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Results from our study indicate that 8 weeks of supplementation of our formulation helps in improving tear production, stabilizes tear film, and eventually reduces hyperosmolarity of the tears in subjects suffering from DES. (springer.com)
Dry eye is a multifactorial disease related to impaired tear film homeostasis and is accompanied by tear film instability and hyperosmolarity, and ocular surface inflammation [ 1 ]. (ekjo.org)
Dry eye disease (DED) is a common ocular surface disease characterized by a loss of homeostasis of the tear film, ocular surface inflammation, and hyperosmolarity, and associated with ocular surface irritation symptoms, visual disturbance, and quality of life impairment. (arvojournals.org)
That report points to a three-part chain of causative events: (1) tear film instability, causing and accompanied by (2) localized hyperosmolarity, leading to (3) epithelial damage and inflammation. (reviewofoptometry.com)
The team decided to explore the potential of a multi‐ingredient SIME eye drop designed to target (1) tear film instability, (2) tear hyperosmolarity and (3) ocular surface damage and inflammation in moderate or severe dry eye. (reviewofoptometry.com)

Overall, we have demonstrated statistically significant clinical improvements in dry eye symptoms as compared to the placebo in subjects validated through well-established subjective questionnaire-based approaches such as OSDI and SPEED. (springer.com)
To evaluate the clinical symptoms of patients with dry eyes, based on the ocular surface disease index (OSDI) and analyze the relationship between OSDI and various ocular surface parameters. (ekjo.org)
It often results in ocular symptoms and visual disturbance due to underlying tear film instability, ocular suface inflammation and damage, and neuorsensory abnormalities. (medscape.com)
The questionnaire has 3 subscales: ocular symptoms, vision-related function, and environmental triggers. (alliedacademies.org)
1 The report exhaustively reviewed the subject of contact lens symptomatology, finding that 50% of contact lens wearers report dry eye symptoms. (reviewofoptometry.com)
Of these respondents, 90.3% (205 students) reported experiencing the ocular and extra-ocular symptoms of digital eye strain (DES). (thebusinessresearchcompany.com)
Blurred vision and diplopia (double-vision) are possible symptoms. (digitalnaturopath.com)
The idea is that the formulation can disrupt that self-perpetuating cycle of dryness via biophysical protection of the ocular surface, facilitating the body's ability to resolve cellular damage and inflammation, ultimately leading to a relief of symptoms. (reviewofoptometry.com)
3,4 The administration of artificial tears is recommended and common practice in the event of subjective symptoms such as dry eyes, fluctuating visual quality or burning eyes due to lack of tears or tear film instability. (ocl-online.de)

Several previous studies evaluated the correlation between the ocular surface disease index (OSDI) and objectively quantifiable parameters in dry eye patients [ 3 4 ]. (ekjo.org)
We examined almost all ocular surface parameters using appropriate techniques to analyze the correlation between OSDI and these parameters. (ekjo.org)
As limited data is available of the lipid layer thickness in patients undergoing SMILE surgery assessed by an ocular surface analyser, the present study will provide more information on the lipid layer thickness in patients undergoing SMILE surgery and provide validation with the subjective assessment by OSDI [ 4 ]. (alliedacademies.org)
Clinical evaluations included the Ocular Surface Disease Index (OSDI), lipid layer thickness (LLT), spontaneous eye blink pattern analysis, fluorescein tear film break-up time (FBUT), and so on. (arvojournals.org)
The investigators tested for superiority of SIME over HA using the ocular surface disease index (OSDI) and other ocular assessments. (reviewofoptometry.com)

Dry eye syndrome (DES) is a multifactorial disease of the ocular surface associated with reduced tear secretion, increased osmolarity of the tears and inflammation that may lead to ocular surface damage. (springer.com)
Dry eye disease (DED), also known as dry eye syndrome (DES), keratoconjunctivitis sicca (KCS), and keratitis sicca, is a multifactorial disease of the ocular surface due to a loss of homeostasis of the tear film. (medscape.com)

