Study proliferation and apoptosis. Medical search. Frequent questions

In-depth study of small non-coding RNA molecules confirmed that microRNA (miR) has an important regulatory role in cell proliferation, differentiation, metabolism, apoptosis and development processes ( 3 ). (spandidos-publications.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
In addition to being found in plants, IP6 is contained within almost all mammalian cells, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. (naturalnews.com)
In addition to the arresting of cell proliferation, this process also induces the differentiation of malignant cells. (naturalnews.com)
This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
The impairment of proliferation, differentiation, and mineralization in osteoblast is the main pathophysiological mechanism of osteoporosis, which has been proven by previous studies ( 4 , 5 ). (frontiersin.org)
Imbalance in the process of cell proliferation, differentiation and programmed cell death (apoptosis) is involved in carcinogenesis. (cdc.gov)
PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)
Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)

Reishi inhibits proliferation and induces programmed cell death in human prostate cancer cells. (greenmedinfo.com)
Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
Open up in another window Shape 3 Leucine deprivation induces apoptosis of human being breast tumor BAY 293 cell(A and B) MDA-MB-231 or MCF-7 cells had been incubated in charge (+leu) or leucine-deficient (?leu) moderate for 48h, accompanied by dedication of cleaved caspases inside a and annexin-V assay in B. (C and D) Nude mice. (racetab.org)
PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)

Our data demonstrate that Ganoderma lucidum inhibits cell proliferation in a dose- and time-dependent manner by the down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression. (greenmedinfo.com)
Preclinical studies demonstrated that crizotinib inhibits cell proliferation and promotes apoptosis in ALK-positive anaplastic large cell lymphoma cells. (medpagetoday.com)

Review our assay kits for the study of apoptosis. (abcam.com)
An MTT assay was used to assess cell proliferation. (spandidos-publications.com)
3′-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and flow cytometric analysis were used to measure cell proliferation and apoptosis, respectively in the human pancreatic cancer Capan-1 cells. (academicjournals.org)
relative mRNA expression was evaluated by real-time polymerase chain reaction (RT-PCR), and relative protein expressions were measured by western blot assay in an in vitro study. (medscimonit.com)
In the present study, we have induced apoptosis in non-transformed, transformed and tumor cells induced by CdCI2 and BeSO4 using actinomycin D. Apoptosis was measured using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling [TUNEL] assay and enzyme-linked immuno-sorbent assay [ELISA]. (cdc.gov)
Bromodeoxyuridine (BrdU) incorporation assay and migration studies were performed to elucidate antiproliferative activity of the drug, if any. (jcimjournal.com)
Bax-Bcl2 regulation and expression studies were performed through indirect enzyme-linked immunosorbent assay (ELISA). (jcimjournal.com)
Effects of Thuja occidentalis ethanolic extract on cellular proliferation tested by BrdU incorporation assay Cells were exposed to three different concentration of Thuja occidentalis ethanolic extract for 6, 12 and 24 h along with incorporation of BrdU. (jcimjournal.com)
The cell viability and apoptosis were determined by CCK-8 assay and acridine orange/ethidium bromide (AO/EB) fluorescence staining assay. (greenmedinfo.com)

Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
Existing studies have shown that there is crossover between Renin-Angiotensin-Aldosterone (RAAS) signaling pathway and TGF-β pathway, but little is known about whether ARB drug losartan can block Angiotensin-II (Ang-II) signaling pathway, inhibit the activation of Transforming Growth Factor- Beta (TGF-β) pathway, and regulate vascular remodeling. (ijpsonline.com)
Further, melatonin synergized with epirubicin to promote the activation of the mitochondria-mediated apoptosis pathway and increased the accumulation of epirubicin in DLBCL cells by inhibiting the expression and function of P-gp. (greenmedinfo.com)
Beneficial effects of collagen type III on β-cell function via activation of the cAMP/protein kinase A pathway, suppression of RhoA and caspase-3 activity, increased β-cell viability, and proliferation were abolished when ADGRG1 was downregulated in β-cells. (lu.se)

Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)
Functional analysis revealed that knockdown of PTGR1 significantly inhibited proliferation and colony formation by PC cells. (go.jp)
The findings were that IP6 significantly decreased cellular growth and increased late apoptosis in melanoma, suggesting its potential therapeutic value. (naturalnews.com)
Researchers concluded that treatment of pancreatic cancer with IP6 significantly decreased cellular growth and increased apoptosis. (naturalnews.com)
Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
From RT-PCR, indirect ELISA and Western blot studies, caspase 3 activity was also found to be significantly increased along with cleaved poly ADP-ribose polymerase expression. (jcimjournal.com)
Melatonin significantly enhanced the epirubicin-induced cell proliferation suppression, epirubicin-induced apoptosis, and reduced the IC50 value of epirubicin. (greenmedinfo.com)

The aim of this study was to characterize the expression of DcR3 in pancreatic carcinoma and to evaluate the role of DcR3 in cell proliferation and apoptosis, which may lead to the development of novel treatments for this disease. (academicjournals.org)
In the present study, we examined five cell lines including three cell lines from pancreatic cancer (SW1990, Capcan-1 and PANC-1) and two cell lines from colon cancer (HCT116 and RKO) for DcR3 expression by reverse transcriptase-polymerase chain reaction (RT-PCR) and quantitative real time PCR. (academicjournals.org)
DcR3 protein in our experimental results showed significant expression among the pancreatic cancer cell lines and their decreased expression by lentivirus-mediated shRNA resulted in the inhibition of cell proliferation and augmentation of apoptosis. (academicjournals.org)
Design: Genes associated with the ADGRG1 in human islets was probed by RNA-sequencing of human pancreatic islet isolated from cadaveric donors, followed by functional studies on β-cell proliferation, apoptosis, and insulin secretion in human and mouse islets and in INS-1 cells. (lu.se)

The inhibition of cell proliferation was related to arrest of the cell cycle in the G0/G1 phase and increased apoptosis in response to PTGR1 knockdown as indicated by flow cytometry. (go.jp)
In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
It is postulated that inhibition of apoptosis may help altered cells escape cell death and acquire a tumorigenic phenotype. (cdc.gov)

The aim of the present study was to assess the effects of sprouty homolog 2 (SPRY2) gene regulation by miR-21 on the occurrence, development and tumor metastasis in multiple myeloma (MM). The miR‑21 expression lentiviral vector (LV)‑anti‑miR‑21 and a liposome transfection method were used to screen MM cell lines with stable silent SPRY2. (spandidos-publications.com)

In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential med. (emf-portal.org)

Fluorescence-activated cell sorting analysis after annexin V-fluorescein isothiocyanate and propidium iodide (annexin V-FITC-PI) dual staining method was done to ascertain early stage of apoptosis, if any. (jcimjournal.com)
Annexin-V-FITC positivity of cells up to 11.72% as compared to the untreated control revealed early state of TO-induced apoptosis. (jcimjournal.com)

