Study growth inhibitors. Medical search. Frequent questions

The receptor for epidermal growth factor (EGFR) is overexpressed in many cancers. (aacrjournals.org)
Recent reports have shown that the sensitivity of non-small-cell lung cancer cell lines to EGFR inhibitors such as erlotinib (Tarceva, OSI Pharmaceuticals) is dependent on inhibition of the phosphatidylinositol 3′-kinase-phosphoinositide-dependent kinase 1-Akt-mTOR pathway. (aacrjournals.org)
Epidermal growth factor receptor (EGFR) gene mutations are frequent in lung cancer arising in patients of Asian ethnicity, female sex, nonsmokers, and adenocarcinoma histology. (nih.gov)
About 70% of the patients with EGFR mutations respond to EGFR tyrosine kinase inhibitors (TKIs) including gefitinib and erlotinib, whereas only 10% of those without the mutations do so. (nih.gov)
Met5-enkephalin (ME)-induced cardioprotection occurs via epidermal growth factor receptor (EGFR) transactivation with the subsequent activation of phosphatidylinositol 3-kinase (PI3K). (biongenex.com)
Quantitative structure-activity relationship (QSAR) and docking studies have been performed on a large series of cinnamic acid analogues studied by various authors as Epidermal Growth Factor Receptor (EGFR) inhibitors. (alquds.edu)
The epidermal growth factor receptor (EGFR) is among the most well-studied signaling pathways in cancer progression. (bio-biz-navi.com)
Evaluation of Treatment Efficacy of Tyrosine Kinase Inhibitors in Rare Single EGFR Exon 21 L861Q Mutation: Single Center Experience. (cdc.gov)
Do patient characteristics affect EGFR tyrosine kinase inhibitor treatment outcomes? (cdc.gov)
Survival outcomes of east Asian patients with advanced non-small cell lung cancer treated with first-line EGFR tyrosine kinase inhibitors: A network meta-analysis of real-world evidence. (cdc.gov)

Pazopanib is a vascular endothelial receptor tyrosine kinase inhibitor with anti-angiogenesis and anti-tumor activity in several preclinical models. (johnshopkins.edu)
Phase I study of OSI-906, dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) in combination with erlotinib (E) in patients with advanced solid tumors. (ox.ac.uk)
3098^ Background: OSI-906 is an oral inhibitor of IGF-1R and IR tyrosine kinases. (ox.ac.uk)

We believe peptide inhibitors offer non-toxic, less-expensive alternatives to humanized monoclonal antibodies and small-molecule inhibitors for the treatment of solid tumors, with the potential for improved efficacy and better clinical outcomes," he says. (sciencedaily.com)
This article reviews current anticancer small-molecule inhibitors targeting epigenetic modified enzymes and displays their performances in different stages of clinical trials. (frontiersin.org)
In this review, we summarize the basic principles manipulating the abovementioned epigenetic pathways and highlight the evidence of the promising clinical and preclinical results using small-molecule inhibitors against chromatin regulators for cancer treatment. (frontiersin.org)
We show that topical treatment of mouse and human skin with small-molecule inhibitors of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway results in rapid onset of anagen and subsequent hair growth. (nextbigfuture.com)

25 Furthermore to kinase inhibitors, medical tests have also examined the addition of the ligand obstructing monoclonal antibody cetuximab towards the DNA-alkylating agent carboplatin. (bio-biz-navi.com)
Among approved kinase inhibitors, Xeljanz is a successful product in Pfizer's portfolio. (nasdaq.com)
Successful development of kinase inhibitors and Humira biosimilar along with approved drugs, will create a strong portfolio of inflammatory drugs going forward. (nasdaq.com)
and potent inhibition of NHK proliferation and migration by two Src family kinase inhibitors PP1 and PD173952. (aspetjournals.org)
Moreover, the effect of Src family kinase inhibitors on EGF-stimulated ERK phosphorylation was transient, prompting a search for other targets of Src family kinase action. (aspetjournals.org)

A new therapeutic approach to diabetes that combines insulin and an inhibitor of the epidermal growth factor (EGF) betacellulin could limit the progression of diabetic macular edema (DME), Cleveland Clinic researcher Bela Anand-Apte, MD, PhD, said at the American Society for Cell Biology Annual Meeting, on Dec. 17 in San Francisco. (biospace.com)
Bromodomain and extra-terminal domain (BET) inhibitors have been shown to provide therapeutic benefits against many different cancers. (medicalxpress.com)
The TGFβ superfamily includes several growth factors which are promising therapeutic targets for metabolic disorders and muscular dystrophies. (wada-ama.org)
The proactive development detection assays for therapeutic Fc-fusion proteins, TGFβ cytokines and TGFβ inhibitors is of great interest as several drugs of these categories are already available on the black market as well as for research purposes. (wada-ama.org)
Studies have therefore proposed that blocking ACVR1 kinase activity may represent a useful therapeutic strategy for the DIPG subgroup carrying ACVR1 mutations 14 , 17 . (nature.com)
Compound (1) demonstrates superiority against the therapeutic gold standard paclitaxel by diminishing spheroid growth by 40% at 100 nM. (bath.ac.uk)
We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. (lu.se)

