The (-) isomers of cyclazocine and SKF-10047 are far more potent than the (+) isomers as displacers of [ 3 H]dihydromorphine from receptors. (johnshopkins.edu)
The (-) isomers of cyclazocine and SKF-10047 are far more potent than the (+) isomers as displacers of [3H]dihydromorphine from receptors. (johnshopkins.edu)
Electrophysiological interactions of isomers of cyclazocine with the phencyclidine antagonist metaphit in rat cerebellar Purkinje neurons. (nih.gov)
Pentazocine4
It was found to have affinity for the (+)-stereoisomers of several benzomorphans (e.g., (+)-pentazocine and (+)-cyclazocine), as well as various structurally and pharmacologically distinct psychoactive chemicals such as haloperidol and cocaine, and neuroactive steroids like progesterone. (wikipedia.org)
They are distinguished from σ 2 receptors as they have high affinity and stereoselectivity for the (+)-isomers of pentazocine, SK&F 10047 and cyclazocine, and different subcellular localizations. (tocris.com)
These receptors are distinguished from σ 2 receptors as they exhibit high affinity and stereoselectivity for the (+)-isomers of pentazocine, SK&F 10047 and cyclazocine, as well as having different tissue distribution patterns and subcellular localizations. (tocris.com)
NARCAN is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids, including propoxyphene, methadone and certain mixed agonist-antagonist analgesics: nalbuphine, pentazocine, butorphanol, and cyclazocine. (techarp.com)
Naloxone2
One outcome of his studies was the recognition that naloxone and cyclazocine could be used in the treatment of opioid overdose and dependence. (stonybrook.edu)
In some studies, treatment with naloxone in the setting of septic shock has been associated with adverse effects, including agitation, nausea and vomiting, pulmonary edema, hypotension, cardiac arrhythmias, and seizures. (techarp.com)
Nalorphine2
"The Discriminative Stimulus Properties of Cyclazocine: Generalization Studies Involving Nalorphine, Morphine and LSD" Res.Commun.Chem.Pathol.Pharmacol. . (erowid.org)
In reports in which nalorphine is substituted for codeine or cocaine, fenfluramine for cocaine (drugs given i.v.) or in experiments comparing chlorpromazine, saline and imipramine, the punishing effect of drugs was studied as responding was under going extinction. (erowid.org)
Psychoactive1
The introduction of psychoactive drugs led to quantitative studies of drug effects on EEGs. (stonybrook.edu)
Drugs2
Drugs have also been studied in procedures in which responding terminated drug infusions and associated stimuli. (erowid.org)
Dr. Fink is a pioneer in the study of drugs of abuse. (stonybrook.edu)
Patients2
A psychiatrist who has had experience with both methadone and antagonist maintenance programs contrasts 'the relaxed, jovial atmosphere of a methadone ward,' where patients are free of the postaddiction syndrome, with 'the tension, frustration, and anxiety that characterize a cyclazocine ward. (druglibrary.org)
The study suggests, but does not prove, that the few patients who accept cyclazocine do significantly better than similar patients who attempt abstinence without cyclazocine. (druglibrary.org)
Treatment1
His studies of ECT began at Hillside Hospital in 1952 and he has published broadly on predictors of outcome in electroconvulsive therapy (ECT), effects of seizures on electroencephalograms (EEGs) and speech, hypotheses of the mode of action, and how to achieve an effective treatment. (stonybrook.edu)
Support1
In 1994, with NIMH support he organized the CORE study program with Charles Kellner as Principal Investigator, which studied continuation therapies after ECT and compared the benefits and risks of different electrode placements. (stonybrook.edu)
Twenty2
The most recent study of cyclazocine, reported in the International Journal of the Addiction, 3 in 1971, indicates that of 186 addicts offered cyclazocine, 33 accepted, of whom 11 were believed to be abstinent twenty months later. (druglibrary.org)
There has been extensive study of σ receptors since their discovery over twenty years ago. (tocris.com)
it was found that i.m. naloxone (0.12 mg/kg) which can block the LSD-like side effects of cyclazocine, also reversed the catalepsy induced by 375 m'g/kg LSD given i.p. (erowid.org)
Pharmacological2
NIDA prepares potential treatment drugs for use in preclinical toxicology evaluation, pharmacological studies and clinical trials. (nih.gov)
Pharmacological studies with σ1 agonists often follow a bell-shaped dose-response curve. (wikipedia.org)
Drugs2
Studies with psilocybin and delta-9-THC show that these drugs induce a pattern of cerebral perfusion and function that is confined to subcortical regions. (erowid.org)
HIMMELSBACH, C.K., ANDREWS, H.L. Studies on the modification of the morphine abstinence syndrome by drugs. (nih.gov)
Tests1
NIDA is soliciting proposals from qualified organizations having the capacity to carry out the development of analytical methods, conduct quality control tests and dosage form preparation, and perform stability studies for compounds and dosage forms to be used in its medications development program. (nih.gov)