Subgroup lymphoid precursor cells. Medical search. Frequent questions

Immunophenotypic and Molecular Features of Acute Myeloid Leukemia with Plasmacytoid Dendritic Cell Differentiation Are Distinct from Blastic Plasmacytoid Dendritic Cell Neoplasm. (atlasgeneticsoncology.org)
It can induce and promote T lymphocytes and their subgroup differentiation, maturation and activation, regulate the proportion of T lymphocytes, and make Cd4/Cd8 tend to be normal. (snbiopharm.com)
Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)
The basic and common immunologic defect in common variable immunodeficiency is a failure of B-lymphocyte differentiation into plasma cells that produce the various immunoglobulin (Ig) isotypes. (medscape.com)
These studies described failure of B-cell differentiation because of altered B-cell surface-molecule expression. (medscape.com)
In the last decade, there has been an increased desire for the characterization of this precursor from differentiating hESCs using several methods, generally through three-dimensional embryoid body (EB) differentiation (Ditadi et?al. (bioskinrevive.com)
2006). Moreover, in both these experimental strategies, the hemogenic potential of endothelium precursor people has been examined at differing times from the differentiation procedure, with or with out a prior purification stage of this people (Ditadi et?al. (bioskinrevive.com)
Following hemogenic potential of endothelium cell populations frequently during the period of hESC differentiation would address a few of these problems but to time this has hardly ever been reported. (bioskinrevive.com)
2006). Using EB differentiation protocols, the onset of hematopoietic commitment was also defined from the manifestation of CD43, growing from a CD34+ endothelial precursor human population (Kennedy et?al. (bioskinrevive.com)
Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)

Milatuzumab: a promising new agent for the treatment of lymphoid malignancies. (myelomacenter.org)
Venetoclax is active in other lymphoid malignancies including several B cell non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, with the highest intrinsic sensitivity observed in mantle cell lymphoma and Waldenstrom macroglobulinemia. (biomedcentral.com)

Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia? (johnshopkins.edu)
We conclude that trisomy 5 as the sole numerical abnormality occurs predominantly in older children, may be associated with a poor outcome, and may represent a distinct, albeit rare, cytogenetic subgroup in ALL. (johnshopkins.edu)
Dive into the research topics of 'Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia? (johnshopkins.edu)
For patients with chronic myelomonocytic leukemia, the overall response rate was higher for azacitidine plus lenalidomide vs azacitidine alone (68% vs 28%, P = .02) but similar for all arms across cytogenetic subgroups, as was remission duration and overall survival. (ascopost.com)
First, compared with control blood cells, the methylomes of ALL cells shared 9,406 predominantly hypermethylated CpG sites, independent of cytogenetic background. (biomedcentral.com)
In the present study we provide a comprehensive, genome-wide map of de novo DNA methylation changes in ALL cells at diagnosis and relapse by interrogating the methylation levels of 435,941 CpG sites distributed genome-wide in a large collection of pediatric ALL cells of diverse cytogenetic backgrounds. (biomedcentral.com)

It is a clonal genetic heterogeneous disease generally thought to arise from the malignant transformation and expansion of a single lymphoid progenitor at various stages of development ( 3 - 5 ). (frontiersin.org)
Because ALL cells arise from the oncogenic transformation of a single lymphoid precursor, they have clonal antigen-receptor (immunoglobulin and/or T-cell receptor) gene rearrangements in most cases, which can be used to distinguish ALL cells from normal lymphoid cells (expressing gene rearrangements with different sequences) and nonlymphoid cells (lacking the rearrangements). (ashpublications.org)

Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
I am an MRC Clinician Scientist and Honorary Consultant Paediatric Oncologist, providing a clinical service for young people with lymphoma or Langerhans cell histiocytosis at the Great North Children's Hospital, Newcastle. (ncl.ac.uk)
Our aim is to deeply characterise paediatric B-cell non-Hodgkin lymphoma to provide a comprehensive understanding of disease initiation and evolution in response to therapy. (ncl.ac.uk)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Abstract B38: FOXP1 truncated isoforms differentially regulate target genes in diffuse large B cell lymphoma. (growkudos.com)
The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)
Venetoclax combination with standard regimens in follicular lymphoma, multiple myeloma and aggressive B cell neoplasms has shown some promise, but further studies are required to optimize dose and scheduling to mitigate increased myelosuppression and infection risk, and to find validated biomarkers of venetoclax sensitivity. (biomedcentral.com)

The researchers used whole-exome sequencing to detect the presence of clonal hematopoiesis of indeterminate potential in peripheral blood cells and associated that discovery with coronary heart disease using samples from 4 case-control studies that together enrolled 4,726 participants with coronary heart disease and 3,529 controls. (ascopost.com)
Chronic lymphocytic leukemia (CLL) is a B-cell hematological malignancy characterized by the clonal expansion and accumulation of morphologically mature B-lymphocytes in peripheral blood, bone marrow, and secondary lymphoid tissues. (oncotarget.com)
ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). (biomedcentral.com)
ALL cells can be recognized by their clonal rearrangement of immunoglobulin and T-cell receptor genes, expression of gene fusions, and leukemia-associated immunophenotypes. (ashpublications.org)
Our data show that a subset of IHES may be of clonal origin not related to the classical molecular aberrations of FGFR, PDGFRA/B , or T-cells, and that the initiating hits could be point mutations in a variety of genes, including spliceosome mutations or hypermethylated tumor suppressor genes. (oncotarget.com)

Pediatric acute lymphoblastic leukemia (ALL) originates from the malignant transformation of lymphocyte progenitor cells into leukemic cells in the B-cell and T-cell lineages. (biomedcentral.com)
derivation of this specialized endothelium Ezetimibe enzyme inhibitor from human being embryonic stem cells (hESCs) provides an priceless platform to study and dissect blood specification and the emergence of hematopoietic stem and progenitor cells. (bioskinrevive.com)

Regulate and enhance the immune function of human body cell, to mitogen activated T lymphocytes in peripheral blood of mature, increase T cells in various antigen or mitogen activated all sorts of lymphatic factor (such as: alpha and gamma interferon, interleukin 2 or interleukin 3) secretion, increase the level of T cells in lymphoid factor receptor. (snbiopharm.com)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
The efficacy of cellular or humoral immunotherapy has been demonstrated with the success of chimeric antigen receptor T-cell therapy and the bispecific engager blinatumomab in treating advanced disease. (haematologica.org)
CD3 is a generic T-cell receptor and will identify all T-cells while CD8 is a marker for cytotoxic T-cells and suppressor T cells [ 10 ]. (biomedcentral.com)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)
Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)

It also enhances the lymphocyte response by activating t-helper cells. (snbiopharm.com)

Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia. (atlasgeneticsoncology.org)
Acute myeloid leukemia (AML) is a molecularly diverse malignancy with a poor prognosis whose largest subgroup is characterized by somatic mutations in NPM1 , which encodes nucleophosmin 1 . (nature.com)
The precise pathogenetic events leading to the development of ALL are still unknown, but evidence supports the hypothesis of driver mutations followed by secondary events, that can occur in subclones of the original leukemic cell following different evolution patterns ( 5 , 6 ). (frontiersin.org)
Cytogenetics advances of B-ALL have led to the discovery of numerous additional genetic changes, including mutations involving key cellular pathways in lymphoid development, tumor suppression, and cell cycle regulation. (biomedcentral.com)

I also work closely with UK and European colleagues (iBFM, EICNHL, ESID) to develop our understanding of development of lymphoid malignancy in children with inherited immune deficiency or DNA repair disorders and provide the paediatric clinical service for Langerhans cell histiocytosis and collaborate with Newcastle Human Dendritic Cell Laboratory ( http://www.hudendritic.org/ ) run by Professor Matt Collin. (ncl.ac.uk)

