OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
DronabinolAppetite StimulantsCannabinoid Receptor AgonistsMarijuana SmokingAnorexiaPain PerceptionCannabisMarijuana AbusePsychotropic DrugsPlacebo EffectAnalgesics, Non-NarcoticSubstance Withdrawal SyndromeDouble-Blind MethodCross-Over StudiesSleepEatingDrug Administration ScheduleDose-Response Relationship, DrugTreatment Outcome
NabiloneDelta-9-tetrahydrocannabinInhaled THC-basedCannabinoidsSyntheticDoses of dronabinolCannabidiolEfficacySyndrosCannabisNabiximolsSubstancesDosagePlaceboAdverseAnorexiaAppetiteDoseCapsulesSpasticityDrugPatientsAdministrationFoundScientistsEffectivelyEvaluationEffectsClinicalStudyManufactureTreatment OptionResearchersSignificantPotentialTreatIndividualEffectStudies
Nabilone6
  • The next year saw an additional study noting improved appetites and a reduction of agitation in patients with hepatitis C. This time, both Dronabinol and Nabilone, a THC-mimicking synthetic cannabinoid, were analyzed. (hightimes.com)
  • The U.S. Food and Drug Administration (FDA) has approved THC-based medications, dronabinol (Marinol ® ) and nabilone (Cesamet ® ), prescribed in pill form for the treatment of nausea in patients undergoing cancer chemotherapy and to stimulate appetite in patients with wasting syndrome due to AIDS. (nih.gov)
  • The products most frequently evaluated were formulations based on synthetic THC Dronabinol and Nabilone - which, in general, were compared to placebo or Prochlorperazine. (wecann.academy)
  • So, many synthetic forms of cannabinoids such as nabilone and dronabinol and are now commercially available and they are used as adjunctive medications to reduce the symptoms of bipolar disorder. (compcaremd.com)
  • Eventually, the detect summarizes the present state of Meals and Drug Administration-approved artificial cannabinoids, dronabinol and nabilone, that are becoming employed to treat chemotherapy. (hemptips.best)
  • 2001). Today, the only available cannabinoids are THC (dronabinol, Marinol) and the dronabinol derivative nabilone. (420magazine.com)
Delta-9-tetrahydrocannabin2
  • The International Nonproprietary Name dronabinol, also known under the trade names Marinol, Syndros, Reduvo and Adversa, is a generic name for the molecule of delta-9-tetrahydrocannabinol in the pharmaceutical context. (wikipedia.org)
  • Marinol and Syndros include the active ingredient dronabinol, a synthetic delta-9-tetrahydrocannabinol (THC) that is considered the psychoactive component of cannabis. (simplycannabisseeds.co.uk)
Inhaled THC-based1
  • an inhaled THC-based dronabinol drug and their mucoadhesive-delivery dronabinol drug Adversa®, which are both in the accelerated 505(b)(2) New Drug Application (NDA) pathway for the U.S. and Canadian markets. (wikipedia.org)
Cannabinoids1
  • She rejected Gilg's suggestion that there were 100s of studies showing marijuana's efficacy, estimating that there were only five to ten double-blind, placebo-controlled studies of natural marijuana (as opposed to pure cannabinoids) purporting to show medical efficacy, and that these all had methodological deficiencies and insufficient subject populations. (canorml.org)
Synthetic4
  • Dronabinol , a synthetic form of delta-9-THC, is used to relieve nausea and vomiting caused by chemotherapy drugs and to enhance appetite in people with AIDS. (merckmanuals.com)
  • While dronabinol was initially approved by the United States Food and Drug Administration on May 31, 1985, it was not until May 13, 1986, the Drug Enforcement Administration (DEA) issued a Final Rule and Statement of Policy authorizing the "rescheduling of synthetic dronabinol in sesame oil and encapsulated in soft gelatin capsules from Schedule I to Schedule II" (DEA 51 FR 17476-78). (wikipedia.org)
  • One-third of the subjects will smoke marijuana cigarettes while others will be given either synthetic THC or a dummy pill that resembles dronabinol. (druglibrary.net)
  • The majority of medicinal cannabis is a plant-based product, however certain, like the FDA-approved drug dronabinol, is synthetic. (gaskination.com)
Doses of dronabinol2
  • Another experimental objective was to test the effect of repeated doses of dronabinol on OSA severity measured by Apnea Hypopnea Index (AHI). (frontiersin.org)
  • Neither the 2.5 mg b.i.d. nor the 5 mg b.i.d. doses of dronabinol had any statistically significant effects on gastric, small bowel, or colonic transit. (digitalmackintosh.co.uk)
Cannabidiol1
  • Dronabinol does not include any other tetrahydrocannabinol (THC) isomers or any cannabidiol. (wikipedia.org)
Efficacy5
  • monitor for potential dronabinol-related adverse reactions or loss of efficacy. (nih.gov)
  • On this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ 9 THC), an exogenous Cannabinoid type 1 and type 2 (CB1 and CB2) receptor agonist in patients with Obstructive Sleep Apnea (OSA). (frontiersin.org)
