Study inhalation exposure. Medical search. Frequent questions

Endosulfan is a cream-to-brown colored exposure for pesticide applicators and by the dose (how much), the The main target of endosulfan toxicity is solid that may appear crystal ine or in crop pickers, particularly if the former do duration (how long), and the the nervous system. (cdc.gov)
Toxicity from inhalation of cyanide gas manifests rapidly. (medscape.com)
This revised Test Guideline 413 (TG 413) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a period of 90 days, and to provide data for quantitative inhalation risk assessments. (oecd.org)
Based on the available toxicity data for the substance and its structural analogues, adverse effects concerning toxicity to reproduction are not to be expected and therefore no further study is needed. (europa.eu)
1) From a 12-months oral study with cross over mating after 9 months in rats NOEL values for maternal toxicity and developmental toxicity were given with 50 and 250 mg/kg, respectively (Larionov AG & Cherkasova TE, 1977). (europa.eu)
Data gap filling for the acute inhalation toxicity endpoint is achieved using the category approach according to ECHA guidance on read-across (ECHA, 2017c). (europa.eu)
The lack of mortality in the available acute oral toxicity across the available studies, alongside the lack of gross lesions in distal tissues ( e.g. liver, kidney etc.) supports the lack of systemic bioavailability. (europa.eu)
The available acute dermal toxicity studies indicate that all substances of the MDI category have low acute dermal toxicity. (europa.eu)
The Hazard Communication Standard has generated a great deal of information for workers concerning the immediate and acute hazards of these chemicals to the extent that their toxicity has been studied. (osha.gov)
Notable human health toxicity effects identified from human and/or animal studies include respiratory cancer, non-cancer toxicity effects following inhalation, dermatitis, and reproductive effects. (mdpi.com)
Dermal exposure to hazardous substances can lead to skin diseases and systemic toxicity. (weitzlux.com)
This assessment report does not provide a detailed examination of potential effects from exposure to polymeric aluminum, as polymeric aluminum is most likely to form, and to cause toxicity, during the neutralization of acidic aluminum-rich waters and this is unlikely to occur in the release scenarios considered in this assessment (Roy 1999b). (canada.ca)

they derived for acute-duration oral exposure disease in humans. (cdc.gov)
Humans can become infected from exposure to infected animals or contaminated animal products (including meat, hides, and hair) or to contaminated dust associated with these products ( 1 ). (cdc.gov)
Evidence for transdermal passage and presence in the food chain (fish) suggests potential exposure of humans during development. (researchgate.net)
chain (fish) suggests potential exposure of humans during development. (researchgate.net)
While more studies could be done to better understand the effects of exposure on humans, it is clear ethylbenzene is a biologically dangerous chemical, and there should be protections in place to ensure that people are not exposed to it. (chej.org)
Production and use of nickel and its compounds can, however, result in additional exposures to humans and the environment. (mdpi.com)
The U.S. Environmental Protection Agency (EPA) has concluded that inhalation exposure to ethylene oxide is carcinogenic to humans. (cdc.gov)
Cigarettes are probably the single most significant source of toxic chemical exposure and chemically mediated illness in humans. (bmj.com)
Exposure to air pollution is associated with adverse health effects in humans, with special concern for exposure to fine particulate matter (PM2.5). (lu.se)
This could be due to the recent introduction of MNMs, the precautionary approach to avoid exposure and ethical concerns about conducting studies on humans. (bvsalud.org)
Health recommendations must, therefore, be based on extrapolation of the evidence from in vitro, animal or other studies from fields that involve exposure to nanoscale particles, such as air pollution, to the possible effects in humans. (bvsalud.org)
The moderate risk of RESTV recurring among humans in the Philippines and its potential pathogenicity in humans reinforces the need for early detection, surveillance and continued studies of RESTV pathogenesis and its health consequences. (who.int)

With most users, peak opioid effects are reached in 10 minutes with the intravenous route, 10-15 minutes after nasal inhalation and 30-45 minutes with the intramuscular route [5]. (ems1.com)
Heating during vaporization can expose the user to a cocktail of parent compound and thermolytic degradants, which could lead to different toxicological and pharmacological effects compared to ingesting the parent compound alone via injection or nasal inhalation. (rti.org)
How much is deposited depends on particle properties such as size, and physiological factors such as oral or nasal inhalation and exercise or rest. (lu.se)

