAR2CSA variants, and inhibited binding of all isolates to CSA. (elifesciences.org)
ELISA was done to verify cross reactivity of L. major antiserum to antigen derived from both L. major and L. infantum . (cwu.edu)
Results indicate substantial cross reactivity to the two antigens. (cwu.edu)
Importantly, the study used concomitant testing of Zika virus in patient serum as well as cerebral spinal fluid (CSF) samples and was the first to simultaneously test for CSF, Zika virus, and dengue IgM antibodies in order to exclude the confounder of cross-reactivity from flavivirus, which is highly common in Central and South America. (medscape.com)
We believe that our method of matching CSF and blood serologic findings offers a substantial aid to minimize cross-reactivity in countries with a high prevalence of other concurrent flavivirosis," the authors note. (medscape.com)
13-15 Exposure to NTM has been suggested to impact on the efficacy of the Bacille Calmette-Guérin vaccine 16 and to exhibit cross-reactivity to the tuberculin skin test (TST), leading to increased difficulties in interpreting TST-positive results and evaluating the protection through the only available vaccine against TB. (who.int)

These particles display different surface charges and hydration structures on different crystalline facet, which lead to different chemical, photochemical, and electrochemical reactivity. (utwente.nl)
Given that water serves as a universal solvent, understanding its central role in regulating electrochemical reactivity has transformative implications. (jhu.edu)

We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)

The five VAR2CSA variants purified ~0.7% of total IgG and yielded both strain-transcending and strain-specific reactivity to VAR2CSA and IE-surface antigen. (elifesciences.org)

Serologic reactivity suggesting SIV infection was found in 13 of 16 primate species, including 4 not previously known to harbor SIV. (cdc.gov)

Its significant skin-calming and skin-normalizing properties may aid in the reduction of skin sensitivity concerns such as redness and reactivity. (generaltopic.us)
CBD oil offers significant soothing properties, and its substantial skin normalizing and skin-calming effects greatly help to minimize skin sensitivity, including reactivity, and redness. (serendipitymommy.com)

They usually have one or more of the following hazardous traits: ignitability, reactivity, corrosivity, toxicity. (wikipedia.org)
Hazard profiles are based principally on metrics regarding mode of toxic action, chemical reactivity, food web-derived internal toxicity thresholds, bioavailability, and chemical and biological activity. (canada.ca)

Uncertain reactivity was classified as present. (tropmedres.ac)

Binding of CO 2 to the clay nanoparticles minimizes the risk of CO 2 leakage, which has been the source of substantial societal opposition against conventional CCS (carbon capture and storage) technologies. (utwente.nl)

We examined the X-ray Raman spectra of silica, borate and carbonate glasses to search for signatures indicating substantial changes in the local bonding environment. (anl.gov)
Nanoparticles of silica showcase a substantial specific surface area, yielding ample surface area per unit volume. (edomyzbali.com)
Nanoparticles of silica exhibit noteworthy thermal stability and chemical reactivity. (edomyzbali.com)
Silica nanoparticles represent nanomaterials possessing unique properties, such as high specific surface area, elevated activity, remarkable permeability, outstanding thermal stability, and chemical reactivity. (edomyzbali.com)
Nanoparticles of silica showcase a substantial specific surface area, leading to significant surface area per unit volume. (libriz.net)
Nanoparticles of silica display impressive thermal stability and chemical reactivity. (libriz.net)
Silica nanoparticles represent nano-sized materials endowed with noteworthy properties, such as elevated specific surface area, elevated activity, impressive permeability, outstanding thermal stability, and chemical reactivity. (coachbagscherry.com)

Thus, the chemical conversion of a small polar, cationic lysine residue on the antibody surface to a large hydrophobic, polyanionic dye derivative has the potential to produce substantial changes in antibody folding and physiochemical properties, leading to lower antibody stability and decreased target specificity. (vectorlabs.com)

Data obtained from Vaxart's oral COVID-19 vaccine Phase I trial showed substantial CD8 + T-cell responses, as measured by IFN-g and TNF-a induction. (vaxart.com)

Significant differences in the reactivity of norbornene derivatives in the inverse electron-demand Diels-Alder reaction with tetrazines were revealed by kinetic studies. (cipsm.de)

Little data are available on the prevalence of NTM infections in TB high-burden countries, but the incidence can nevertheless be substantial. (who.int)

The chemical industry relies on aluminum isopropoxide for its excellent reactivity and ability to facilitate diverse chemical reactions. (credenceresearch.com)