This study revealed that the C1-C10b double bond is required for inhibition of this crucial metabolizing enzyme. (mcmaster.ca)
By specifically binding to MEK 1 and 2, GSK'212 may result in an inhibition of cellular signalling and cellular growth in certain cancers. (gsk.com)
The significant growth inhibition by the steroid sulfatase and aromatase inhibitors were also observed in the co-culture system. (scirp.org)
Table 1 A listing of medical studies looking into EGFRi therapies for the treating breast malignancy metastasis, cells produced from pulmonary metastases are inherently resistant to EGFRi and go through robust development inhibition in response to EGF. (bio-biz-navi.com)
1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
Synthesis, in vitro transcription inhibition assays, and biological testing of the hybrids identified a range of potent anti-transcription inhibitors with activity against a range of pathogenic bacteria with MICs as low as 3.1 μM. (edu.au)
A structure activity relationship study identified the key structural components necessary for inhibition of both bacterial growth and transcription. (edu.au)
Using tumor cells (HeLa), the researchers demonstrated in cell culture that inhibition of HDAC10 by DKFZ-748 curbed cancer cell growth when sufficient polyamines were not available. (dkfz.de)
Cellular studies with O(6)-cyclohexylmethyl-2-(4'- sulfamoylanilino) purine demonstrated inhibition of MCF-7 cell growth and target protein phosphorylation, consistent with CDK1 and CDK2 inhibition. (rcsb.org)
Based on enzymatic studies, that is galactosylation and its inhibition, conformational analysis and molecular modeling using the crystal structure, we propose that the binding pocket of beta 4GalT7 is very narrow, with a precise set of important hydrogen bonds. (lu.se)

When BET inhibitors block BET proteins, it causes the reduction of tumor growth. (pharmacytimes.com)
Researchers have known that BET inhibitors can halt tumor growth, but whether or not the drugs are able to kill cancer cells completely or just pause their growth has been unclear. (pharmacytimes.com)
Regular ultrasound checks of the kidneys are important to make sure there is no tumor growth. (medlineplus.gov)
Angiotensin II is now regarded as a tumor growth promoter via angiogenesis from activation of the VEGF pathway[ 4 - 6 ]. (jcancer.org)
Inactivating immune system checkpoints such as PD-1 and treating cells with 4SC-202 can inhibit tumor growth. (genengnews.com)

Technavio has been monitoring the corrosion inhibitors market and it is poised to grow by $ 2.22 bn during 2021-2025, progressing at a CAGR of 5.22% during the forecast period. (marketresearch.com)
Corrosion Inhibitors Market was valued at USD 7.9 billion in 2021 and is projected to reach USD 10.1 billion by 2026 globally, growing at a cagr 4.9% from 2021 to 2026. (marketsandmarkets.com)

The efficacy of vascular endothelial growth factor (VEGF), COX-2, calcium and aromatase inhibitors in an ovarian hyperstimulation syndrome (OHSS) rat model was tested. (nih.gov)
However, its proliferation was significantly decreased by the treatment of steroid sulfatase or aromatase inhibitors. (scirp.org)
We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)

The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. (cdc.gov)
c-Src potentiates proliferation, survival, and invasiveness in response to epidermal growth factor (EGF) in human mammary carcinoma cells. (aspetjournals.org)
Olaparib is also approved by US Food and Drug Administration (FDA), European Medicines Agency (EMA) and in other countries for treating women with BRCA-mutated, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer. (cancersa.org.au)
Updated Overall Survival and Exploratory Analysis From Randomized, Phase II EVAN Study of Erlotinib Versus Vinorelbine Plus Cisplatin Adjuvant Therapy in Stage IIIA Epidermal Growth Factor Receptor+ Non-Small-Cell Lung Cancer. (cdc.gov)
Comparison of afatinib and erlotinib combined with bevacizumab in untreated stage IIIB/IV epidermal growth factor receptor-mutated lung adenocarcinoma patients: a multicenter clinical analysis study. (cdc.gov)

The studies will separately assess the efficacy and safety of two investigational agents, GSK2118436 and GSK1120212, to determine their individual ability to stop or slow the progression of skin cancer in patients whose tumours contain a BRAF V600 mutation, which occurs in 50 to 60 percent of melanoma patients. (gsk.com)
The studies will separately assess the efficacy and safety of two investigational agents, GSK2118436 and GSK1120212, to determine their individual ability to stop or slow the progression of skin cancer in patients whose tumours contain a BRAF V600 mutation, which occurs in 50 to 60 percent of melanoma patients.Commencement of these studies confirms previously announced plans to progress these assets into Phase III. (gsk.com)
BRF113683 is a Phase III, randomised, open-label study comparing the efficacy, safety, and tolerability of GSK'436 to DTIC in patients with advanced (Stage III) or metastatic (Stage IV) melanoma who harbour a BRAF V600 mutation. (gsk.com)
The BET and GSK3 inhibitor combination shows remarkable efficacy but also no increase in toxicity because the GSK3 and BET inhibitors synergize, but on its own, the GSK3 inhibitor doesn't seem to have an effect. (medicalxpress.com)
Tildrakizumab for Psoriasis Shows Durable Efficacy Over 5 Years The full 5-year results of a study of tildrakizumab for psoriasis show a high rate of sustained disease control coupled with a favorable safety profile during more than 5400 patient-years of follow-up. (medscape.com)
Beyond showing how BMP signaling impacts DIPG, our study also identified the potent antitumor efficacy of Dacinostat for DIPG. (nature.com)
This study evaluated the safety and efficacy of switching HIV-infected patients with stable viral suppression on nonnucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) therapy to lopinavir/ritonavir (LPV/r) monotherapy. (researchgate.net)
Preclinical studies also suggest INCB059872 could help combat small-cell lung cancer and Ewing Sarcoma, and clinical trials are currently underway to test the drug's efficacy in patients with sickle-cell disease, as well as its safety in patients with advanced malignancies. (genengnews.com)
This is an open-label, randomized, multicentre study to evaluate safety and preliminary efficacy of the human anti-CD19 antibody Tafasitamab in addition to R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristin, Prednison) or Tafasitamab and Lenalidomide in addition to R-CHOP in adult patients with newly diagnosed, previously untreated Diffuse Large B-cell Lymphoma (DLBCL). (clinicaltrials.gov)

