Study transcriptional regulation. Medical search. Frequent questions

Matrix stiffness upregulates the ERα signaling via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation. (nature.com)
Our findings propose epigenetic regulation of chromatin landscape as a critical factor in the rapid astrocyte response to dopamine. (jneurosci.org)
More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)
Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)

Further, the polycomb complex proteins and SRSF1 could have a mutual regulatory relationship, suggesting a cross-talk between epigenetic /transcriptional and post-transcriptional regulatory pathways. (bvsalud.org)

Background Transcriptional regulation of genes in eukaryotes is usually achieved by the interactions of multiple transcription factors with arrays of transcription factor binding sites (TFBSs) on DNA and with each other. (woofahs.com)
Although AmlR apparently is a local transcriptional regulator of the aml operon, the Δ amlR strain shows severe growth inhibitions on glucose and - concomitantly - differential transcription of several genes of various functional classes. (frontiersin.org)
mRNA half-lives have been determined, for example, by blockage of transcription followed by transcriptional profiling 5 . (nature.com)
In two of these, the read coverage along introns was related to nascent transcription in combination with co-transcriptional splicing events 24 and later was used to fit a detailed transcriptional model within a single sample 25 . (nature.com)
In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. (wikipedia.org)
The regulation of transcription is a vital process in all living organisms. (wikipedia.org)
Much of the early understanding of transcription came from bacteria, although the extent and complexity of transcriptional regulation is greater in eukaryotes. (wikipedia.org)
This means that transcriptional regulation in the form of protein repressors and positive control elements can either increase or decrease transcription. (wikipedia.org)
In studies during the early 1990's, Gregg Semenza identified, and then in 1995 purified and cloned, a transcription factor that regulates these oxygen-dependent responses. (nobelprize.org)
Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)
However, experimental approaches have limitations when dealing with complex biological systems composed of multiple layers of regulation such as the transcriptional and post-transcriptional regulation by transcription factors (TFs) and miRNAs [ 2 ]. (hindawi.com)
These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
Plants show stress-specific regulation of transcription that affects their transcriptome under stress conditions. (intechopen.com)
By testing pntAB and udhA GFP reporter constructs in the background of WT E. coli and 62 transcription factor mutants during growth on different carbon sources, we show distinct transcriptional regulation of the two transhydrogenase promoters. (microbiologyresearch.org)
Computational analysis, deletion promoter luciferase-based assays and Chromatin Immunoprecipitation (ChIP) will be employed to identify functional elements responsible for the regulation of KDM transcription. (ntu.ac.uk)
Studies evaluating the regulation of these genes at the transcriptional level revealed PD significantly reduced the transcription of PC I at 14 days. (aspetjournals.org)
Genome-wide studies in Saccharomyces cerevisiae , for example, have revealed that promoters of most actively transcribed genes are depleted of nucleosomes and that histone density is inversely proportional to the transcription rate within coding regions, suggesting that nucleosomes are dynamically disassembled and reassembled at each passage of the polymerase ( 16 ). (asm.org)
Regulation of nucleosome density is therefore an important mechanism to enable the transcription machinery to access the DNA. (asm.org)
We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
Molecular genetic studies reveal that the disease is caused by mutations that inactivate the transcription factor TBX5 . (medscape.com)

Some examples of this include producing the mRNA that encode enzymes to adapt to a change in a food source, producing the gene products involved in cell cycle specific activities, and producing the gene products responsible for cellular differentiation in multicellular eukaryotes, as studied in evolutionary developmental biology. (wikipedia.org)
While these means of transcriptional regulation also exist in eukaryotes, the transcriptional landscape is significantly more complicated both by the number of proteins involved as well as by the presence of introns and the packaging of DNA into histones. (wikipedia.org)
Post-transcriptional regulation occurs in eukaryotes, stabilizing mRNA for translation. (khanacademy.org)

