• mean age, 62 years) who underwent lobectomy (n=574) or sublobar resection (n=330) for stage IA non-small cell lung cancer. (arrs.org)
  • BACKGROUND: The increased detection of small-sized peripheral non-small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy. (duke.edu)
  • CONCLUSIONS: In patients with peripheral NSCLC with a tumor size of 2 cm or less and pathologically confirmed node-negative disease in the hilar and mediastinal lymph nodes, sublobar resection was not inferior to lobectomy with respect to disease-free survival. (duke.edu)
  • Increased detection of small-sized, peripheral, non-small- cell lung cancer has renewed interest in sublobar resection instead of lobectomy, the traditional standard of care for early-stage lung cancer . (bvsalud.org)
  • Trainees will be involved with daily hands-on experience in a stepwise training process that will eventually allow them to safely perform VATS lobectomy in patients undergoing resection for early-stage lung cancer. (eacts.org)
  • In sub-lobar resection, the surgeon removes only the tumour and a small portion of the lung compared to a lobectomy where an entire portion of the lung is removed. (ecancer.org)
  • The increased detection of small-sized peripheral non-small cell lung cancer has renewed interest in sub-lobar resection in-lieu of lobectomy, according to N.K. Altorki, MD, from Weill Cornell Medicine-New York Presbyterian Hospital in New York City. (ecancer.org)
  • The results of this large North American/international randomised trial show that for patients with peripheral NSCLC 2 cm or less in size who have pathologically confirmed node-negative disease in major hilar and mediastinal lymph nodes, sub-lobar resection is non-inferior to lobectomy. (ecancer.org)
  • Surgical resection via lobectomy is the standard treatment for patients with early-stage lung cancer. (universimed.com)
  • Sublobar resections vs lobectomy for early stage lung cancer: where do we stand? (ers-education.org)
  • Lobectomy remains the standard treatment for early-stage non-small cell lung cancer (NSCLC).In practice, however, sublobar resection has been selectively offered for patients with clinical Stage IA NSCLC as curative treatment. (iaslc.org)
  • Initial direct overall health care charges per case for stage I non-small cell lung cancer charges stratified by treatmentTreatment strategy Standard radiotherapy SABR Sublobar resection Lobectomy Amebae Storage & Stability Pneumonectomy Ideal supportive care Initial direct wellness care expenses ( ) 7,646.98 eight,815.55 12,161.17 16,266.12 22,940.59 14,582.Fees are shown in 2013 Canadian dollars. (rockinhibitor.com)
  • Two large trials in the past two years compared lobectomy - the surgery most patients undergo - with a sub lobar resection, taking a portion of the lobe instead. (lungcancerresearchfoundation.org)
  • Stereotactic body radiotherapy (SBRT) had been increasingly recognized as a favorable alternative to surgical resection in patients with high risk for surgery. (e-crt.org)
  • In recent years, stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy has been increasingly recognized as a reasonable alternative to surgical resection for the patients who are at increased risk of postoperative morbidity and mortality [ 1 ]. (e-crt.org)
  • Although surgical resection is the first-line treatment, the indication for the surgical intervention is controversial, especially in mildly symptomatic or asymptomatic patients. (biomedcentral.com)
  • Even for CBA patients with subtle symptoms, early surgical treatments may be beneficial from the point of view of minimally invasive interventions, and sublobar resection will be sufficient for treatments and preservation of respiratory function. (biomedcentral.com)
  • Surgical resection is the standard treatment, and the number of cases of thoracoscopic surgeries for treating this condition is on the rise [ 3 ]. (biomedcentral.com)
  • When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy has been used increasingly both preoperatively (neoadjuvant chemotherapy) and postoperatively (adjuvant chemotherapy). (wikipedia.org)
  • Complete surgical resection is the treatment of choice for operable early-stage non-small cell lung cancer (NSCLC) and resectable stage IIIA. (ascopost.com)
