Proteasome Endopeptidase ComplexUbiquitin-Protein LigasesUbiquitinUbiquitinsUbiquitinationCysteine EndopeptidasesMultienzyme ComplexesProteolysisI-kappa B ProteinsF-Box ProteinsLigasesPhosphorylationCullin ProteinsCell LineI-kappa B KinaseProtein Processing, Post-TranslationalProtein BindingMolecular Sequence DataNF-kappa BSignal TransductionAmino Acid SequenceUbiquitin-Conjugating EnzymesPeptide HydrolasesEndocytosisMutationCell Cycle ProteinsHeLa CellsHydrolysisProtein-Serine-Threonine KinasesProtein TransportCells, CulturedCell NucleusEndoplasmic ReticulumKineticsDNA-Binding ProteinsDown-RegulationSaccharomyces cerevisiae ProteinsAmino Acid MotifsBiodegradation, EnvironmentalModels, BiologicalRNA, Small InterferingProtein Structure, TertiaryLysosomesCarrier ProteinsCell Line, TumorCOS CellsCytoplasmTranscription FactorsRecombinant ProteinsApoptosisNuclear ProteinsBlotting, WesternAdaptor Proteins, Signal TransducingSaccharomyces cerevisiaeRNA, MessengerProto-Oncogene ProteinsRecombinant Fusion ProteinsIntracellular Signaling Peptides and ProteinsBase SequenceEnzyme ActivationMembrane ProteinsTime FactorsTumor Necrosis Factor-alphaBiological Transport3T3 CellsGene Expression RegulationTransfectionBinding SitesEndoplasmic Reticulum-Associated DegradationRNA StabilityProteasome InhibitorsCysteine Proteinase InhibitorsAutophagyProtein StabilityEndopeptidasesProtease InhibitorsProteinsSubstrate Specificitybeta-Transducin Repeat-Containing ProteinsPolyubiquitinSKP Cullin F-Box Protein LigasesHEK293 CellsUbiquitin-Protein Ligase ComplexesElectrophoresis, Polyacrylamide GelFibroblastsChromatography, High Pressure LiquidEndopeptidase ClpHalf-LifeEscherichia coliRNA InterferenceImmunoprecipitationBacterial ProteinsCalpainImmunoblottingTranscription, GeneticOxidation-ReductionExoribonucleasesTemperatureMolecular ChaperonesPeptide Fragments