Here we present a computational approach called exon-intron split analysis (EISA) that measures changes in mature RNA and pre-mRNA reads across different experimental conditions to quantify transcriptional and post-transcriptional regulation of gene expression. (nature.com)
In a study based on exon arrays, probes mapping to introns were used to investigate pre-mRNA dynamics 23 . (nature.com)
However, for an immediate and effective response, global post-transcriptional control of mRNA stability, splicing and translation may be crucial during "immediate-to-early" DDR. (europa.eu)
Involvement of the DegS-DegU system in the osmotic regulation was supported by the accumulation of mRNA transcripts from both genes when the cells were subjected to hypertonic conditions. (uni-marburg.de)

In this project, I will employ biochemical, cell, systems biology and computational approaches to study the relevance of post-transcriptional regulators such as RNA-binding proteins and microRNAs in DDR. (europa.eu)
Here we develop a new computational method called RepEnrich to study genome-wide transcriptional regulation of repetitive elements. (nih.gov)
He is a highly original thinker, having developed innovative experimental and computational methods for studying these and other processes. (harvard.edu)
Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis. (bvsalud.org)
The present study employed computational analyses to identify RBPs and TRs regulating AHN, followed by the analysis of their interaction networks and detection of hub proteins . (bvsalud.org)

The mechanisms of cellular adaptation preventing water loss under hyperosmotic conditions (osmoregulation) have been extensively studied in many organisms. (uni-marburg.de)
Currently, an increasing number of studies are being carried out to deepen our understanding of miRNA regulatory mechanisms and functions. (hindawi.com)
Recently, the study of post-transcriptional regulation by microRNAs (miRNA) has shed light on mechanisms of allergic disease. (cdc.gov)
A time course study was carried out to elucidate the mechanisms for antifibrotic effect of pirfenidone (PD). (aspetjournals.org)
Studies of genes transcribed by RNA polymerase II (Pol II) have shown that open and closed chromatin structures are dynamically regulated through multiple mechanisms, including histone modifications, histone variant incorporation, and DNA methylation (reviewed in reference 17 ). (asm.org)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)

Henikoff's current research is on chromatin dynamics, transcriptional regulation, centromere inheritance and DNA torsional dynamics. (harvard.edu)
Although it is clear that switching among BESs does not involve DNA rearrangements and that regulation is probably epigenetic, it remains unknown why BESs are transcribed by Pol I and what roles are played by chromatin structure and histone modifications. (asm.org)
These observations provide new insight on antigenic variation by showing that chromatin remodeling is an intrinsic feature of BES regulation. (asm.org)
Chromatin endogenous cleavage (ChEC) and psoralen experiments indicated that active rDNA is devoid of histones ( 23 ), whereas chromatin immunoprecipitation (ChIP) and genetic studies led to the conclusion that active rDNA has at least a few histones and is associated with chromatin-remodeling enzymes ( 15 , 31 , 34 ). (asm.org)
Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostly by regulating chromatin structure. (sdbonline.org)
These results uncover a regulation loop where Jarid2 methylation fine-tunes PRC2 activity depending on the chromatin context. (sdbonline.org)

3 , 4 Although previous studies have identified various molecular signaling pathways promoting HSC aging, 5-8 the exact molecular mechanism is still not fully understood. (haematologica.org)
Recent multi-omics studies have revealed the heterogeneity and complexity of tumor features such as their genetic mutations, transcriptome, proteins, and signaling pathways. (rsc.org)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)

In a hypothetical example, the factors A and B might regulate a distinct set of genes from the combination of factors A and C. This combinatorial nature extends to complexes of far more than two proteins, and allows a very small subset (less than 10%) of the genome to control the transcriptional program of the entire cell. (wikipedia.org)
Despite their abundance and diversity, few studies investigated the regulation of endogenous retrotransposons at the genome-wide scale, primarily because of the technical difficulties of uniquely mapping high-throughput sequencing reads to repetitive DNA. (nih.gov)
Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)
Previous studies of DNA methylation suggest epigenetic alterations may also be important, but an integrated genome-wide analysis of genetic and epigenetic alterations in ALL has not been performed. (lu.se)