  • Dronabinol demonstrated analgesic efficacy in a majority of studies in chronic pain, the data in acute pain is less conclusive. (wikipedia.org)
  • A 2003 open study focused on the safety and efficacy of the cannabis-derived drug Dronabinol in Alzheimer's disease patients with anorexia. (hightimes.com)
  • Overall efficacy and in the majority of dronabinol. (myjuicecup.com)
Syndros4
  • Dronabinol is marketed as Marinol and Syndros, a registered trademark of Solvay Pharmaceuticals. (wikipedia.org)
  • Dronabinol is also marketed, sold, and distributed by PAR Pharmaceutical Companies under the terms of a license and distribution agreement with SVC pharma LP, an affiliate of Rhodes Technologies for Marinol and Insys Pharmaceuticals for Syndros. (wikipedia.org)
  • citation needed] Dronabinol is available as a prescription drug (under Marinol and Syndros ) in several countries including the United States, Germany, South Africa and Australia. (wikipedia.org)
  • Marinol and also Syndros, for example, contain dronabinol. (anthonny.info)
Cannabis8
  • Dronabinol is the principal psychoactive constituent enantiomer form, (−)-trans-Δ9-tetrahydrocannabinol, found in cannabis. (wikipedia.org)
  • Dronabinol may be useful in treating cannabis addiction as it has been shown to reduce cannabis withdrawal symptoms and the subjective effects of marijuana. (wikipedia.org)
  • This rescheduling constituted part of the argument for a 2002 petition for removal of cannabis from Schedule I of the Controlled Substances Act, in which petitioner Jon Gettman noted, "Cannabis is a natural source of dronabinol (THC), the ingredient of Marinol, a Schedule III drug. (wikipedia.org)
  • Dr. Madras criticized the adequacy of published studies by the CMCR (California Center of Medicinal Cannabis Research) showing benefits of smoked marijuana for neuropathic pain and multiple sclerosis, on the grounds that the experimental subjects had been limited to experienced marijuana smokers. (canorml.org)
  • In FioCruz technical report on the use of Medicinal Cannabis as an antiemetic effect in cancer treatment, 12 systematic reviews on the subject were identified. (wecann.academy)
  • This intricate interaction has made cannabis an important medicine and the subject of intense scientific research. (gaskination.com)
  • The currently available Cannabis derived medicine in England (Sativex), if imported to South Africa, equates to roughly R210/ml (subject to exchange rate), which only contains 2.7mg THC and only ten doses per ml. (saccra.org.za)
  • Bionorica just started to manufacture dronabinol, and according to personal communication, intends to manufacture a cannabis extract and to start with clinical research shortly (Grotenhermen 2002). (420magazine.com)
Nabiximols1
  • The review of human studies found that oromucosal spray nabiximols and oral dronabinol are effective in treating MS-related symptoms. (heritagebcstops.com)
Substances1
  • Substances classified in Schedules II-V are still subject to varying degrees of control, but have a recognized medical use and may be dispensed with a prescription under certain circumstances. (brookings.edu)
Dosage2
  • Avoid concomitant use of drugs with similar effects and monitor for hemodynamic changes after initiating or increasing the dosage of dronabinol capsules. (nih.gov)
  • monitor for adverse reactions to concomitant highly protein-bound drugs and narrow therapeutic index drugs (e.g., warfarin, cyclosporine, amphotericin B) when initiating or increasing the dosage of dronabinol capsules. (nih.gov)
Placebo3
  • The National Institute on Drug Abuse (NIDA) officially announced Dr. Donald Abrams of UC-San Francisco will receive his full grant request of $978,000 for a study of the use of smoked marijuana, oral dronabinol, and a placebo, in HIV-positive patients. (druglibrary.net)
  • In addition to standard therapy, the participants took dronabinol (2.5 mg twice daily) or placebo for 4 weeks. (cannigma.com)
  • The study found that dronabinol increased appetite by 38% compared to only 8% for placebo and helped people maintain their body weight, with 22% gaining 2 kg or more. (cannigma.com)
Adverse1
  • Therefore, by design, dose-escalation of dronabinol was permitted only if the lower dose was not associated with adverse events. (frontiersin.org)
Anorexia2
  • Most studies of anorexia show improvement in subjects' body weight and psychological symptoms. (cannigma.com)
  • The key piece of evidence is a 2014 study that examined the effects of the THC-based drug dronabinol on 25 women with anorexia. (cannigma.com)
Appetite2
  • Dronabinol is used to stimulate appetite and therefore weight gain in patients with HIV/AIDS and cancer. (wikipedia.org)
  • A 2007 study also focused on Dronabinol as a possible appetite stimulant for people in long-term care. (hightimes.com)
Dose1
Capsules6
  • These highlights do not include all the information needed to use dronabinol capsules safely and effectively. (nih.gov)