  • To seek optimal surgical procedure for early stage lung cancer, we carried out retrospective analyses of 2122 patients who had undergone limited resection for c-T1N0M0 NSCLC from 26 institutions of Japanese association for chest surgery. (iaslc.org)
  • The results of a randomized study have previously shown that preoperative lesion localization is superior to no localization in terms of increased number of successful VATS wedge resections, reduced surgical time, and less frequent use of staples [ 3 ]. (biomedcentral.com)
  • In this article, we will describe only significant anatomical features of most common sublobar resections (SLR) and only those which have surgical consequences. (amegroups.org)
  • Adjuvant is treatment that's delivered after surgical resection, and perioperative is where it's given on both ends of the spectrum. (lungcancerresearchfoundation.org)
  • ADAURA trial, which Dr. Mohindra noted "was a big headliner for ASCO this year," looked at the use of osimertinib, an EGFR-directed therapy, after a surgical resection. (lungcancerresearchfoundation.org)
  • METHODS: We conducted a multicenter, noninferiority, phase 3 trial in which patients with NSCLC clinically staged as T1aN0 (tumor size, ≤2 cm) were randomly assigned to undergo sublobar resection or lobar resection after intraoperative confirmation of node-negative disease. (duke.edu)
  • RESULTS: From June 2007 through March 2017, a total of 697 patients were assigned to undergo sublobar resection (340 patients) or lobar resection (357 patients). (duke.edu)
  • Background: Z4032 was a randomized study conducted by the American College of Surgeons Oncology Group comparing sublobar resection alone versus sublobar resection with brachytherapy for high-risk operable patients with non-small cell lung cancer (NSCLC). (elsevierpure.com)
  • Methods: Eligible patients with stage I NSCLC tumors 3 cm or smaller were randomly allocated to undergo sublobar resection with (SRB group) or without (SR group) brachytherapy. (elsevierpure.com)
  • Conclusions: Adjuvant intraoperative brachytherapy in conjunction with sublobar resection did not significantly worsen pulmonary function or dyspnea at 3 months in a high-risk population with NSCLC, nor was it associated with increased perioperative pulmonary adverse events. (elsevierpure.com)
  • This study compared survival outcomes between sublobar resection (SLR) and SBRT for clinical stage I non-small cell lung cancer (NSCLC). (e-crt.org)
  • Dr. Altorki and his research colleagues conducted CALGB140503 (Alliance), a multicenter international non-inferiority phase III trial in which NSCLC patients clinically staged as T1aN0 ≤ 2 cm were randomly assigned to lobar or sub-lobar resection. (ecancer.org)
  • From a clinical point of view, the use of SABR prevented 566.2 deaths from lung cancer per year, with an typical annual obtain of 8663.six life-years or five,979.6 QALYs.DISCUSSIONThis model indicates that inside a population of about 35 million Canadians, SABR was the most cost-effective therapy modality for medically inoperable and borderline operable stage I NSCLC, dominating traditional RT, BSC, and sublobar resection. (rockinhibitor.com)
  • The rate of sublobar resection (SLR) for early-stage non-small cell lung carcinoma (NSCLC) is increasing, mainly because of a growing rate of early-stage lung carcinomas and ground-glass opacities. (amegroups.org)
  • One thousand one hundred fifty-six NSCLC patients who underwent complete resection in Kanazawa Medical University between January 2002 and December 2018 were identified. (researchsquare.com)
  • In the context of a prospective longitudinal study (Life after Lung Cancer-LiLAC) involving 244 patients with early-stage NSCLC, 158 (64.7%) patients completed the DSE either on paper or electronically online prior to treatment with SABR or VATS pulmonary resection. (biomedcentral.com)
  • Scholars@Duke publication: Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer. (duke.edu)
  • Patients were randomly assigned intraoperatively to either lobar or sublobar resection. (bvsalud.org)
  • 59% wedge resection). (bvsalud.org)