Although mutation- or pathway-directed targeted therapy (e.g., using tyrosine kinase inhibitors to treat Philadelphia chromosome [Ph]-positive and Phlike B-cell-ALL) is currently available for only a minority of children with ALL, many of the newly identified molecular alterations have led to the exploration of approaches targeting deregulated cell pathways. (haematologica.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Using Ingenuity pathway analysis, we found that differentially methylated genes were highly enriched in functional pathways such as cancer, cell death and survival, and hematological disease. (oncotarget.com)

Lin and Hamann's group show all human cytotoxic lymphocytes, including CD56dull NK cells and CD27-CD45RA+ effector-type CD8+ T cells, express GPR56. (wikipedia.org)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
Chromosomal aberrations (hypo- and hyperdiploidy, deletions, breaks, and gaps) in peripheral lymphocytes and bone marrow cells are the predominant effects seen in humans. (cdc.gov)
A slow clearance of leukemic cells by the initial course of chemotherapy, as measured by the morphologic analysis of peripheral blood or bone marrow smears 1 to 3 weeks from diagnosis, predicts a higher risk of relapse, but can be inaccurate because ALL blast cells are remarkably similar in appearance to bone marrow lymphoid precursors (alias hematogones) and, in some instances, to mature lymphocytes. (ashpublications.org)
The first demonstration that bone marrow samples apparently devoid of ALL cells may, in fact, contain measurable levels of leukemia (ie, "minimal residual disease" or MRD) was provided soon after the advent of polyclonal antisera against leukocyte antigens: combinations of cell markers were used to distinguish T-lineage ALL cells from normal immature and mature lymphocytes by immunofluorescence microscopy. (ashpublications.org)
Kupffer cells, hepatic stellate cells and sinusoidal endothelium) and infiltrating leukocytes (e.g., monocytes, monocyte-derived macrophages, neutrophils and lymphocytes). (mdpi.com)

90% leukemic cells. (aacrjournals.org)
The progressive accumulation of leukemic cells is mostly ascribed to extended cellular survival rather than excessive cellular proliferation [ 1 ]. (oncotarget.com)
Complete morphologic, immunologic, and genetic examination of the leukemic cells is necessary to establish the diagnosis of ALL. (medscape.com)

The National Cancer Institute's Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J. (medscape.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
Here, we studied the expression of 2 monocyte-derived markers, CD14 and CD169 (sialoadhesin), in reactive human lymphoid tissue as well as in a series of 51 B-cell lymphomas by immunohistochemistry on paraffin-embedded tissue. (cnrs.fr)

Studies in the hematopoietic system disclosed that during endothelial to hematopoietic stem cell transition, Gpr56 is a transcriptional target of the heptad complex of hematopoietic transcription factors, and is required for hematopoietic cluster formation. (wikipedia.org)
Other reports also show that DN is highly associated with accelerated aging in various types of cells such as tubular cells, podocytes, mesangial cells, and endothelial cells [ 21 - 23 ]. (hindawi.com)

CD11c(low) langerin+ cells represent skin-derived Langerhans cells, as demonstrated by their high expression of DEC-205/CD205, maturation markers, and recruitment to skin-draining lymph nodes upon imiquimod-induced inflammation. (cnrs.fr)

They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
Aberrant activation of lymphoid enhancer-binding factor-1 (LEF1) has been identified in several cancers, including chronic lymphocytic leukemia (CLL). (oncotarget.com)
Lymphoid enhancer binding factor-1 (LEF1) is a member of the LEF/T-cell factor (TCF) family. (oncotarget.com)
a beta-cell-specific transcriptional enhancer found in the insulin gene. (embl.de)

The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro. (cancerindex.org)

