Study denervation. Medical search. Frequent questions

Twenty-Four-Hour Blood Pressure Monitoring to Predict and Assess Impact of Renal Denervation: The DENERHTN Study (Renal Denervation for Hypertension). (insa-lyon.fr)
A Medtronic Renal Denervation (RDN) video covering Professor Markus Schlaich's presentation discussing Global Symplicity Registry data in patients with resistant hypertension (HTN), at the TCT 2020 conference as part of the latest interviews and symposia congress content on the videos and presentation page for Medtronic. (medtronic.com)
Renal Denervation in high-risk patients with hypertension. (medtronic.com)
Modeled Clinical Event Reductions at Three Years in High-Risk Hypertension Patients Treated with Renal Denervation. (medtronic.com)
Renal sympathetic denervation (RSDN) is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation or ultrasound ablation aimed at treating resistant hypertension (high blood pressure not controlled by medication). (wikipedia.org)
A 2014 consensus statement from The Joint UK Societies did not recommend the use of renal denervation for treatment of resistant hypertension on current evidence. (wikipedia.org)
A study published in 2014, Symplicity HTN-3, was a prospective, single-blind, randomised, sham-controlled trial in which 535 patients with severe resistant hypertension were randomized to undergo renal denervation or a sham procedure (in a 2:1 ratio). (wikipedia.org)
Following the publication of Symplicity HTN-3 the Joint UK Societies produced a consensus statement that did not recommend the use of renal denervation for treatment of resistant hypertension in routine clinical practice. (wikipedia.org)
CHICAGO-Catheter-based renal denervation significantly decreases blood pressure (BP) in patients with treatment-resistant essential hypertension , according to results released at the American Heart Association Scientific Sessions 2010 and simultaneously published online in The Lancet . (renalandurologynews.com)
Catheter-based renal denervation is a minimally invasive procedure that uses a catheter to ablate renal sympathetic nerves, which are frequently activated in chronic hypertension. (renalandurologynews.com)
Surgical renal denervation has been shown to reduce BP in animal models of hypertension. (renalandurologynews.com)
Future studies will test the efficacy of renal denervation in milder hypertension and also in populations that have not yet been examined, including African-American, Hispanic, and Asian patients. (renalandurologynews.com)
Pulmonary artery denervation (PADN) plus a phosphodiesterase-5 inhibitor improved exercise capacity, cardiac function, and some clinical outcomes in patients with pulmonary arterial hypertension (PAH) in a sham-controlled trial. (medscape.com)
St Jude Medical, the company behind the Enlightn renal denervation system, has announced that its new study-Enlightnment-will investigate the long-term effects of renal denervation in patients with resistant hypertension to see if the treatment can reduce the risk of major cardiovascular events (such as myocardial infarction) as well as lower blood pressure. (cardiovascularnews.com)
To date, the renal denervation studies that have been conducted only looked at reducing blood pressure in patients with uncontrolled or resistant hypertension," said Michael Böhm, director and chief of internal medicine and cardiology at the University of Saarland in Homburg/Saar, Germany, a principal investigator for the trial. (cardiovascularnews.com)
St Jude Medical is currently conducting two additional renal denervation studies called Enlightn I and Enlightn II that are evaluating the Enlightn system for hypertension. (cardiovascularnews.com)
WASHINGTON (March 29, 2014) - Renal denervation fell short of primary and secondary efficacy goals in patients with severe resistant hypertension but did meet the primary safety endpoints, according to keenly awaited data from SYMPLICITY HTN-3 presented at the American College of Cardiology's 63rd Annual Scientific Session. (acc.org)
This pivotal trial is the largest study conducted of renal artery denervation as a treatment for resistant hypertension and the most rigorously designed, including blinding and a sham treatment in the control arm. (acc.org)
Although renal denervation is in clinical use for uncontrolled hypertension in more than 80 countries, it is still considered an experimental approach in the United States. (acc.org)
This study randomly assigned 535 patients with resistant hypertension and systolic blood pressure of 160 mmHg or higher to renal denervation or angiography alone. (acc.org)
We saw no added treatment benefit of renal denervation for patients with severe resistant hypertension who were closely monitored and optimally treated with medications. (acc.org)
Bhatt commented on the value of the study's cooperation between interventional and non-interventional blood pressure doctors, which demonstrated that a "good proportion" of patients with resistant hypertension in this study responded to expert medical therapy. (acc.org)
Currently, percutaneous endovascular catheter-based renal sympathetic nerve denervation (RDN) has been regarded as a promising method for the treatment of resistant hypertension [ 3 ]. (biomedcentral.com)
If trials of antihypertensive drugs are any indication, the first results from randomized trials of renal denervation for resistant hypertension will show smaller reductions in blood pressure compared with those from the unblinded trials, a study in Heart indicated. (medpagetoday.com)
Renal denervation is a catheter-based procedure designed to treat resistant hypertension (high blood pressure that remains uncontrolled even with medication) by using radiofrequency or ultrasound ablation on nerves in the wall of the renal artery. (mddionline.com)
Vessix Vascular has developed a catheter-based renal denervation system for the treatment of uncontrolled hypertension. (centerwatch.com)
Renal denervation is an emerging, catheter-based therapy for medication-resistant hypertension that uses radiofrequency energy to disrupt the renal sympathetic nerves whose hyperactivity leads to uncontrolled high blood pressure. (centerwatch.com)
Renal denervation represents a potential breakthrough therapy for the treatment of uncontrolled hypertension and is an important part of the Boston Scientific growth strategy," said Mike Mahoney, president and CEO, Boston Scientific. (centerwatch.com)
Other procedures discussed in this review are the percutaneous left atrial appendage closure as a non-pharmacologic therapy to prevent strokes, and renal denervation for resistant hypertension. (bmj.com)
Other important developments are the percutaneous treatment options for mitral regurgitation (MR) (MitraClip), non-pharmacologic therapy to prevent cerebral embolisation in patients with atrial fibrillation (AF) such as left atrial appendage (LAA) closure and closure of the patent foramen ovale, and renal denervation to treat resistant hypertension. (bmj.com)
Patients who received a Medtronic interventional treatment for hypertension while staying on their blood-pressure pills saw noticeably better results than with a placebo, new results from a small study show. (startribune.com)
Medtronic is hotly pursuing a blood-pressure reduction therapy known as "renal denervation," which involves inserting a narrow device into the arteries that lead to the kidneys and then applying radio-frequency energy to zap away nerves in the vessel wall carrying signals that trigger hypertension. (startribune.com)
Renal denervation is a medical procedure to treat high blood pressure by applying radio frequency energy to the walls of the renal artery with electrodes to interrupt neurological signals that trigger hypertension. (startribune.com)
The results of a new study released Tuesday in the journal JAMA Cardiology showed that the device routinely reduced daytime ambulatory blood pressure by an average of 8.5 points among middle-aged people with hypertension. (upi.com)
The study pulled together information from three randomized trials encompassing more than 500 middle-aged patients with varying degrees of hypertension and medication use. (upi.com)
Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension. (bvsalud.org)
For CKD with hypertension, renal denervation (RD) interrupts the afferent renal sympathetic nerves, which are connecting to the NTS. (bvsalud.org)
The objective of the present study was to investigate how RD improves CKD-induced hypertension . (bvsalud.org)