  • Uniportal thoracoscopic left lower lobe wedge resection was performed, following which the symptoms disappeared. (biomedcentral.com)
  • Right S6 segmentectomy and S2 wedge resection were carried out by multiportal thoracoscopic approach. (biomedcentral.com)
  • A wedge resection was carried out, and yellow mucus was observed in the resected lung (Fig. 1 d). (biomedcentral.com)
  • We performed a wedge or segmental resection. (iaslc.org)
  • The most effective treatment options for curative lung cancer are video assisted thoracoscopic (VATS) resection or stereotactic ablative body radiotherapy (SABR) for patients unfit for surgery. (biomedcentral.com)
  • The program will cover recent advances in neoadjuvant and adjuvant immunotherapy for resectable lung cancer, robotic surgery, sublobar anatomic lung resection, surgery for advanced thoracic malignancies, new technologies in thoracic surgery, interventional bronchoscopy, chest trauma, and other important topics. (ctsnet.org)
  • Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer: post-hoc analysis of an international, randomised, phase 3 trial (CALGB/Alliance 140503). (bvsalud.org)
  • Regular follow-up after curative resection of nonsmall cell lung cancer: a real benefit for patients? (ers-education.org)
  • So far, however, HRCT scans appear to predict non- or minimally invasive sub-solid lung cancers with high reliability, warranting limited resection as curative surgery in this cohort. (iaslc.org)
  • Leesburg, VA, May 13, 2021 - According to an open-access Editor's Choice article in ARRS' American Journal of Roentgenology ( AJR ) , CT features may help identify which patients with stage IA non-small cell lung cancer are optimal candidates for sublobar resection, rather than more extensive surgery. (arrs.org)
  • An adverse event of any grade occurred in 193 (54%) of 355 patients after lobar resection and 172 (51%) of 337 patients after sublobar resection. (bvsalud.org)
  • Adverse events of grade 3 or worse occurred in 54 (15%) patients assigned lobar resection and in 48 (14%) patients assigned sublobar resection. (bvsalud.org)
  • Grade 3 haemorrhage (requiring transfusion) occurred in six (2%) patients assigned lobar resection and eight (2%) patients assigned sublobar resection. (bvsalud.org)
  • Traditionally, sublobar resection (SLR) has been recommended to preserve as much functioning lung as possible for these patients. (e-crt.org)
  • Conclusions - Patients undergoing sublobar/lobar resections had higher survival rate. (ices.on.ca)
  • Of the 1,080 patients enrolled, 697 patients were intraoperatively randomly assigned to either lobar (357 patients) or sub-lobar (340 patients) resection. (ecancer.org)
  • Findings from a phase 3 trial that included 697 patients with the disease found that there were similar disease-free survival and overall survival (time from treatment until death of any cause) outcomes among patients who underwent a sublobar resection (removal of a small section of the lung) compared to those who had a lobar resection (removal of one or multiple lobes of the lung). (curetoday.com)
  • The objective of this study is to confirm limited resection efficacy as radical surgery in patients with minimally invasive lung cancer as indicated by high-resolution (HR) computed tomography (CT), and to confirm intraoperative cytology as a negative margin indicator and reliable margin non-recurrence predictor. (iaslc.org)
  • Study objectives: To describe the frequency and outcome of patients with acute lung injury (ALI) and AMDS who require mechanical ventilation (MV) after lung resection, and to analyze preoperative and perioperative variables associated with mortality. (elsevierpure.com)
  • Methods: We retrospectively reviewed the case records of all patients who underwent lung resection and acquired ALI and/or ARDS and required invasive MV and ICU admission at a tertiary-care cancer center from January 1, 2002, to December 31, 2004. (elsevierpure.com)
  • Results: During the study period, 2,039 patients underwent a total of 2,192 lung resections. (elsevierpure.com)
  • Conclusions: Our results confirm that ALI/ARDS after lung resection is associated with a high mortality, in patients who require invasive MV and ICU care. (elsevierpure.com)