Studying the different check points of the VEGF pathway, we conclude that targeting calcium pathways could be beneficial for the vascular permeability control in an OHSS animal model. (nih.gov)
The other inhibitor blocks the action of vascular endothelial growth factor (VEGF), which stimulates the growth of new blood vessels that tumors need to grow beyond a certain size. (sciencedaily.com)
When we combined our peptide HER-2 inhibitor with the VEGF peptide that inhibits angiogenesis, we observed significant additive benefits in reducing tumor burdens in preclinical studies," says principal investigator Pravin Kaumaya, professor of obstetrics and gynecology, of molecular and cellular biochemistry, and of microbiology, and director of the division of vaccine development at the OSUCCC -- James. (sciencedaily.com)
Peptide inhibitors consist of short chains of amino acids (the VEGF inhibitor is 22 amino acids long) that conform in shape to the active site of the target receptor. (sciencedaily.com)
Background Vascular endothelial growth factor (VEGF) is produced by bladder cancer cell lines in vitro and expressed in human bladder tumor tissues. (johnshopkins.edu)
In animal studies, ACEI administration has led to decreased neo-vascularization and VEGF levels[ 7 , 8 ]. (jcancer.org)

the other describes the HER-2 inhibitor and the preclinical testing of the two agents together. (sciencedaily.com)
Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
Preclinical tests show that the inhibitor can change the microenvironment of a tumor by increasing populations of antitumor immune cells in the area. (genengnews.com)

Although histone deacetylase (HDAC) inhibitors are known to suppress synovial sarcoma in vitro and in vivo , the exact mechanism is not clear. (nature.com)
2006). Anticancer activities of histone deacetylase inhibitors. (nature.com)
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
Findings from a study at The University of Texas MD Anderson Cancer Center revealed the leukemia-boosting abilities of ENL, which contains a protein component called YEATS that "reads" histone proteins. (mdanderson.org)
Research results, which build upon a previous MD Anderson study of histone-reading proteins, are published in the March 1 online issue of Nature . (mdanderson.org)
Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
Recent achievements highlight the accelerated development of epigenetics, such as the definition of a human DNA methylome at single-nucleotide resolution, the various discoveries of histone variants and modifications, the study of the CpG island in the genome, and the progress of genome-wide nucleosome positioning maps ( Baldi, 2019 ). (frontiersin.org)
Research has shown that lysine-specific histone demethylase 1 (LSD1) plays an essential role in the self-renewal of these "leukemic stem cells," Incyte principal investigator Sang Hyun Lee, Ph.D., tells GEN . Building on this finding, Dr. Lee and colleagues developed an LSD1 inhibitor called INCB059872, which spurs myeloid cell differentiation. (genengnews.com)

This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. (wikipedia.org)

The results of this study may aid in achieving improved clinical responses from patients treated with STS inhibitors. (scirp.org)
Drug resistance to fibroblast growth factor receptor inhibitors (FGFR) has emerged as a major challenge to their clinical use. (mayo.edu)
Combined peptide inhibitors might be appropriate in several types of cancer to overcome acquired resistance and provide clinical benefit," he adds. (sciencedaily.com)
Other categories of targeted drugs in clinical use are humanized monoclonal antibodies and small-molecule TKI inhibitors. (sciencedaily.com)
Future studies are further needed to address their off-target effects and cytotoxicity to improve their clinical translation. (frontiersin.org)
In addition, fascial fibroblasts express transforming growth factor-beta I and connective-tissue growth factor mRNA, which may account for the clinical fibrosis. (medscape.com)
Proper use of these scores will help early identify PNF, standardize grading of EAF and reasonably select clinical endpoints in relative studies. (bvsalud.org)

This project studies the influence of IDH1/2 mutations on tumor environment in vitro and in vivo. (mayo.edu)
Depletion of ENL led to anti-leukemic effects, suppressing growth both in vivo and in vitro. (mdanderson.org)
The effects of PIP5K1α and its inhibitor on growth and invasion of BC were confirmed by using in vitro assays including. (lu.se)
Functional studies revealed that ectopic expression of BEST4 promoted CRC cell proliferation and metastasis, whereas the depletion of BEST4 had the opposite effect both in vitro and in vivo. (bvsalud.org)
This study evaluated the in vitro effects of the combination of PKC412 and ara-C or daunorubicin, studying the effect of co-incubation, pre-incubation and sequential incubation of the drugs in patient samples and cell lines. (lu.se)

Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. (wikipedia.org)

