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  • hamartomas
  • Other brain findings in TS include subependymal hamartomas. (encyclopedia.com)
  • Mammalian target of rapamycin (mTOR) is a key player in pathways involved for cellular growth, proliferation, and survival via a cytoplasmic serine/threonine kinase .In cells that lack either TSC1 or TSC2, mTOR activity is increased many-fold, and this would cause uninhibited growth and subsequent hamartomas in various organs. (medscape.com)
  • glial
  • Current evidence suggests that they are of a mixed neuronal and glial lineage, although they continue to be classified as astrocytomas 5 . (radiopaedia.org)
  • Unlike
  • Genes are the biochemical instructions found inside the cell, not unlike the programs found inside computers. (tsalliance.org)
  • cellular
  • When these genes are defective, mTOR activity is increased, which can cause uncontrolled tumor cell growth and proliferation, blood vessel growth and altered cellular metabolism(2,9). (drugs.com)
  • tend
  • Some special types, known as non-infiltrating astrocytomas , tend to grow very slowly and do not grow into (infiltrate) nearby tissues, so they often have a good prognosis. (cancer.org)