  • The pathological staging of patients after radical resection of the primary tumor was based on the 8th edition of the American Joint Committee on Cancer TNM staging. (researchsquare.com)
  • Moreover, models incorporating these features independently predicted recurrence-free survival after sublobar resection (hazard ratio=5.37-6.05). (arrs.org)
  • We have repeatedly warned that delayed cut-end recurrence is possible following limited resection even for small sub-solid lung cancers. (iaslc.org)
  • here, we report a post-hoc, exploratory, comparative analysis of perioperative mortality and morbidity associated with lobar and sublobar resection. (bvsalud.org)
  • 2019. Extent of lymphadenectomy is associated with oncological efficacy of sublobar resection for lung cancer ≤2 cm. . (cornell.edu)
  • In the search for the next breakthrough in lung cancer surgery, a number of promising candidates have emerged, including screening, sublobar resections, 3D technology, enhanced peri-operative care pathways, ablative therapy and multi-modality management. (annalscts.com)
  • We aimed to assess morbidity and mortality associated with lobar and sublobar resection for early-stage lung cancer . (bvsalud.org)
  • Thirty- and 90-day mortality were 1.1% and 1.7% after lobar resection and 0.6% and 1.2% after sub-lobar resection. (ecancer.org)
  • However, indications for sublobar resection of early-stage lung cancer have recently expanded to include small-sized, peripheral tumors with no lymph node involvement. (universimed.com)
  • Long time survival after resection for multiple primary lung cancers. (ers-education.org)
  • The primary endpoints will be negative margin (R0) resection rate, resection margin (staple line-to-tumor distance), and thoracotomy conversions. (biomedcentral.com)
  • Next they separate the tumor from the chest wall and then resect the lung, pleura, pericardium and diaphragm en bloc (in one piece) dividing the arteries, veins and bronchi that connect the lung to the heart. (bcm.edu)
  • With division of the bronchus, the en bloc resection is complete, and the tissue is removed from the chest. (bcm.edu)
  • At 6 months postoperatively, a between-group difference of 2 percentage points was measured in the median percentage of predicted forced expiratory volume in 1 second, favoring the sublobar-resection group. (duke.edu)
  • Results of a recent, larger randomized trial in Japan (JCOG 0802/WJOG 4607L) showed that segmentectomy, a type of sublobar resection, is equivalent to lobectomy. (ascopost.com)
  • Segmentectomy provided similar OS and RFS compared to lobectomy, while wedge resection had a detrimental effect on patient prognosis. (nevinmanimala.com)
  • 4. Survival Rates After Lobectomy, Segmentectomy, and Wedge Resection for Non-Small Cell Lung Cancer. (nih.gov)
  • 6. A propensity score matching analysis of survival following segmentectomy or wedge resection in early-stage lung invasive adenocarcinoma or squamous cell carcinoma. (nih.gov)
  • 1 to 2 cm Among Lobectomy, Segmentectomy, and Wedge Resection: A Population-Based Study. (nih.gov)
  • 2 Segmentectomy, anatomic sublobar resection of one or more bronchopulmonary segments, has a role in the management of some patients with early-stage NSCLC. (jnccn.org)
  • In these patients, limited resection procedures (segmentectomy, or nonanatomic wedge resection) have been used if negative surgical margins are achievable. (jnccn.org)
  • 28 analyzed the outcomes of 1272 patients with lung cancer who underwent resection with lobectomy or segmentectomy. (jnccn.org)
  • In this video, the authors demonstrate the adoption of this technique for a sublobar resection, namely a left upper division segmentectomy. (ctsnet.org)
  • In the case of the latter, patients received either a wedge resection, which involves removing a nonanatomic, wedge-shaped piece of tissue containing the tumor, or an anatomical segmentectomy in which surgeons remove the anatomic lung segment with the tumor, along with the small airway, individual artery and vein that feed and drain the region. (uchicago.edu)
  • The research follows a study by Japanese researchers published last year in The Lancet that compared lobectomy to segmentectomy (but not wedge resection). (uchicago.edu)
