• Male and female Harlan Sprague-Dawley rats and B6C3F1 mice were administered TCAB (at least 97.8% pure) in corn oil:acetone (99:1) by gavage for 3 months (rats only) or 2 years. (nih.gov)
  • Source: Harlan Sprague-Dawley, Inc. (europa.eu)
  • Consequently, the National Toxicology Program conducted this subchronic study of HCB, including measurement of a variety of toxicological and biochemical endpoints, to allow comparison to TCDD data obtained in a previous 2-year bioassay. (nih.gov)
  • Rider received her B.S. from Tulane University, New Orleans, LA in Environmental Studies and Biology and her Ph.D. from North Carolina State University, Raleigh, NC in Environmental Toxicology. (nih.gov)
  • This manuscript reports on the reliable estimates of internal dose of a compound or a key workshop where a process and criteria that were created for PBPK model review were discussed along with other issues related to model metabolite are available, the results of toxicology studies can review and application in HHRA. (cdc.gov)
  • Methods Male Sprague-Dawley rats were used. (thieme-connect.com)
  • Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al. (cdc.gov)
  • Methods: MRMT-1 breast cancer cells were injected into the proximal segment of tibia in female Sprague-Dawley rats. (amrita.edu)
  • METHODS: Young (2-month-old) and old (24-month-old) Sprague-Dawley rats were subjected to splenectomy under isoflurane anaesthesia. (imperial.ac.uk)
  • Methods: The experiments were performed using the hemi-skull model and dissected TGs from male Sprague-Dawley rats. (lu.se)
  • Methods: Male Sprague-Dawley rats (n = 5 - 7/group) were administered verapamil i.p. 15 minutes before a one hour unilateral noise exposure (16 kHz, 106 dB SPL). (cdc.gov)
  • Male and female Sprague-Dawley rats were exposed from prenatal life until natural death to a 1.8 GHz GSM far field of 0, 5, 25, 50 V/m with a whole-body exposure for 19 h/day. (stopumts.nl)
  • All male and female rats survived to the end of the study. (nih.gov)
  • The hematology results indicate that TCAB induced a microcytic normochromic responsive anemia in male Sprague-Dawley rats. (nih.gov)
  • The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticle s (CeO2NPs) treatment in male Sprague Dawley rats. (cdc.gov)
  • Male Sprague-Dawley rats received s.c. (aspetjournals.org)
  • Brains were is lated, from male Sprague-Dawley rats (7-12 wk old). (erowid.org)
  • In the study groups of male and female Crl:WI(Han) rats (10 animals/group) were administered with the test substance orally by gavage, at dose levels of 100, 300 and 1000 mg/kg bw/day. (europa.eu)
  • Based on this study, The No-Observed-Adverse-Effect-Level (NOAEL) for the effects of the substance on fertility in male and in female rats and for developmental toxicity was considered to be 1000 mg/kg bw/day (i.e. the highest dose tested). (europa.eu)
  • Thirty-five adult male Sprague Dawley were divided into five groups (n=7) according to extract/drug. (researchgate.net)
  • Ninety four adult (150-250 g) male Sprague-Dawley rats (obtained from Zivic-Miller Laboratories, Allison Park, Pa. (erowid.org)
  • Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg) to male Sprague Dawley rats. (iasp-pain.org)
  • Dorsoventral radiographic view of a 2-month-old Sprague-Dawley outbred male rat included in a biomedical research project involving surgical placement of an intramedullary pin in a femur. (avma.org)
  • Male Sprague-Dawley rats (270 ~290 g) were used for this study. (koreamed.org)
  • Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
  • Adult male Sprague Dawley rats were evaluated for neurobehavioral, neuroinflammatory, and neural damage endpoints both acutely and longer-term (up to 72 h) post-TBI following impact with either an aluminum or stainless-steel projectile. (cdc.gov)
  • Therefore, the aim of this study was to obtain safety data for new TiO 2 powder, GST produced through sludge recycling of the sewage treatment plant through repeated-dose toxicity in Sprague-Dawley (SD) rats in according to the OECD test guideline (TG 408). (eaht.org)
  • dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine on fertility have been investigated in a combined repeated dose/reproductive screening toxicity study conducted according to OECD Test Guideline 422 (Perks, 2013). (europa.eu)
  • Sole study providing data from a guideline compliant study. (europa.eu)
  • The study design was chosen on the basis of OECD guideline 421. (europa.eu)