To study the nonthermal effects of radiofrequency fields on human immune cells ( peripheral blood mononuclear cells ) exposed to a Global System for Mobile Communication ( GSM ) signal generated by a commercial cellular phone and by a sinusoidal non- modulated signal ( continuous wave ). (emf-portal.org)
In this study, we investigated the effects of Ganoderma lucidum on cell proliferation, cell cycle, and apoptosis in human prostate cancer cells PC-3. (greenmedinfo.com)
Furthermore, Ganoderma lucidum induced apoptosis of PC-3 cells with a slight decrease in the expression of NF-kappaB-regulated Bcl-2 and Bcl-xl. (greenmedinfo.com)
This study aimed to investigate the effects of xanthoxyletin, a plant-derived coumarin, on human oral squamous cancer cells in vitro and in mouse xenografts in vivo . (medscimonit.com)
The study included SCC-1 human oral cancer cells and EBTr normal embryonic bovine tracheal epithelial cells, which were treated with 0 µM, 5 µM, 10 µM, and 20 µM of xanthoxyletin for 24 hours. (medscimonit.com)
Under in vitro conditions, changes in the proliferation and invasion ability were detected in myeloma cells. (spandidos-publications.com)
Open up in another window Shape 2 Leucine deprivation inhibits breasts tumor cell proliferation(A) MDA-MB-231 or CORIN MCF-7 cells had been seeded in 12-well plates and incubated in charge (+leu) or leucine-deficient (?leu) moderate. (racetab.org)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
This study aimed to evaluate the effects of 15,16-dihydrotanshinone I on FLT3-ITD acute myeloid leukemia cells. (banglajol.info)
Duan P, Huang Y, Chen K, Cheng C, Wu Z, Wu Y. 15,16-dihydrotanshinone I inhibits EOMA cells proliferation by interfering in posttranscriptional processing of hypoxia-inducible factor 1. (banglajol.info)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)
Apoptosis (necessary programmed cell death) of the adenocarcinoma cells was increased. (naturalnews.com)
The SignalStain ® Proliferation/Apoptosis IHC Sampler Kit from Cell Signaling Technology allows the researcher to examine paraffin-embedded tissues or cells with antibodies that will detect cellular apoptosis or proliferation. (cellsignal.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
In this study, we found that the SCARA5 expression was lower in CAL-27 and SCC-9 cells than that in human normal oral epithelial keratinocytes. (degruyter.com)
We investigated L-DOPA effects on the proliferation and apoptosis of anterior pituitary cells. (conicet.gov.ar)
In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
Decreased apoptosis in tumor cells and transformed cells induced by cadmium chloride and beryllium sulphate. (cdc.gov)
In our previous study, BALB/c-3T3 cells were transformed with either cadmium chloride (CdCI2) or beryllium sulphate (BeSO4). (cdc.gov)
Immuno-staining indicates that there was increased apoptosis in the nontransformed cells compared to transformed cells, and that transformed cells had a higher percentage of apoptotic cells compared to tumor cells. (cdc.gov)
It is possible that the neoplastically transformed cells induced by CdCI2 and BeSO4 may have undergone molecular changes allowing them to bypass apoptosis or they may not have accumulated enough genetic damage to induce an apoptotic response. (cdc.gov)
To study the possible anticancer and antiproliferative activities of ethanolic leaf extract of Thuja occidentalis (TO) on A549 non-small lung carcinoma cells in vitro . (jcimjournal.com)
Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. (cancerindex.org)
The present study aimed to screen the sensitivity of bladder cancer to natural compounds by using six classic anti‑inflammatory and detoxifying herbs, including the ethanol extract of Paris polyphylla (PPE), Scutellaria barbata, Pulsatillae decoction, Dahuang Huanglian Xiexin decoction, Bazhengsan and Hedyotis diffusa combined with S. barbata, were used to treat bladder cancer cells in vitro. (spandidos-publications.com)
Research studies showed that parthenolide had a positive effect on the bone marrow microenvironment and a 'multi-faceted effect against MM cells, causing apoptosis. (canceractive.com)
This study was designed to assess the molecular mechanism of decursinol angelate (DA) against murine melanoma cell line (B16F10 cells ). (bvsalud.org)
In summary, our study revealed that DA is an effective treatment against B16F10 melanoma cells and xenograft mice model. (bvsalud.org)
A study by White et al (2009) found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)
PKC isozymes are LR-dependent molecules that link psychosine-induced LR disruption to reduced PKC function and altered cell signaling activity, possibly driving demyelination and apoptosis in oligodendrocytes and Schwann cells. (medscape.com)
Immunopathologic examination during infection showed cleavage of caspase 3 in brain cells adjacent to CD8+ cells and widespread p53 expression, hallmarks of apoptosis. (cdc.gov)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
Targeting activated Gα subunits to specific cells in vivo permits identification of downstream effector pathways independent of receptor activation, and thus permits insight into disease mechanisms otherwise impossible to study in vivo . (medscape.com)
In this context, in the present study, we examined if exposure of non-transformed intestinal cells to LTD4, a well known inflammatory mediator would make the cells more sensitive to transformation. (lu.se)
We investigated the effects of LTD4 in bringing about changes in survival, proliferation and migration of these cells, all of which are hallmarks of cancer. (lu.se)
We also show that Int 407 cells produce CysLTs and blocking this autocrine signaling using three different CysLT1 receptor antagonists for longer time points led to attenuation in cell proliferation and induction of apoptosis in the cells. (lu.se)
Malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived hematopoietic progenitor cell results in a high circulating number of blasts, replacement of normal marrow by malignant cells, and the potential for leukemic infiltration of the central nervous system (CNS) and testes. (msdmanuals.com)