  • Lobectomy, segmentectomy, or wedge resection for peripheral clinical T1aN0 non-small cell lung cancer: A post hoc analysis of CALGB 140503 (Alliance). (ivy.fm)
  • The authors suggest that the difference in overall survival rates between the two trials might be due to anatomical segmentectomy being "considered by most surgeons to be more oncologically sound than wedge resection. (medscape.com)
  • However, wedge resection may have provided comparable outcomes for patients aged 75 years or older. (nevinmanimala.com)
  • 12. Impact of tumor size on outcomes after anatomic lung resection for stage 1A non-small cell lung cancer based on the current staging system. (nih.gov)
  • Lobectomy is associated with better outcomes than sublobar resection in spread through air spaces (STAS)-positive T1 lung Adenocarcinoma: a propensity score-matched analysis. (mskcc.org)
  • Listen as we compare and contrast the North American CALGB trial and Japanese JCOG trial which were both designed to investigate survival and recurrence outcomes by randomizing stage 1A patients to lobectomy versus a sublobar resection. (ivy.fm)
  • When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy has been used increasingly both preoperatively (neoadjuvant chemotherapy) and postoperatively (adjuvant chemotherapy). (wikipedia.org)
  • Lobar versus sublobar resection in early stage lung cancer. (ascvts2014.org)
  • Stage I non-small-cell lung cancer: long-term results of lobectomy versus sublobar resection from the Polish National Lung Cancer Registry. (figshare.com)
  • I think there is good evidence in this paper that doing a smaller resection preserves the most lung, preserves the most lung function, and gives you an equal benefit in disease-free survival. (medscape.com)
  • 1 Study authors also reported noninferiority with respect to recurrence rate and overall survival for sublobar vs lobar resection. (ascopost.com)
  • Disease-free survival at 5 years for sublobar resection (63.9%) was found to be noninferior to lobar resection (64.3%), and the rates of recurrence or death from lung cancer were also overlapping. (ascopost.com)
  • With respect to the secondary endpoint of overall survival, sublobar resection was again found to be noninferior to lobar resection (HR = 0.95). (ascopost.com)
  • The 5-year overall survival rate was 80% with sublobar resection vs 78% with lobar resection. (ascopost.com)
  • There may even be an overall survival advantage to sublobar resection, but we could not show that in our trial," said Dr. Altorki. (ascopost.com)
  • The overall analysis revealed no statistically significant difference in overall survival (OS) (HR=1.28, 95% CI: 0.98-1.69) between sublobar resection and lobectomy, but lobectomy was associated with better recurrence-free survival (RFS) (HR=1.39, 95% CI: 1.10-1.75). (nevinmanimala.com)
  • 4. Sublobar resections in stage IA non-small cell lung cancer: segmentectomies result in significantly better cancer-related survival than wedge resections. (nih.gov)
  • An increasing number of studies have suggested that surgical resection can prolong the overall survival (OS) in patients with SCLC at an advanced stage ( 9 , 10 ). (frontiersin.org)
  • After a median follow-up of seven years, the multicenter, phase 3 randomized trial found disease-free survival was similar between lobectomies and sublobar resections. (uchicago.edu)
  • These improvements have been shown to decrease the morbidity and mortality after lung resection and to improve long-term survival, even in patients with limited pulmonary reserve. (bmj.com)
  • It also ensures reliable tumor resection by automatically measuring the distance between the tumor and resection line/tumor and lobe and checking margins. (fujifilm.com)
  • Sublobar anatomical segmentectomies are indicated for specific early stage primary lung cancer, as well as pulmonary metastasis and some benign conditions. (figshare.com)
  • Thoracic surgeons will need to expand their expertise in sublobar resections, especially complex segmentectomies, and will need to collaborate closely with pathologists in assessing margins of resection, adequacy of lymph-node staging, and tumor characteristics that may predict recurrence. (medscape.com)