As a result, substantial progress has been made in stopping the spread of infection through large-scale, annual treatment of eligible people in areas where infection is present. (msdmanuals.com)

A structural comparison suggests that the wide cavity at the substrate binding site is likely responsible for the high reactivity of the enzyme toward both L- and D-serine enantiomers. (rcsb.org)
Substantial SARS-CoV-2 reactivity was seen in high malaria burden with or without high dengue burden (14% and 12%, respectively), and not without high malaria burden (2% and 0%, respectively). (medrxiv.org)
These include the effects of small size, significant specific surface area, high surface energy, and chemical reactivity. (edomyzbali.com)

Taken together, these findings suggest a substantial role of airway inflammatory disease in WTC-associated obstructive airway disease, and, by extension, in any lung injury caused by massive inhalation of particulates. (cdc.gov)
Muscarinic reactivity was determined by measuring specific airway resistance (sRaw) in response to increasing doses of aerosolized acetylcholine in guinea pigs that were either exposed to air or to ozone (3.0 ppm, 2 h). (cdc.gov)

5.1 These test methods are used to assess the chemical (pozzolanic or hydraulic) reactivity of SCMs over a curing time of 7 days. (astm.org)
1.1 These two alternative test methods are used to assess the chemical reactivity of a supplementary cementitious material (SCM) as determined by measurements of cumulative heat release or bound water content of hydrated pastes composed of the SCM, calcium hydroxide, calcium carbonate, potassium sulfate, and potassium hydroxide cured at 40 °C for 3 and 7 days. (astm.org)
10 years after 9/11, to define the natural history of WTC-associated OAD, to determine whether clinical outcomes varied according to their degree of bronchial reactivity, and to assess the influence of anti-inflammatory treatment (oral and/or inhaled corticosteroids). (cdc.gov)

do not cite [5] show that, in households where one person was confirmed as having COVID-19, a substantial proportion of other household members had negative PCR test results, implying that they were not infective, despite most of them having typical COVID-19 symptoms. (wattsupwiththat.com)
Schnurr, 2017) and a substantial proportion of individuals discontinue treatment prematurely (Garcia et al. (div12.org)
These data document for the first time that a substantial proportion of wild monkeys in Cameroon are SIV infected and that humans who hunt and handle bushmeat are exposed to a plethora of genetically highly divergent viruses. (cdc.gov)

PCA clustering showed that the overall immune responses were altered by immunization, but no substantial changes were observed following direct worm challenge with either Ascaris suum or Trichuris suis . (frontiersin.org)

The overexpressed enzyme appears to be the most thermostable L-SerDH described to date, and no loss of activity was observed by incubation for 30 min at temperatures up to 100 °C. The enzyme showed substantial reactivity towards D-serine, in addition to L-serine. (rcsb.org)
Its underlying concept involves initiating gas-phase reactions at substantial temperatures to generate solid materials, that are subsequently deposited onto substrates. (edomyzbali.com)

Our study presents a substantial stride forward by unveiling a strategic approach to optimizing the electrochemical reduction of CO 2 into coveted C2+ products. (jhu.edu)

Hazardous waste is waste that has substantial or potential threats to public health or the environment. (wikipedia.org)
5.4 These test methods allow for the direct measurement of the hydraulic or pozzolanic reactivity of a potential SCM. (astm.org)
This particular trait bestows enhanced reactivity and noteworthy adsorption potential, enabling ideal interaction with the surrounding surroundings and optimization of performance. (edomyzbali.com)
This aspect conveys substantial chemical reactivity and biological potential. (libriz.net)

This technology continues to result in substantial clarification of the role of established agents in the pathogenesis of previously undocumented disease sequelae. (vin.com)

Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium. (vanderbilt.edu)

Manganese sulfate, a compound of substantial interest, commands attention for its unique properties and diverse applications. (imarcgroup.com)
In some other studies, substantial pre-existing T-cell reactivity to SARS-CoV-2 was detected in many people from diverse geographical locations without a history of exposure. (bvsalud.org)

This study will re-examine a large number of firefighters who had bronchial reactivity soon after 9/11 to determine whether those with bronchial hyper-reactivity at onset have persistent hyperactivity more than ten years later, whether they have accelerated lung function decline, and whether those treated with anti-asthma medications were more likely to show resolution of bronchial hyperactivity and/or show less rapid decline in lung function. (cdc.gov)

In addition, both total and percent released NAGA in bronchoalveolar lavage fluid obtained immediately after reactivity testing were significantly greater in the ozone -exposed group. (cdc.gov)
In addition, tem- reactivity and self-regulation, influenced over time by perament is a relevant construct for understanding of heredity, maturation, and experience (Rothbart, 1981). (bvsalud.org)

