Study diabetic fatty rats zucker. Medical search. Frequent questions

Several reports support the notion that an increase in plasma free fatty acids (FFAs) is key in the development of insulin resistance and T2D ( 2 - 4 ). (frontiersin.org)

Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)
Anti-diabetic drugs such as metformin and rosiglitazone have been reported to act via modulation of the TGF-β signaling pathway. (frontiersin.org)
Alternatively, such findings may simply reflect the limitations of current anti-diabetic therapies, due to off-target effects that counter the potential benefits of glucose lowering. (ddw-online.com)
Objective: This review aims at summarizing the current state of knowledge of the pharmacological potential of V and the mechanisms underlying its anti-viral, anti-bacterial, anti-parasitic, anti-fungal, anti-cancer, anti-diabetic, anti-hypercholesterolemic, cardioprotective, and neuroprotective activity as well as the mechanisms of appetite regulation related to the possibility of using this element in the treatment of obesity. (nutrahacker.com)
Abstract Cocoa constitutes one of the richest sources of dietary flavonoids with demonstrated anti-diabetic potential. (biosferteslab.com)

Researchers in Spain have analyzed the effects of melatonin on obesity, dyslipidemia and high blood pressure in young diabetic obese rats. (sciencedaily.com)
University of Granada researchers have analyzed in young Zucker diabetic obese rats the effects of melatonin on obesity, dyslipidemia and high blood pressure associated with obesity. (sciencedaily.com)
Rimonabant reduced basal hypersecretion in islets from obese rats and GL-treated low fat rats without reducing the fold upsurge in GSIS. (bioskinrevive.com)

In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
He works on molecular therapeutics and also studies the connections between obesity and cancer. (newswise.com)
a study in human skeletal muscle biopsies of young lean and older individuals with obesity. (bioblast.at)
Background Genome-wide association studies (GWAS) are useful to reveal an association between single nucleotide polymorphisms and different measures of obesity. (uni-regensburg.de)
Although not all studies are unanimous [ 11 - 13 ], most agree that this type of training is also a time-effective alternative to MICT, leading to higher weight loss, particularly visceral fat mass, and better improvement of the metabolic profile and cardiorespiratory fitness in people with obesity [ 14 - 16 ]. (hindawi.com)
Studies have yet to be done on the effect of taurine on obesity in humans. (wikidoc.org)
Abstract Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. (biosferteslab.com)

METHODS AND PROCEDURES Animals Islets were isolated from 7- to 11-week-old male ZF and Zucker diabetic rats and their lean siblings. (bioskinrevive.com)
Methods: It was an experimental study carried out at the Department of Biochemistry & Molecular Biology, Army Medical College, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan, from Jun 2014 to Oct 2018. (nutrahacker.com)

Moreover, it did not cause a plasma volume increase or a cardiac enlargement in Wistar-Imamichi rats, even at 100 mg/kg. (rcsb.org)
rect in both Wistar rats and diabetic fatty Zucker rats One unit of DP IV activity is defined as the release of 1.0 ␮mol/lnitroaniline (yellow product) per minute measured spectrophoto- (9, 10). (health-abstracts.com)
36 Wistar rats were divided into normal diet (ND) (control, RET, AET) and high-fat diet (HFD) + STZ (control, RET, AET) groups. (biomedcentral.com)

At 6weeks of age, Zucker lean control (ZLC) and Zucker diabetic fatty (ZDF) rats were put on a treadmill with or without running for 1h/session/day for 5weeks. (mcmaster.ca)
The objective of this study was to investigate the effects of melatonin in diabetes in relation to the levels and regulation of plasma chromium (Cr), vanadium (V), and magnesium (Mg) in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. (uaeu.ac.ae)
Figure 3: Macrophage content and Nlrp3 expression in islets of lean and diabetic rats. (nature.com)
As expected basal secretion was significantly elevated in islets from obese or GL-treated lean rats whereas the fold increase in GSIS was diminished. (bioskinrevive.com)
The abbreviations used for lean siblings of the obese (153-353 g) and obese diabetic (178-396 g) are ZL and ZL-D respectively. (bioskinrevive.com)
Interestingly, the expression pattern in the hypothalamus showed no differences between obese ZDF and lean ZL rats. (uni-regensburg.de)