Historically, inhalation anthrax was considered an occupational hazard for those working in wool and goat hair mills and tanneries ( 5 ). (cdc.gov)
Inhalation of FSD is a potential hazard to workers inasmuch as respirable crystalline silica causes silicosis, and levels of FSD at drilling work sites have exceeded occupational exposure limits set by OSHA. (cdc.gov)
The ecological risks of the 11 substances in the Antimony-containing Substances Group were characterized using the Ecological Risk Classification of Inorganic Substances (ERC-I). The ERC-I is a risk-based approach that employs multiple metrics considering both hazard and exposure in a weight of evidence. (canada.ca)
All of the necessary components of the risk assessment framework-hazard identification, hazard characterisation, exposure assessment, and risk characterisation-can be used to address cigarette smoke constituents. (bmj.com)
However, for the same reason, MNMs may also present health hazards that differ from those of the substance in bulk form, and may require different test methods for hazard, exposure and risk assessment from their bulk material counterparts. (bvsalud.org)
It included conducting hazard, exposure and context assessments to determine the level of risk. (who.int)

People can become ill from cyanobacteria or their toxins through ingestion, direct skin contact, or inhalation. (cdc.gov)
induces hyperactivity and convulsions, Endosulfan is a restricted-use pesticide general population through ingestion of regardless of the route of exposure. (cdc.gov)
Cyanide exposure most often occurs via inhalation or ingestion, but liquid cyanide can be absorbed through the skin or eyes. (medscape.com)
OBJECTIVES: This commentary aims to summarize the knowns and unknowns around child- and pregnancy-relevant exposures to NMPs via inhalation, placental transfer, ingestion and breastmilk, and dermal absorption. (lu.se)

Ocular and pulmonary exposure may cause incapacitating inflammation, systemic absorption and death. (cdc.gov)
Inhalation and systemic absorption may result in pulmonary edema, necrotizing bronchiolitis, and pulmonary thrombosis. (cdc.gov)
Inhalation and systemic absorption may cause pulmonary edema, necrotizing bronchiolitis and pulmonary thrombosis. (cdc.gov)
In the case of dermal exposure, before the reactive NCO groups present on MDI substances have opportunity to be absorbed to any significant extent through the stratum corneum they react with proteins and moisture at the skin surface leading to the formation of an insoluble polymerized mass thereby limiting dermal absorption and systemic availability (Leibold 1999). (europa.eu)
Apart from few studies investigating the placental transfer of NMPs, the physicochemical properties (e.g., polymer, size, shape, charge) driving the absorption, biodistribution, and elimination in early life have yet to be benchmarked. (lu.se)

ㆍ Exposure factor is important for inhalation exposure assessment of chemicals used in household products. (e-jehs.org)
The Office of Technology Assessment has reported that as many as 20,000 cancer deaths annually may be caused by workplace exposures. (osha.gov)
Mohammed A. Al Mutairi, Hatim A. Al Herbish, Rakan S. Al-Ajmi, Hatim Z. Alhazmi, Reham A. Al-Dhelaan & Abdullah M. Alowaifeer (2022) Analyzing pesticides and metal(loid)s in imported tobacco to Saudi Arabia and risk assessment of inhalation exposure to certain metals, Inhalation Toxicology. (unitedchem.com)
The NIOSH was presented with an opportunity to assist in the evaluation of CI by conducting the exposure assessment through an interagency agreement with the National Institute of Environmental Health Sciences/NTP. (elcosh.org)
Margins of exposure were not calculated for non-cancer effects in this assessment since non-cancer effects occurred at a dose at which tumours were observed and because the information available indicates that exposures of the general Canadian population to 2-nitrotoluene from either environmental media or consumer products are expected to be negligible. (gc.ca)

Post World War II studies indicate that concentrations below 8% cause no or inconsistent effects. (cdc.gov)
I. The response following exposure to high concentrations. (fluoridealert.org)
Traditionally exposure is estimated based on outdoor concentrations at the residential address. (wikipedia.org)
Exposure profiling considered two approaches: predictive modeling using a generic near-field exposure model for each substance, and an analysis of measured concentrations collected by federal and provincial water quality monitoring programs using antimony concentrations as a conservative indicator of exposure for the 11 substances. (canada.ca)
The study by ORNL and the University of Kentucky will address what Jenkins describes as a major flaw in previous studies that typically measure outdoor particulate concentrations. (news-medical.net)
The big challenge -- and the only way to get a real handle on the problem -- is to simultaneously measure heart rate variability, respiration and particulate concentrations," said Jenkins, who has published several papers about real-world exposures to environmental tobacco smoke. (news-medical.net)
Peak plasma concentrations following administration were achieved following inhalation within minutes, and the rapid onset of pharmacodynamic effects of somnolence and sedation were observed. (drugdiscoverynews.com)
Organic particle concentrations are often high indoors, which promotes the sorption of DEHP and other SVOCs, which in turn may contribute to increased human exposure to DEHP and other SVOCs. (lu.se)
4 did not find any loss of volume, resistance or bone mass with serum concentrations of nicotine which are superior to those that were found in smoking when the exposure of female rats that are growing with nicotine for two or three months. (bvsalud.org)

