The subgranular zone is a narrow layer of cells located between the granule cell layer and hilus of the dentate gyrus. (wikipedia.org)
Using in vivo and in vitro approaches the present study shows that p21 is expressed in the subgranular zone of the dentate gyrus of the hippocampus in early neuronal progenitors and in immature neurons, but not in mature neurons or astroglia. (blogspot.com)
Within the subgranular zone, called dentate gyrus, the developing cells are differentiated to form excitatory granule cells. (news-medical.net)
Eight of 1000 small molecules tested enhanced neuron formation in the subgranular zone of the dentate gyrus. (nih.gov)
Morphological analysis of the dentate gyrus in adulthood revealed a disorganised subgranular zone and a dispersed granule cell layer. (karger.com)
Introduction: The adult mammalian brain retains neural stem cells (NSCs) that continually generate new neurons within two restricted regions, the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus in the hippocampus (HC). (uni-marburg.de)
DESCRIPTION (provided by applicant): In the mammalian adult brain, there are two regions where stem cells continuously give rise to new neurons, a process termed neurogenesis: the subventricular zone and the subgranular zone of the dentate gyrus. (neurotree.org)
Katanin p60 haploinsufficiency induced an accumulation of neuronal progenitors in the subventricular zone during corticogenesis, and impaired their proliferation in the adult hippocampusdentate gyrus (DG) subgranular zone. (monash.edu)
Here, we showed that conditional knock out (cKO) of Atg5 (autophagy related 5) in microglia inhibited postnatal neurogenesis in the dentate gyrus (DG) of the hippocampus, but not in the subventricular zone (SVZ) of a 5×FAD mouse model. (bvsalud.org)
On the other hand, the repeated oral administration of celecoxib to 4-week-old ZDF rats significantly decreased the neuroblasts in the subgranular zone of the dentate gyrus. (mcmaster.ca)
In line with these studies, we observe a signi cant decrease in doublecortin, a marker for neuronal precursor cells/neurogenesis, in the subgranular zone in the dentate gyrus of the hippocampus, a major site of neurogenesis in the mouse brain, following irradiation, which remains reduced following monocyte in ltration ( Fig. (scite.ai)
Upon stimulation, stem cells within the subventricular and subgranular zones begin to proliferate to form neuroblasts, eventually maturing into neurons. (news-medical.net)
Alternately, within the subventricular zones, neural progenitor cells migrate via the rostral migratory stream (RMS) to the olfactory bulb, where they differentiate further into many types of highly specialised neuron. (news-medical.net)
Although steady-state conditions revealed no increase in primitive cell proliferation in p21-null mice, a significantly larger fraction of quiescent neural precursors was activated in the hippocampus and subventricular zone after brain ischemia. (rupress.org)
A: Sagittal view showing the adult mouse subventricular zone (SVZ) and the migrating neuroblasts (red) reaching the olfactory bulb (OB) through the rostral migratory stream (rms). (wjgnet.com)
In mice, they exist in two regions that are important for learning and memory: the subventricular zone of the anterior forebrain and the subgranular zone of the hippocampus. (cosmosmagazine.com)
We prospectively identified, and isolated by flow cytometry, adult mouse lateral ventricle subventricular zone (SVZ) NICs as Glast mid EGFR high PlexinB2 high CD24 −/low O4/PSA-NCAM −/low Ter119/CD45 − (GEPCOT) cells. (elifesciences.org)
When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
have used a technique called flow cytometry to identify and isolate neural stem cells and neurosphere-forming cells directly from the subventricular zone. (elifesciences.org)
During the postnatal and adult period, Notch signalling is still present in the major neurogenic areas, the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampus. (medecinesciences.org)
It takes place in the subventricular Zone (SVZ) and the subgranular zone (SGZ). (yoga4brainhealth.com)
In the monkey ( Macaca mulatta ) hippocampus, proliferation of neurons in the subgranular zone was found in early postnatal life, but this diminished during juvenile development as neurogenesis decreased. (nature.com)
The fluorescent biomarker (in green) revealed that the adult mouse brain could be infected by Zika in a region called the subgranular zone of the hippocampus. (cosmosmagazine.com)
Neurons3
D: Coronal view showing the adult mouse subgranular zone (SGZ) and the newborn neurons (red) being integrated in the granular cell layer (gr). (wjgnet.com)
In both the granular zone and the periglomerular zone of the OB, over 90 % of the total amount of new built cells differentiated into neurons in both groups. (uni-marburg.de)
Also the rate of differentiation into a dopaminergic phenotype of the newly born neurons in the periglomerular zone of the OB was not significantly changed with 93 % in the orexin/ataxin-3 mice compared to 91 % in the WT mice. (uni-marburg.de)
Progenitor cells1
Here we show that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development. (nature.com)
Adult mouse1
Conclusion: In the absence of orexin in the adult mouse brain, the proliferation of adult neural stem/precursor cells was increased, the survival rate was significantly increased in the granular zone of the OB and a consistent not significant trend was seen in the HC. (uni-marburg.de)
Proliferation1
Therefore, in this chapter we will review the literature toward the goal of highlighting which inflammatory signals affect the proliferation and differentiation of the stem cells and progenitors of the brain's germinal zones. (eurekaselect.com)
Stem cells1
Neural stem cells are located within the ventricular zone, where they divide to form the ventricular system of the brain. (news-medical.net)
Neural1
Au cours de la période post-natale et adulte, la signalisation Notch reste présente dans les principales aires de neurogenèse adulte, la zone sous-ventriculaire des ventricules latéraux et la zone sous-granulaire de l'hippocampe, où elle maintient la quiescence des CSN adultes, contribue au caractère hétérogène de ces cellules et exerce des effets pléiotropes au cours de la régénération du tissu neural lésé. (medecinesciences.org)
Cells1
We were able to demonstrate a significantly higher survival of newly built cells in the granular zone, but not for the periglomerular zone of the OB in the orexin/ataxin group. (uni-marburg.de)
Dentate4
The subgranular zone is a narrow layer of cells located between the granule cell layer and hilus of the dentate gyrus. (wikipedia.org)
The neuroprotective effects of CBL might be related to its ability to promote neurogenesis in the hippocampal subgranular zone (SGZ) of the dentate gyrus (DG). (nih.gov)
Conditional knocking out of VPS35 in microglia of male mice results in regionally increased microglial density and activity in the subgranular zone of the hippocampal dentate gyrus (DG), accompanied by elevated neural progenitor proliferation, but decreased neuronal differentiation. (elsevierpure.com)
Neurogenesis1
Modest radiation doses cause apoptosis decline in neurogenesis in the subgranular zone and then the extinction of short-term memory [ 7 - 9 ]. (hindawi.com)
Proliferation1
all mice, both resilient and sensitive , showed decreased proliferation in subgranular zone ( SGZ ) for new cells immediately after stress exposure. (the-mouse-trap.com)
Brain1
This zone is also one of the few areas in the adult brain where stem cells are known to reside. (nih.gov)