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells. (atlasgeneticsoncology.org)
After more than four decades of intensive research, the cellular origins of acute lymphocytic leukemia (ALL) have been well defined, and several distinct genetic mechanisms that lead to malignant transformation of these cells have been identified ( 1 - 4 ). (aacrjournals.org)
We propose that powerful machine-learning techniques based on 'joint manifold learning', often used in the 'alignment' of massive imaging datasets to recognized shared high-dimensional features, can be used to recognize shared cellular phenotypes across single cell datasets. (authorea.com)
Pathobiology: Cells and Genes;Cellular and Molecular Haematology. (nottingham.ac.uk)

Leukemia and colorectal cancer cells have been shown to resist asparagine depletion by utilizing GSK3-dependent proteasomal degradation, termed the Wnt-dependent stabilization of proteins (Wnt/STOP), to replenish their amino acid pool. (bvsalud.org)
Targeted deletion of the Hoxa cluster affects B lymphopoiesis through depletion of early lymphoid progenitors. (nottingham.ac.uk)
His research has involved both translational research and clinical trials including the role of B cell depletion and mesenchymal stem cells in systemic lupus erythematosus. (rochester.edu)

Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. (atlasgeneticsoncology.org)

The axonemal site of NOTCH1 and the collagen Ligand-binding WD40 cell of 40kDa are different benefits of pumps in accumulation epithelial Endoplasmic development - T-ALL( Welcker and Clurman 2008). (evakoch.com)
Langerin/CD207 is expressed by a subset of dendritic cells (DC), the epithelial Langerhans cells. (cnrs.fr)

In parallel, we used a version of the SMART-Seq2 protocol to obtain deep sequencing data (4-7,000 genes/cell) from 400 mitotic progenitors. (authorea.com)
Finally, we added data produced using the 10X genomics system for 7,000 postmitotic progenitors with significantly increased sequencing depth (1,500-11,000 UMI/cell, 1,000-4,000 genes/cell), and observed identical branching patterns as in our original Drop-seq dataset. (authorea.com)
Cre ;Ai9 line that uniformly marks interneuron progenitors, We therefore collected a set of 15,522 single cells across a developmental timecourse (E13.5, E18, P10), obtaining 3,432 additional P56 cells from a public resource hosted by the Allen Brain Atlas. (authorea.com)
2012). At later EB stage, most CD43+ cells upregulated the manifestation of CD41a and CD235a, and were enriched for megakaryocyte and erythroid progenitors, respectively (Klimchenko et?al. (bioskinrevive.com)

Immunoglobulin Heavy Chain High-Throughput Sequencing in Pediatric B-Precursor Acute Lymphoblastic Leukemia: Is the Clonality of the Disease at Diagnosis Related to Its Prognosis? (frontiersin.org)
High-throughput sequencing (HTS) of the immunoglobulin heavy chain ( IgH ) locus is a recent very efficient technique to monitor minimal residual disease of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). (frontiersin.org)
During B-cell development, the V, D, and J segments of the immunoglobulin genes are rearranged, with deletion and random insertion of nucleotides at the junctional sites, generating a unique gene sequence for each cell and its progeny. (ashpublications.org)

Genomic signatures are associated with phenotypically and molecularly well defined subgroups of adult ALL. (aacrjournals.org)

In somatic mammalian cells, the majority of CpG sites are methylated. (biomedcentral.com)

Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors. (atlasgeneticsoncology.org)
The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)

Abstract The eﬀect of long-term administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) on dendritic cell (DC) activation and survival in patients with locally advanced breast cancer (LABC) was studied. (coek.info)