Cardiac sympathetic denervation for treatment of ventricular arrhythmia: Where are we now? (cardiacrhythmnews.com)
Chance M Witt and Christopher J McLeod (Rochester, USA) review current treatment of ventricular arrhythmias with cardiac sympathetic denervation. (cardiacrhythmnews.com)
What is cardiac sympathetic denervation? (cardiacrhythmnews.com)
Cardiac sympathetic denervation generally refers to interrupting the sympathetic input to the heart by removing or blocking the extrinsic sympathetic nerves (outside the pericardium), typically in or around the stellate ganglion. (cardiacrhythmnews.com)
Cardiac sympathetic denervation is now commonly accomplished by a video-assisted thoracoscopic surgical procedure which bisects the stellate ganglion removing the lower half along with a few ganglia below it. (cardiacrhythmnews.com)
Cardiac sympathetic denervation can also more broadly refer to procedures which attempt to block the effect of the sympathetic nerves by a percutaneous injection of a local anaesthetic and thus temporarily denervate the heart. (cardiacrhythmnews.com)
Cardiac sympathetic denervation has primarily been used as a treatment for various causes of ventricular tachycardia (VT). (cardiacrhythmnews.com)
Based on multiple studies, including hundreds of patients, over many years, cardiac sympathetic denervation is an effective treatment for preventing VT in certain patients with long QT syndrome. (cardiacrhythmnews.com)
4 The positive effect of cardiac sympathetic denervation extends to another genetic condition, catecholaminergic polymorphic VT. (cardiacrhythmnews.com)
5 With the obvious autonomic involvement, it is intuitive that cardiac sympathetic denervation would be a beneficial treatment in these patients. (cardiacrhythmnews.com)
One large study demonstrated that prophylactic cardiac sympathetic denervation in patients with recent myocardial infarction has a similar beneficial effect to beta-blockers at preventing VT. (cardiacrhythmnews.com)
6 Furthermore, many case reports and small series suggest that some patients with recurrent VT and VT storm may be successfully treated by cardiac sympathetic denervation in the form of surgery and stellate ganglion block with anaesthetic injection. (cardiacrhythmnews.com)
In general, however, the role of cardiac sympathetic denervation for preventing recurrent VT in acquired, ischaemic and non-ischaemic cardiomyopathy is not entirely clear. (cardiacrhythmnews.com)
In this study, cardiac sympathetic denervation surgery will be performed on both the left and right side, which is supported by some recent evidence, although there have been questions in the past about the effects of right sided denervation. (cardiacrhythmnews.com)
The efficacy of cardiac sympathetic denervation for patients in the throes of a VT storm is even less clear, with cohort studies including relatively few patients and the urgency of the clinical situation preventing a stepwise or randomised approach. (cardiacrhythmnews.com)
Anecdotally, stellate ganglion block with an injected anaesthetic as the method of cardiac sympathetic denervation is expeditious and potentially effective in this group. (cardiacrhythmnews.com)
Left Cardiac Sympathetic Denervation for Long QT Syndrome: 50 Years' Experience Provides Guidance for Management. (cdc.gov)