Avanafil is a PDE5 inhibitor that inhibits cGMP degradation and thereby enhances the effects of NO in smooth muscle relaxation of the corpus cavernosum. (medscape.com)
BRAF inhibitor GSK'436 binds to and inhibits the activity of BRAF, which may inhibit the proliferation of tumor cells containing a mutation in BRAF. (gsk.com)
PKC412 inhibits the growth of leukemic cell lines with FLT3 mutations such as the MV4-11. (lu.se)

In this study we used real-time reverse transcriptase polymerase chain reaction to evaluate erbB-2 expression in seven canine OSA cell lines and 10 canine OSA tissue samples. (cdc.gov)
Inhibitors of bacterial RNA polymerase transcription complex" by Daniel S. Wenholz, Michael Miller et al. (edu.au)
Olaparib is a type of drug called a PARP (poly [adenosine diphosphate-ribose] polymerase) inhibitor. (cancersa.org.au)

In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significantly increased after HDAC inhibitor treatment. (nature.com)
On the contrary, EGR1 knockdown leads to a decrease in HDAC inhibitor-induced apoptosis. (nature.com)
Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of PTEN contributes to HDAC inhibitor-induced apoptosis in synovial sarcoma. (nature.com)
Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
However, in order to study the exact function of HDAC10, only non-specific inhibitors have been available so far, which also block a number of other HDAC family members. (dkfz.de)
Based on this specificity, the DKFZ team succeeded in synthesizing a highly specific HDAC10 inhibitor on the basis of an already known drug that does not selectively block HDAC enzymes. (dkfz.de)
Like the developers of LSD1 combination therapies, 4SC AG researchers are pairing an epigenetic drug, in this case an HDAC inhibitor, with immunotherapies. (genengnews.com)

This study elevates the status of trans-dihydronarciclasine (5) as a highly privileged, readily available molecule, with potent and selective anticancer activity. (mcmaster.ca)
A new study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells. (sciencedaily.com)

ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are the two widely used RAS antagonists. (jcancer.org)

The new inhibitor is 1,000-fold more potent than the parent compound (K(i) values for CDK1 = 9 nM and CDK2 = 6 nM versus 5,000 nM and 12,000 nM, respectively, for O(6)-cyclohexylmethylguanine). (rcsb.org)
The work represents the first successful iterative synthesis of a potent CDK inhibitor based on the structure of fully activated CDK2-cyclin A. Furthermore, the potency of O(6)-cyclohexylmethyl-2-(4'- sulfamoylanilino)purine was both predicted and fully rationalized on the basis of protein-ligand interactions. (rcsb.org)

GlaxoSmithKline (GSK) announced today the start of two global Phase III studies in advanced or metastatic melanoma patients with a BRAF V600 mutation. (gsk.com)
The BRF113683 Phase III study compares GSK'436, a BRAF inhibitor, to dacarbazine (DTIC) in previously untreated patients with BRAF V600 mutated advanced or metastatic melanoma. (gsk.com)
The METRIC study compares GSK'212, a MEK inhibitor, to chemotherapy (DTIC or paclitaxel) in advanced or metastatic melanoma patients with a BRAF V600 mutation. (gsk.com)
By focusing our research programme on patients with the V600 mutation, we are striving to understand how our investigational MEK and BRAF inhibitors can best be used to treat patients with metastatic melanomA," said Paolo Paoletti, President, GSK Oncology. (gsk.com)
The METRIC Phase III study of GSK'212, a MEK inhibitor, in patients with advanced/metastatic melanoma focuses on patients with BRAF V600 mutation who have had no more than one prior regimen of chemotherapy and no prior BRAF inhibitor treatment. (gsk.com)
The METRIC study has begun dosing patients. (gsk.com)
Based on a recent report [ 2 ], the mortality of ARDS was 40-45% among patients in observational studies and 35-40% among those in randomised controlled trials. (ersjournals.com)
Transforming growth factor (TGF)-β, especially its isoform TGF-β1, is a profibrotic cytokine that is overexpressed in patients with fibrosis and was directly associated with fibrosis in multiple human settings and animal models [ 5 ]. (ersjournals.com)
The study, published in the August 1 issue of Cancer Research, a journal of the American Association for Cancer Research, suggests a potential role for COX-2 inhibitors in pancreatic cancer prevention among high-risk patients. (eurekalert.org)
A 2-stage phase II study was conducted to assess the activity and toxicity profile of pazopanib in patients with metastatic, urothelial carcinoma. (johnshopkins.edu)
The study will evaluate the safety and effectiveness of the candidate in nearly 660 patients, including adults and adolescents with 50% or greater scalp hair loss. (nasdaq.com)
Yet, it is conspicuous that no studies have considered the possible involvement of BMP signaling in the etiology of the remaining DIPG cases (that is, fully 60% of DIPG cases occur in patients carrying wild-type (WT) ACVR1 and H3K27M). (nature.com)
Given the paucity of literature guiding dermatologists in this process, a systematic review was performed to better understand the physiologic changes of hair in patients on masculinizing and feminizing hormonal therapy as well as the variety of treatment options that exist to help transgender patients to attain their desired hair growth pattern. (springer.com)
however, supplemental treatments are frequently required to achieve the hair growth patterns that patients desire. (springer.com)
As altering patterns of hair growth continue to play an integral part in the affirmation of gender in patients with gender dysphoria, the relevance of dermatologic techniques must be emphasized. (springer.com)
Patients were seen every 4 weeks throughout the 48-week study. (researchgate.net)
Our study revealed the prognostic value of PRGs in PAAD and created a reliable model for predicting the prognosis of PAAD patients. (hindawi.com)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
In patients with an established diagnosis of hemophilia B, laboratory evaluations include periodic screening for the presence of FIX inhibitor and screening for transfusion-related or transmissible diseases such as hepatitis and HIV. (medscape.com)
The distinction is clinically significant, as patients with low-titer inhibitors may respond to higher doses of FVIII concentrate. (medscape.com)
METHODS: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. (bvsalud.org)
The aim of the present study was to eluci- date the biology and prognostic role of the second ER, ERh, in patients treated with adjuvant tamoxifen. (lu.se)
This study assessed its validity in determining cerebral small vessel disease in patients with type 2 diabetes mellitus. (who.int)
La vitesse d'écoulement du flux sanguin et l'index de pulsatilité ont été mesurés dans les artères carotides internes intercrâniennes, les artères basilaires et cérébrales moyennes d'un échantillon de 141 patients diabétiques sans autre facteur de risque et de 132 témoins en bonne santé appariés pour l'âge et le sexe. (who.int)
Les patients ont été répartis en deux groupes : 73 patients souffrant d'un diabète compliqué dans le premier groupe et 68 patients atteints d'un diabète non compliqué dans le deuxième groupe. (who.int)
Influence of esomeprazole on the bioavailability of afatinib: A pharmacokinetic cross-over study in patients with non-small cell lung cancer. (cdc.gov)