  • This study was designed to ascertain the accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of ultrasonography in the localisation of the undescended testes in children. (bvsalud.org)
  • Results: Forty boys with 52 undescended testes were studied. (bvsalud.org)
  • Based on the above results, it is suggested that exposure to food -based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats . (bvsalud.org)
  • The findings from a proposed 90-day repeated dose oral toxicity study and a pre-natal developmental toxicity study will provide a further characterisation of the reproductive hazard potential of Fatty acids, C18-unsatd. (europa.eu)
  • The tumors observed in the NTP study are of the type similar to the ones observed in some epidemiological studies of cell phone users. (stopumts.nl)
  • The RI findings on far field exposure to RFR are consistent with and reinforce the results of the NTP study on near field exposure, as both reported an increase in the incidence of tumors of the brain and heart in RFR-exposed Sprague-Dawley rats. (stopumts.nl)
  • These tumors are of the same histotype of those observed in some epidemiological studies on cell phone users. (stopumts.nl)
  • Voss C, Zerban H, Bannasch P, Berger MR. Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. (who.int)
  • This study investigated the protective effects of lyophilized aqueous seed extract of Buchholzia coriacea (B. coriacea) in enhancing memory and neuroprotection in scopolamine-induced learning and memory impairment using Morris water maze and Y maze. (researchgate.net)
  • CFC-12 was tested by inhalation on Sprague-Dawley rats and Swiss Mice using whole body exposure. (europa.eu)
  • In the current study, mice received intraperitoneal administrations of LPS (0.5 mg/kg, daily, Escherichia coli O55:B5) for seven consecutive days and their different cohorts were used for behavioral assessment with open field, Y maze, and novel object recognition test or for electrophysiology recordings of mEPSC, LFP or LTP in in vivo or ex vivo preparation. (imperial.ac.uk)
  • 2003). The therapeutic effects of different genes delivered by ment of the hGFAP promoter used here has been extensively studied and lentiviral vectors have been documented in a number of animal found to be up-regulated after several different stimuli both in vitro and models, both in rodents and primates, and examples include delivery in vivo in transgenic mice (Brenner et al. (lu.se)
  • Studies conducted in vivo more than two decades ago suggested that the postcapillary venules were more important than the arterial vessels in the process of edema formation. (bvsalud.org)
  • In this review, we discuss the various factors of BNNT production that can influence its toxicity followed by summarizing the toxicity findings from in vitro and in vivo studies conducted to date, including a review of particle clearance observed with various exposure routes. (cdc.gov)
  • No evidence of an effect on the reproductive organs was seen in a combined repeated dose and reproductive/developmental screening study (OECD 422) in rats after repeated oral doses upto 1000 mg/kg bw/day. (europa.eu)
  • This study investigated the activity of the HPA axis in selected markers of glucose handling, and the stress response relative to components of the HPA axis in a diet-induced pre-diabetic rat model. (researchsquare.com)
  • Sprague Dawley Rats were randomly divided into non-prediabetic group (NPD) and pre-diabetic group (PD) (n=6, per group) over a 20-week induction period and a further 12-week experimental period to get 32 weeks. (researchsquare.com)
  • While T2DM is often associated with macro-and microvascular complications, studies indicate that poor management of everyday stress in diabetic patients is associated with increased risk of depression and anxiety (5-7). (researchsquare.com)
  • Perspective: This study emphasizes the involvement of Wnt signaling pathway in diabetic peripheral neuropathy (DPN). (iasp-pain.org)
  • Transgenic Ren-2 rats that overexpress the RAS were randomized to be nondiabetic, diabetic, or diabetic+candesartan (5 mg/kg/day) and studied over 20 weeks. (diabetesjournals.org)
  • Comparisons were made with diabetic Sprague-Dawley rats. (diabetesjournals.org)
  • This study is classified as reliable without restrictions because it was conducted according to OECD 413 guidelines and was GLP compliant. (europa.eu)
  • Information is available from a prenatal development toxicity (OECD 414) study carried out on read across substance TOFA_TETA_PAA_BADGE_CGE_Adduct. (europa.eu)