It is also associated with inflammation that often leads to ocular surface damage. (springer.com)
The LCD supplement showed significant improvements in the production, stability and quality of tears by reducing ocular surface damage and tear inflammation and can be used as an adjuvant to artificial tears in subjects with DES. (springer.com)
This further results in decreased inflammation as measured by reduced MMP-9 levels in the tear fluid and decreased ocular surface damage as measured by corneal and conjunctival staining during the supplementation. (springer.com)

In the third part of the test, TBUT increased significantly-by approximately 50%-in subjects using SIME compared with only 25% (insignificant) in the HA controls. (reviewofoptometry.com)

The pre-corneal tear film maintains the health of the ocular surface. (singaporeoptometricassociation.com)
In connection with an increased susceptibility to glaucoma and the progression of such a disease, several risk factors, including age, Intra Ocular Pressure (IOP), race, severe myopia, genetic background, vascular dysregulation and central corneal thickness, have been identified [ 4 ] [ 5 ] . (encyclopedia.pub)

Therefore it is important for the optometrist to understand patients' chief complaints with a thorough investigation of his anterior ocular health and a detailed history taking of his systemic, ocular health and environmental conditions that may suggest DE. (singaporeoptometricassociation.com)

[ 1 , 2 ] Dry eye disease is a common form of ocular surface disease (OSD) and may overlap with other causes of OSD, such as limbal steam cell insufficiency and ocular graft-versus-host disease. (medscape.com)

There is a causal relationship with regard to the secretion produced by the Meibomian glands, which is subject to changes due to the hyperkeratinisation of the squamous epithelium of the lid margin. (ocl-online.de)

Chronic subjective dizziness (CSD) is a chronic, subjective, nonrotational dizziness and instability caused by mental or physical factors, and patients generally have no existing vestibular system diseases. (hindawi.com)
Patients often seek medical attention for chronic and persistent head dizziness or a subjective sense of instability, which accounts for approximately 10.6% of all dizziness visits in outpatient clinics and can be twice as common in women as in men [ 2 ]. (hindawi.com)
Twenty-five DED patients and 25 healthy subjects were included in this prospective case-controlled study. (arvojournals.org)
Six eyes of 5 patients with PUK and associated anterior scleritis that had a history of ocular alkali injury. (entokey.com)
This is a descriptive case series of patients with late-onset PUK following alkali ocular injury. (entokey.com)
The medical records of 5 patients presenting with signs and symptom of delayed-onset PUK following ocular alkali injury were reviewed. (entokey.com)
Not unexpectedly, given the complex coordination and multisensory integration underlying curved walking [ 8 ], studies requiring subjects to travel both linear and circular pathways have detected abnormalities in patients with neurological disorders [ 9 - 13 ]. (hindawi.com)
However, these approaches are not sufficiently successful for many patients who continue to lose their vision [ 11 ] . (encyclopedia.pub)
All subjects were patients visiting the National Hospital Organization Tokyo Medical Center or collaborating hospitals. (biomedcentral.com)

Meibomian Gland Dysfunction leads to tear film instability and direct damage to the ocular surface epithelium. (pafmj.org)
The ocular surface is an integrated anatomical unit consisting of 7 key interactive and interdependent components: the tear film, the lacrimal and accessory lacrimal apparatus, the nasolacrimal drainage system, the eyelids, the bulbar and tarsal conjunctiva, cranial nerve V, and cranial nerve VII. (medscape.com)
[3] Dry eye syndrome can lead to blurred vision, instability of the tear film, increased risk of damage to the ocular surface such as scarring of the cornea, and changes in the eye including the neurosensory system. (wikipedia.org)
The research was based on the 2017 Tear Film and Ocular Surface Society's (TFOS) Dry Eye Workshop II (DEWS II) report and its updated pathophysiology of DED. (reviewofoptometry.com)
The lipid component with sacha inchi is a novel supplement which improves ocular surface protection and tear film characteristics in addition to HA, trehalose and glycerol," the study authors conclude in their paper. (reviewofoptometry.com)