The ErbB inhibitor PD158780 and the mitogen-activated protein kinase kinase inhibitor U0126 also markedly inhibited NHK proliferation, migration, and amphiregulin production. (aspetjournals.org)

Tadalafil is a PDE5-selective inhibitor that is chemically unrelated to sildenafil and vardenafil. (medscape.com)
Second posthypoxic cellular viability in the presence and absence of the nonselective and selective Akt inhibitors was assessed. (biongenex.com)
Our study examined the effect of a selective Rho kinase inhibitor, Y-27632, on corneal wound healing and potential stromal scarring after superficial keratectomy. (molvis.org)
Scientists from the German Cancer Research Center (DKFZ) have now for the first time synthesized a highly selective inhibitor that can be used to study the function of HDAC10. (dkfz.de)

33,34 Furthermore, the acknowledged growth-promoting functions of estrogen in BC are in conjunction with accounts of estrogen-induced apoptosis, termed the estrogen paradox perfectly examined in Jordan and Ford. (bio-biz-navi.com)
A study published in Leukemia found that BET inhibitors primarily kill cancer cells through apoptosis. (pharmacytimes.com)
We found that when apoptosis was impaired, for instance by loss of BIM, the BET inhibitors were no longer effective," said researcher Zhen Xu. (pharmacytimes.com)
This suggests that cancer cells that acquire mutations in genes that drive apoptosis will lose sensitivity to BET inhibitors and thus will be able to survive treatment, leading to disease relapse. (pharmacytimes.com)

Akt also regulates the mammalian target of rapamycin (mTOR)-S6K-S6 pathway to control cell growth in response to growth factors and nutrients. (aacrjournals.org)
Herein, we sought to determine if rapamycin, an inhibitor of mTOR, could enhance erlotinib sensitivity for cell lines derived from a variety of tissue types (non-small-cell lung, pancreatic, colon, and breast). (aacrjournals.org)
Brain tumors can be treated with medicines called mTOR inhibitors (sirolimus, everolimus). (medlineplus.gov)
mTOR inhibitors are being studied as another treatment for kidney tumors. (medlineplus.gov)

Corrosion inhibitors are used in applications, such as water treatment, process & product additives, and oil & gas production in various end-use industries, including power generation, oil & gas and refinery, metal & mining, pharmaceutical and utilities, among others. (marketsandmarkets.com)
The corrosion inhibitor market is rapidly growing in water treatment sectors across the globe. (marketsandmarkets.com)
Cooling water is the largest segment for corrosion inhibitors in the water treatment process to protect the metal machinery from the water flow. (marketsandmarkets.com)
The Hepatobiliary Cancer Laboratory is engaged in ongoing basic science research projects that study diagnosis, treatment and prevention of hepatocellular carcinoma and hepatobiliary cancers. (mayo.edu)
Through this study, the research team is detecting the function of UCK2 and determining whether this gene can be a potential target for treatment of hepatocellular carcinoma. (mayo.edu)
The Hepatobiliary Cancer Lab is identifying and characterizing fibroblast growth factor receptor family gene aberrations and determining the effectiveness of targeting the aberrations in the treatment of cholangiocarcinoma. (mayo.edu)
In September 2018, Pfizer announced data from the phase IIa study, which demonstrated that the candidate improved hair re-growth on the scalp compared to the baseline after 24 weeks of treatment. (nasdaq.com)
The findings indicated treatment against ENL with a class of experimental drugs called bromodomain and extra-terminal (BET) inhibitors may be effective for treating AML. (mdanderson.org)
Small growths on the face (facial angiofibromas) may be removed by laser treatment. (medlineplus.gov)
Some parts of this study are experimental, which means that durvalumab and the combination of olaparib and durvalumab are still in the development stage for the treatment of breast cancer, and they are not approved for treatment of breast cancer, except for use in research studies like this. (cancersa.org.au)
Our study suggests that our developed PIP5K1α inhibitor has a great potential on refining targeted therapeutics for treatment of triple-negative and ER+ BC with abnormal PI3K/AKT pathways. (lu.se)
Treatment must be individualized and based on susceptibility studies. (cdc.gov)
Expand surveillance system capacity and availability of data on people living with birth defects, infant disorders, and disabilities and conditions across the lifespan to monitor and study trends in screening, diagnosis, treatment, healthcare access, and outcomes. (cdc.gov)
2. Radiotherapy within 2 weeks prior to study treatment initiation. (who.int)
3. Major surgery or significant traumatic injury within 4 weeks of the first dose of study treatment. (who.int)
radiotherapy, surgery) and clinically stable off steroids for management of symptoms for at least 4 weeks prior to study treatment initiation. (who.int)
In addition, SAMS will evaluate prognostic factors, criteria for intervention and the effects of 5-alpha-reductase inhibitors, the outcome after treatment with curative intent, time to symptoms and metastases from prostate cancer, prostate cancer specific survival, and overall survival. (cancercentrum.se)