  • Based on an ECHA decision (decision number TPE-D-2114449866-32-01/F), an extended one-generation reproductive toxicity study (test method OECD TG 443) in rats by the oral route has been requested by ECHA. (europa.eu)
  • A dose-range finding study similar to OECD TG 421 has been conducted to determine the doses for the main study (see section 7.8.1). (europa.eu)
  • Not all parameters measured as the study was conducted as a range finding study for the main OECD 443 study. (europa.eu)
  • Based on the results of the dose-range finding study (28-day repeated toxicity), GST was orally administered to rats at doses of 0, 500, 1000, and 2000 mg/kg B.W/day for 90-day and reversibility of effects of 2000 mg/kg bw/day was assessed after 4 weeks. (eaht.org)
  • However, the toxicity studies on TiO 2 NPs have focused on inhalation and skin exposure and study on oral exposure has been limited. (eaht.org)
  • Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS). (bvsalud.org)
  • The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats . (bvsalud.org)
  • No adverse effects were observed in sub-chronic and chronic inhalation toxicity and carcinogenicity studies at relatively high concentrations. (europa.eu)
  • No developmental effects, effects on reproductive parameters or treatment-related signs of systemic toxicity were observed in the study. (europa.eu)
  • In accordance with Column 2 of Annex X of the REACH regulation, a waiver is proposed for the two-generation reproductive toxicity study. (europa.eu)
  • The Sprague-Dawley rat (sexually mature and virgin) is an accepted species for reproductive toxicity studies by regulatory agencies and historical control data are available. (europa.eu)
  • It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. (cdc.gov)
  • Aim This study aimed to evaluate the effects of vitamin C (VC) and deferoxamine (DF) against V-induced LPO in brain tissue homogenates in vitro. (thieme-connect.com)
  • D-LSD binding to brain homogenates was studied. (erowid.org)
  • Biotransformation of the triazolobenzodiazepine alprazolam (ALP) was studied in vitro using hepatic microsomal preparations from human, monkey, mouse, and rat liver tissue. (nih.gov)
  • At the end of the 3-month study, absolute and relative liver weights were significantly greater than those of the vehicle controls in all dosed groups of males and in females administered 10 mg/kg or greater. (nih.gov)
  • Under the conditions of this 3-month gavage study, oral administration of HCB in female Sprague Dawley rats resulted in dose-related lesions in the liver, lung, spleen, mammary gland, skin, thymus, and teeth. (nih.gov)
  • TiO 2 have been studied on inhalation and skin exposure due to the properties of the materials' use (cosmetics, paints and other products) and the additional safety information on other intake routes for the potential risk assessment is limited. (eaht.org)
  • The Ramazzini Institute (RI) performed a life-span carcinogenic study on Sprague-Dawley rats to evaluate the carcinogenic effects of RFR in the situation of far field, reproducing the environmental exposure to RFR generated by 1.8 GHz GSM antenna of the radio base stations of mobile phone. (stopumts.nl)
  • No studies were available regarding cardiovascular, musculoskeletal, renal, dermal or ocular effects in humans after inhalation exposure to tetryl. (cdc.gov)
  • No studies were located regarding systemic effects in animals after inhalation exposure to tetryl. (cdc.gov)
  • Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
  • A recent study evaluated the urinary levels of 9 atrazine metabolites in humans and concluded that DACT was the primary metabolite regardless of exposure scenario, and that exposure assessment based on measuring only AM or any single atrazine metabolite resulted in an underestimate of atrazine exposure (Barr et al. (who.int)
  • 2007). This study found that AM accounted for only 2-12% of the detected metabolites, that most of the subjects had detectable atrazine exposure, and that future biomonitoring studies would likely need to include analysis of at least AM, DACT, DIA, and DEA in order to characterize the extent of atrazine exposure in a population. (who.int)
  • 2008) concluded that the amount of atrazine applied to the fields by an agricultural worker is likely to provide a valid surrogate of atrazine exposure in epidemiologic studies. (who.int)
  • Virus was transmissible venison, raising the possibility that other animals or modes to seronegative Sprague-Dawley rats, but transmission was of zoonotic transmission exist. (cdc.gov)