5.1 A tiered strategy for characterization of nanoparticle properties is necessary to draw meaningful conclusions concerning dose-response relationships observed during inhalation toxicology experiments. (astm.org)
This test method describes the determination of the as administered surface area of airborne metal oxide nanoparticles in inhalation exposure chambers for inhalation toxicology studies. (astm.org)
The Institute is a leading authority world wide on the study of airborne pollutants (inhalation toxicology). (europa.eu)
These results explore the toxicology of stimulant vapor inhalation in mice using an e-cigarette device. (rti.org)

However, cyanide exposure occurs relatively frequently in patients with smoke inhalation from residential or industrial fires. (medscape.com)
These combustion gases likely contribute to the morbidity and mortality from smoke inhalation. (medscape.com)
Be aware of pertinent historical risk factors when treating patients with potential smoke inhalation injury. (medscape.com)
Corticosteroids are attractive for suppressing inflammation and reducing edema, but no direct data support their use in smoke inhalation. (medscape.com)
Smoke inhalation injuries predispose the airways to infection because of cellular injury, reduction of mucociliary clearance, and poor macrophage function. (medscape.com)
Acute bacterial colonization and invasion peaks at 2-3 days after smoke inhalation. (medscape.com)
The most common organisms in secondary pneumonia after smoke inhalation injury are Staphylococcus aureus and Pseudomonas aeruginosa . (medscape.com)

Exposure is commonly understood to be the concentration of the airborne pollutant in the air at the mouth and nose boundary. (wikipedia.org)
Whenever possible the use of local exhaust ventilation or other engineering controls is the preferred method of controlling exposure to airborne dust and fume to meet established occupational exposure limits. (espimetals.com)
A human exposure study was conducted to elucidate the dermal and inhalation uptake in 16 volunteers from exposure to airborne gas- and particle phase phthalates, with participants wearing clean clothing. (lu.se)

The primary endpoint of the study was the change in standardized photosensitivity range (SPR) in participants receiving each dose of Staccato alprazolam. (drugdiscoverynews.com)

The greater epilepsy community of patients, families and health care providers knows full well that there is an urgent need for acute rescue options to reduce or even halt seizure activity," said lead author Jaqueline A. French, M.D., the study's principal investigator, professor in the department of Neurology at NYU Langone Health's Comprehensive Epilepsy Center, and founder/director of the Epilepsy Study Consortium . (drugdiscoverynews.com)
The encouraging data from this Phase 2a study served as the foundation for advancing Staccato alprazolam in the clinic as a potential rescue medication for the acute treatment of seizures. (drugdiscoverynews.com)
In a case series by Huang et al, 25% of patients presented after HC exposure with acute lung injury requiring ventilatory support. (medscape.com)

Each exposure cycle will be less than three hours in duration, and actual exposures to the test aerosols likely will be less than one hour. (news-medical.net)
The overall aim of the research presented in this thesis was to characterize the physicochemical properties of indoor aerosols from cookstoves, candles, and phthalate sources, and to assess their contribution to human exposure. (lu.se)

Inhalation is a major route of exposure that occurs when an individual breathes in polluted air which enters the respiratory tract. (wikipedia.org)
Identification of the pollutant uptake by the respiratory system can determine how the resulting exposure contributes to the dose. (wikipedia.org)
While ORNL has vast experience in sampling and studying exposures to environmental tobacco smoke, researchers at the University of Kentucky's Center for Biomedical Engineering provide expertise in the cardio-respiratory interface and measurement techniques. (news-medical.net)
Jadhav, 2020 ) taking into account the differences in bioavailability, differences between experimental and human exposure conditions and respiratory volumes. (europa.eu)
Epidemiological studies have demonstrated that there is an increase in hospital admissions for respiratory diseases 1 day after peak levels of ambient ozone. (portlandpress.com)
This study aimed to characterize the common chronic respiratory diseases, along with their lung function and possible determinants in symptomatic patients attending clinics at Bishoftu General Hospital, Ethiopia. (who.int)
Conclusion: This study demonstrated a high burden of abnormal lung function in patients attending clinics due to chronic respiratory symptoms. (who.int)

