Subfamily protein tyrosine phosphatase non receptor type 11. Medical search. Frequent questions

Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins: [a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate Protein tyrosine (pTyr) phosphorylation is a common post-translational modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability, and regulate enzyme activity. (wikipedia.org)
Those which bind phosphorylated tyrosine residues may recruit multi-phosphorylated substrates for the adjacent active domains and are more conserved, while the other class have accumulated several variable amino acid substitutions and have a complete loss of tyrosine binding capability. (embl.de)
Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA's primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma. (biomedcentral.com)
Typically Rho proteins are 190-250 residues long and consist only of the GTPase domain and short terminal C-terminal extensions. (biomedcentral.com)
Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. (assaygenie.com)

Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signalling molecules, such as the MAP kinase family. (wikipedia.org)
PTPs are increasingly viewed as integral components of signal transduction cascades, despite less study and understanding compared to tyrosine kinases. (wikipedia.org)
By analyzing PTPRO substrates that are neurocognition-associated tyrosine kinases, we found that SRC and EPHA4 are highly phosphorylated/activated in the hippocampi of Ptpro-/- female mice, with increased sensitivity to DOX-induced CRCI. (bvsalud.org)
Mammalian Cdc25 phosphatase is responsible for the dephosphorylation of Cdc2 and other cyclin-dependent kinases at Thr14 and Tyr15, thus activating the kinase and allowing cell cycle progression. (embl.de)
Glycogen synthase kinase 3 (GSK-3) / SHAGGY kinase (SGG) are multifunctional non receptor serine/threonine kinases. (biomedcentral.com)
Rho GTPase effectors are a large group of proteins and include actin nucleation promoting molecules, adaptors, as well as kinases. (biomedcentral.com)
In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue . (kinase.com)

HCK proto-oncogene, Src family tyrosin. (gsea-msigdb.org)
Both receptors belong to the TAM (TYRO3, AXL and MER - MER proto-oncogene, tyrosine kinase) receptor tyrosine kinase family, which emerged as new potential targets in many oncological diseases, from leukaemia to solid tumours ( Graham et al, 2014 ). (nature.com)

Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase, Non Receptor Type 11 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
Description: Quantitativesandwich ELISA kit for measuring Human Receptor-type tyrosine-protein phosphatase F (PTPRF) in samples from serum, plasma, urine, tissue homogenates, cell lysates. (scalegen.com)
Description: A sandwich ELISA kit for detection of Transient Receptor Potential Cation Channel Subfamily V, Member 2 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)

LMW (low-molecular-weight) phosphatases, or acid phosphatases, act on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. (wikipedia.org)

Ser/Thr and Tyr dual-specificity phosphatases are a group of enzymes with both Ser/Thr (EC 3.1.3.16) and tyrosine-specific protein phosphatase (EC 3.1.3.48) activity able to remove the serine/threonine or the tyrosine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase. (wikipedia.org)

As a consequence, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. (wikipedia.org)
Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. (embl.de)
Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. (biomedcentral.com)
Phosphorylation of both the threonine and tyrosine are required for activity. (assaygenie.com)
Protein phosphorylation of G-protein-coupled receptors (GPCR) is central to the myriad of functions that these ubiquitous receptors perform in biology. (biomedcentral.com)

These events are influenced by and activate other molecular pathways, including phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK),[2] and therapies are now available that target these pathocellular processes. (cancernetwork.com)

Dual-specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. (wikipedia.org)
The catalytic domain of this dual-specificity phosphatase has recently been mapped to the 180 most C-terminal amino acids. (embl.de)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Transient Receptor Potential Cation Channel Subfamily V, Member 2 (TRPV2) in Tissue homogenates and other biological fluids. (tuberculosisdrugresearch.org)
30°C), TRPM8, a member of the melastatin TRP channel subfamily [ 2 , 3 ]. (nih.gov)

The subfamily EYA (eyes absent) is believed to be pTyr-specific, and has four members in human, EYA1, EYA2, EYA3, and EYA4. (wikipedia.org)

The heparan Golgi-resident selenide receptors in interconnectivity a state of interactions that are to mitochondrial influx membrane used by the irreversible expression( HA) response, and the sustained polypeptide of the archival distinct knot km2 into the tail of the complex dementia. (evakoch.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

In terms of structure, all known receptor PTPases are made up of a variable-length extracellular domain, followed by a transmembrane region and a C-terminal catalytic cytoplasmic domain. (wikipedia.org)
Non-receptor (intracellular) PTPases All PTPases, other than those of the EYA family, carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and possess a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif. (wikipedia.org)
A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain. (embl.de)
Its substrate specificity suggests that Tsp may contain a substrate recognition domain, which selectively binds to the nonpolar C-termini of substrate proteins, separate from its catalytic site. (embl.de)

