AnatomyOrganismsChemicals and DrugsPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, Agriculture
Penicillium chrysogenumPenicillium2-Aminoadipic AcidSulfate AdenylyltransferasePenicillin VPenicillinsAcremoniumL-Aminoadipate-Semialdehyde DehydrogenasePhenylacetatesPenicillin GAcyltransferasesAspergillus nidulansPipecolic AcidsPenicillin-Binding ProteinsHeterocyclic Compounds with 4 or More RingsPeptide SynthasesSpores, FungalAdenosine PhosphosulfateFungal ProteinsMyceliumSaccharopine DehydrogenasesIndustrial MicrobiologyOvomucinGenes, FungalPhosphoadenosine PhosphosulfateAspergillusGene Expression Regulation, FungalPenicillanic AcidDNA, FungalFungi
AspergillusFungiStrainsFungus Penicillium chrysogenumFusariumNotatumSporesPenicillin productionGenusAnti-fungal effectChaetomiumMetaboliteSpeciesFermentationConidiaRubensAntibioticSamsonGenomeNewly isolatedBatchRoquefortineExtractEurotiumAntimicrobial activityMoldMicrobiologyCompoundsBacteriaEnzymeProductionAirborneOptimizationFilamentousPhenotypeCarbon sourceNigerCulturesDegradationExtractsEffectImageActivityImmune systemBiotechnologyClusterAntioxidantResearchResultsPresentMajorImportantConditions
Aspergillus8
Fungi13
  • Similar to other filamentous fungi, CRISPR/Cas9-mediated genome editing techniques are available for editing the genome of Penicillium chrysogenum. (wikipedia.org)
  • The present study compared the airborne fungi collection performance of a two-stage cyclone sampler (active method) to the performance of the Personal Aeroallergen Sampler (passive method) using quantitative polymerase chain reaction (qPCR) assays. (cdc.gov)
  • The present study quantifies cellular fatty acid composition of four filamentous, marine fungi viz. (nio.res.in)
  • The results also show proof of principle for the employment of metabolic profiling for biological discovery studies of metabolites produced by fungi that could be applied to natural product screening programmes. (westminster.ac.uk)
  • Overall, this study has provided insights on the understanding on the effect of triglycerides and sugar as carbon source in fungi global metabolic pathway, which might become important for future optimization of carbon flux engineering in fungi to improve organic acids production when vegetable oil is applied as the sole carbon source. (biomedcentral.com)
  • Endophytic fungi present in crown, stem, and petiole tissues included soil-colonizing and cellulolytic fungi, such as species of Chaetomium , Trametes , Trichoderma , Penicillium , and Fusarium . (cannaqa.wiki)
  • The fact that this specimen once belonged to Fleming, no doubt, but hardly anyone can say with certainty, if this sample were used in the initial studies of fungi Penicillium chrysogenum, which was actually synthesized the different components of penicillin. (scienews.com)
  • Mycology, a specialized branch of biology, delves into the intricate study of fungi. (microbiologynote.com)
  • Professionals dedicated to the study of fungi are termed mycologists. (microbiologynote.com)
  • However, it's imperative to note that some fungi can be detrimental to human health, leading to the emergence of medical mycology, a study dedicated to fungi-induced diseases in animals. (microbiologynote.com)
  • Mycology is the scientific study of fungi, encompassing their genetic, biochemical, and ecological attributes, as well as their classification, benefits, and potential threats to other organisms. (microbiologynote.com)
  • Mycology, the scientific study of fungi, has undergone significant transformations since its inception. (microbiologynote.com)
  • Evaluation of antimicrobial potential of the extracts using the minimial inhibitory concentration (MIC) assay against 6 bacteria (Actinomyces odontolyticus, Lactobacillus sakei, Staphylococcus aureus, Enterobacter cloacae, Pseudomonas aeruginosa and Bacteriodes thetaiotomicron) and 4 fungi (Candida albicans, Microsporium gypsum, Penicillium chrysogenum and Trichophyton tonsurans) revealed that the plants possess antimicrobial activity. (ru.ac.za)
Strains6
  • The sexual stage of P. chrysogenum was discovered in 2013 by mating cultures in the dark on oatmeal agar supplemented with biotin, after the mating types (MAT1-1 or MAT1-2) of the strains had been determined using PCR amplification. (wikipedia.org)
  • The principal genes responsible for producing penicillin, pcbAB, pcbC, and penDE are closely linked, forming a cluster on chromosome I. Some high-producing Penicillium chrysogenum strains used for the industrial production of penicillin contain multiple tandem copies of the penicillin gene cluster. (wikipedia.org)
  • The main aim of this study is to isolate the fungal endophytes from the medicinal plant Corchorus olitorius seeds (F. Malvaceae ), followed by antimicrobial screening against various bacterial and fungal strains. (biomedcentral.com)
  • The method has been tested on Streptomyces clavuligerus and two strains of Penicillium chrysogenum, one of which was in a medium containing undissolved solids. (ucl.ac.uk)