Irritation occurs with exposures to 0.2 mg-min/m³ and becomes unbearable at 3 mg-min/m³. (cdc.gov)
In vitro and in vivo animal studies have shown that cromolyn sodium inhibits sensitized mast cell degranulation which occurs after exposure to specific antigens. (nih.gov)

The duration of each exposure was 2 h with alternating periods of 15 min rest and exercise. (portlandpress.com)

A study by Oak Ridge National Laboratory and partners might help explain whether there is a relationship between inhalation of small particles, reduced heart rate variability and death. (news-medical.net)
Understanding the relationship between heart rate variability and particle exposure could help explain increased mortality associated with inhalation of small particles," Jenkins said. (news-medical.net)
The exposures will average out to the levels of indoor air particles that many of us encounter in our daily lives," said Jenkins, who hopes to accomplish two major goals. (news-medical.net)
Beware that patients may appear asymptomatic on arrival but may develop significant signs and symptoms as long as 36 hours after exposure, especially in fires, which produce small particles with low water solubility. (medscape.com)
The uptake of the gas-phase DEP via inhalation was four times higher compared to the particle phase DEHP, which reflects the differences in the lung deposition of gases and particles. (lu.se)
Although plastic chemicals are a well-established research topic, the impacts of plastic particles are unexplored, especially with regard to early life exposures. (lu.se)

Cromolyn sodium inhalation solution USP is a prophylactic agent indicated in the management of patients with bronchial asthma. (nih.gov)
Cromolyn sodium inhalation solution is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium. (nih.gov)
Occasionally, patients may experience cough and/or bronchospasm following inhalation of cromolyn sodium. (nih.gov)
SUMMIT, N.J.- Engage Therapeutics, Inc . has announced that data from a Phase 2a study of Staccato alprazolam to suppress seizures in patients with epilepsy were published in Epilepsia . (drugdiscoverynews.com)
This proof-of-concept study demonstrated that Staccato alprazolam delivered the drug deep into to the lung and rapidly suppressed seizure or epileptiform activity in five photosensitive patients with epilepsy. (drugdiscoverynews.com)
Engage Therapeutics is now enrolling up to 123 patients in the multi-center StATES study (Staccato Alprazolam Terminates Epileptic Seizures), a Phase 2b trial designed to evaluate the safety, efficacy and usability of Staccato alprazolam in subjects with epilepsy who have a predictable seizure pattern. (drugdiscoverynews.com)
Studies establishing effectiveness included patients with NYHA Functional Class II-IV symptoms and etiologies of idiopathic or heritable PAH (58%), PAH associated with congenital systemic-to-pulmonary shunts (23%), or PAH associated with connective tissue diseases (19%) [see Clinical Studies ]. (rxlist.com)
clinical studies with racemic formoterol suggested a higher incidence of serious asthma exacerbations in patients who received racemic formoterol than in those who received placebo. (medscape.com)

however, animal studies suggest that hemorrhagic inflammatory lesions may occur throughout the gastrointestinal tract. (cdc.gov)
Although rare, inhalation anthrax can occur naturally in the United States. (cdc.gov)
Consequently, if exposure were to occur by the oral route this would not lead to local or systemic effects. (europa.eu)
Loss of consciousness can occur within a minute of exposure at 300,000 ppm and within 5-10 minutes (min) of exposure at 100,000 ppm (HSDB 2004). (nationalacademies.org)

To characterize exposure, intake estimates from environmental media, food, drinking water and uses of certain product types were derived. (canada.ca)
In a Swedish study to characterize welding fume aerosol (Isaxon et al. (who.int)

Clinical manifestations vary widely, depending on the dose and route of exposure, and may range from minor upper airway irritation to cardiovascular collapse and death within minutes. (medscape.com)
After administration by inhalation, approximately 8% of the total cromolyn sodium dose administered is absorbed and rapidly excreted unchanged, approximately equally divided between urine and bile. (nih.gov)
The main work of the Institute is research into the effects and mechanisms of action of foreign substances, particularly after chronic exposure in the low dose range. (europa.eu)

The results of the study did not indicate a carcinogenic potential for ATBC in rats, as no substance-related neoplastic lesions were noted. (europa.eu)
In detail, performing oral-to-dermal extrapolation no defalut factor (i.e. factor 1) was introduced (as dermal aborption will not be higher than oral aborption) and a correction factor of 1.4 for differences in human and experimental exposure conditions: workers (5 working days) vs. rats (7 days continuous exposure) have been used. (europa.eu)
In this study, we found how the action of this compound present in everyday life affects the development of the rats. (dailymail.co.uk)
The researchers say more studies are needed to determine if the chemical actually does increase the risk of breast cancer in rats. (dailymail.co.uk)