Diabetes was induced by the intraperitoneal injection of STZ in male Sprague-Dawley rats. (hindawi.com)
Eight-week-old male Sprague-Dawley rats (Guangdong Medical Laboratory Animal Center, Foshan, China) weighing 200-220 g were adopted for this study. (hindawi.com)
The study was carried out on 105 Sprague Dawley rats for duration of 24 weeks. (nutrahacker.com)

The aim of the current study was to predict changes in plasma methionine and homocysteine concentrations after simulated consumption of methionine-rich foods, following the development of a mathematical model for MMC in Zucker Diabetic Fatty (ZDF) rats, as a representative T2DM animal model. (biomedcentral.com)
Thus, 0we hypothesized that long-term administration of a high-methionine diet to T2DM rats with normal renal function may create metabolic changes, culminating in an elevated level of circulating homocysteine. (biomedcentral.com)
Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta cell failure resulting in uncompensated hyperglycemia, a process replicated in the Zucker diabetic fatty (ZDF) rat. (nature.com)
An emerging lesser known, but potentially fatal complication of T2DM is the accumulation of fat in hepatocytes (steatosis), that leads to the chronic liver disorder Non-Alcoholic Fatty Liver Disease (NAFLD) and its more advanced form, Non-Alcoholic Steato-Hepatitis (NASH). (ddw-online.com)
Prospective studies in T2DM have shown an association between the degree of hyperglycemia and the risk of micro- and macrovascular complications, including fatal CVD events. (ddw-online.com)
New therapeutics must therefore address the multi-factorial nature of T2DM, and aim to treat diabetic patients at an earlier stage of the disease, if pharmacological interventions hope to halt the epidemic. (ddw-online.com)

This mitochondrial adaptation failed to rescue the progressive development of insulin resistance in fa/fa rats. (bioblast.at)

Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. (jci.org)
Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)
Paksu MS, Kalkan G, Asilioglu N, Paksu S, Dinler G. Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis. (medscape.com)
Remarkably, reduced fat oxidative capacity in 6-week-old fa/fa rats was compensated for by an adaptive increase in intrinsic mitochondrial function at week 12, which could not be maintained toward week 19 (140.9 +/- 11.2 and 57.7 +/- 9.8 nmol O(2)/mg/min, weeks 12 and 19, respectively), whereas hyperglycemia had developed (13.5 +/- 0.6 and 16.1 +/- 0.3 mmol/l, weeks 12 and 19, respectively). (bioblast.at)
rent hyperglycemia, accounts for ninety to ninety-five circulating amount of active glucagon-like peptide-1 percent of diagnosed diabetic patients (1). (health-abstracts.com)

Plasma Mg levels were significantly lower in C-ZDF vs. C-ZL rats, demonstrating the presence of hypomagnesemia in this diabetes mellitus model. (uaeu.ac.ae)
Therefore, AVANDIA should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. (healthyplace.com)
PubMed database was searched, from November to December of 2008, and several studies comprising the current and classic literature were listed, using the following uniterms: periodontitis and diabetes mellitus. (bvsalud.org)
Conclusion: In present study examination exhibits that hypertension and diabetes mellitus have an independent positive impact on left ventricular diastolic dysfunction. (fortuneonline.org)
The recurrence of diabetes mellitus is enormously expanding on the planet about 40% of patients with diabetes present with diastolic dysfunction and pervasiveness of diabetes in grown-ups overall was assessed to be 4% in 1995 and to ascend to 5.4% continuously 2025 and will be a 42% expansion in diabetic patients in the created nations and 70% expansion in the creating nations constantly 2025 [3]. (fortuneonline.org)

Melatonin administration ameliorates glucose homeostasis in Zucker diabetic fatty (ZDF) rats. (uaeu.ac.ae)

Although hepatic gene expression, content, and activity of XO increased significantly in diabetic rats, febuxostat only slightly decreased its content. (hindawi.com)
Figure 1: Effects of peripheral CB 1 R blockade on body weight, adiposity, hepatic lipogenesis and glycemic control in ZDF rats. (nature.com)

Figure 4: Effects of macrophage depletion on glycemic control and proinflammatory signaling in islets of ZDF rats. (nature.com)
Ten of these studies presented beneficial results regarding to the glycemic control. (bvsalud.org)