  • [1] [2] In contrast, the pathogens affecting Cannabis have not been extensively studied, and the different growing environments, cultivation methods, as well as differences among the strains or genetic selections of hemp and Cannabis can influence disease development. (cannaqa.wiki)
  • Only three fungal strains (Candida albicans, Microsporium gypsum and Penicillium chrysogenum) were susceptible to the organic extracts with an MIC 0.3125 mg/mL to 5 mg/mL while the aqueous extracts showed no activity against all the fungal strains. (ru.ac.za)
Fungus Penicillium chrysogenum2
  • Reprogramming the antibiotics-producing fungus Penicillium chrysogenum, with discovery and engineering of a cytochrome P450 enzyme involved in the hydroxylation of the precursor compactin, enabled high level fermentation of the correct form of pravastatin to facilitate efficient industrial-scale statin drug production. (manchester.ac.uk)
  • The fungus, Penicillium chrysogenum , comes from deep in the Earth's subsurface and shows potential as a source for new antibacterial compounds. (nasa.gov)
Fusarium1
  • On inflorescences, Penicillium bud rot (caused by Penicillium olsonii and Penicillium copticola ), Botrytis bud rot ( Botrytis cinerea ), and Fusarium bud rot ( F. solani , F. oxysporum ) were present to varying extents. (cannaqa.wiki)
Notatum3
Spores3
  • Like the many other species of the genus Penicillium, P. chrysogenum usually reproduces by forming dry chains of spores (or conidia) from brush-shaped conidiophores. (wikipedia.org)
  • The airborne asexual spores of P. chrysogenum are important human allergens. (wikipedia.org)
  • In the presence of WTE, Penicillium spores and Saccharomyces cerevisiae yeast cells were totally inactivated. (hindustantimes.com)
Penicillin production2
  • flow chart of penicillin production from penicilium chrysogenum Unit 6 VTU eLearning Centre. (dzwigigrudziadz.pl)
  • For instance, palm oil was found to not only replace lactose but led to a better cell growth and penicillin production in Penicillium chrysogenum culture [ 3 ]. (biomedcentral.com)
Genus2
  • Penicillium is considered to be a very important genus for the production of valuable products of pharmaceutical use 4 . (ijpsr.com)
  • After isolating the mold and identifying it as belonging to the Penicillium genus, Fleming obtained an extract from the mold, naming its active agent penicillin. (cdc.gov)
Anti-fungal effect2
Chaetomium1
Metabolite6
  • The paper presents the first proof-of principle study of metabolite profiles of the interacting mycelial fronts of a wood decomposer basidiomycete, Stereum hirsutum, paired with two competitor basidiomycetes, Coprinus disseminatus and C. micaceus, using TLC and GC-TOF-MS profiling. (westminster.ac.uk)
  • His Microbiology study integrates concerns from other disciplines, such as Virology, Secondary metabolite and Burkholderia pseudomallei. (research.com)
  • As per the results of our previous study, a bioactive metabolite, P5, from Penicillium rubens JGIPR9 had highly promising cytotoxic and anti-cancer potentials. (ijpsr.com)
  • This prompted us to undertake the current study, so as to optimize the culture conditions of this fungal isolate and thereby to enhance its growth, i.e. , biomass (response 1) and production of the anti-cancer metabolite P5 (response 2). (ijpsr.com)
  • Hence, this study aimed to investigate the overall metabolite changes of an omnipotent fungus and to reveal changes at central carbon metabolism corresponding to both carbon sources. (biomedcentral.com)
  • For example, the Gα subunit Pga1 from Penicillium chrysogenum regulates conidiation and secondary metabolite production in this fungus. (iec.cat)
Species4
  • Indoor air concentrations of the common fungal species Alternaria alternata, Cladosporium cladosporioides, Epicoccum nigrum, and Penicillium chrysogenum were considered. (cdc.gov)
  • Swabs taken from greenhouse-grown and indoor buds pre- and post-harvest revealed the presence of Cladosporium and up to five species of Penicillium , as well as low levels of Alternaria species. (cannaqa.wiki)
  • Mechanical trimming of buds caused an increase in the frequency of Penicillium species, presumably by providing entry points through wounds or spreading endophytes from pith tissues. (cannaqa.wiki)
  • Field explorations, termed 'forays', are organized to discover and study diverse fungal species. (microbiologynote.com)
Fermentation2
  • In a study published in Proceedings of the National Academy of Sciences , the researchers have devised a single-step fermentative method for the industrial production of the active drug pravastatin that previously involved a costly dual-step fermentation and biotransformation process. (manchester.ac.uk)
  • Batch fermentation of Penicillium chrysogenum, MTCC 5108 was carried out using potato dextrose broth medium prepared in seawater: distilled water (1:1). (nio.res.in)
Conidia1
  • In P. chrysogenum, the conidia are blue to blue-green, and the mold sometimes exudes a yellow pigment. (wikipedia.org)
Rubens1