Increasing cases of dry eyes from excessive time spent on electronic devices such as phones and computers has led to the development of the term "digital eye strain" or "computer vision syndrome. (thebusinessresearchcompany.com)

Chronic subjective dizziness (CSD) is a group of chronic nonspecific syndromes with high sensitivity to motor signals and low tolerance to visual signals, accompanied by a significant subjective dizziness and instability [ 1 ]. (hindawi.com)
Dry eye disease is an inflammatory disease of the ocular surface that is often chronic and may be progressive. (multivu.com)

The latter, combined with the possible direct displacement of the chlorine atoms by sulfhydryl groups of amino acids or proteins, accounts for the instability of cisplatin in biological matrices. (nih.gov)

The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. (mdpi.com)
The internal jugular vein gets compressed by anterior subluxation of C1 and C0-C1 instability. (caringmedical.com)

Traditionally, optometry has asserted that dryness is a relative contraindication for wearing contact lenses, with the exception of fitting scleral lenses for cases of Sjögren's, cicatricial pemphigoid or other disease-related desiccation of the ocular surface. (reviewofoptometry.com)
The disease is most commonly associated with dryness and overall eye discomfort, as well as stinging, burning, a gritty feeling or episodes of blurred vision. (multivu.com)
A formulation in the works takes aim at the etiological factors of ocular surface dryness. (reviewofoptometry.com)

Multiple questionnaires are available to determine whether or not a patient is symptomatic, such as the Ocular Surface Disease Index, Contact Lens Dry Eye Questionnaire and McMonnies questionnaire. (reviewofoptometry.com)

Patient subjected to strenuous exercise, extreme heat, and concomitant use of anticholinergic medications. (azurewebsites.net)

On the other hand, visual fixation allows the subject to identify an object by observing its particular characteristics. (scirp.org)

[ 4 ] Abnormalities or deficiencies in any of the 7 ocular surface components may worsen dry eye disease, yet promise opportunities for effective therapeutic intervention. (medscape.com)
Retinitis pigmentosa (RP) is an inherited neurodegenerative disease involving progressive vision loss, and is often linked to mutations in the rhodopsin gene. (jneurosci.org)

Indeed, ocular saccades are very fast movements of both eyes, in the same direction and with the same amplitude. (scirp.org)
Training subjects to step in place on a rotating platform while maintaining a fixed body orientation in space produces a posteffect consisting in inadvertent turning around while stepping in place eyes closed (podokinetic after-rotation, PKAR). (hindawi.com)
Sixteen subjects performed 12 min of voluntary turning while stepping around their vertical axis eyes closed and 12 min of stepping in place eyes open on the center of a platform rotating at 60°/s (pretests). (hindawi.com)
Then, subjects continued stepping in place eyes closed for at least 10 min (posteffect). (hindawi.com)
Ocular protection index (OPI) increased in both eyes by 59% with SIME and by 41% with HA. (reviewofoptometry.com)

The objective of this study was to evaluate the efficacy and safety of our multi-ingredient supplement in subjects with dry eye syndrome (DES). (springer.com)
This study was conducted to evaluate efficacy of a multi-ingredient supplement containing lutein, zeaxanthin, curcumin and vitamin D3 in subjects with dry eye syndrome (DES). (springer.com)

[13] These activities include prolonged reading, computer usage ( computer vision syndrome ), driving, or watching television. (wikipedia.org)

Medical histories were obtained, and clinical information, such as the results of physical, audiological, and blood tests, were collected from subjects and family members, when available. (biomedcentral.com)