  • In the present study, we tested if smaller tubes, inserted within a larger tube, could be used to create multiple new nerves or "fascicles," thus offering the possibility to obtain multiple signals from one and the same nerve. (hindawi.com)
  • In this study, we aim to understand how tumor-induced primary and distal pain sensitivities are affected by bupivacaine-induced block of bone nerve endings in a rat model of CIBP. (amrita.edu)
  • This study was designed to investigate any correlation between the mechanism of pain development and changes of histochemically-reactive zinc contents in the rat spinal cords following peripheal nerve ligation. (koreamed.org)
  • According to IARC, animals studies, as well as epidemiological ones, showed limited evidence of carcinogenicity. (stopumts.nl)
  • As a study scientist, she designs and evaluates results from toxicological studies of chemicals selected for investigation by the NTP. (nih.gov)
  • In vitro study of the protective effect of manganese against vanadium-mediated nuclear and mitochondrial DNA damage. (thieme-connect.com)
  • The goal of this study was to investigate the impact of multiple exposomal factors (genetics, lifestyle factors, environmental/occupational exposures) on pulmonary inflammation and corresponding alterations in local/systemic immune parameters. (cdc.gov)
  • This is the largest long-term study ever performed in rats on the health effects of RFR, including 2448 animals. (stopumts.nl)
  • Our study conforms to the National Institutes of Health Guide for the Care and Use of Laboratory Animals . (jneurosci.org)
  • In core study animals, the mean body weight gains of 10 and 25 mg/kg/day groups and the final mean body weight of the 25 mg/kg/day group were significantly increased compared to the vehicle control group. (nih.gov)
  • No other health effects were studied in animals. (cdc.gov)
  • As many as 8-12 metabolites of atrazine have been identified or postulated to occur in animals and humans, with some studies showing DACT as the primary metabolites and others showing atrazine mercapturate (AM) as the primary one (Barr et al. (who.int)
  • This study may provide a basis for exploring the therapeutic potential of Wnt inhibitors in DPN patients. (iasp-pain.org)
  • These experimental studies provide sufficient evidence to call for the re-evaluation of IARC conclusions regarding the carcinogenic potential of RFR in humans. (stopumts.nl)
  • Only two studies reporting death in humans were located. (cdc.gov)
  • This section will be updated with the results of the EOGRTS as soon as the study is finalized (presumably end of 2023). (europa.eu)
  • No adverse effects were observed in a 2-year chronic study in rats administered 15 or 150 mg/kg/day by gavage. (europa.eu)
  • These studies determined the effects of continuous phencyclidine (PCP) administration on cytochrome P 450 2C11 (CYP2C11) function, protein expression and mRNA levels. (aspetjournals.org)
  • Novel studies investigating cannabinoids and obstructive sleep apnea suggest that synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep apnea due to their modulatory effects on serotonin-mediated apneas. (springer.com)
  • Therefore, the purpose of this study is to evaluate the effects of commission and omission errors on the treatment of pediatric food refusal. (abainternational.org)
  • This study evaluated the effects differential reinforcement of alternative behavior on response persistence. (abainternational.org)
  • The dermal effects noted in these studies were most likely caused by direct skin contact and are described in Section 2.2.3. (cdc.gov)
  • This study was therefore aimed at establishing the dose-response effect of EPO stimulation on rat BMSCs and investigating the effects of mechanical stretch combined with EPO on the proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
  • Future studies aim to examine the localization of L-type calcium channels in the central auditory system and explore effects of direct verapamil administration. (cdc.gov)
  • Groups of 10 female Sprague Dawley (Hsd:Sprague Dawley SD) rats (core study) were administered doses of 0.03, 0.1, 0.3, 1, 3, 10, or 25 mg HCB/kg body weight/day (mg/kg/day) in corn oil:acetone (99:1) by gavage, 5 days/week for 13 weeks (3 months). (nih.gov)
  • The analysis of CGRP release data was combined with immunohistochemistry in order to study the cellular localization of CB1, cannabinoid receptor type 2 (CB2), CGRP and receptor activity modifying protein 1 (RAMP1), a subunit of the functional CGRP receptor, in the TG. (lu.se)
