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  • genes
  • During my PhD studies, I focused on understanding function(s) of some components and target genes of this signaling cascade. (cuni.cz)
  • Candidate genes for clefting, including TGFA, BCL3, DLX2, MSX1, and TGFB3, were screened for LD with either CL/P or CPO in a predominantly Caucasian population, with both case-control- and nuclear-family-based approaches. (uiowa.edu)
  • Significant LD was found between CL/P and both MSX1 and TGFB3 and between CPO and MSX1, suggesting that these genes are involved in the pathogenesis of clefting. (uiowa.edu)
  • In addition, a mutation search in the genes DLX2, MSX1, and TGFB3 was performed in 69 CPO patients and in a subset of the CL/P patients. (uiowa.edu)
  • These results form the basis for future research, including (a) mutation searches in the MSX1 and TGFB3 genes in Caucasian CL/P patients and (b) extension of the search for MSX1 mutations in CPO patients to the noncoding regions. (uiowa.edu)
  • are members of the Tbx2 subfamily of the T-box family of transcription factor genes. (biologists.org)
  • While characterizing a Hoxa2 gain-of-function transgenic mouse model in order to study the functional relationship between Hox genes activity and the control of chondrogenic differentiation, we observed that the persistent and ectopic activity of Hoxa2 in cartilage led to a reduction of ossification centers. (mdpi.com)
  • The genes Bmp-2, Bmp-4, Fgf-4 and Shh encode signal molecules, Lef-1 , Msx-1 and Msx-2, are transcription factors and p21 CIP1/WAF1 participates in the regulation of cell cycle. (springer.com)
  • The TCF/LEF family, which was first discovered during a study of T lymphocytes, has been shown to regulate the expression of specific genes, such as c-myc , cylinD1 , runt-related transcriptional factor 2 ( Runx2 ), and Osx . (medsci.org)
  • regulatory
  • Although the canonical Wnt signaling pathway has been the subject of scientific studies for several decades, all regulatory mechanisms and consequences of its hyperactivation have not been completely elucidated yet. (cuni.cz)
  • findings
  • The findings hold promise for the future of cell replacement therapy for the debilitating and incurable disease characterized by tremors, said study authors Thomas Perlmann and Johan Ericson. (bio-medicine.org)
  • Some important findings have recently come from studies involving syndromic forms of the disorder. (pubmedcentralcanada.ca)
  • targets
  • The structures of the Drosophila Paired homodimer and the yeast a1/alpha2 heterodimer bound to DNA, along with a high-resolution study of a Drosophila eve-DNA complex, have deepened our understanding of how homeodomains locate their DNA targets. (embl.de)
  • genetic studies
  • Exploitation of ES cell-derived cardiomyocytes has facilitated the analysis of early cardiac development and has permitted in vitro "gain-of-function" or "loss-of-function" genetic studies. (ahajournals.org)
  • development
  • Teeth have been a constant object of study in developmental biology because of their histological simplicity and autonomous development. (biomedcentral.com)
  • The study, published online July 11 in the journal Nature , reveals that this enzyme is a histone demethylase and works with a key genetic partner to help keep neuronal cells alive during development of the embryonic brain. (medicalnewstoday.com)
  • The cerebral spinal fluid (CSF) flow tract is a vital lifeline for supplying the brain with essential nutrients and growth factors throughout development and into adulthood. (physiology.org)
  • formation
  • This study was undertaken in order to investigate the formation of lateral ventricular choroid plexus from the stage when it first becomes clearly differentiated from the neuroependyma. (biomedcentral.com)
  • Cell
  • Two studies in the Jan. 27 2006 Cell h. (bio-medicine.org)
  • Two studies in the Jan. 27, 2006 Cell have yielded evidence that could prove a boon for stem cell therapies aimed at patients with Parkinson's disease and those with compromised immune systems due to intensive cancer therapy or autoimmune disease, according to researchers. (bio-medicine.org)
  • Acquiring pure hepatocytes is a crucial factor for hepatotoxicity screening of drug candidates and stem cell-derived hepatocyte therapy. (biomedcentral.com)
  • activity
  • A subtle mutation affecting the epigenome - a set of dynamic factors that influence gene activity - may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. (medicalnewstoday.com)
  • literature
  • Combined with our observations from a careful review of the literature, the results of the case study suggest that keratocystic odontogenic tumor and dental agenesis probably do not develop through a common genetic cause. (biomedcentral.com)
  • results
  • Any retrieved information shall not be used for any commercial purposes or claimed as results of studying, scientific or any other creative activities of any person other than the author. (cuni.cz)
  • The results reveal significant overlap of transcription factors characteristic of multiple lineages in individual border cells from gastrula through neurula stages. (elifesciences.org)
  • The results show that individual border cells have a high degree of overlap of multiple transcription factors at early gastrula stages. (elifesciences.org)
  • cells
  • Of these molecules, YM155 is one of the inhibitors targeting the BIRC5 ( Survivin ) gene, an anti-apoptotic factor, which is highly overexpressed in ESCs/iPSCs and cancer stem cells. (biomedcentral.com)