For many years, several mechanisms including renal hemodynamic alterations, renin-angiotensin-aldosterone system (RAAS) activation, inflammatory pathways, and reactive oxygen species (ROS) were widely studied in DKD, and various corresponding therapeutic agents have been developed [ 2 ]. (hindawi.com)
Criteria for eligibility were animal-based studies, evaluating the therapeutic effects of vanadium on inflammatory and oxidative stress biomarkers in diabetes. (nutrahacker.com)
The majority of the studies confirmed the advantageous properties of vanadium on inflammatory and oxidative stress biomarkers. (nutrahacker.com)
MetAssist from Cornerstone Wellness is a collection of several key nutraceuticals that have demonstrated clinical efficacy in multiple published, peer reviewed studies to lower insulin and serum glucose levels, lower inflammatory markers, decrease appetite and feeding behavior resulting in demonstrated loss of body weight as much as 5.4% in 8 weeks. (iprogressivemed.com)

Diabetic rats showed significantly increased serum uric acid (SUA), serum creatinine (SCr), and urea nitrogen (BUN) levels. (hindawi.com)
Daily urinary albumin (UAE), uric acid (UUA), and creatinine (UCr) excretion were also significantly increased in these rats. (hindawi.com)
Despite these promising data, we noticed that the plasma uric acid (UA) levels in most studies were normal or even low because of the degradation of uricase, an enzyme that converts uric acid to allantoin, which is much more soluble than uric acid [ 10 ]. (hindawi.com)
In addition, PPARγ-responsive genes also participate in the regulation of fatty acid metabolism. (globalrph.com)
When the Fatty acid (FA) oxidation capacity in the muscle decreases, the intramyocellular lipid concentration increases ( 5 ). (frontiersin.org)
PPARα activates fatty acid catabolism, stimulates gluconeogenesis and ketone body synthesis and is involved in the control of lipoprotein assembly [ 4 ]. (biomedcentral.com)

We chose Zucker diabetic fatty (ZDF) rats as a model of progressive insulin resistance to examine whether intrinsic mitochondrial defects are required for development of type 2 diabetes. (bioblast.at)
Thus, in ZDF rats insulin resistance develops progressively in the absence of mitochondrial dysfunction. (bioblast.at)
In fact, improved mitochondrial capacity in hyperinsulinemic hyperglycemic rats does not rescue the progression toward advanced stages of insulin resistance. (bioblast.at)
Taken together, these studies confirm that muscle insulin resistance represents a major factor in the pathogenesis of T2D. (frontiersin.org)

Taken together, this study provides a proof of principle for the exploration of amoxicillin treatment as a potential therapy in the people affected with metabolic syndrome. (biomedcentral.com)

Type 2 diabetes and weight problems are seen as a elevated nocturnal circulating free of charge essential fatty acids elevated basal insulin secretion and blunted glucose-stimulated insulin secretion (GSIS). (bioskinrevive.com)
Diabetes has been linked to an impaired ability to oxidize fatty acids. (frontiersin.org)
Almost all studies highlighted the beneficial effects of this beverage against liver fibrosis with the most solid results indicating a pivot role for both caffeine and chlorogenic acids. (mdpi.com)
Abstract Lipid profiling, which includes fatty acids, phospholipids, glycerides, and cholesterols is extremely important because of the essential role lipids play in the regulation of metabolism in animals. (biosferteslab.com)
In part, this occurs because of the mitochondria's continual burning of fatty acids to produce energy. (lifeextension.com)

Rosiglitazone reduces blood glucose concentrations and reduces hyperinsulinemia in the ob/ob obese mouse, db/db diabetic mouse, and fa/fa fatty Zucker rat. (globalrph.com)

Abstract This study aimed to assess whether the advanced characteristics of serum lipoprotein subclasses could better predict the risk of developing diabetic retinopathy (DR) and its severity compared to other established risk factors in subjects with type 1 (T1D) and type 2 (T2D) diabetes. (biosferteslab.com)