  • In the current study, a bioactive anti-cancer fraction, P5 was identified from a newly isolated strain of Penicillium rubens as to contain Indole-2, 3-(4,4-dimethyl-3-thiosemicarbazone). (ijpsr.com)
Antibiotic2
  • Penicillin is an antibiotic isolated from growing Penicillium mold in a fermenter. (wikipedia.org)
  • Kenneth Raper is best known for his work on Penicillium , the organism which produces the antibiotic Penicillin, as well as his work on slime molds. (unc.edu)
Samson1
Genome2
  • His studies in Gene and Genome size are all subfields of Genetics research. (research.com)
  • The two smallest sequenced genomes (A. terreus and P. chrysogenum) do not contain introns in protein-coding genes, whereas the largest genome (T. stipitatus), contains a total of eleven introns. (umd.edu)
Newly isolated1
  • Xylanase production by Penicillium chrysogenum PCL501, newly isolated from wood-wastes, was monitored at 24 h intervals for a period 168 h in media containing four different carbon sources (oat-spelt xylan, wheat bran, sawdust, and sugarcane pulp). (academicjournals.org)
Batch1
Roquefortine1
  • In this work, the effect of the constitutively active Pga1G42R Gα subunit on conidial germination, stress tolerance, and roquefortine C production of P. roqueforti was studied. (iec.cat)
Extract5
  • New studies conducted at Pace University, US have revealed that White Tea Extract (WTE) may have prophylactic applications in retarding growth of bacteria that cause Staphylococcus infections, pneumonia and dental caries. (hindustantimes.com)
  • Study after study with tea extract proves that it has many healing properties. (hindustantimes.com)
  • Aim of this study was to investigate the antioxidant activity, cytotoxicity and antiproliferative effects of ethyl acetate extract of Penicillium chrysogenum var. (ogu.edu.tr)
  • In this study, free radical scavenging effect and total phenolic contend of hPc.var.c extract was found 73 +/- 0.34 % and 53 +/- 0.1 mg/GAE, respectively. (ogu.edu.tr)
  • Studies carried out at Pace University have indicated that White Tea extract may have prophylactic applications which can help to retard the growth of bacteria which can cause Staphylococcus infections, Steptococcus infections, Pneumonia and Dental Caries. (hasen-chat.org)
Eurotium1
Antimicrobial activity1
  • The demonstrated promising results for the antioxidant and antimicrobial activity of the studied essential oils would give reason for their inclusion in the development of bio-preservation strategies for food emulsion preservation. (unboundmedicine.com)
Mold3
  • He discovered and described the slime mold Dictyostelium discoideum , which has become a model organism to study cell communication, differentiation, and programmed cell death. (unc.edu)
  • Studies have shown that exposure to mold can cause allergic reactions and poor health. (moldprotips.com)
  • During that time, Fleming sent his Penicillium mold to anyone who requested it in hopes that they might isolate penicillin for clinical use. (cdc.gov)
Microbiology2
  • His Gene study frequently links to related topics such as Microbiology. (research.com)
  • His Microbiology study combines topics in areas such as Phenotype, Aspergillosis and Burkholderia. (research.com)
Compounds1
Bacteria1
  • The anti-alga properties and anti-bacteria effects of composite nanofiltration (NF) membranes prepared from sulfated chitosan (SCS) and N, O-carboxymethyl chitosan (NOCC) were investigated in this study. (edu.au)
Enzyme1
  • Out of the three agro-wastes used in this study, wheat bran holds the greatest promise for cost-effective production of the xylanase enzyme. (academicjournals.org)
Production2
  • The paper ' Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum' , was published in Proceedings of the National Academy of Sciences. (manchester.ac.uk)
  • Its highly promising anti-cancer properties prompted us to undertake this study to statistically optimize the culture conditions so as to enhance the production of this compound and thereby to obtain its higher yield for future application studies. (ijpsr.com)
Airborne1
  • The passive sampler, in conjunction with growth-independent qPCR detection methodologies, can be utilized in future exposure assessment studies to deepen our understanding of how individuals are affected by inhalation of airborne fungal pathogens and allergens, especially for those with an aerodynamic diameter greater than 5 um. (cdc.gov)
Optimization2
  • After optimization of culture conditions, P. chrysogenum was mass cultured and citrinin was isolated and purified from the medium using a combination of chromatographic techniques (Thin layer and column chromatography). (nio.res.in)
  • Central composite design (CCD) is one of the widely used statistical methods that is based on a multivariate nonlinear model for the optimization of process variables and more importantly in studying the interactions between variables that affect the process. (ijpsr.com)
Filamentous1
  • Characterisation of mycelial morphology is important for physiological and engineering studies of filamentous fermentations, and in the design and operation of such fermentations. (ucl.ac.uk)