Cell apoptosis was investigated using 4',6-diamidino-2-phenylindole (DAPI), annexin V, and propidium iodide (PI) fluorescence flow cytometry, which was also used to investigate the cell cycle. (medscimonit.com)

Reductions in cellular proliferation were observed in both cell lines. (naturalnews.com)

BCD-022 is a trastuzumab biosimilar which was shown to be equivalent to reference trastuzumab in a wide panel of physicochemical studies as well as preclinical studies in vitro and in vivo. (biomedcentral.com)
The aim of this study was to examine the effects and mechanisms of tenacigenin B in lymphoma treatment by in vitro and in vivo experiment. (medscimonit.com)
In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
Combined with in-vitro proliferation assays using CRISPR-Cas9/RNAi and patient survival analysis, MEK inhibitors PD19830 and BRD-K12244279, pilocarpine, and tremorine were discovered as potential new drug options for treating breast cancer. (cdc.gov)

Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis. (bvsalud.org)

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy. (wikipedia.org)
Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Studies showed that miRNAs can regulate glioma progression. (hindawi.com)
Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
Commonly biological processes such as proliferation and apoptosis have been linked to cancer progression. (bioconductor.org)
During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)
In this study, we investigated the relationship between endogenous MafF expression and HCC progression and explored the regulatory mechanism of MafF expression in HCC. (techscience.com)

Gα12 couples to numerous G-protein-coupled receptors (GPCRs) and regulates multiple epithelial responses, including proliferation, apoptosis, permeability and the actin cytoskeleton. (medscape.com)
We observed that stimulation of intestinal epithelial cell line, Int 407 with LTD4 led to enhanced cell survival and proliferation through the activation of series of signaling cascades like Ras, Erk-1/2, p90RSK, and CREB. (lu.se)

However, the role of LEPR and its underlying mechanisms in lymphatic metastasis of hepatocarcinoma have not yet been studied. (biomedcentral.com)

The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
Studies have also shown that AA women tend to develop estrogen receptor (ER) negative tumors at an earlier age, and EA women are more likely to develop ER positive tumors at later ages [3-8]. (cdc.gov)

Further, only one study has reported that miR-637 can inhibit tumorigenesis through disruption of signal transducers and activation of transcription 3 signalings in hepatocellular carcinoma [9]. (scirp.org)

This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
Further studies are in progress to investigate the involvement of apoptosis-related genes (BcI2, Bax, Bel-Xi. (cdc.gov)
The occurrence of mutations in genes of the first category leads to faster cell proliferation while mutations in genes of second category increases or changes their function. (bioconductor.org)
Mutations in other genes have been studied as possible causes of this condition, but most of these genetic changes have been described only in single families or have not been confirmed in subsequent studies. (medlineplus.gov)
SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)

Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation and induced cell apoptosis. (techscience.com)

Earlier studies have revealed that the embryonic stem (ES) cell/early PGC state is associated with tumourigenicity. (biomedcentral.com)
proliferation), cell specialization, and the normal shaping (patterning) of many parts of the body during embryonic development. (medlineplus.gov)

For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
The Ki-67 proliferation index and the apoptotic index using the terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling method were also evaluated. (aacrjournals.org)

Cell proliferation was reduced in a time-dependent manner of drug exposure as revealed from BrdU incorporation and migration studies. (jcimjournal.com)
This lactone ring is a Michael acceptor that is known to affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with nucleophilic sites in cell signalling pathways. (lu.se)

NAC treatment was able to ameliorate DA-induced apoptosis and cell cycle arrest to support our finding. (bvsalud.org)