In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats. (hindawi.com)
Febuxostat significantly attenuated renal damage in STZ-induced diabetic rats in addition to exerting hypouricemic effect. (hindawi.com)
Diabetic kidney disease (DKD) is the leading cause of end stage renal failure (ESRD) worldwide [ 1 ]. (hindawi.com)
Several clinical studies using hypouricemic agents such as allopurinol showed positive outcomes such as improving renal damage and postponing renal failure in patients with either diabetes or chronic kidney disease (CKD) [ 6 ]. (hindawi.com)
Some of the renal protective effects of Fx were clarified in animal models with diabetes, such as db/db mice [ 8 ] and diabetic Zucker rats [ 9 ]. (hindawi.com)
In the present study, we investigated the effects of Fx on renal injury in STZ-induced diabetic rats with the aim to search novel therapeutic method for DKD. (hindawi.com)
In a review of 25 studies including 1804 patients with diabetic nephropathy, injections of astragalus had a renal protective effective. (earthtokathy.com)

In this study we aimed to investigate the effects of ABCA 1 gene on lipid levels, and patient's clinical parameters under various polymorphic conditions in patients with primary hyperlipidemia. (researchsquare.com)
In Zucker Diabetic Fatty (ZDF) rats, beta cell dysfunction and apoptosis were accompanied by excess lipid accumulation in islets [2], suggesting that beta cell apoptosis is induced by ectopic fat deposits in the pancreas, so called lipotoxicity hypothesis. (mathewsopenaccess.com)

[12] Recent studies have also shown that taurine can influence (and possibly reverse) defects in nerve blood flow, motor nerve conduction velocity, and nerve sensory thresholds in experimental diabetic neuropathic rats. (wikidoc.org)

Recent studies show that taurine supplements taken by mice on a high-fat diet prevented them from becoming overweight. (wikidoc.org)
In this study, we have addressed these knowledge gaps by examining how the gut microbiota profile changes in HFD-fed mice receiving antibiotic intervention in the form of amoxicillin. (biomedcentral.com)
Importantly though, infection studies with S. aureus and A. baumannii , revealed that macrophages isolated from amoxicillin-treated HFD-fed mice are comparable to those isolated from mice receiving only HFD or CD in terms of susceptibility, and progression of microbial infection. (biomedcentral.com)

Sixty male and 78 female patients participated in the study. (researchsquare.com)
Sixty male (mean age, 45.96 ± 15.19 years), and 78 female (48.30 ± 11.56 years) patients participated in the study. (researchsquare.com)
In one study, 160 male and female heart attack survivors between 39 and 86 years old received either 4 grams/day of L-carnitine or a placebo for 12 months. (lifeextension.com)

The Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used for assessing the methodological quality of included studies. (nutrahacker.com)

There are multiple in vitro and in vivo studies, but human studies are needed. (earthtokathy.com)
In the last two decades, various in vitro and in vivo studies evaluated the molecular determinants for the hepatoprotective effects of coffee. (mdpi.com)

A 3-phased project was conducted by the HESI Pro-Arrhythmia Working Group starting with a detailed literature review and followed by a collaborative HESI-FDA database of 150 new drug candidates to evaluate how predictive nonclinical studies are to clinical outcomes. (hesiglobal.org)
In this study we sought to determine longitudinally whether subjects not affected by MetS and T2D with a high fasting RQ would have a higher risk of developing these clinical conditions than those with a lower fasting RQ and, consequently whether RQ during fasting would predict MetS and T2D. (frontiersin.org)
Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. (earthtokathy.com)
A recent meta-analysis confirms the benefits of whole-fruit, full-spectrum pomegranate extract (Pomanox) and pomegranate juice consumption on BP.10 Following is a discussion of one animal study and two human clinical trials on Pomanox. (naturalpractitionermag.com)
These ingredients all have a tremendous safety profile having been tested individually and in combination in multiple published clinical and animal studies. (iprogressivemed.com)

Pyruvate oxidation in 6-week-old fa/fa rats was similar to controls. (bioblast.at)

The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. (hindawi.com)

Conversion of S-adenosyl-L-homocysteine (SAH) to homocysteine increased and the metabolism of homocysteine was reduced under diabetic conditions, and consequently homocysteine accumulated in the elimination phase. (biomedcentral.com)
Using our model, we performed simulations to compare the changes in plasma methionine and homocysteine concentrations between ZDF and normal rats, by multiple administrations of the methionine-rich diet of 1 mmol/kg, daily for 60 days. (biomedcentral.com)
The levels of methionine and homocysteine were elevated approximately two- and three-fold, respectively, in ZDF rats, while there were no changes observed in the normal control rats. (biomedcentral.com)
Here, we focused on the fact that a high-fat diet affects the metabolism of both methionine and homocysteine in a diabetic rat model [ 14 ]. (biomedcentral.com)