  • In this study, 697 patients with peripheral stage 1 tumors less than 2 centimeters in size were randomly assigned to undergo a lobectomy or a sublobar resection, where part of the cancerous lobe is removed. (uchicago.edu)
  • 11. Video-assisted wedge resection and local radiotherapy for peripheral lung cancer in high-risk patients: the Cancer and Leukemia Group B (CALGB) 9335, a phase II, multi-institutional cooperative group study. (nih.gov)
  • 2]Phase III Randomized Study of Sublobar Resection With or Without Brachytherapy Versus Stereotactic Body Radiotherapy in High-Risk Patients With Stage I Non-Small Cell Lung Cancer. (varian.com)
  • Initial direct overall health care costs per case for stage I non-small cell lung cancer costs stratified by treatmentTreatment technique Traditional radiotherapy SABR Sublobar resection Lobectomy Pneumonectomy Finest supportive care Initial direct health care costs ( ) 7,646.98 8,815.55 12,161.17 16,266.12 22,940.59 14,582.Fees are shown in 2013 Canadian dollars. (squalene-epoxidase.com)
  • 7. Video-assisted thoracic surgery pulmonary resection for lung cancer in patients with poor lung function. (nih.gov)
  • Thirteen of 44 patients who underwent sublobar resection for lung cancer were found to have a k-ras mutation at codon 12.1. (nih.gov)
  • Patients who underwent limited resection had a 75% increase in recurrence rates ( P = .02) associated with a tripling of the local recurrence rate ( P = .008). (jnccn.org)
  • PATIENTS AND METHODS: All enrolled patients (n=350) underwent curative resection of rectal cancer with D3 lymph node dissection, with either IMA (high-tie) or superior rectal artery (SRA) (low-tie) ligation. (bvsalud.org)
  • I think that's an important point that Dr Rusch brought out in her editorial - and I'd like to quote her directly - that the patients in this trial "were selected meticulously and included very, very strict criteria for lymph node staging and complete resection. (medscape.com)
  • Besides, surgical resection of small lesions without lymph node involvement has been considered a curative strategy for patients with SCLC at an early stage. (frontiersin.org)
  • Patient selection has contributed significantly to improve the incidence of postoperative complications after anatomical lung resection. (bmj.com)
  • Precise Anatomical Sublobar Resection Using a 3D Medical Image Analyzer and Fluorescence-Guided Surgery With Transbronchial Instillation of Indocyanine Green , Semin Thorac Cardiovasc Surg. (fujifilm.com)
  • With the suspicion of malignant growth within the lesion (probable lepidic adenocarcinoma), a sublobar anatomical resection was indicated to avoid a left upper lobectomy. (figshare.com)
  • 9. Surgical techniques and results for partial or circumferential sleeve resection of the pulmonary artery for patients with non-small cell lung cancer. (nih.gov)
  • In addition, pneumonectomy (surgical removal of one of the lungs) or sleeve resection (surgery to remove a tumor in a lobe of the lung and a part of the main bronchus) might be performed to remove the cancer completely. (royalphnompenhhospital.com)
  • One third of the patients will not be cured despite a complete resection of a 2-cm or smaller tumor at the time of diagnosis. (medscape.com)
  • Right thoracotomy was performed, and complete resection was carried out by extrapleural and intrapericardial pneumonectomy. (hindawi.com)
  • However, sublobar resection is associated with high local recurrence rates in the context of tumor-free parenchymal margins. (nih.gov)
  • Finally, analysis of forced expiratory volume and idle capacity showed some preservation of pulmonary function with sublobar vs lobar resection. (ascopost.com)
  • 1. Wedge resection and brachytherapy for lung cancer in patients with poor pulmonary function. (nih.gov)
  • Nevertheless, some patients are considered poor candidates for lobectomy based on pulmonary function, previous resections, or other medical conditions. (jnccn.org)
  • Pulmonary arterioplasty and vena cava reconstruction as part of lung cancer resection. (ascvts2014.org)
  • The risk of pulmonary lobectomy for elderly patients is greatly reduced along with the maturity of thoracoscopic lobectomy and lymphadenectomy , and advanced age is no longer a barrier of the VATS radical resection[ 12 ]. (biomedcentral.com)