We recruited 60 subjects with mild to moderate DES who were randomized in a 1:1 ratio in a single-center study to receive LCD (lutein 20 mg, zeaxanthin 4 mg, curcumin 200 mg curcuminoids, vitamin D3 600 IU) or placebo (soybean oil) capsules for 8 weeks. (springer.com)
Fifty-nine subjects, 30 from LCD and 29 from placebo group, completed the study. (springer.com)
The results from this study has now provided useful scientific data to enhance an existing statistical model, based on industrial workers' (age range: 21 to 55 years) data which demonstrated the relationship between postural instability and loss of balance potential and the independent variables characterizing the Environmental, Job Task and Personal workers' risk factors. (cdc.gov)
The algorithm was applied to a sample of images from a second study with 142 dry-eye subjects. (maio-journal.com)

In future field studies this statistical model, can be used to help evaluate the postural instability and loss of balance potential by measuring, in a walkthrough evaluation, existing risk factors at the worksite. (cdc.gov)
Glaucoma represents a group of neurodegenerative diseases where the slow progressive death of RGCs results in a permanent loss of vision. (encyclopedia.pub)
Trios from families with non-syndromic or syndromic hearing loss (n = 72) were subjected to WES. (biomedcentral.com)
Rods are primarily affected, resulting in poor night and peripheral vision, with subsequent cone death and loss of central vision. (jneurosci.org)

Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. (mdpi.com)

Certain diseases of the pulleys (heterotopy, instability, and hindrance of the pulleys) cause particular patterns of incomitant strabismus. (wikipedia.org)

The choice of risk factors and worker age groups were based on published epidemiological literature showing potential impact of these factors in contributing injur y and the impact of these risk factors on age associated changes in afferents (somatosensory, vision and vestibular systems) necessary for maintaining safe upright postural balance. (cdc.gov)

Cho P, BrownB, Chan I,Conway R, Yap M. Reliability of the Tear Break-Up Time Technique of Assessing Tear Stability and the Locations of the Tear Break-Up in Hong Kong Chinese: en.Optometry and Vision Science, Nov. 1992;69(11): 879-885. (maio-journal.com)

This PKAR has been considered the effect of adaptation to the continuous perturbation of the foot position by the podokinetic stimulation (produced by the rotation of the platform upon which subjects step while keeping the orientation of trunk and head fixed relative to space) [ 20 ]. (hindawi.com)

It is a new instrument of individual analysis which allows a full assessment of the ocular surface through a combination of tests. (alliedacademies.org)

Precisely how the integration between voluntary and involuntary control of the eye occurs is a subject of continuing research. (wikipedia.org)
Research on cervical instability and Prolotherapy. (caringmedical.com)

Found more on the periphery of the retina, the rods number in the hundreds of millions and are adept at black and white vision in dimmer environments. (naturalproductsinsider.com)
When walking in everyday environments, subjects frequently change direction to negotiate corners and avoid obstacles. (hindawi.com)

Material and methods: Thirty non-athlete underweight female students qualified with an average age of 23±1.64 years, weight of 43.53±0.28 kg, height of 162.66±6.6 cm and BMI of 16.31±0.2 kg/m 2 were selected and randomly assigned into three groups of 10 subjects (traditional, TRX and control). (researchgate.net)

Headache was more associated with Azithromycin treatment (3.4%), whereas Rash (1.1%) and blurring of vision (1.1%) were seen in the Doxycycline-Group. (pafmj.org)
Although techniques are being developed to treat thinner corneas as well [ 4 ], it may be less suitable for more advanced KC, given that the rates of treatment failure and vision-threatening complications may increase [ 5 ]. (biomedcentral.com)

Due to its unique chemical structure, the chlorine atoms of cisplatin are more subject to chemical displacement reactions by nucleophiles, such as water or sulfhydryl groups, than to enzyme-catalyzed metabolism. (nih.gov)

Anatomy41

Organisms2

Diseases99

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Psychiatry and Psychology21

Phenomena and Processes42

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Health Care6

Hyperosmolarity5

Symptoms9

OSDI5

Multifactorial disease2

Inflammation3

TBUT1

Corneal2

Systemic1

Insufficiency1

Secretion1

Patients9

Film5

Excessive1

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Questionnaire1

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Visual1

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Eyes5

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