Type 2 diabetics, but also prediabetics, are at increased risk for a wide range of debilitating diseases and diabetes is the leading cause of new cases of kidney failure and blindness and of nontraumatic lower limb amputation. (ddw-online.com)
However, LYPLAL1, TFAP2B, SEC16B and FAIM2 were significantly lower expressed in the kidney fat of ZDF than ZL rats. (uni-regensburg.de)
Aloe had an antioxidant effect in the liver and kidney of diabetic rats. (earthtokathy.com)
In this in vitro study, 47 herbs traditionally used to treat urinary and kidney disfunction were tested for their antioxidant potential and toxicity. (earthtokathy.com)

The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)

Cohort and case-control studies reported an inverse association between coffee consumption and the degree of liver fibrosis as well as the development of liver cancer. (mdpi.com)
ABSTRACT Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are serious health concerns for which lifestyle interventions are the only effective first-line treatment. (biosferteslab.com)

Cross-sectional human studies have associated mitochondrial dysfunction to type 2 diabetes. (bioblast.at)

In one study, participants (AN group compared to a control group) were presented with a list of words divided into four categories: positive, negative, neutral and anorexia-related. (wikipedia.org)
The control and diabetic rats were treated with and without febuxostat for 8 weeks, respectively. (hindawi.com)
Muscle mitochondrial function was examined in 6-, 12-, and 19-week-old ZDF (fa/fa) and fa/+ control rats (n = 8-10 per group) using respirometry with pyruvate, glutamate, and palmitoyl-CoA as substrates. (bioblast.at)
The objective of the present study is to determine, through a literature review, the influence of the periodontal disease on the metabolic control of diabetic patients. (bvsalud.org)
The group I rats were marked as control while rats of group II & III were administered vanadyl sulphate 0.06mg/day and 0.3mg/day respectively. (nutrahacker.com)

Six-week-old normoglycemic-hyperinsulinemic fa/fa rats had reduced mitochondrial fat oxidative capacity. (bioblast.at)
Fortunately, studies have proven that supplementing with carnitine can restore mitochondrial function to near-youthful levels. (lifeextension.com)

The patients participated in this study consisted of primary dyslipidemia patients who consulted to the outpatient clinics of Department of Endocrinology, and Diseases of Metabolism of Ege University. (researchsquare.com)

The objective of this study was to analyse its safety in usual therapeutic dose range. (nutrahacker.com)

In the exercised-ZLC and ZDF rats, COX-2 immunoreactivity was significantly increased compared to that in the ZLC and ZDF rats, showing that COX-2 immunoreactivity in the exercised-ZDF rats was slightly low than that in the exercised-ZDF rats. (mcmaster.ca)

In combination, S-Amlodipine and Pioglitazone significantly reduced blood glucose (115.1 ± 6.6 vs. 81.7 ± 4.2), BP (184.4 ± 5.0 vs. 155.1 ± 5.0), serum triglycerides (362.5 ± 47.5 vs. 211.1 ± 23.7) and glucose intolerance when compared with vehicle treated Zucker fa/fa rats. (biomedcentral.com)

Some studies have shown contradictory results to ED individuals' heightened attention and enhanced memory, however the difference could be attributed to an anxiety-induced response and avoidance behaviour. (wikipedia.org)
The results of these studies suggest that there are clear differences in the explicit cognitive processing of stimuli between AN individuals and healthy controls and that length of the illness can affect the extent of these memory biases. (wikipedia.org)
Detailed information about study designs, exposure conditions, and results is provided in Appendix E . (nationalacademies.org)
The results of epidemiologic (n = 5), literature review, and meta-analysis (n = 14) studies were positively similar to the studies in humans after the periodontal treatment, in 4 and 11 articles, respectively. (bvsalud.org)
Results and conclusions: Multidirectional studies on V have shown that further analyses are still required for this element to be used as a metallodrug in the fight against certain life-threatening diseases. (nutrahacker.com)
Results: In the present study, 341 articles were evaluated out of which 42 studies were eligible for inclusion. (nutrahacker.com)
We suppose that one of the reasons for these inconsistent results is due to the intricate structure of the pancreas, since it is difficult to distinguish intra-pancreas fat from fat tissue outside the pancreas by computed tomography (CT) or magnetic resonance imaging (MRI) studies. (mathewsopenaccess.com)
showed conflicting results that presence of non-alcoholic fatty pancreas is independent of age and BMI [7]. (mathewsopenaccess.com)