The man was hospitalized on August 2, following onset of illness while he was en route to Minnesota. (cdc.gov)
Route of administration: Inhalation use. (medicines.org.uk)
Inhalation is not a relevant route of exposure. (europa.eu)
Based on current knowledge, the most important exposure route for nanoparticles is inhalation. (lu.se)

Roger Jenkins of the lab's Chemical Sciences Division hopes to address the situation with a two-year study involving 40 participants who will be exposed to three commonly encountered indoor air pollutants. (news-medical.net)
With the new Environmental Protection Agency Particulate Matter 2.5 standard, which is stricter than the previous PM10 standard regarding acceptable quantities of pollutants in the air, Jenkins believes this study has special importance. (news-medical.net)
The study aimed to improve understanding of the biological mechanisms by which air pollutants can cause effects in human health, thereby expanding our knowledge of potential causal links between exposure and health. (healtheffects.org)
Exposure to air pollutants released by greenhouse gases and geographic proximity to polluting facilities, for example, are ways in which disadvantaged communities of color are made especially vulnerable to climate change. (healthline.com)
The Department of Environmental Chemistry conducts research and develops techniques of relevance for studies of the environmental fate of natural and anthropogenic pollutants occurring in various matrices. (europa.eu)
Women were divided into high and low exposure groups according to the mean density of exposure to pollutants during pregnancy. (who.int)
There was no statistically significant relationship between exposure to air pollutants including CO, particulate matter, SO , NO and O and pre-eclampsia. (who.int)

And wildland firefighters rarely have the opportunity to, as the video recommends, change clothes and shower within an hour after exposure. (wildfiretoday.com)
I wholeheartedly agree that smoke exposure to wildland firefighters should be studied, and it's disheartening that little such research is published. (wildfiretoday.com)

To avoid exposure through the gastrointestinal tract, food and drinks should never be ingested in the same laboratory or room as nanoparticles are handled. (lu.se)
Welders are exposed to a range of fumes and gases (evaporated metal, metal oxides, hydrocarbons, nanoparticles, ozone, oxides of nitrogen (NOx) ) depending on the electrodes, filler wire and flux materials used in the process, but also physical exposures such as electric and magnetic fields (EMF) and ultraviolet (UV) radiation. (who.int)

Mice studies have indicated that the inhalation of allergens induces notable eosinophil infiltration and degranulation, and a pilot study conducted in New York City found that EoE symptoms peaked during the July-to-September period when grass pollen counts were at their highest. (medscape.com)

Observed differences in LD50 values between pMDI and 4,4'-MDI/TPG are not considered to be significant or represent a trend since they are significantly higher than the limit for classification and are indicative of a lack of systemic exposure. (europa.eu)
The Staccato system aerosolizes a drug and, via inhalation, delivers it deep into the lung for rapid systemic exposure. (drugdiscoverynews.com)

There are no data regarding potential effects of chronic exposure to phosgene oxime. (cdc.gov)
The most up-to-date and comprehensive source for studies on fluoride's systemic, multifaceted effects on human health, with 80+ years of research organized by health category, type of study, and date. (fluoridealert.org)
The effects of the inhalation of hydrogen fluoride. (fluoridealert.org)
In the 9th month of the study, a cross-mating of the animals was performed, male gonads were evaluated and embryotoxic effects were examined. (europa.eu)
Little else is known about the human health effects of short- or long-term exposure to the chemical. (chej.org)
This study examined the in vivo toxicological and pharmacological effects of vaporized and injected methamphetamine (METH) and alpha-pyrrolidinopentiophenone (alpha-PVP). (rti.org)
Vapor exposure and injection led to more similarities than differences in toxicological and pharmacological effects. (rti.org)
Despite the current technological and methodological difficulties, studying drug vapor promises to allow determination of toxicological effects of thermolytic products and flavor additives. (rti.org)
In 2010 we began calling for the wildland fire agencies to conduct a study led by medical doctors and epidemiologists to evaluate the short and long term effects of smoke on firefighters. (wildfiretoday.com)
In this study, we investigated the in vitro inhibitory effects of the individual major cannabinoids and metabolites ∆9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), 11-nor-THC-carboxylic acid, and 11-hydroxy-THC on CES1 activity. (aspetjournals.org)
Cancer potency factors were available for 40 of these compounds and reference exposure levels (RELs) for non-cancer effects were found for 17. (bmj.com)
Exposure to 2-nitrotoluene has also been associated with non-cancer effects in experimental animals, including developmental and reproductive effects as well as effects in the lungs, liver, spleen, bone marrow and the hematopoietic system. (gc.ca)
Discerning secondary infection from the effects of inhalation injury can be very difficult because both may produce fever, elevated white blood cell counts, and abnormal radiography findings. (medscape.com)
There is currently a paucity of precise information about human exposure pathways for MNMs, their fate in the human body and their ability to induce unwanted biological effects such as generation of oxidative stress. (bvsalud.org)
Workers in all countries will be at the front line of exposure to these materials, placing them at increased risk for potential adverse health effects. (bvsalud.org)
Yet the health effects of exposure to nano- and microplastics (NMPs) remain largely uninvestigated or unknown. (lu.se)