The primary endpoint of the study is progression free survival. (gsk.com)

MEK is a key component of the RAS/RAF/MEK/ERK signalling pathway that regulates cell growth. (gsk.com)
Thus, our study delineates context-dependent features of the BMP signaling pathway in a DIPG subtype. (nature.com)
On coagulation studies, the bleeding time and prothrombin time (which assesses the extrinsic coagulation pathway) are normal. (medscape.com)

Study first author Shaela Fields (Wright), from the lab of Chunliang, Li, PhD, St. Jude Department of Tumor Cell Biology, led research to understand BET inhibitor resistance. (medicalxpress.com)
The researchers found that loss of the SPOP gene causes significant BET inhibitor resistance, which they confirmed in cell lines and xenograft mouse models. (medicalxpress.com)
Shaela Wright et al, Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens, Proceedings of the National Academy of Sciences (2023). (medicalxpress.com)
The lab's research team is investigating the mechanisms of resistance to selected FGFR inhibitors. (mayo.edu)
Ethambutol (or streptomycin in children too young to be monitored for visual acuity) should also be included until the results of drug susceptibility studies are available, unless there is little possibility of drug resistance (see Section 1 above). (cdc.gov)
Six species in the insect resistance to neem compounds family Meliacea have been studied for pes- seems likely to be low [ 8-10 ]. (who.int)

In addition to our ongoing research in metastatic melanoma, we are also studying GSK'212 and GSK'436, both alone and in combination with other agents, in other difficult to treat forms of cancers including pancreatic cancer, refractory or relapsed leukaemias and other solid tumours. (gsk.com)

Because commercially available pharmacological inhibitors of Akt3 were not available at the time of this study RNA interference was used to assess sex differences in both Akt1/2- and Akt3-mediated posthypoxic survival. (biongenex.com)
In following studies, the mix of cetuximab with antimicrotubule brokers or topoisomerase inhibitors didn't increase patient general survival in comparison with one of these chemotherapies only, leading to early trial termination. (bio-biz-navi.com)

To test whether there is a sex difference in ME-induced cardioprotection following the blockade of PI3K posthypoxic cellular viability was assessed in the presence and absence of the dissimilar PI3K inhibitors LY-294002 and wortmannin. (biongenex.com)

More work needs to be done to test if JAK inhibitors can induce hair growth in humans using formulations specially made for the scalp. (nextbigfuture.com)
It's likely that the drugs act on the same pathways in human follicles as they do in mice, suggesting they could induce new hair growth and extend the growth of existing hairs in humans. (nextbigfuture.com)
Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). (nextbigfuture.com)
Information from studies of exposed humans and laboratory animals indicates that absorbed CDDs are distributed preferentially to fatty tissues and to a lesser extent, the liver (ATSDR 1998). (cdc.gov)

Christiano and her colleagues serendipitously discovered the effect of JAK inhibitors have on hair follicles when they were studying alopecia areata, a form of hair loss that's caused by an autoimmune attack on the hair follicles. (nextbigfuture.com)

Estrogens significantly contribute toward the growth and development of endometrial cancers. (scirp.org)
These new inhibitors are considered a promising new drug for treating blood cancers, such as lymphomas and leukemias. (pharmacytimes.com)
Studies of breast, colon, and pancreatic cancers have led researchers to believe COX-2 plays a key role in the development and growth of tumors. (eurekalert.org)
In addition, although still controversial, epidemiologic studies have found that the use of ACEIs was associated with decreased risk of developing cancers including solid and skin cancers[ 9 - 12 ]. (jcancer.org)

While EPO-Fc can be simultaneously detected with other recombinant erythropoietins by routine doping control assays, there are currently no tests for other doping-relevant Fc-fusion proteins such as the myostatin inhibitor ActRIIB-Fc (ACE031) or the cytokine GDF15/Fc, which is a member of the transforming growth factor beta (TGFβ) superfamily. (wada-ama.org)
Within this study, a proteomics-based detection assay for emerging Fc-fusion proteins relevant as performance-enhancing agents in sports will be developed. (wada-ama.org)
The aim of this research project was to develop detection assays for two emerging Fc-fusion proteins potentially relevant as performance-enhancing agents in sports: The TGF-β cytokine GDF-15/Fc and an ActRIIB-Fc fusion protein related to the TGF-β/myostatin inhibitor ACE-031. (wada-ama.org)
A more recent NMR pulsed-gradient, spin-echo misfolded proteins (Kelly, 1998), and the nucleation, growth, (PGSE) self-diffusion study concluded that BPTI is pre- and polymorphism of protein crystals (Rosenberger et al. (lu.se)