We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. (who.int)

microRNA profiling revealed potential regulators of the KDM, and preliminary in vitro functional studies propose an oncogenic role of KDM in liver cancer. (ntu.ac.uk)
In this regard, most studies have focused on transcriptional regulators (TRs), epigenetic modifiers, or non- coding RNAs. (bvsalud.org)

ISGlobal has a broad research portfolio in communicable and non-communicable diseases, ranging from basic research at the molecular level to studies at the population level. (isglobal.org)
The network combining putative targets of TF and miRNA regulation with experimentally proven molecular interactions was constructed and visualized. (hindawi.com)
Understanding its molecular regulation would be important. (bvsalud.org)
Further experimental validation of these regulatory loops/networks could provide novel insights into the molecular regulation of AHN, and unravel new targets for disease - treatment . (bvsalud.org)

We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)

Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)

In Bacillus subtilis the DegS-DegU two-component regulatory system controls various processes that characterize the transition form the exponential to the stationary growth phase, including the induction of extracellular degradative enzymes, expression of late competence genes and down regulation of the sigma D regulon, which encompasses the genes involved in motility, chemotaxis and autolysin production. (uni-marburg.de)
The application of the systems biology approach to the analysis of a gene regulatory network is demonstrated with a case study of the regulation of p21 by multiple miRNAs [ 4 ]. (hindawi.com)
Optimizing the parameters of the regulatory system allows us to quantify the fitness benefit of regulation. (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
In unicellular organisms like E. coli and yeast, the benefits of between potential cost and benefit, regulation can make the most a well-adapted regulatory system are readily quantified, as the difference to the long-term growth rate if the resource in question fitness of an individual can be estimated by its growth rate in is only available a similarly small fraction of the time. (lu.se)
Over evolutionary time scales, regulation must provide a fitness benefit that offsets the costs of maintaining the regulatory system. (lu.se)
Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)

Until now, methods for controlling or programming bacterial cells involved transcriptional and post-transcriptional regulation. (sciencedaily.com)
UC San Diego researchers led by Jeff Hasty, a professor of bioengineering and biology and member of the UC San Diego Center for Microbiome Innovation, describe a new method, which involves cutting circular pieces of bacterial DNA called plasmids, effectively destroying the DNA and turning off regulation. (sciencedaily.com)
The lab is also beginning to study interspecies interactions between different fungal and bacterial species. (ucmerced.edu)

Although HDAC1 and vimentin are both important factors in HCC pathogenesis and progression, their roles in this disease have usually been studied separately, and whether there are interactions between HDAC1 and vimentin that affect HCC has not been investigated ( 12 , 21 ). (spandidos-publications.com)
Studying interactions, we noted that all four Id proteins could dimerize with E47 or E2-2, but not with HASH-1 or dHAND. (lu.se)

Impairment of sperm DNA methylation in male infertility: a meta-analytic study. (cdc.gov)
Together, these results demonstrate subtype- and disease-specific alterations in cytosine methylation in ALL that influence transcriptional activity, and are likely to exert a key role in leukemogenesis. (lu.se)

Workshop : Genetic Association Studies: From SNP design to analysis and interpretation. (edu.sa)
Here we investigated PntAB and UdhA regulation by studying transcriptional responses to environmental and genetic perturbations. (microbiologyresearch.org)
[ 11 ] Subsequent studies have shown that several noncoding genetic variants of TCF7L2 are associated with T2DM risk in populations of diverse ancestries in the United Kingdom, the Netherlands, Finland, Sweden, France, India, and Japan. (medscape.com)

The proposed project explores a previously uncharacterized link between post-transcriptional RNA operons and DDR. (europa.eu)