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
40535) Transcription factor TFIIB cyclin-related protein CP001857 CDS Arcpr_0047 complement(40887. (go.jp)
The role of MSY genes in important cellular processes such as transcription regulation, translation, and protein stability in males is vital not only in sex determination but also in sex-dependent organ development [ 3 ]. (biomedcentral.com)
Additionally, activated GR can affect transcription through mechanisms independent of DNA binding that modulate the activity of other transcription factors, including nuclear factor-κB, activator protein-1, and STAT (signal transducer and activator of transcription) [ 4 ]. (biomedcentral.com)
A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. (biomedcentral.com)

Possible mechanisms for developing acquired resistance to anti-cancer drugs include mutations of genes encoding proteins that are the targets of drugs or are present in downstream pathways of proteins inhibited by drugs as well as the activation of collateral pathways ( 19 , 20 ). (spandidos-publications.com)
PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. (biomedcentral.com)
We further demonstrate that PTPRD has a tumor suppressor function in neuroblastoma through dephosphorylating and destabilizing AURKA, leading to a downstream decrease of MYCN protein. (biomedcentral.com)
The exchange of GDP to GTP and thus the activation of Rho GTPases is catalyzed by guanine nucleotide exchange factors (GEFs), which act downstream of numerous growth factor receptors, integrins, cytokine receptors, and cadherins. (biomedcentral.com)

Rho GTPase activating protein 32 [Sour. (gsea-msigdb.org)
A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. (biomedcentral.com)
A structural feature that distinguishes the Rho proteins from other small GTPases is the so-called Rho insert domain located between a β strand and an α helix within the small GTPase domain [ 1 - 3 ]. (biomedcentral.com)
Within their GTPase domains, they share approximately 30% amino acid identity with the Ras proteins and 40-95% identity within the family. (biomedcentral.com)

Cdc25 phosphatases (dTyr and/or dThr) The Class III PTPs contains three members, CDC25 A, B, and C These are members of the HAD fold and superfamily, and include phosphatases specific to pTyr and pSer/Thr as well as small molecule phosphatases and other enzymes. (wikipedia.org)

and high protein levels of stomatin-like protein 2 and epidermal growth factor receptor ( 17 , 18 ). (spandidos-publications.com)

Despite extensive studies on the effect of these genes on the development pathways, some MSY genes have remained as missing proteins with no experimental protein evidence due to highly transient and spatio-temporal restricted expression patterns. (biomedcentral.com)

actin related protein 1B [Source:H. (gsea-msigdb.org)

The class II PTPs contain only one member, low-molecular-weight phosphotyrosine phosphatase (LMPTP). (wikipedia.org)
Children with Down syndrome: association of Bcl-I polymorphism of nuclear receptor subfamily 3 group C member 1 gene with obesity. (cdc.gov)
The peptidyl-prolyl cis / trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis / trans isomerisation of a prolyl bond. (biomedcentral.com)
Protein is a member of a gene family with other members found plants, animals and fungi. (or.jp)

Links to all 107 members of the protein tyrosine phosphatase family can be found in the template at the bottom of this article. (wikipedia.org)
DnaJ heat shock protein family (Hsp40). (gsea-msigdb.org)
In turn, GTP-bound active GTPases can interact with a plethora of different effectors which mediate the different cellular functions of this family of proteins. (biomedcentral.com)
The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. (kinase.com)
Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
1251 orc1%2Fcdc6 family replication initiation protein CP001857 CDS Arcpr_0002 1251. (go.jp)
9195) PhoH family protein CP001857 CDS Arcpr_0008 9278. (go.jp)
41666) ExsB family protein CP001857 CDS Arcpr_0048 41748. (go.jp)
45756) PEBP family protein CP001857 CDS Arcpr_0056 45795. (go.jp)
47904) TATA-box binding family protein CP001857 CDS Arcpr_0059 47991. (go.jp)
Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12. (biomedcentral.com)
DnaJ heat shock protein family (Hs. (gsea-msigdb.org)

1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)

Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)

EC 3.1.3.48) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. (wikipedia.org)

This gene subfamily is constitutively active at physiological resting membrane potentials in excitable cells, including smooth muscle cells, and has been particularly linked to the human pulmonary circulation. (ersjournals.com)
The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)

Based on their cellular localization, PTPases are also classified as: Receptor-like, which are transmembrane receptors that contain PTPase domains. (wikipedia.org)
Some of the receptor PTPases contain fibronectin type III (FN-III) repeats, immunoglobulin-like domains, MAM domains, or carbonic anhydrase-like domains in their extracellular region. (wikipedia.org)
This entry represents the PTPase domain found in several tyrosine-specific protein phosphatases (PTPases). (embl.de)

Rho proteins belong to the Ras superfamily. (biomedcentral.com)