Phosgene oxime is known to cause more severe tissue damage than vesicants and other urticants but it has not been well studied and the mechanism of action is unknown. (cdc.gov)
A study has shown that butyl benzyl phthalate, or BBP, can interfere with the healthy development of breast tissue. (dailymail.co.uk)
We are the first to report that neonatal/prepubertal exposure to BBP induced modifications in the gene expression of the mammary tissue," said team leader Dr Jose Russo. (dailymail.co.uk)

The biggest concern when using household chemical products is the health risk from inhalation exposure. (e-jehs.org)
174) 1.Cyclohexanones 2.Environmental exposure 3.Occupational exposure 4.Solvents I.Series ISBN 92 4 157174 8 (NLM Classification: QV 633) ISSN 0250-863X The World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. (inchem.org)
Recent studies have also found that facing racism in society, day in and day out, can take a measurable toll on health. (healthline.com)
Exposure of the general population to ethylene oxide usually involves levels that are lower than those known to cause health problems. (cdc.gov)
1 However, despite the public health significance of these toxicant exposures, comparatively little effort has been spent to assess and quantify the health risks associated with the individual chemicals in cigarette smoke, and almost nothing has been done in terms of product regulation to reduce human exposure to these constituents. (bmj.com)
The health impacts of exposure to microplastics is of great concern because as well as attracting pathogens, they carry and release toxic chemicals that act as endocrine disruptors interfering with the immune system and other bodily functions, including brain development. (iucn.org)
On the basis of the carcinogenic potential of 2-nitrotoluene, for which there may be a probability of harm at any exposure level, it is concluded that 2-nitrotoluene is a substance that may be entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health. (gc.ca)
Normal laboratory values and imaging studies, coupled with clinical improvement, can give the health care provider a false sense of security. (medscape.com)
We also summarize research needs for linking child health and NMP exposures and address the unknowns in the context of public health action. (lu.se)

There is potential for exposures to total dust greater than the OSHA limit during all CI application operations. (elcosh.org)
Black lung results from exposure to coal dust. (npr.org)
Progressive massive fibrosis is an especially aggressive form, blamed on inhalation of silica dust from the cutting of quartz rock and coal together. (npr.org)
Sliced sections of lungs show the damage and disease caused by excessive exposure to coal and silica dust. (npr.org)

METHODS: This observational cohort study includes data from individuals diagnosed with type 1 diabetes before age 20 years who participated in the SEARCH for Diabetes in Youth Study across five sites in the USA. (cdc.gov)
Methods for UV filter analysis followed the principles of European standardized methods for pesticide residue analysis (EN 15289). (researchgate.net)
This was an inclusive review of studies reporting yields of cigarette smoke constituents using standard ISO methods. (bmj.com)
Methods: A cross-sectional study was conducted at the outpatient department of Bishoftu Hospital from June 2019 to March 2020. (who.int)
Three welding methods were included in this study: Shielded-metal arc welding (manual welding), gas metal-arc welding shields (semi-automatic), and fluxed-core arc welding (automated). (who.int)

He and his wife were interviewed to identify potential sources of exposure. (cdc.gov)
Hosted a webinar to discuss research on dermal exposure, epigenetic age, and potential liberation of PFAS from PPE. (cdc.gov)
2-Nitrotoluene was identified as presenting an intermediate potential for exposure of individuals in Canada and had been classified by other agencies on the basis of carcinogenicity and genotoxicity. (gc.ca)

0.02) compared with exposure to air, in non-asthmatic as well as asthmatic subjects. (portlandpress.com)
5. Exposure to ozone causes a transient increase in the maximal degree of airway narrowing to methacholine in both non-asthmatic and asthmatic subjects. (portlandpress.com)