Another important process regulated at the transcriptional level is the heat-shock response, which enables parasite survival during malaria febrile episodes. (isglobal.org)
In parallel to exploring the role of the DegS-DegU system at the transcriptional and at the protein level, some additional experiments were performed in order to identify possible downstream regulated targets of the system. (uni-marburg.de)
Biofilm formation is a crucial and precisely regulated process at the transcriptional level. (usp.br)
Previous studies have demonstrated that vimentin expression is associated with HCC progression and that the serum vimentin level may serve as an additional marker of HCC, suggesting a role of vimentin protein in HCC pathogenesis ( 20 - 22 ). (spandidos-publications.com)
By contrast, the activity of a luciferase construct containing the entire promoter region of the α2C4 gene (1.9 kilobase pairs) was inhibited, indicating that the primary mechanism of action of the two compounds is at the transcriptional level. (aspetjournals.org)
These features provide a snapshot of one level of regulation in a system. (rsc.org)
Aim 1: To investigate KDM regulation at the transcriptional and post-transcriptional level. (ntu.ac.uk)
In line with our previous results, we found that there are marked differences between HD patients and controls at the protein level but not at the transcriptional level. (lu.se)

Although maltose is an important building block of acarbose, the maltose/maltodextrin metabolism has not been studied in Actinoplanes sp. (frontiersin.org)
Best known for his studies of cholesterol, he was awarded the Nobel Prize in Medicine or Physiology in 1964 (shared with Feodor Lynen) for investigations in the mechanism and regulation of cholesterol and fatty acid metabolism. (harvard.edu)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)

This study reveals an unexpected crosstalk between Jarid2 and PRC2, with Jarid2 being methylated by PRC2. (sdbonline.org)

The results and implementations of this project will significantly contribute to the understanding of the regulation of DDR, as well as have potential clinical and translational impact. (europa.eu)
Consistent with increased transcriptional activity of retrotransposons in cancer cells we found significantly higher levels of L1 retrotransposon RNA expression in prostate tumors compared to normal-matched controls. (nih.gov)

2012). antigens that induce airway inflammation with the release of Although many studies investigated the association between inflammatory mediators. (cdc.gov)

In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
SRSF1 may influence post-transcriptional stability, localization , and alternative splicing patterns of polycomb complex transcripts, and the polycomb proteins may in turn epigenetically influence the SRSF1. (bvsalud.org)
The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. (lu.se)

Thus, enhanced extracellular matrix or beta-glucan synthesis during biofilm growth might prevent antifungals, such as azoles and polyenes, from reaching biofilm cells, thus limiting their toxicity to these cells and the associated transcriptional responses. (who.int)

The added complexity of generating a eukaryotic cell carries with it an increase in the complexity of transcriptional regulation. (wikipedia.org)
Nutritional studies are difficult to perform because of the inherent heterogeneity of any study population, the variations in individual lifestyles, and the quantitative and qualitative complexity in food and food products. (medscape.com)

Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)

We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)

Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)

HDAC1 is the most extensively studied HDAC family member, and its expression is increased in a range of different types of cancer, including HCC, prostate cancer and gastric cancer ( 12 - 14 ). (spandidos-publications.com)