Investigation of Gpr56 knockout mice and BFPP patients showed that GPR56 is required for in vitro myoblast fusion via signaling of serum response factor (SRF) and nuclear factor of activated T-cell (NFAT), but is not essential for muscle development in vivo. (wikipedia.org)
To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
In this study, we determined LEF1 gene expression levels in CLL ( n = 197) and monoclonal B-cell lymphocytosis (MBL) ( n = 6) patients through real-time RT-PCR. (oncotarget.com)
LEF1 was significantly up-regulated in both MBL and CLL patients compared with normal B cells. (oncotarget.com)
2017. Carfilzomib and dexamethasone vs bortezomib and dexamethasone in patients with relapsed multiple myeloma: results of the phase 3 study ENDEAVOR (NCT01568866) according to age subgroup. . (myelomacenter.org)
I. To compare the overall survival (OS) of blinatumomab in conjunction with chemotherapy to chemotherapy alone in patients with BCR-ABL-negative B cell precursor acute lymphoblastic leukemia (ALL) who are minimal residual disease (MRD) positive after induction and intensification chemotherapy, based on multiparameter flow cytometric (MFC) assessment of residual blasts. (clinicaltrialsgps.com)
Patients may then undergo allogeneic stem cell transplant (SCT) or proceed to consolidation therapy per investigator discretion. (clinicaltrialsgps.com)
Patients feel fatigued because they are anemic (low red cells), they can have easy bruising or bleeding due to low platelets, and they may have frequent fevers or infections as a result of low numbers of infection-fighting cells. (symptoma.com)

GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic precursor, muscle, and developing neural cells in the mouse. (wikipedia.org)
More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells. (wikipedia.org)
In addition, this product may affect chemotaxis of NK precursor cells, which become more cytotoxic after exposure to interferon. (snbiopharm.com)

In melanocytic cells GPR56 gene expression may be regulated by MITF. (wikipedia.org)
T-lineage ALL was characterized by a homogeneous gene expression pattern, whereas several subgroups of B-lineage ALL were evident. (aacrjournals.org)
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. (nature.com)

Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells ONCOTARGET. (nottingham.ac.uk)
No myeloid or erythroid precursors are seen. (medscape.com)

Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
A phase 1 study of bendamustine and melphalan conditioning for autologous stem cell transplantation in multiple myeloma. (myelomacenter.org)
2017. A Phase I Trial of High-Dose Lenalidomide and Melphalan as Conditioning for Autologous Stem Cell Transplantation in Relapsed or Refractory Multiple Myeloma. . (myelomacenter.org)

Here, we set out to define the mechanisms driving dependence toward this degradation machinery upon asparagine starvation in cancer cells. (bvsalud.org)
As a key transcription factor of the Wnt/β-catenin pathway, LEF1 helps to regulate important genes involved in tumor cell death mechanisms. (oncotarget.com)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)
This seminal observation instigated the ensuing decades of research that characterized the complex mechanisms of intrinsic cell death and lay the foundations for the development of therapeutics capable of restoring apoptosis in malignant cells. (biomedcentral.com)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)

BI-78D3 forms a covalent adduct with ERK in mammalian cells We next evaluated the ability of BI-78D3 to covalently modify C159 of ERK in intact cells. (cell-signaling-pathways.com)
Three isoforms have been described in mammalian cells. (lookformedical.com)

All cases had a precursor B-cell immunophenotype and there was a male predominance. (johnshopkins.edu)

I lecture on Cancer Stem Cells, Heterogeneity and Evolution within the Biomedical Sciences undergraduate degree programme. (ncl.ac.uk)
At present, the phenotypic heterogeneity and functional variation of human γδ T cells are increasing. (explorationpub.com)
The heterogeneity of the non-DC mononuclear phagocyte population in human lymphoid tissue has been little addressed. (cnrs.fr)

Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
Furthermore, Wnt inhibitor ethacrynic acid (EA) induced both apoptosis and necroptosis in primary CLL cells. (oncotarget.com)
TG 003 signaling dynamics and to induce cell cycle arrest and apoptosis in ERK-dependent cancers. (cell-signaling-pathways.com)
BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. (biomedcentral.com)
In brief, apoptosis is triggered when "pro-death/damage sensing" BH3-only proteins activate the downstream effector molecules BAX and BAK, which dimerize on the mitochondrial outer membrane surface and permeabilize it, triggering the release of cytochrome C, caspase activation and committing the cell to programmed death. (biomedcentral.com)
Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)