Phenotype2
  • His Sequence analysis study combines topics from a wide range of disciplines, such as Phenotype, Fungus and Genomic organization. (research.com)
  • The dominant activating allele, pga1G42R, encoding a constitutively active Pga1 Gα subunit, was introduced in Penicillium roqueforti by transformation, resulting in a phenotype characterized by low sporulation and slow growth. (iec.cat)
Carbon source1
  • These studies showed that plant triglycerides could serve as an alternative carbon source for microbial growth. (biomedcentral.com)
Niger1
  • Paecilomyces lilacinus resulted in a high reduction in galling and nematode multiplication, followed by P. putida, B. subtilis, A. niger, A. chroococcum and P. chrysogenum. (bvsalud.org)
Cultures1
  • In 1944 Raper and colleagues discovered Penicillium chrysogenum , which Raper called "the great grand-daddy" of all the cultures used to produce Penicillin, on a molded cantaloupe that a Peoria woman brought to the lab. (unc.edu)
Degradation1
  • Rigid and film bioplastics degradation under suboptimal composting conditions: A kinetic study. (unifi.it)
Extracts1
  • From this study, all the extracts tested had IC50 values were greater than 20 μg/mL which connotes that they are not toxic. (ru.ac.za)
Effect2
  • According to the study results, in terms of the likelihood of environmental impacts on the main considered criteria of natural and man-made environments, the former's effect is a priority risk, weighing 0.670 and primarily important. (magiran.com)
  • There is also epidemiological evidence that drinking green and black variety may help prevent diabetes, although it is worth noting that this is evidence of an association, and that future studies are needed to confirm the effect. (nuwaraeliya.com)
Image1
  • The image analysis method for biomass and cell volume estimation is shown to estimate successfully concentrations of mycelia from 0.03 to 38g/L for a number of fermentations of Penicillium chrysogenum. (ucl.ac.uk)
Activity1
  • Our findings, supported by the parallel analysis of the Mtm1-null mouse and an in vivo study, reveal a direct function of MTM1 enzymatic activity in SR remodeling and a key role for PtdIns3P in promoting SR membrane curvature in skeletal muscle. (jak-signaling.com)
Immune system3
  • Past studies have shown that green tea stimulates the immune system to fight disease. (hindustantimes.com)
  • Several studies have reported space flight effects on the human immune system, but the relationship between microbiota and immune dysfunction during flight remains unclear. (nasa.gov)
  • After approximately 30 days aboard the ISS, the mice will be returned to Earth where scientists on the ground will study how their time in space has affected various tissues, including brain, muscle, heart, joints, eyes and the immune system. (nasa.gov)
Biotechnology1
  • These growing number of studies on P. curvatum highlighted its significance in biotechnology. (biomedcentral.com)
Cluster1
  • His Gene cluster study is related to the wider topic of Gene. (research.com)
Antioxidant2
  • The antioxidant and antimicrobial activities of the essential oils have been studied by the DPPH radical-scavenging assay and the disc-diffusion method, respectively. (unboundmedicine.com)
  • There has been a dearth of scientific reports on the two plants and to the best of our knowledge, this study is the first to investigate the nutritional, antioxidant, antimicrobial, safety and anti-obesity potentials of the two plants and their combination. (ru.ac.za)
Research1
  • A research study conducted on mice showed that scent leaves were efficacious in lowering blood sugar levels. (com.ng)
Results1
  • Obtained results revealed that Penicillium chrysogenum depolymerized the lignin material by 34.8% during the 28-day experimentation period. (org.bo)
Present2
  • To explore the involvement of enzymes of drug metabolism in bladder cancer, in the present study, we analyzed the gene expression profiles of tumor and normal looking tissues obtained from the same patient by cDNA macroarray. (jak-signaling.com)
  • The aim of the present study was to increase the competitiveness and efficacy of biocontrol agents by using them together with cattle manure. (bvsalud.org)
Major1
  • This study was undertaken to scientifically validate two major medicinal plants used traditionally in the Raymond Mhlaba Municipality for the mespilifolia Less. (ru.ac.za)
Important1
  • This important background has ledto the current study on ammonia, a single quality parameter to understand the trend of deterioration, its probable causes, and the probable remedy.Water samples have been collected and tested for ammonia for a period of fifteen years, from 2002 to 2017, mostly in the laboratory of the existing plant. (magiran.com)
Conditions1
  • Initially, the single factor method was adopted to screen the individual culture conditions that would enhance the responses under the study. (ijpsr.com)