The estimated LCt 50 (the product of concentration times time that is lethal to 50% of the exposed population by inhalation) is 1,500 to 2,000 mg-min/m³. (cdc.gov)
The response following exposure to low concentration. (fluoridealert.org)

Experimental exposures were to filtered air, 0.40 ppm ozone and filtered air respectively, at 1-week intervals. (portlandpress.com)
The objective of this experimental study was to evaluate, through bone densitometry, the performance of two factors that may influence the osseointegration process: nicotine and superficial texturization of the implants. (bvsalud.org)
The nicotine inside the experimental conditions used in this study and the superficial texturization of the implants indicated that they were not influencing bone density. (bvsalud.org)

In order to obtain information on human exposure, we conducted a monitoring study on human milk with three series of mother-child pairs (2004, 2005, 2006), with focus on cosmetic UV filters in relation to other endocrine disrupters. (researchgate.net)
They also indicate that it may be possible to reduce human exposure during critical periods such as pregnancy and lactation by transiently abstaining from use. (researchgate.net)
Thus, human and environmental nickel exposures are ubiquitous. (mdpi.com)
Data from in vitro, animal and human MNM inhalation studies are available for only a few MNMs. (bvsalud.org)

Dr. Contreras and colleagues evaluated how exposure of lung cells to volatile organic compounds plus ozone affects oxidation of ribonucleic acid, a key component of cells. (healtheffects.org)
The objective of our study was to describe the CT features of "hot tub lung" caused by exposure to Mycobacterium avium complex (MAC) organisms in contaminated water. (nih.gov)
So far, Laney's team has published one study focused on a single clinic in Kentucky, reporting 60 cases there of advanced black lung. (npr.org)
Researchers at the University of Illinois at Chicago are also conducting an independent study of the spike in advanced black lung. (npr.org)

At 12 h after exposure, methacholine inhalation challenge tests and sputum induction were performed. (portlandpress.com)

Cyanogen chloride (CNCl or CK) is heavier and will sink to low-lying areas and increase the risk of exposure. (medscape.com)
More studies are needed to better understand the risk of exposure during pregnancy. (cdc.gov)
The physicochemical properties of SVOCs influence their gas-particle partitioning and the likelihood of uptake via both inhalation and the skin, which should be considered in risk assessments of SVOCs. (lu.se)

Inhalation anthrax occurred in a man who vacationed in 4 US states where anthrax is enzootic. (cdc.gov)
Recently, inhalation anthrax cases have resulted from exposure to African-style drums made of animal hides and from bioterrorist attacks ( 6 , 7 ). (cdc.gov)

Comprehensive overview of scientific findings from major ozone field studies in North American and Europe : final report. (epa.gov)
Multicenter Ozone Study in oldEr Subjects (MOSES): Part 2. (healtheffects.org)
Research Report 192, Part 2, describes the second part of the Multicenter Ozone Study in oldEr Subjects (MOSES), led by Drs. David Rich and Mark Frampton of the University of Rochester Medical Center in Rochester, New York. (healtheffects.org)
2. In the present study we therefore studied the effect of a controlled exposure to ozone on the maximal degree of airway narrowing to a non-specific bronchoconstrictor, methacholine, 12 h after exposure. (portlandpress.com)
All changes had returned to baseline values 1 week after exposure to ozone. (portlandpress.com)
These laboratory results, obtained using relatively high ozone exposure in carefully selected subjects, might provide an explanation for the temporal relationship between ambient ozone levels and hospital admissions for asthma. (portlandpress.com)
Ozone is formed during most electric arc welding, and exposures can be high in comparison to the exposure limit, particularly during metal inert gas welding of aluminium. (who.int)

Subcutaneous epinephrine has been used in zinc oxide (HC) exposures. (medscape.com)
Animal models with varied protocols in the use of nicotine have been often tested through subcutaneous injections, inhalation of cigarette smoke or subcutaneous osmotic mini-pumps, evaluating its influence in the bone repair of implants 5-6 . (bvsalud.org)

The uptake was measured, via combined inhalation and dermal air-to-skin transfer and via air-to-skin transfer only for the gas-phase diethyl phthalate (DEP) and for particle phase DEHP. (lu.se)
Dermal uptake via air-to-skin transfer only with clean clothing acting as a barrier was ten times lower than the uptake via inhalation for DEP. (lu.se)
Only uptake via inhalation was measurable for the particle phase DEHP. (lu.se)

Any patient with significant exposure to toxic smokes should be observed for 24-48 hours and imaged with serial chest radiographs. (medscape.com)
Difficulty arises in defining a significant exposure, since the clinical response is so varied. (medscape.com)