AD is associated with abnormal proliferation, apoptosis and phenotype of VSMCs[ 4 ]. (ijpsonline.com)

Learn about the assays used to assess cell proliferation and the cell cycle. (abcam.com)

This study verified that MafF acted as a tumor suppressor in HCC and revealed the upstream regulation mechanism of MafF, which provided a new perspective for potential therapeutic targets of HCC. (techscience.com)

Each antibody in the SignalStain ® Proliferation/Apoptosis IHC Sampler Kit detects endogenous levels of its target protein and does not cross-react with any related proteins. (cellsignal.com)
This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)

The aim of this study was to investigate the biological role of prostaglandin reductase 1 (PTGR1) in prostate cancer. (go.jp)
Based on expression data we perform functional enrichment analysis, infer gene regulatory networks and upstream regulator analysis to score the importance of well-known biological processes with respect to the studied cancer. (bioconductor.org)

Silence of miR-769-5p conspicuously suppresses glioma cell proliferation and fosters cell apoptosis [ 8 ]. (hindawi.com)

Our hypothesis is that L-DOPA produces direct effects on anterior pituitary function, including the modulation of proliferation and apoptosis processes. (conicet.gov.ar)

Liver and lung samples were collected for cell proliferation and apoptosis analyses. (nih.gov)

CEBPD is involved in regulation of apoptosis and cell proliferation. (wikipedia.org)
Bax up-regulation and Bcl-2 down-regulation suitably altered ratio of Bax/Bcl-2 in favor of apoptosis. (jcimjournal.com)

Preclinical and clinical studies have established plant derived dietary substances as suitable candidates for treating various types of cancers due to their broad chemical diversity. (nature.com)

Since international federation of gynecology and obstetrics (FIGO) staging is mainly based on clinical assessment, an integrated approach for mining RNA based biomarkers for understanding the molecular deregulation of signaling pathways and RNAs in cervical cancer was proposed in this study. (cancerindex.org)

Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)
This study aimed to explore the role and related molecular mechanisms of SCARA5 in OSCC. (degruyter.com)
RESEARCH OBJECTIVES Background An efficient way of identifying clinically useful chemopreventive agents is to perform short term pilot clinical studies examining the effect of interventional agents on molecular, imaging, and histologic endpoints in populations at high risk for developing invasive cancer. (nih.gov)

BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)

The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)

Recent studies have found that losartan can delay the occurrence and development of AD and aneurysm[ 6 ], but its mechanism remains unclear. (ijpsonline.com)

Future studies are needed to validate our findings and to explore the underlying mechanisms. (cdc.gov)

Studies suggest that inappropriate responses to proinflammatory stimuli might contribute to inflammation in cystic fibrosis (CF) lungs. (nih.gov)
The CF pig model provides an opportunity to study the inflammatory responses of CF airways at birth, before the onset of infection and inflammation. (nih.gov)

Taken together, these studies suggest that Gα12 activation promotes glomerular injury without podocyte depletion through a novel mechanism regulating collagen (α)IV expression, and supports the notion that glomerular damage may accrue through persistent GPCR activation in podocytes. (medscape.com)

Anatomy36

Organisms11

Diseases13

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes53

Disciplines and Occupations1

Information Science3

Differentiation11

Induces6

Inhibits cell proliferation2

Assay9

Pathway5

Significantly8

Pancreatic4

Inhibition3

Multiple myeloma1

Mitochondrial1

Annexin V-FITC2

Cells39

Flow cytometry1

Cellular1

Vitro4

Induction1

Progression7

Epithelial2

Metastasis1

Tumors2

Hepatocellular carcinoma1

Genes5

Overexpression1

Embryonic2

Apoptotic2

Migration2

Arrest1

Abnormal1

Assays1

Tumor suppressor1

Protein2

Biological2

Suppresses1

Modulation1

Analyses1

Regulation2

Preclinical1

Pathways1

Molecular3

Antiproliferative1

Gene expression1

Occurrence1

Findings1

Inflammation2

Mechanism1