According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
ALL, and assess the efficacy of blinatumomab in each molecular subgroup. (clinicaltrialsgps.com)

Here the authors use innovative approaches to combine spatial profiling with single cell transcriptomics to define tumor-proximal populations of fibroblasts that predict clinical outcome. (elifesciences.org)
Fibrotic livers are characterized by an inflammatory microenvironment that is composed of various immunologically active cells, including liver-resident populations (e.g. (mdpi.com)

Here we report that activation of a humanized Npm1c knock-in allele in mouse hemopoietic stem cells causes Hox gene overexpression, enhanced self renewal and expanded myelopoiesis. (nature.com)
Solid as well as blood cancers are associated with overexpression of HOX proteins in the nucleus, which is traditionally a difficult area of the cell to target with conventional drugs. (nottingham.ac.uk)

Children with Down syndrome have an augmented risk for B-cell acute lymphoblastic leukemia (DS-ALL), which is associated with lower survival than in non-DS-ALL. (bvsalud.org)
The presence of intratumoural CD3 positive cells was associated with improved survival (p = 0.028), and intratumoural and stromal CD3 in combination also correlated with improved survival (p = 0.043). (biomedcentral.com)
BCL2 and other components of the intrinsic cell death pathway are critical regulators of cell survival, frequently perturbed by cancer cells resulting in evasion of programmed cell death [ 1 ]. (biomedcentral.com)
Cell survival. (lookformedical.com)
It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION . (lookformedical.com)

The mutational landscape of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the most common pediatric cancer, is not fully described partially because commonly applied short-read next generation sequencing has a limited ability to identify structural variations. (bvsalud.org)
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common pediatric neoplasm ( 1 , 2 ). (frontiersin.org)
Immunotherapy with monoclonal antibodies, such as blinatumomab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread It is not yet known whether combination chemotherapy is more effective with or without blinatumomab in treating newly diagnosed acute lymphoblastic leukemia. (clinicaltrialsgps.com)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)

2014). Definitive hematopoiesis, defined by T lymphoid potential, was restricted to the CD43? (bioskinrevive.com)

Development of pre-clinical models using stem cell technologies. (nottingham.ac.uk)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)
Assays based on polymerase chain reaction or flow cytometry can detect one ALL cell among 10,000 to 100,000 normal cells in clinical samples. (ashpublications.org)
In healthy individuals, eosinophilic granulocytes (eosinophils) constitute less than five percent of all white blood cells [ 1 ], and in clinical practice blood eosinophilia is defined as an eosinophil count ≥ 0.5x10 9 /l. (oncotarget.com)

Special advances are achieved in HER-positive tumors using targeted therapy with drugs which suppress the tumor cell growth factors (trastuzumab, herceptin). (cttjournal.com)
Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)

Dr. Abutalib is Assistant Director in the Stem Cell Transplant & Cell Therapy Program at Cancer Treatment Centers of America in Chicago. (ascopost.com)
Combining gene signatures with bioinformatics databases (connectivity mapping) and drug repurposing to target leukaemic whilst sparing normal blood stem cells. (nottingham.ac.uk)
The group are currently focused on the pivotal role that HOXA cluster genes play in the demarcation and possible emergence of haematopoietic stem cells (HSCs) and their role in cancer. (nottingham.ac.uk)
However, eradication of the leukaemia repopulating cell or stem cell whilst retaining normal HSCs remains a challenge with current experimental therapies. (nottingham.ac.uk)
You can always go to salvage treatment and a stem cell transplant rather than intensifying treatment right away. (oncologytube.com)
2008. Stem cell mobilization with cyclophosphamide overcomes the suppressive effect of lenalidomide therapy on stem cell collection in multiple myeloma. . (myelomacenter.org)
Part of this funding has been used to support research on mesenchymal stem cells in SLE. (rochester.edu)