Cued recall tasks, recognition tasks and Stroop task tests are used to study these effects. (wikipedia.org)
A manuscript was submitted detailing a study investigating the effects of doxorubicin in Zucker diabetic fatty rats. (hesiglobal.org)
2000a) reviewed a number of human studies of fluoride effects, including three that dealt with goiter and one that dealt with age at menarche. (nationalacademies.org)
In this study, we observed the effects of a physical exercise on COX-2 immunoreactivity in the hippocampus using immunohistochemistry in rats. (mcmaster.ca)
To the best of our knowledge, this is the first study demonstrating beneficial effects of L-citrulline/L-arginine from watermelon supplementation in arterial function in humans. (blogspot.com)
Figure 5: Effects of macrophage-selective siRNA knockdown of CB 1 R in ZDF rats. (nature.com)
To investigate whether supplementation with a pomegranate extract rich in polyphenols imparts beneficial effects on coronary function, and to characterize the underlying mechanisms, a study was conducted in which pigs were fed a 10-day normocholesterolemic or hypercholesterolemic diet (normal and high cholesterol, respectively). (naturalpractitionermag.com)
To evaluate this assumption, we investigated the effects of aerobic exercise training (AET), resistance exercise training (RET), and 4 weeks of de-training on serum leptin and TNF-α levels in diabetic rats. (biomedcentral.com)

We determined the behaviour of the phenols present in EVOO and its total antioxidant capacity before and after the use of various culinary techniques such as deep frying, boiling (in a water/oil mixture (W/O) and sauteing, observing that the study parameters varied according to the variety of oil and the culinary technique used. (bvsalud.org)

Melatonin administration ameliorates the diabetic status of ZDF rats by enhancing plasma Cr and V concentrations. (uaeu.ac.ae)
This appears to be the first report of a beneficial effect of melatonin treatment on plasma Cr and V regulation in ZDF rats. (uaeu.ac.ae)
Melatonin was found to be beneficial for young rats that had not still developed any metabolic or heart disease. (sciencedaily.com)
June 23, 2021 Researchers have created a mouse model that allows the study of naturally occurring melatonin. (sciencedaily.com)

Several cohort and cross-sectional studies definitively established the relationship between hyperuricemia and the progress of DKD in either type 1 or type 2 diabetes [ 3 - 5 ]. (hindawi.com)
In this study, metabolomics tools have been used to investigate the potential metabolic changes induced by cocoa in type 2 diabetes (T2D). (biosferteslab.com)

Oral administration of the potassium salt remarkably improved the plasma glucose levels of female Zucker diabetic fatty rats at 1 mg/kg. (rcsb.org)

Been shown in human studies to lower serum glucose and 24 hour urinary glucose excretion by 54% and also to significantly improve glucose tolerance tests, lower LDL and VLDL while not changing HDL. (iprogressivemed.com)

We next sought an animal model where this observation could be studied further. (jci.org)

In research studies, whole-fruit, full-spectrum pomegranate extract (Pomanox) improved the health of the endothelium (the inner layer of the arteries) by counteracting vascular inflammation and oxidative damage.5,6 Unpublished research conducted at La Paz University Hospital, Madrid, Spain, on modulation of gene expression of markers associated with cardiovascular disease (CVD), confirmed 12 genes to be differentially expressed after administration of the extract to subjects with high waist circumference. (naturalpractitionermag.com)

Moreover, cardiovascular disease (CVD) is 2-4 times higher in diabetics (2). (ddw-online.com)
Epidemiological studies with prospective cohorts showed that coffee intake is associated with reduced cardiovascular and all-cause mortality independently of caffeine content. (mdpi.com)

