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  • Efficacy
  • The FDA approval is based on results from clinical studies, which demonstrated that subcutaneous administration of Rituxan Hycela resulted in non-inferior levels of rituximab in the blood (pharmacokinetics) and comparable clinical efficacy outcomes compared to intravenous Rituxan. (roche.com)
  • Repeated subcutaneous injections of a monoclonal antibody against the p40 subunit of interleukins 12 and 23, ustekinumab, were used to treat patients with relapsing-remitting multiple sclerosis (RRMS) to assess the drug's safety, efficacy, and pharmacokinetics. (nih.gov)
  • Multicenter, randomized, double-blind, placebo-controlled, 5-arm, dose-ranging study to assess the efficacy of subcutaneous injections of Golimumab (CNTO 148), 50 or 100 mg, at either 2- or 4- week intervals in subjects with active RA despite MTX therapy. (clinicaltrials.gov)
  • Safely
  • BERKELEY HEIGHTS, N.J., June 06, 2007 /PRNewswire-FirstCall/ -- Genta Incorporated announced the publication of preliminary clinical results that show the Company's lead anti-cancer drug, Genasense(R) (oblimersen sodium) injection, can be safely administered by intermittent subcutaneous (SC) injection, as well as by brief intravenous (IV) infusion. (bio-medicine.org)
  • skin
  • Subcutaneous means *under* the skin. (lymphomation.org)
  • Subcutaneous means injected below the skin. (lymphomation.org)
  • A subcutaneous (sub-Q) injection is a shot that delivers medication into the layer of fat between the skin and the muscle. (doctors-hospital.net)
  • Before the injection, press gently in the area to find places where the skin is less sensitive. (doctors-hospital.net)
  • Subcutaneous emphysema is a medical term used to indicate a condition where pockets of air have collected underneath the skin. (healthtap.com)
  • A subcutaneous injection port is generally a disposable device usually inserted into the skin for a period of up to 5 days. (medgadget.com)
  • Other advantages of injectables are that active ingredients do not have to pass the gastrointestinal tract or skin barrier, and that the point of injection can be chosen in line with acupuncture trigger points to achieve an optimal systemic or local effect. (echamp.eu)
  • OTCQX: RHHBY) announced today that the US Food and Drug Administration (FDA) approved Rituxan Hycela™ (rituximab and hyaluronidase human) for subcutaneous (under the skin) injection, for the treatment of adults with the following blood cancers: previously untreated and relapsed or refractory follicular lymphoma, previously untreated diffuse large B-cell lymphoma (DLBCL), and previously untreated and previously treated chronic lymphocytic leukaemia (CLL). (roche.com)
  • For subcutaneous (s.c., under the skin), single dose administration at two separate dosing visits. (clinicaltrials.gov)
  • pharmacokinetic
  • The purpose of this study is to characterize the pharmacokinetic (PK) profile of pembrolizumab (MK-3475) following single subcutaneous (SC) injection of pembrolizumab Dose A versus pembrolizumab Dose C in adults with advanced melanoma. (centerwatch.com)
  • In a dose-ranging pharmacokinetic (PK) and pharmacodynamic trial, bolus SC injections of 75, 150 and 225 mg yielded dose-proportional plasma concentrations that were associated with down-regulation of Bcl-2 in blood cells. (bio-medicine.org)
  • route
  • The review considers the favourable and unfavourable effects, the uncertainty of the effects and the possible mode of action of the subcutaneous route of administration. (echamp.eu)
  • injector
  • The injector (11) includes an injection head (16), a chamber (27) to contain medicament which cooperates with a piston (28), an outlet aperture (15) for the medicament, means (30) to convey the medicament into the containing chamber (27), means to compress means which expel the medicament and a cocking and trigger assembly to actuate the expulsion means. (google.com)
  • routes
  • Mean weight gain from baseline was similar for women receiving medroxyprogesterone by the subcutaneous or intramuscular routes (3.4kg versus 3.5kg at the end of year 2 and 4.5kg versus 5.8kg at the end of year 3). (mims.co.uk)
  • physician
  • Anthroposophic and homeopathic practitioners often favour injectables as their first choice of medication in the treatment of acute and chronic conditions because of the anticipated quicker and better clinical effect, the possibility to control compliance (the injection is generally given by the physician/therapist or nurse), and the fact that the exact location of administration can be chosen. (echamp.eu)
  • Africa
  • Moreover, the Middle East and Africa and Latin America are expected to show slow growth in the global subcutaneous injection ports market due to delayed introduction of the product in these regions. (medgadget.com)
  • Baseline
  • The observed median BMD decreases from baseline at the total hip and lumbar spine at 2 years and 3 years were slightly smaller in the subcutaneous group than in the intramuscular group (-3.3% vs -3.6%, respectively at the total hip and -4.3% vs .5.0%, respectively at the lumbar spine). (mims.co.uk)
  • dose
  • This study will investigate the safety of three fixed dose levels of tanezumab (2.5 mg, 5 mg, and 10 mg) administered at an 8-week interval by subcutaneous injection multiple (7) times during the study treatment period. (clinicaltrials.gov)
  • drug
  • The aim of the trial is to investigate the bioequivalence (assessment of the expected biological equivalence of two pharmaceutical drug products with identical active ingredient) between subcutaneous injections of semaglutide produced by two manufacturing processes. (clinicaltrials.gov)