2) various primary or secondary t-cell defects (such as congenital immunodeficiency in children). (snbiopharm.com)

The host response to presence of tumour cells can be represented by the presence of tumour infiltrating immune cells. (biomedcentral.com)

lymphoid tissue, and digestive tract), which the animal model captures the It can be difficult to parse out concordance has often been ob- range of potential human response reasons for lack of tumour site con- served among different species after to the particular agent tested. (who.int)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
However, langerin is also detected among lymphoid tissue DC. (cnrs.fr)
It will be of interest to determine the role of lymphoid tissue-resident compared to skin-derived langerin+ DC. (cnrs.fr)
volume = {37}, number = {0046-8177 (Print)}, pages = {68--77}, abstract = {The mononuclear phagocyte system of human lymphoid tissue comprises macrophages and dendritic cells (DCs). (cnrs.fr)

EA also enhanced the cytotoxicity of both fludarabine and cyclophosphamide against CLL cells in vitro. (oncotarget.com)
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)

Both new datasets strongly validate our original findings, producing nearly identical developmental trajectories, and exhibiting no evidence of distinct subpopulations of fate-restricted cells in the subventricular zone. (authorea.com)
While langerin+ cells are observed in comparable numbers and with comparable phenotypes in the epidermis, two distinct DC subsets bear langerin in peripheral, skin-draining lymph nodes of BALB/c mice (CD11c(high) CD8alpha(high) and CD11c(low) CD8alpha(low)), whereas only the latter subset is present in C57BL/6 mice. (cnrs.fr)

Since the mid-1990's I became interested in investigator-initiated trials of new agents for immune-mediated diseases, most notably one of the very first trials of B cell targeted therapy for autoimmunity (anti-CD20 for SLE). (rochester.edu)

GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development. (wikipedia.org)
Recently, two studies showed that GPR56, is a cell autonomous regulator of oligodendrocyte development through Gα12/13 proteins and Rho activation. (wikipedia.org)
Similar to αβ T cells, γδ T cells also develop in embryos, and their intra-thymic development shows strict regulation and flexible plasticity [ 2 ]. (explorationpub.com)
The most characteristic systemic effect resulting from intermediate and chronic benzene exposure is arrested development of blood cells. (cdc.gov)

Therefore, this product has the function of regulating and enhancing the immune function of human cells. (snbiopharm.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
It is hoped that the host immune status can be accurately predicted and gradually advance γδ T cell precise individualized medicine. (explorationpub.com)
It responds poorly to immunotherapy for instance, despite this approach often succeeding in enlisting immune cells to fight tumours in other organs. (elifesciences.org)

Anatomy64

Organisms24

Diseases5

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Psychiatry and Psychology1

Phenomena and Processes54

Disciplines and Occupations1

Information Science4

Health Care3

Differentiation13

Malignancies2

Cytogenetic6

Single lymphoid2

Lymphoma10

Clonal5

Progenitor cells2

Receptor8

Lymphocyte1

Mutations4

Malignancy1

Pathways3

Lymphocytes6

Leukemic3

Lymphomas3

Endothelial2

Maturation1

Enhancer4

Proliferation1

Cellular4

Depletion3

Malignant transformation1

Epithelial2

Progenitors4

Immunoglobulin3

Molecularly1

Somatic1

Bone2

Dendritic cell1

Patients8

Cytotoxic3

Gene expression3

Myeloid2

Autologous stem cell trans3

Mechanisms5

Mammalian2

Immunophenotype1

Heterogeneity3

Apoptosis6

Efficacy2

Populations2

Overexpression2

Survival5

Leukemia4

Hematopoiesis1

Clinical5

Tumor cell growth2

Stem7

Secondary1

Tumour cells1

Tissue5

Vitro2

Distinct2

CD201

Development4

Immune5