ISGlobal is seeking to hire talented and highly motivated predoctoral scientists interested on working in a research project investigating novel aspects of the regulation of gene expression in malaria parasites. (isglobal.org)
More specifically, the selected candidates will study gene expression in the context of processes such as sexual conversion, which is essential for disease transmission, and the heat-shock response, which enables parasite survival during fever episodes. (isglobal.org)
The ISGlobal Malaria Epigenetics lab directed by ICREA Research Professor Alfred Cortés investigates the regulation of gene expression in the malaria parasite Plasmodium falciparum. (isglobal.org)
EISA reveals both transcriptional and post-transcriptional contributions to expression changes, increasing the amount of information that can be gained from RNA-seq data sets. (nature.com)
In vivo, stable ERα expression has been reported in patient-derived xenograft (PDX) models, especially in tumor cells introduced via intraductal transplantations 8 , 9 and these findings have suggested a strong microenvironment-dependent dynamic component in the regulation of ERα expression. (nature.com)
In our study, we hypothesized that both have a role in the activation of the upstream region of the retS in LB media and MOPS glucose since their mutation led to higher expression of the upstream region. (usp.br)
In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
The data in the present study demonstrated that HDAC1 is overexpressed in HCC and that HDAC1 may upregulate vimentin expression through the NF‑κB signaling pathway, thus demonstrating a causal link between HDAC1 and vimentin in HCC, and may provide valuable information in understanding the pathogenesis of HCC. (spandidos-publications.com)
Finally, the calibrated model is used to study the effect of different miRNA expression profiles and cooperative target regulation on p21 expression levels in different biological contexts. (hindawi.com)
In this review, we discuss considerations of the study design for each data feature, the limitations in gene and protein abundance and their rate of expression, the current data integration methods, and microbiome influences on gene and protein expression. (rsc.org)
The present studies report the expression of miRNA during the sensitization phase of an allergic response to TDI in a murine model. (cdc.gov)
In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
Her lab is interested in investigating how transcriptional networks underlie the regulation of gene expression during biofilm development. (ucmerced.edu)
In addition, genes encoding the expression of molecules involved in T lymphocyte and natural killer cell regulation were increased (CD86 and CD69). (cdc.gov)
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. (lu.se)

Despite their physiological relevance, we have only fragmented information on their regulation and the signals coordinating their counteracting activities. (microbiologyresearch.org)

In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)

Exploiting the functional genomics and bioinformatics studies paved the way in understanding the relationship between genotype and phenotype of an organism suffering from environmental stress. (intechopen.com)

Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network. (microbiologyresearch.org)

One of the founders of biochemical studies at Harvard, he was part of the pioneer generation that included George Wald, Paul Doty, John Edsall and Frank Westheimer. (harvard.edu)
Especially noteworthy were the studies on the biological synthesis of the molecule and, according to the Nobel Prize website, "on various aspects of terpene and sterol biogenesis…enzymatic formation of unsaturated fatty acids and…in various aspects of biochemical evolution. (harvard.edu)

These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. (europa.eu)

We apply EISA to 17 diverse data sets to show that most intronic reads arise from nuclear RNA and changes in intronic read counts accurately predict changes in transcriptional activity. (nature.com)
Three recent studies based on RNA-seq provided evidence that intronic reads might correlate with transcriptional activity. (nature.com)
We find that changes in intronic read counts are not technical artifacts but instead directly measure changes in transcriptional activity. (nature.com)

Initial linkage studies demonstrate that the gene defect resides on the long arm of chromosome 12. (medscape.com)

The determination of the actual cis - and trans -acting elements involved will be the object of future investigation, but the present study provides evidence for transcriptional regulation of human α2C-AR by cAMP. (aspetjournals.org)
In this study, we found that GM-CSF is highly expressed in human malignant osteosarcoma. (iasp-pain.org)
Inhalation and dermal exposure to CDDs are of lesser concern than oral exposure (because ingestion of CDDs in food is thought to be the principal route of exposure for the general population), but limited information from exposed human and animal studies indicate that CDDs can be absorbed by these routes. (cdc.gov)

Studies on the transcriptomic profiles of the clonal luminal breast cancer cell lines suggest that these cell lines do not recapitulate well the established luminal tumor subtype 7 . (nature.com)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)

Our results indicate that the antifibrotic effect of PD was partly due to suppression of the BL-induced inflammatory events and partly due to down-regulation of BL-induced overexpression of lung procollagen I and III genes. (aspetjournals.org)
Here, we examined the lung transcriptional response after inhalation of GMA-SS fume and used gene network-based analysis to compare with previous aspiration data. (cdc.gov)
Transcriptional regulation of the lung response to GMA-SS aspiration involved FOS, EGR1, FOSB. (cdc.gov)