The immune-specific amplification of prednisolone anti-inflammatory activity by dipyridamole did not extend to glucocorticoid-mediated adverse effects, including corticosterone suppression or increased expression of tyrosine aminotransferase, in vivo after repeat dosing in rats. (biomedcentral.com)

By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)
The changes in protein expression associated with the development of resistance were analyzed using a proteomic approach, detecting 1,321 proteins and significant changes in the expression of 267 proteins. (spandidos-publications.com)
Using Ingenuity Pathway Analysis bioinformatics software, it was revealed that the activity of multiple signaling pathways varied alongside the changes in expression of these proteins, and c‑SRC was identified as a protein involved in a number of these signaling pathways, with its activity varying markedly upon the acquisition of resistance. (spandidos-publications.com)
encodes a protein that is induced in expression in response to water deprivation such as cold, high-salt, and dessication. (or.jp)

with us one can be cytosol proteins, " badenova( 2009) is four primary photoreceptors, the most non-crossover-generating of which chloroplasts release, phosphorylated, and ready ataxia bacterial to a cascade of challenging glycoprotein GTPases. (evakoch.com)
The diverse effects of glucocorticoids are mediated by the glucocorticoid receptor (GR). Unliganded GR is retained in the cytosol by heat shock proteins that are released upon binding and activation by glucocorticoid [ 3 ]. (biomedcentral.com)

amyloid beta precursor protein binding. (gsea-msigdb.org)

A cellular DNA-repair protein, namely O 6 -methylguanine-DNA methyltransferase (MGMT) protein, reverses alkylation at the O 6 position of guanine, thereby inhibiting the lethal cross-linking and bringing about resistance to alkylating agents ( 2, 3 ). (aacrjournals.org)
There are two types of nitrogenous bases: purines (adenine and guanine) and pyrimidines (cytosine, uracil and thymine). (pancreapedia.org)
After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)

55699) Ribosomal protein L15e CP001857 CDS Arcpr_0066 complement(55738. (go.jp)

C-C motif chemokine receptor 7 [So. (gsea-msigdb.org)

PTPs have been implicated in regulation of many cellular processes, including, but not limited to: Cell growth Cellular differentiation Mitotic cycles Oncogenic transformation Receptor endocytosis PTP activity can be found in four protein families. (wikipedia.org)

During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
The process of ischemia and reperfusion is known to cause inducible nitric oxide synthase induction and activation, and there is evidence that interleukin (IL)-1β (46), IL-1 receptor (47), and IL-1 receptor along with nuclear factor-kappa beta (48) may have an important role in that induction. (ectrx.org)
With the histone of synthesis, the signaling glutamate is to introduce released well nuclear after protein. (evakoch.com)

All members contain the sequence motifs characteristic of all GTP-binding proteins, bind to GDP and GTP with high affinity. (biomedcentral.com)
This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)

NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity. (biomedcentral.com)

25637 PKD domain containing protein CP001857 CDS Arcpr_0030 complement(25624. (go.jp)

GCA (grancalcin) is usually a cytosolic protein that is translocated to the granule membrane upon neutrophil activation [26,27]. (abic2004.org)
PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. (embl.de)

One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)

32303) chromosome segregation and condensation protein%2C ScpB CP001857 CDS Arcpr_0039 complement(32287. (go.jp)
32898) chromosome segregation and condensation protein ScpA CP001857 CDS Arcpr_0040 complement(32907. (go.jp)
36314) chromosome segregation protein SMC CP001857 CDS Arcpr_0041 complement(36316. (go.jp)
With the launch of the human proteome project (HPP), the association of Y chromosome proteins with pathological conditions has been increasingly explored. (biomedcentral.com)
In this article, the role of Y chromosome in male-specific diseases (male infertility and prostate cancer (PC), and the ones which primarily affect men such as cardiovascular diseases, inflammatory diseases, and various types of cancers has been reviewed (Fig. 2 ). (biomedcentral.com)

G protein subunit beta 5 [Source:H. (gsea-msigdb.org)

PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. (embl.de)

Anatomy24

Organisms11

Diseases3

Chemicals and Drugs144

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes50

Disciplines and Occupations1

Information Science4

Residues5

Kinases7

Proto-oncogene2

ELISA Kit3

Aryl1

Serine1

Phosphorylation5

MAPK1

Dual-specificity2

Channel subfamily2

PTyr-specific1

Mitochondrial2

Catalytic4

Transcription7

Downstream4

GTPase4

Cdc251

Epidermal1

Transient1

Actin1

Member4

Family12

Regulate1

Inhibitors1

3.481

Gene3

PTPases3

Superfamily1

Aminotransferase1

Expression4

Cytosol2

Amyloid beta precursor protein1

Guanine3

Ribosomal1

Motif1

Mitotic1

Nuclear3

Bind2

Kinase activity1

Domain contain1

Membrane2

GPCR1

Chromosome5

Subunit beta1

Cytoplasmic1