4 and are a result of the work of RILEM Technical Committee 267 - Tests for Reactivity of Supplementary Cementitious Materials. (astm.org)
Les panels se sont avérés utiles pour déterminer la performance des tests anti-VHC, ce qui a permis aux autorités nationales, notamment dans les pays disposant de ressources limitées, de choisir en connaissance de cause des tests abordables et fiables. (who.int)

gao Z , 2001 , 'Laser ablation mass spectrometry of binary clusters: an investigation of their relative stabilities and reactivities. (edu.au)

For good outcome prediction, specificity increased from 70% to 89%.InterpretationEEG-R testing in itself is not sufficiently reliable for outcome prediction in patients after CA. For poor outcome prediction, it has no substantial added value to EEG background, neurological examination, and SSEPs. (tropmedres.ac)

2022). Regarding PTSD symptom clusters, in a study of 203 trauma-exposed community participants, more PTSD symptom cluster severity (i.e., intrusions, negative alterations in cognitions/mood, and alterations in arousal and reactivity) was associated with fewer retrieved specific positive autobiographical memories (Contractor et al. (div12.org)

For this reason multivariate cluster analysis was carried out to examine the relationship between heart rate and blood pressure reactivity patterns and hypertension in a large prospective cohort (age range 55-60 years). (stir.ac.uk)
Drop-based energy harvesting has attracted substantial attention in recent years. (utwente.nl)
The global aluminum isopropoxide market has witnessed substantial growth in recent years and is expected to continue its upward trajectory. (credenceresearch.com)

Our results hint at UFR's relationship to baseline testosterone and may indicate functional connections between outcomes of pubertal organizational hormone effects and contest-induced steroid reactivity. (springer.com)
Substantial evidence links exaggerated mental stress induced blood pressure reactivity to future hypertension, but the results for heart rate reactivity are less clear. (stir.ac.uk)

Method A can also provide an indication of rate of reactivity because measurements are taken continuously during the test period, while Method B provides the level of reactivity up to a single point in time. (astm.org)
Cluster 3 was characterised by blunted cardiovascular stress reactivity across all variables and cluster 4, by an exaggerated blood pressure response and modest heart rate response. (stir.ac.uk)
Substantial rate enhancement for the exo norbornene isomers was observed (see scheme). (cipsm.de)

FcRγ-deficient NK cells displayed dramatically reduced expression of the natural cytotoxicity receptors NKp46 and NKp30 but still expressed substantial levels of CD16. (nih.gov)

Did bronchial reactivity influence the course of recovery or worsening function after WTC exposure? (cdc.gov)

Both effects were fairly strong, with the highest steroid dose predicting about 5 percentage points better result than those who did not receive steroids, and the most bronchial reactivity predicting about 5 percentage points worse result. (cdc.gov)

In this work, we examined the Utica Shale and its reactivity with CO2 and water from the perspective of understanding the Utica Shale play as a storage reservoir for CO2, adapting CO2 as an enhanced hydrocarbon recovery agent, and investigating the sealing properties in the presence of CO2. (nist.gov)

Further, retrieval of one positive memory increases the likelihood of retrieving other positive memories, and the affect experienced when recalling positive memories tends to remain for a substantial period of time (Ritchie et al. (div12.org)

The Utica Shale is expected to be a substantial fossil fuel resource in the future. (nist.gov)

Reactivity of Utica Shale was studied for outcrop and production samples at 40°C and CO2 pressures up to 10.3 MPa for 14 days. (nist.gov)

Anatomy27

Organisms15

Diseases11

Chemicals and Drugs76

Analytical, Diagnostic and Therapeutic Techniques and Equipment61

Psychiatry and Psychology11

Phenomena and Processes56

Disciplines and Occupations3

Information Science8

Named Groups1

Health Care20

Geographicals1

Cross-reactivity24

Electrochemical reactivity2

Antibodies2

Antigen1

Serologic1

Redness2

Toxicity2

Uncertain1

Carbon capture1

Silica7

Antibody1

Vaccine1

Derivatives1

Prevalence1

Chemical reactions1

Infection1

High3

Airway2

Assess3

Proportion3

Immune1

Temperatures2

Reduction1

Potential4

Role1

Structure1

Diverse2

Determine1

Addition2

Tests2

Relative1

Poor1

Specific1

Years3

Results2

Rate3

Levels1

Influence1

Result1

Properties1

Time1

Future1

Production1