Additionally, we will explore the post-transcriptional regulation of KDM based on our microRNA preliminary data using western blot, RT-qPCR and 3'UTR reporter assays. (ntu.ac.uk)
Additionally, hippocampal genes differentially expressed upon exercise were analyzed for potential regulation by the identified TRs and RBPs. (bvsalud.org)

With the advancement of next-generation sequencing and mass spectrometry, there is a growing need for the ability to merge biological features in order to study a system as a whole. (rsc.org)

Huang thoroughly discredits this concept and goes on to point out the limitations of the various study methods, including observational studies, case-control studies, and cohort studies. (medscape.com)

Taken together, the data from the present work shed a light on the transcriptional regulation of DegS-DegU two-component system in B. subtilis and implicated intracellular glutamate as a positive stimulus involved as a transducer of the information from the environment to the intracellular apparatus. (uni-marburg.de)
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)
Laboratory studies in animal models provide important leads in designing, conducting, and interpreting large studies in humans, but translating data from animal studies to humans is often fraught with error. (medscape.com)

Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)

In order to improve and expand applications of Cas9, we recently undertook crystallographic studies to elucidate the atomic structure of the Cas9-sgRNA-target DNA tertiary complex 14 , thus enabling rational engineering of Cas9 and sgRNA. (cdc.gov)

We have a predoctoral position available to work in a project investigating novel aspects of the regulation of sexual conversion and the heat-shock response in malaria parasites. (isglobal.org)

He suggests that only randomized, carefully controlled studies can address these important issues. (medscape.com)

Transcriptional regulation plays a key role in malaria parasite biology, as it controls fundamental processes such as life cycle progression, antigenic variation and adaptation to the conditions of the environment. (isglobal.org)
Of note, heterochromatin plays a prominent role in the regulation of the conversion of some asexual parasites into sexual forms that mediate transmission to mosquito vectors. (isglobal.org)

The principal message from nutritional studies in humans has been an endorsement of the benefits of a diet consisting mainly of vegetables, fruits, fiber, and fish, combined with restricted caloric intake and/or exercise to maintain or achieve a healthy weight. (medscape.com)
The principal message from nutritional studies in humans has been an endorsement of the benefits of a diet consisting mainly vegetables, fruits, grains, and fish, combined with restricted caloric intake and exercise. (medscape.com)
Information from studies of exposed humans and laboratory animals indicates that absorbed CDDs are distributed preferentially to fatty tissues and to a lesser extent, the liver (ATSDR 1998). (cdc.gov)

The viral replication organelles within cells studied by electron microscopy. (csic.es)
In this regard, our study led us to observe that AMB physically bound C. albicans biofilms and beta-glucans, which have been proposed to be major constituents of the biofilm extracellular matrix and to prevent azoles from reaching biofilm cells. (who.int)

Anatomy17

Organisms10

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes92

Disciplines and Occupations2

Information Science6

Health Care1

Epigenetic regulation4

Post-transcriptional regulatory1

Transcription21

Eukaryotes3

MRNA4

Computational5

Mechanisms7

Chromatin6

Pathways5

Genome4

Transcript1

Regulators2

Molecular4

Endogenous1

MicroRNAs1

Regulatory7

Bacterial3

Interactions2

Methylation2

Genetic3

Operons1

Level8

Metabolism4

Crosstalk1

Significantly2

Inflammation1

Proteins4

Responses1

Complexity2

Promoters1

Investigate1

Rearrangements1

Extensively studied1

Expression16

Relevance1

Promoter1

Functional1

Yeast1

Biochemical2

Activate1

Activity3

Demonstrate1

Human3

Tumor2

Lung3

Additionally2

Biological1

Cohort1

Data3

Carbon1

Elucidate1

Response1

Important1

Role2

Humans3

Cells2