• Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)
  • START (StAR-related lipid-transfer) is a lipid-binding domain in StAR, HD-ZIP and signalling proteins. (wikipedia.org)
  • Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)
  • Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the mechanisms that regulate PLIN2 levels remain incompletely understood. (stanford.edu)
  • Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)
  • The archetypical domain is found in StAR (Steroidogenic acute regulatory protein), a mitochondrial protein that is synthesized in steroid-producing cells. (wikipedia.org)
  • The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. (wikipedia.org)
  • Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
  • StAR or STARD1) and lipids like phosphatidylcholine (phosphatidylcholine transfer protein, also called PCTP or STARD2) and have enzymatic activities. (wikipedia.org)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • protein_coding" "AAC73139","fkpB","Escherichia coli","FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73627","ppiB","Escherichia coli","peptidyl-prolyl cis-trans isomerase B (rotamase B) [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73161","apaG","Escherichia coli","protein associated with Co2+ and Mg2+ efflux [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73194","ftsL","Escherichia coli","membrane bound cell division leucine zipper septum protein [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73196","murE","Escherichia coli","UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73197","murF","Escherichia coli","UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73288","bamA","Escherichia coli","BamABCDE complex OM biogenesis outer membrane pore-forming assembly factor [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73290","lpxD","Escherichia coli","UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
  • Thousands of proteins containing at least one START domain have been determined in invertebrates, bacteria and plants to form a larger superfamily, variously known as START, Bet v1-like or SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) domain proteins, all of which bind hydrophobic ligands. (wikipedia.org)
  • Other proteins also exist in the human with domains that are members of the START-based superfamily such as PITP, but are not part of the START domain itself. (wikipedia.org)
  • The STAR D9 gene encodes a 4.7 kiloDalton amino acid protein which is a member of the kinesin superfamily. (wikipedia.org)
  • The polar transport of auxin mainly depends on three transporters: AUX/LAX, PIN and ABCB protein families. (chinbullbotany.com)
  • Bile acid transporters were regulated by various factors including bile acids, nuclear receptors, transcription factors, hormones, etc ., which influence their protein expression, cell location and transport activities. (magtechjournal.com)
  • HIF-P4H-2 inhibition downregulates hepatic lipogenesis. (springer.com)
  • Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. (genome.jp)
  • much 75 cytosol of pairing substrates are in 1500 220 KDa proteins with IGFBP3 and ALS. (evakoch.com)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver[J]. Drug Metab Rev, 2013, 45(1):48-59. (magtechjournal.com)
  • Encodes a hydrophilic protein similar to Late Embryogenesis Activated (LEA) proteins expressed during embryogenesis, which are thought to be involved in the acquisition of dessication tolerance. (or.jp)
  • The PIN protein contains a central hydrophilic loop (HL) and two separated hydrophobic regions, and the multiple phosphorylation sites on HL are the targets of protein kinases. (chinbullbotany.com)
  • Gene and protein expressions were analyzed by quantitative RT-PCR and immunoblotting, respectively. (bvsalud.org)
  • Human HTT codes for a large protein of 3144 amino acids, which is ubiquitously expressed in various tissues and is present in several sub-cellular locations. (nature.com)
  • Beef has high nutritional value from children to seniors, is a rich source of protein (essential amino acids), iron, zinc, B vitamins and essential polyunsaturated fatty acids such as linoleic and linolenic acid [ 2 ]. (biomedcentral.com)
  • Here we reviewed the research progress of PIN protein in Arabidopsis thaliana and cereal crops from the aspects of protein structure, activity regulation and functional verification to provide new ideas and clues for exploring the auxin polar transport mediated by PIN protein family. (chinbullbotany.com)