  • The vibrissal system is a model system in neuroscience to study the processing of sensory inputs, elicited by the whisker/object contacts. (frontiersin.org)
  • Elimination of HCB after repeated dosing was evaluated in a group of 10 female rats (elimination study) administered 0.03 or 25 mg/kg/day for 13 weeks (3 months) and then held without dosing until necropsy at 21 (5 rats) or 29 (5 rats) weeks. (nih.gov)
  • Vehicle control female rats (10 core study and 10 elimination study) were administered the corn oil:acetone vehicle only. (nih.gov)
  • High mobility group box-1 protein (HMGB-1) is perhaps the most studied alarmin. (jneurosci.org)
  • Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg-1 for 10 weeks ( males ) and 2 weeks ( females ) and then mated. (bvsalud.org)
  • To understand better the cellular mechanisms of NE's contributions to fear learning, we examined the anatomical organization of NE terminals and βARs in the LA. In this study, we employed immunoelectron microscopy to determine whether terminals immunoreactive for dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, form synaptic junctions in the LA and if so, examine these synapses and identify the post-synaptic targets on NE terminals. (frontiersin.org)
  • A study of pesticide urinary metabolite levels of farm worker children aged 1-6 found detectable levels of the metabolite atrazine mercapturate (Arcury et al. (who.int)
  • Before initiation of these studies, approval was received by the Institutional Animal Care and Use Committee at the Medical University of South Carolina (MUSC). (jneurosci.org)
  • This procedure enhanced detection of inhibitory responses, and protected against pre-selection of spontaneously rapid-firing cells for study. (erowid.org)
  • Previous studies have demonstrated efficacy of nimodipine, an L-type calcium channel blocker, on reversing these changes in salicylate and quinine induced tinnitus in rat models (Jastreboff, 1991). (cdc.gov)
  • According to Shomron 7 (2010), this field of the clinical pharmacology studies the contribution of genomes, transcriptomes and proteomes in determining drug-response phenotypes (safety and efficacy). (bvsalud.org)
  • studied the mechanisms of 11 C-5-HTP uptake in cell lines derived from rodent insulinoma (INS-1) and human ductal cells (PANC1) and reported DDC- and MAO-A-specific uptake in INS-1 but not in PANC1 cells ( 10 ). (snmjournals.org)
  • Therefore, the present results show that the NOAEL (no observed adverse effect level) of new TiO 2 powder, GST was considered to be 2000 mg/kg B.W/day in rats after repeated oral administration for 90-day under the present study conditions and no target organs were identified. (eaht.org)
  • The present investigation should have included measurement of antioxidant enzymes in brain tissues as a further extension of this study. (thieme-connect.com)
  • The present study attempted to evaluate serotonin antagonism on the ypramidal cells of the hippocampus (HPC) which receive serotonin containing afferents from the raphe nuclei. (erowid.org)
  • Thus, in the present study, involvement of Wnt signaling was investigated in DPN using Wnt signaling inhibitors namely LGK974 (Porcupine inhibitor), NSC668036 (Disheveled inhibitor) and PNU74654 (β-catenin inhibitor). (iasp-pain.org)
  • The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)
  • Conclusions: Results from the present study indicate that ACEA per se does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1, and thereby inhibition and stimulation of CGRP release, respectively. (lu.se)
  • The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (bvsalud.org)
  • This study was conducted to investigate the possible role of TAK1/RIPK1 signalling in POCD development following surgery in rats. (imperial.ac.uk)
  • The purpose of this study was to compare the results of arthroscopic isolated Bankart repair (B) with Bankart repair plus Remplissage (B + R) procedure in contact overhead athletes with on-track anterior shoulder instability. (researchgate.net)
  • One theory, examined in a 1988 study by Lee et al, is that increased sympathetic tone to the colon results in the inhibition of colonic motility. (medscape.com)
  • Dose levels were selected based on the results of a 14-day range finding study. (europa.eu)
  • Conclusions: Our results demonstrate that verapamil may prevent development of noise induced tinnitus and thus warrants further study. (cdc.gov)