  • See full prescribing information for dronabinol capsules. (nih.gov)
  • Inform patients not to operate motor vehicles or other dangerous machinery until they are reasonably certain that dronabinol capsules do not affect them adversely. (nih.gov)
  • Weigh the potential risk versus benefits before prescribing dronabinol capsules to patients with a history of seizures, including those requiring anti-epileptic medication or with other factors that lower the seizure threshold. (nih.gov)
  • Assess risk for abuse or misuse in patients with a history of substance abuse or dependence, prior to prescribing dronabinol capsules and monitor for the development of associated behaviors or conditions. (nih.gov)
  • In Germany, Dronabinol ® is supplied as a commercial product in options of 2.5mg, 5mg or 10mg, and also as drops or in the form of capsules. (wecann.academy)
Spasticity1
  • It is also recommended that dronabinol be administered orally for the treatment of spasticity in people suffering from MS and spinal cord injuries. (gaskination.com)
Drug2
  • The study tracked 48 subjects using the drug. (hightimes.com)
  • Gilg pointed to an exhibit of the new drug approval for Marinol (dronabinol) , noting that it cited just a single clinical trial of 139 subjects. (canorml.org)
Patients5
  • Dronabinol treatment is safe and well-tolerated in OSA patients at doses of 2.5-10 mg daily and significantly reduces AHI in the short-term. (frontiersin.org)
  • proof of concept study aimed to test the hypothesis that dronabinol, an exogenous CB 1 and CB 2 receptor agonist can reduce abnormal respiratory events and associated hypoxemia in patients with OSA. (frontiersin.org)
  • The primary objective was to assess the safety and tolerability of dronabinol in patients with moderate to severe OSA. (frontiersin.org)
  • For example, Dr. Abrams' study on marijuana and weight gain in HIV patients did not show whether the subjects in question actually had reduced morbidity or mortality. (canorml.org)
  • Both a day of eliglustat: moderate patients with fluoxetine and ventricular arrhythmia, non-randomized subject reference 1577. (myjuicecup.com)
Administration1
  • A marked tachycardia and psychologic "high" occurred within 3-5 min after the i.v. administration of 11-OH-Delta(9)-THC (1 mg) to all subjects. (nih.gov)
Found2
Scientists1
  • The NOSI concludes by inviting scientists whose focus on these subject areas (Cancer Hazard, Cannabinoid Ligands and Receptors, Cancer Biology, Cancer Procedure and Symptom Management) can guide to a vast assortment of investigation alternatives. (hemptips.best)
Effectively1
  • The chlorine dioxide compositions are injected directly into the cancerous tumor and the resulting tumor is effectively eliminated from the patient or subject over a period of one to several days to a few weeks, often after a single injection, or multiple injections at one session into the tumor. (justia.com)
Evaluation1
  • Subjects will undergo a medical evaluation (H&P, toxicology screening, and for females of childbearing potential, pregnancy testing (utilizing a human chorionic gonadotropin (hCG) urine test). (ucsd.edu)
Effects2
  • One landmark 1995 study examined the effects of dronabinol on 139 people suffering from AIDS-related wasting. (cannigma.com)
  • While treatment with dronabinol appeared to decrease colonic transit in subjects carrying the CNR1 rs CT/TT polymorphism, these effects were not statistically significant. (digitalmackintosh.co.uk)
Clinical1
  • For subjects in BD group, DSM-5 criteria for Bipolar Disorder as determined by the Structured Clinical Interview for DSM-5 (SCID). (ucsd.edu)
Study1
  • Should any of these items be answered affirmatively, e.g., the subject has endorsed these items for at least 1-2 days in the last week, the subject will not be enrolled in the study. (ucsd.edu)
Manufacture1
  • They are also subject to robust research, testing, and manufacture. (brookings.edu)
Treatment Option1
  • A scientific research conducted in 2016 clearly showed that all the subjects using medical marijuana as a treatment option for bipolar disorder didn't experience any form of mental impairment. (compcaremd.com)
Researchers1
  • Researchers stated that subjects reported lower depression levels while caring for their bodies more. (hightimes.com)
Significant1
Potential1
  • The potential medicinal properties of marijuana and its components have been the subject of research and heated debate for decades. (nih.gov)
Treat1
  • Dronabinol is FDA-approved as an antiemetic and to treat cachexia. (frontiersin.org)
Individual1
  • There was some individual variation in response among subjects. (nih.gov)
Effect1
Studies1
  • Madras agreed that CBD showed promise and appeared to "antagonize" THC, but that there had been only two or three "very limited" studies with a handful of subjects. (canorml.org)