Because the pancreases of mice were analyzed at 10 months, before the typical appearance of pancreatic tumors, additional studies will be needed for researchers to conclude whether or not nimesulide can delay the onset of or prevent pancreatic cancer. (eurekalert.org)

What could be truly exciting, Dr. Lee notes, is the combination of LSD1 inhibitors with antibodies that block programmed cell death-1 (PD-1), a cell surface receptor that keeps the immune system in check. (genengnews.com)

Armed with this information, the researchers developed a combination therapy approach that uses both BET and GSK3 inhibitors against KMT2A mutated leukemia. (medicalxpress.com)
The researchers behind this report have studied the market conditions from the past and have forecasted the future market conditions. (pharmiweb.com)
Other Ohio State researchers involved in the two studies were Kevin C. Foy, Daniele Vicari, Eric Liotta, Zhenzhen Liu, Gary Phillips and Megan Miller. (sciencedaily.com)
PHILADELPHIA-- Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA. (eurekalert.org)
While inflammation has been shown to be a factor in many forms of cancer, the researchers say this is the first study to demonstrate the effect of an anti-inflammatory COX-2 inhibitor on the development of pancreatic cancer. (eurekalert.org)
By stalling the growth of PanINs, researchers hope to slow the development of or prevent pancreatic cancer. (eurekalert.org)
Inhibiting a family of enzymes inside hair follicles that are suspended in a resting state restores hair growth, a new study from researchers at Columbia University Medical Center has found. (nextbigfuture.com)
When the researchers looked more closely at normal mouse hair follicles, they found that JAK inhibitors rapidly awakened resting follicles out of dormancy. (nextbigfuture.com)
JAK inhibitors trigger the follicles' normal reawakening process, the researchers found. (nextbigfuture.com)

ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may have anti-tumor properties. (jcancer.org)

A multiple linear regression (MLR) analysis has shown that electronic properties of these compounds are the governing factors of their activity and docking study has shown that compounds can form hydrogen bonds with the receptor and have effective steric interactions involving dispersion forces. (alquds.edu)
Removing the acetyl group makes the polyamines usable by tumor cells, which rely on these compounds for growth," said Raphael Steimbach, lead author of the study, explaining a newly discovered function of HDAC10. (dkfz.de)
There aren't many compounds that can push hair follicles into their growth cycle so quickly," said Dr. Christiano. (nextbigfuture.com)

In order for these inhibitors to successfully kill myeloid leukemia and lymphoma cells, the protein BIM has to be present. (pharmacytimes.com)

Global Neuraminidase Inhibitors Drug Market 2020 Industry. (pharmiweb.com)
Global Neuraminidase Inhibitors Drug Market Growth (Status and Outlook) 2020-2025 showcases the market's comprehensive study and reliable market statistics. (pharmiweb.com)

To study the effects of COX-2 on PanIN progression, Dr. Eibl and colleagues focused on the KrasG12D mouse, an animal model that mimics the early stages of pancreatic cancer. (eurekalert.org)
In the future, Dr. Eibl and others plan to study the long-term effects of nimesulide and additional COX-2 inhibitors on the onset and progression of pancreatic cancer. (eurekalert.org)

In this study, we aimed to evaluate the possible effects of tumor-stromal interactions on local estrogen biosynthesis in endometrial cancer. (scirp.org)
We also assessed the biological effects of inhibitors of steroid sulfatase and aromatase in the co-culture system compared with usual monocultures. (scirp.org)
Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
In this study, we tested the effects of several potential inhibitors of microbial growth. (usda.gov)
The effects of the CH4-inhibitors nitroethane (2 mg/mL), 2-nitro-1-propanol (2 mg/mL), lauric acid (5 mg/mL), the commercial product Lauricidin® (5 mg/mL), and a finely ground product of the Hawaiian marine algae, Chaetoceros (10 mg/mL), were compared in pure cultures of Streptococcus agalactia, Enterococcus faecium, Streptococcus bovis, and in a mixed lactic acid rumen bacterial culture. (usda.gov)
Using mouse models and tumor organoids, this study reported a tripartite motif 21 (TRIM21) protein, exerting potential inhibitory effects on the invasion and metastasis of CRC. (bvsalud.org)
The combination of Lonafarnib, a farnesyl-transferase inhibitor (FTI) and PKC412 had additive and synergistic effects in both FLT3/ITD positive and negative cell lines. (lu.se)

The study will be conducted in Australia, Argentina, Russia and several countries within North America and Europe. (gsk.com)

Our study revealed ENL as a chromatin reader that regulates oncogenic programs, thus establishing ENL as a potential drug target for AML. (mdanderson.org)

The increased potency arises primarily from the formation of two additional hydrogen bonds between the inhibitor and Asp 86 of CDK2, which facilitate optimum hydrophobic packing of the anilino group with the specificity surface of CDK2. (rcsb.org)

Ruxolitinib Cream Meets Endpoints in Phase 3 Vitiligo Trial A topical formulation of the JAK inhibitor ruxolitinib produced statistically significant improvement in all primary and secondary outcomes relative to vehicle alone at 24 weeks. (medscape.com)
Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-MacGregor M. Use of ACE Inhibitors and Angiotensin Receptor Blockers and Primary Breast Cancer Outcomes. (jcancer.org)