Carefully designed clinical studies are warranted to establish the clinical significance of these in vitro findings. (aspetjournals.org)

Chemical exposure at the workplace is a major cause of illness and disease in America. (osha.gov)
Every day you face the possibility of toxic chemical exposure - through the air you breathe, the water you drink, or the products you buy. (weitzlux.com)
But inhalation is not the only way someone can be exposed to and made sick by chemical exposure. (weitzlux.com)
and Joseph E. Fernback of the Chemical Exposure and Monitoring Branch (CEMB) in the Division of Applied Research and Technology (DART). (elcosh.org)

Dr. Philip Landrigan of the Mount Sinai School of Medicine has written that although precise information on the number of occupational illness cases in America is not available, it is estimated that between 50,000 and 70,000 deaths and 350,000 new illnesses are caused by occupational exposure each year. (osha.gov)

In the case of oral exposure, before the reactive NCO groups present on the substances of the MDI category have opportunity to react locally, or be absorbed, they polymerize in the acid environment of the stomach to form solid polyureas that are excreted via the feces without being absorbed. (europa.eu)
Other studies on MDI substances are consistent with this, albeit with lower reliability. (europa.eu)
There are thousands of workers who die each year from illnesses caused by exposure to substances such as asbestos, silica, chromium, and carbon monoxide. (osha.gov)

Treatment of inhalation injuries caused from toxic smokes is based on clinical presentation and involves primarily supportive care directed at the cardiopulmonary system. (medscape.com)

Microplastics also enter the body through skin contact and inhalation. (iucn.org)

Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. (inchem.org)
Biological monitoring was also performed in this Russian study, where Mn in whole blood was 25% higher in welders compared to controls. (who.int)

The exposure factors registered in South Korea's exposure factor handbook have been systematically studied and reflect the most recent data. (e-jehs.org)
Researchers will collect physiological response data during the experiments, and participants will provide information about other exposures they encounter as part of their daily routines. (news-medical.net)
Selected chemical and physical properties, toxicokinetic and mechanistic data, and inhalation exposure levels from the National Research Council (NRC) and other agencies are also presented. (nationalacademies.org)
The subcommittee's recommendations for CO 2 exposure levels are provided at the conclusion of this chapter along with a discussion of the adequacy of the data for defining those levels and the research needed to fill the remaining data gaps. (nationalacademies.org)
Data from this proof‐of‐concept study showed that treatment with Staccato alprazolam was effective in reducing the SPR at the earliest measurable time point (2 minutes). (drugdiscoverynews.com)

The study referenced in the Epilepsia paper demonstrated that three doses of Staccato alprazolam (0.5 mg, 1.0 mg, and 2.0 mg) rapidly suppressed epileptiform activity in photosensitive participants with epilepsy. (drugdiscoverynews.com)

While there is evidence to suggest that breathing air containing particulate matter can cause problems for people with decreased heart rate variability, no one has done a definitive study to examine whether there is a direct link between the two. (news-medical.net)

ATBC was tested in a combined chronic/carcinogenicity study according to current Guidelines with dosing via diet over a period of 104 weeks. (europa.eu)

These opportunities and the feasibility of self‐administration will need to be explored in further efficacy studies. (drugdiscoverynews.com)

Asbestos - As a known carcinogen, asbestos exposure can lead to an aggressive form of cancer called mesothelioma. (weitzlux.com)

Anatomy7

Organisms5

Diseases12

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes19

Disciplines and Occupations1

Technology, Industry, Agriculture9

Named Groups1

Health Care8

Toxicity12

Humans12

Nasal inhalation3

Hazard6

Ingestion4

Absorption5

Assessment5

Concentrations9

Toxicology4

Smoke inhalation7

Airborne3

Endpoint1

Acute3

Aerosols2

Respiratory7

Occurs2

Duration1

Particles6

Patients8

Occur4

Characterize2

Dose3

Rats4

Route4

Pollutants7

Wildland firefighters2

Nanoparticles2

Induces1

Systemic exposure2

Effects16

Tissue3

Health9

Dust4

METHODS5

Potential3

Asthmatic2

Concentration2

Experimental3

Human4

Lung4

Sputum1

Risk3

Anthrax2

Ozone7

Subcutaneous2

Uptake3

Significant2

Clinical studies1

Chemical exposure4

Occupational Exposure1

Substances3

Injuries1

Microplastics1

Biological2

Data5

Doses1

Particulate matter1

Carcinogenicity1

Efficacy1

Aggressive form1