  • RESULTS: The analysis included 12667 patients, with 3488 undergoing sublobar resections and 9179 receiving lobectomies. (nevinmanimala.com)
  • He also presented a review of a current clinical phase III randomized trial of lobectomy vs. sublobar resection for non-small cell lung cancer, as notably, he is the NCIC CTG Study Chair. (lhsc.on.ca)
  • The clinical and research community must continue to adapt guidelines in line with rapidly evolving clinical practice, where minimally invasive approaches are preferred, more sublobar resections are performed and limits are pushed to operate on patients traditionally considered inoperable. (bmj.com)
  • In the current issue, Boujibar and colleagues 1 present the first systematic review and meta-analysis assessing stair-climbing test as a tool to predict postoperative complications after lung resection and to determine which patients require further high-technology cardiopulmonary evaluation. (bmj.com)
  • Boujibar and colleagues describe the first systematic review and meta-analysis, which addresses the role of the stair-climbing test in predicting the incidence of postoperative complications after major lung resection. (bmj.com)
  • Patients with higher perioperative risks such as COPD and older age are at higher risk for postoperative complications and mortality after resection [ 5 ]. (e-trd.org)
  • Conventional approaches to resection may be used, including posterolateral and muscle-sparing thoracotomy. (jnccn.org)
  • The conventional risk patients were treated with VATS radical resection and systematic lymphadenectomy. (biomedcentral.com)
  • A novel fluorescence-based assay for detection of rare copies of mutant DNA in a background of wild-type DNA, fluorescent gap ligase chain reaction, was used to quantitate the mutant/wild-type DNA in a range of 1 to 1/10,000 in histologically normal margins from these resections. (nih.gov)
  • The higher rate of local recurrence associated with sublobar resection of lung cancer is likely due to the occult presence of tumor cells at resection margins. (nih.gov)
  • This finding explained for the excellent prognosis from radical resections with surgical margins of more than 15 mm. (biomedcentral.com)
  • Open versus VATS resections in lung cancer. (ascvts2014.org)
  • Uniportal VATS is a safe and barely invasive approach for these resections and combines a less invasive surgical approach with a lung-sparing procedure. (figshare.com)
  • This study aimed to evaluate the risk and efficacy of wedge resection under video-assisted thoracoscopic surgery (VATS) on elderly high-risk patients with stage I peripheral non-small-cell lung cancer (PNSCLC). (biomedcentral.com)
  • The high-risk patients confirmed in stage I by the examination of positron emission tomography computed tomography (PET-CT) and the postoperative patients in stage I PNSCLC with negative incisal margin were treated with VATS wedge resection. (biomedcentral.com)
  • The operative time and blood loss of the VATS wedge resection group (69.4 ± 15.5 min, 52.1 ± 11.2 ml) were significantly less than those of the VATS radical resection group (128 ± 35.5 min, 217.9 ± 87.1 ml). (biomedcentral.com)
  • It is safe, minimally invasive and meaningful to perform VATS wedge resection on the elderly high-risk patients with stage I PNSCLC. (biomedcentral.com)
  • Therefore, we undertook this study to evaluate the operative risk of VATS wedge resection performed on elderly high-risk patients with stage I peripheral non-small-cell lung cancer (PNSCLC) and the therapeutic effects of the VATS wedge resection for these patients. (biomedcentral.com)
  • 18. Robotic brachytherapy and sublobar resection for T1 non-small cell lung cancer in high-risk patients. (nih.gov)
  • Sublobar resection for early-stage lung cancer has been used for patients who are not candidates for lobar resection. (nih.gov)
  • Surgical resection is the standard treatment for early-stage lung cancer. (e-trd.org)
  • Early-stage lung cancers radiologically manifested as ground-glass opacities (GGOs) have been increasingly identified, among which pure GGO (pGGO) has a good prognosis after local resection. (biomedcentral.com)