Tumor tissue for retrospective central pathology review and correlative studies must be provided. (clinicaltrials.gov)

The report analysts have collected and segregated data for the global Neuraminidase Inhibitors Drug market. (pharmiweb.com)
The report sheds light on important aspects such as global Neuraminidase Inhibitors Drug market segmentation, regional analysis, and company profiles of market players involved in the business. (pharmiweb.com)
The market size section provides historical forecasts for global Neuraminidase Inhibitors Drug market growth and the future. (pharmiweb.com)
Both TGF-β inhibitors and the cytokines themselves have been pursued as drug candidates. (wada-ama.org)
Two JAK inhibitors have been approved by the U.S. Food and Drug Administration. (nextbigfuture.com)
Christiano and colleagues reported last year that JAK inhibitors shut off the signal that provokes the autoimmune attack, and that oral forms of the drug restore hair growth in some people with the disorder. (nextbigfuture.com)

Currently, PF-06651600 enjoys breakthrough therapy designation, which was granted based on positive data from the successfully completed phase IIa study. (nasdaq.com)
Cytokines of the TGF-β superfamily as well as their inhibitors are currently being evaluated as potential protein drugs for the therapy of a variety of diseases such as metabolic disorders and muscular dystrophies. (wada-ama.org)
This study to learn more about olaparib and olaparib plus durvalumab combination therapy and also to better understand the studied disease, breast cancer, and associated health problems. (cancersa.org.au)
Further research into eosinophilic fasciitis has shown elevations of transforming growth factor-beta and interleukin 5, which normalize with corticosteroid therapy. (medscape.com)

Fusions of fibroblast growth factor receptor genes with other partner genes were recently discovered in cholangiocarcinoma. (mayo.edu)
The shape of the peptide HER-2 inhibitor engineered by Kaumaya and his colleagues, for example, is highly specific for the HER-2 receptor. (sciencedaily.com)
It physically binds to the receptor, which prevents another substance, called epithelial growth factor, from contacting the receptor and stimulating the cancer cells to grow. (sciencedaily.com)

Mice treated for five days with one of two JAK inhibitors sprouted new hair within 10 days, greatly accelerating the onset of hair growth. (nextbigfuture.com)

In experiments with mouse and human hair follicles, Angela M. Christiano, PhD, and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when applied to the skin. (nextbigfuture.com)
The study raises the possibility that JAK inhibitors could be used to restore hair growth in forms of hair loss induced by male pattern baldness, and other types of hair loss that occur when hair follicles are trapped in a resting state. (nextbigfuture.com)
Little to no hair growth occurred in control mice during the same timeframe (left photo). (nextbigfuture.com)

Technavio's market research reports provide a complete competitive landscape and an in-depth vendor selection methodology and analysis using qualitative and quantitative research to forecast the accurate market growth. (marketresearch.com)
Fundamental progress in these diverse fields and small-angle x-ray scattering (SAXS) studies (Lafont must ultimately be based on a quantitative understanding of et al. (lu.se)

Mouse studies have suggested that Acvr1 G328V cooperates with Hist1h3b K27M and Pik3ca H1047R to generate high-grade diffuse gliomas, specifically by arresting the differentiation of oligodendroglial lineage cells 16 . (nature.com)
Mammalian cells produce PGs, which are involved in biological processes such as cell growth and differentiation. (lu.se)

CONCLUSION: University students in Lebanon in this study have relatively low rates of use and abuse of substances but this might be changing. (who.int)

MEK 1 and 2 are thought to play a role in the activation of key signalling pathways that regulate cell growth.In BRAF mutant melanoma, MEK activation is a driver of the disease. (gsk.com)

The work demonstrated that the combination could impede the growth of leukemia cells. (medicalxpress.com)
Notably, disrupting ENL further sensitized leukemia cells to BET inhibitors. (mdanderson.org)

Laboratory studies for suspected hemophilia B include a complete blood cell count, coagulation studies, and a factor IX (FIX) assay. (medscape.com)
Laboratory confirmation of a FIX inhibitor is clinically important when bleeding is not controlled after adequate amounts of factor concentrate are infused during a bleeding episode. (medscape.com)
Enhance laboratory safety, quality, and excellence in science while improving early detection of inhibitors in people with bleeding disorders. (cdc.gov)

Anatomy11

Organisms4

Diseases2

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes22

Information Science3

EGFR10

Tyrosine3

Small-molecule inhibitors4

Kinase inhibitors5

Therapeutic7

Inhibition11

Tumor growth5

20212

Aromatase inhibitors3

Epidermal growth5

Efficacy9

VEGF6

Preclinical3

Histone8

Angiogenesis1

Clinical7

Vitro5

Vascular1

Inhibits3

Polymerase3

HDAC8

Anticancer2

Antagonists1

Potent2

Patients26

Proliferation1

Selective4

Apoptosis4

MTOR4

Treatment17

Primary endpoint1

Pathway3

Resistance6

Metastatic1

Survival2

PI3K1

Humans4

Alopecia areata1

Cancers4

Proteins4

Tumors1

Antibodies1

Researchers9

Anti-tumor1

Compounds3

Myeloid1

20202

Progression2

Effects7

North America1

Chromatin1

Hydrogen bonds1

Outcomes2

Correlative1

Drug6

Therapy4

Receptor3

Onset1

Hair Growth3

Quantitative2

Differentiation2

Substances1

Pathways1

Leukemia2

Laboratory3