Plasma V and Cr levels were significantly higher in M-ZDF vs. C-ZDF rats. (uaeu.ac.ae)
These findings indicate that both AET and RET are useful in reducing levels of serum adipocytokines (TNF-α, leptin) in diabetic and non-diabetic rats. (biomedcentral.com)

Here we show that beta cell failure in adult ZDF rats is not associated with CB 1 R signaling in beta cells, but rather in M1 macrophages infiltrating into pancreatic islets, and that this leads to activation of the Nlrp3-ASC inflammasome in the macrophages. (nature.com)
Cannabinoid CB1 and CB2 receptors have been identified in isolated mouse rat and human pancreatic islets with CB1 receptors mainly expressed in non-β-cells and CB2 receptors expressed in both β- and non-β cells (24-27). (bioskinrevive.com)
It has also been shown in a paper by Bermudez-Silva (24) Nakata and Yada have recently reported mRNA for the CB1 receptor but not the CB2 receptor expressed in mouse pancreatic islets and a further immunohistochemical study found the CB1 receptor expressed in β-cells (29). (bioskinrevive.com)
reported that pancreatic fat content was associated with decreased beta cell function in non-diabetic subjects by using magnetic resonance spectroscopy (MRS) [8]. (mathewsopenaccess.com)
A recent study in which pancreatic intralobular fat was measured carefully by using MRI/MRS also showed no association between pancreatic fat and diabetes [9]. (mathewsopenaccess.com)
Our study was a relatively large-scale study including autopsy from 72 Japanese non-diabetic adults and pancreas samples from 99 diabetic and non-diabetic adults who underwent pancreatic surgery. (mathewsopenaccess.com)

Filipović D, Inderhees J, Korda A, Tadić P, Schwaninger M, Inta D, Borgwardt S. Metabolic Fingerprints of Effective Fluoxetine Treatment in the Prefrontal Cortex of Chronically Socially Isolated Rats: Marker Candidates and Predictive Metabolites . (uni-luebeck.de)

The Zucker diabetic fatty rat offered such a model system. (jci.org)
Normalization of circulating glucose in the rat model by either insulin or phlorizin treatment did not result in a reduction in membrane PKC isozyme protein or kinase activity. (jci.org)
Therefore, this rat model is more appropriate for researches on hyperuricemia in diabetic conditions. (hindawi.com)

Figure 6: Proinflammatory gene and protein expression in human macrophages and rat and human isolated islets treated with AEA, IL-1β or high glucose. (nature.com)
Needlessly to say basal secretion was considerably raised in islets from obese or GL-treated low fat rats whereas the collapse upsurge in GSIS was reduced. (bioskinrevive.com)
Nonetheless it reduced GSIS in islets from low fat rats without influencing basal secretion. (bioskinrevive.com)
To determine if the CB1 receptor antagonist Rimonabant affected basal or activated insulin secretion we researched isolated islets from low fat siblings and obese Zucker (ZF) and Zucker Diabetic Fatty (ZDF) rats that were Drospirenone incubated for 24 h and exposed to 11 mmol/l glucose plus 0.3 mmol/l palmitate (GL) with or without Rimonabant. (bioskinrevive.com)

Anatomy8

Organisms6

Diseases20

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes14

Disciplines and Occupations1

Free fatty1

Anti-diabetic5

Obese rats3

Obesity7

Methods2

Wistar3

Lean6

Sprague-Dawley3

T2DM6

Development of insulin resistance1

Hyperglycemia5

Diabetes mellitus5

Homeostasis1

Hepatic2

Glycemic control2

Inflammatory4

Acid6

Insulin resistance4

Metabolic Syndrome1

Acids5

Hyperinsulinemia1

Retinopathy1

Renal7

Lipid2

Experimental1

Mice3

Male3

Systematic Review1

Vitro and in vivo studies2

Clinical5

Oxidation1

Tissues1

Homocysteine4

Kidney4

PPAR1

Liver2

Dysfunction1

Control5

Mitochondrial2

Metabolism1

Objective1

Significantly increased1

Triglycerides1

Results8

Effects8

Parameters1

Melatonin4

Type 2 diabet2

Remarkably1

Serum glucose1

Animal1

Oxidative1

Cardiovascular2

Levels2

Pancreatic6

Metabolites1

Model3

Islets4