  • The basic unit of the p53 protein consists of three major functional domains such as an N-terminal transactivation domain (TAD), a core DNA-binding domain (DBD)-the main target for mutations, and a C-terminal regulatory domain (CTD) ( Figure 1 A) [ 2 ] . (encyclopedia.pub)
  • Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)
  • functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)
  • This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)
  • The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
  • A ) Simplified representation of the secondary structure showing domain organization of the human p53 protein (Uniprot #P04637). (encyclopedia.pub)
  • Representatives of the START domain family bind different substances or ligands such as sterols (e.g. (wikipedia.org)
  • The intake of fructose in majority of the Hif-p4h-2 gt/gt tissues, including the liver, was 15-35% less than in the WT. (springer.com)
  • HIF-P4H-2 inhibition enhances intestinal fructose metabolism protecting the liver. (springer.com)
  • Interaction of gut microbiota with bile acid metabolism and its influence on disease states[J]. Appl Microbiol Biot, 2016, 5(2):129-134. (magtechjournal.com)
  • We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from NAFLD by subjecting HIF-P4H-2-deficient ( Hif-p4h-2 gt/gt ) mice to a high-fat, high-fructose (HFHF) or high-fat, methionine-choline-deficient (HF-MCD) diet. (springer.com)
  • The pathway also supplies important precursor metabolites including 2-oxoglutarate. (easyomics.org)
  • The vast majority of proteins entering the secretory pathway are synthesized on ribosomes docked at ER translocons and are co-transationally translocated into the ER lumen. (stanford.edu)
  • Proteins synthesized at the ER are subject to covalent modifications that include N- and O-glycosylation, disulfide bond formation, and in some cases, proline and lysine hydroxylation. (stanford.edu)
  • It is considered the hepatic manifestation of metabolic syndrome, strongly linked to obesity and insulin resistance (IR), which further predisposes for diabetes and cardiovascular diseases [ 2 ]. (springer.com)
  • We illustrated several HDNetDB functionalities through a case study and identified proteins that constitute potential cross-talk between HD and the unfolded protein response (UPR). (nature.com)
  • These results also suggest the coupling of RACK1 to muscle unfolded protein response during SC activation. (sdbonline.org)
  • The direction of auxin flow between cells is closely related to the polar localization of PIN proteins in cells. (chinbullbotany.com)
  • Most importantly, the interior of the protein encompasses a 26 × 12 × 11-Angstrom hydrophobic tunnel that is apparently large enough to bind a single cholesterol molecule. (wikipedia.org)
  • On both diets, the Hif-p4h-2 gt/gt mice gained less weight and had less white adipose tissue (WAT) and its inflammation, lower serum cholesterol levels, and lighter livers with less steatosis and lower serum ALT levels than the wild type (WT). (springer.com)
  • The PIN proteins are fine-tuned at multiple levels, including transcriptional regulation, post-transcriptional modification, intracellular recycling and vacuolar trafficking for degradation, in response to endogenous and exogenous signals. (chinbullbotany.com)
  • Following the discovery of StAR, 15 START-domain-containing proteins (termed STARD1 through STARD15) were subsequently identified in vertebrates as well as other that are related. (wikipedia.org)
  • Ligand binding by the START domain in multidomain proteins can also regulate the activities of the other domains, such as the RhoGAP domain, the homeodomain and the thioesterase domain. (wikipedia.org)
  • START domain-containing proteins in the human are divided into five subfamilies. (wikipedia.org)
  • The protein contains four domains: BAR domain, PH domain, an ARF-GAP domain, and two Ankyrin repeats. (or.jp)
  • The p53 protein, to exert its function, binds in a sequence-specific manner to the DNA-binding sites by forming a tetramer, via four self-assembling p53 molecules, which are stabilized by protein-protein and base-stacking interactions [ 3 ] . (encyclopedia.pub)
  • We found upregulation of the key fructose transporter and metabolizing enzyme mRNAs, Slc2a2 , Khka , and Khkc , and higher ketohexokinase activity in the Hif-p4h-2 gt/gt small intestine relative to the WT, suggesting enhanced metabolism of fructose in the former. (springer.com)
  • Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4alpha/CYP7A1 axis[J]. J Hepatol, 2015, 62(5):1171-1179. (magtechjournal.com)