  • For instance, some studies show that doctors may recommend either segmentation or wedge resection for those with early-stage lung cancer or lung reserve. (farnorthsurgery.com)
  • Nevertheless, Altorki said that "these results will become increasingly relevant as the proportion of patients with early-stage lung cancer increases with expanded implementation of lung cancer screening, and as the number of older persons with early-stage disease in whom sublobar resection may be the preferred surgical option increases. (medscape.com)
  • For those with early stage lung cancer (stage 1 or 2), the treatment is lobectomy - surgical removal of a large section of lung or sublobar resection - surgical removal of small segment of lung. (royalphnompenhhospital.com)
  • Minimally invasive approaches such as video-assisted thoracoscopic surgery were used for 80% of all resections. (ascopost.com)
  • BACKGROUND: Currently, the impact of sublobar resection versus lobectomy on the prognosis of solid-dominant stage IA lung cancer is contradictory in different studies, which requires further exploration. (nevinmanimala.com)
  • 2. Sublobar resection with brachytherapy versus lobectomy for stage Ib nonsmall cell lung cancer. (nih.gov)
  • 3. Intraoperative (125)I Vicryl mesh brachytherapy after sublobar resection for high-risk stage I non-small cell lung cancer. (nih.gov)
  • 12. Lobar and sublobar resection with and without brachytherapy for small stage IA non-small cell lung cancer. (nih.gov)
  • 19. Mature follow-up for high-risk stage I non-small-cell lung carcinoma treated with sublobar resection and intraoperative iodine-125 brachytherapy. (nih.gov)
  • However, recent studies have suggested that a small proportion of patients with SCLC at an advanced stage may benefit from surgical resection. (frontiersin.org)
  • In conclusion, surgical resection might be associated with improved OS for patients with stage III SCLC and may be considered for the treatment of these patients. (frontiersin.org)
  • Previously, surgical resection was recommended for limited stage SCLC. (frontiersin.org)
  • 16. Sublobar resection versus lobectomy in patients aged ≤35 years with stage IA non-small cell lung cancer: a SEER database analysis. (nih.gov)
  • Subgroup analyses revealed that, for tumors with a diameter ≤2 cm, sublobar resection versus lobectomy showed no significant difference in OS but sublobar resection had lower RFS. (nevinmanimala.com)
  • For 2-3 cm tumors, both OS and RFS were significantly lower in the sublobar resection group. (nevinmanimala.com)
  • In patients that have small tumors we can also perform, not a complete lobectomy but a segment of resection of the lung. (fujifilm.com)
  • Those results from nearly 30 years ago established lobectomy as the standard of surgical care in this patient population, but since then advances in imaging and staging have allowed the detection of smaller and earlier tumors, which has "rekindled interest in sublobar resection," the authors comment. (medscape.com)
  • For the utmost preservation of lung function, surgical options and safe margin for sublobar resection are under discussion. (biomedcentral.com)
  • 8 Practice standardisation and identification of patients at increased risk of morbidity and mortality after lung resection are among the main objectives of the ACCP guidelines. (bmj.com)
  • Of the 1,080 patients enrolled, 697 patients were intraoperatively assigned randomly to either lobar (357 patients) or sublobar (340 patients) resection. (ascopost.com)
  • To investigate the impact of the COVID-19 pandemic on lung cancer surgery, we compared between 2018-2019 (prepandemic group) and 2020-2021 (pandemic group) in the respect of patient characteristics, pathological findings, and short-term outcome after lung cancer resection by Mann-Whitney and Fisher's exact tests. (nagoya-u.ac.jp)
  • Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer. (nih.gov)
  • 1, OS didn't differ significantly, but RFS was significantly lower in sublobar resection. (nevinmanimala.com)
  • Lung cancers with CTR=1 showed significantly lower OS and RFS in the sublobar resection group. (nevinmanimala.com)