Although his team had theorized that sympathetic nerve regrowth could "mitigate" treatment effects, the antihypertensive effect of renal denervation was maintained for up to two years in pilot studies, Dr. Esler said. (renalandurologynews.com)
Researcher also will examine whether catheter-based renal denervation shows benefit in other diseases in which the renal sympathetic outflow is activated, including cardiac failure, chronic kidney disease, and cirrhoses with ascites. (renalandurologynews.com)
This study aims to evaluate the effects and safety of laparoscopic-based perivascular renal sympathetic nerve denervation (RDN) in a porcine model fed a high-fat diet. (biomedcentral.com)
Since renal sympathetic nerves are mainly located near the adventitia and are not distributed through the intima of renal arteries based on anatomy studies, we therefore attempted to perform laparoscopic-based perivascular RDN in this study. (biomedcentral.com)
The stellate ganglion level is chosen because it seems to create an adequate sympathetic block to the heart and denervation above this level can cause side effects, such as Horner's syndrome. (cardiacrhythmnews.com)

Radiofrequency denervation of the facet joints is performed via a well-established method. (iasp-pain.org)
Various therapeutic techniques in the treatment of facet-related pain have been described in the literature, including intraarticular lumbar facet joint steroid injections and radiofrequency denervation. (nih.gov)
In this study, we compared the effectiveness of intraarticular facet joint steroid injections and radiofrequency denervation. (nih.gov)
Our randomized, double-blind, controlled study included patients who received intraarticular steroid infiltrations in the lumbar facet joints (L3/L4-L5/S1) and patients who underwent radiofrequency denervation of L3/L4-L5/S1 segments. (nih.gov)
Intraarticular steroid infiltration or radiofrequency denervation appear to be a managing option for chronic function-limiting low back pain of facet origin with favorable short- and midterm results in terms of pain relief and function improvement, but improvements were similar in both groups. (nih.gov)
In three randomised trials, treatment of chronic low back pain (CLBP) with radiofrequency denervation resulted in either no improvement or no clinically important improvement in pain, according to a study published by the Journal of the American Medical Association ( JAMA ). (spinalnewsinternational.com)
Even though radiofrequency denervation is a commonly-used treatment, high-quality evidence for its effectiveness is lacking. (spinalnewsinternational.com)
Participants in the intervention group received radiofrequency denervation as well, which is usually a one-time procedure, but the maximum number of treatments in the trial was three. (spinalnewsinternational.com)
The researchers found that two trials assessing radiofrequency denervation for the sacroiliac joints and a combination of the facet joints, sacroiliac joints, or intervertebral disks showed a statistically significant but not clinically important improvement in pain intensity three months after the intervention. (spinalnewsinternational.com)
No clinically important or statistically significant differences between the groups were shown in the trial assessing radiofrequency denervation for facet joint pain. (spinalnewsinternational.com)
The findings do not support the use of radiofrequency denervation to treat chronic low back pain from these sources," the authors write. (spinalnewsinternational.com)
Because the aim of the study was to provide evidence of the added value of radiofrequency denervation in a multidisciplinary setting, as done in daily practice, the study was limited by a lack of both participant and clinician blinding. (spinalnewsinternational.com)

Cardiologist Murray D. Esler, MD, Associate Director of the Baker IDI Heart and Diabetes Institute in Melbourne, Australia, presented findings in 106 treatment-resistant hypertensive patients who had been randomized to undergo renal denervation and continue their prior antihypertensive therapy or to continue their prior therapy only. (renalandurologynews.com)

Office-based systolic blood pressure reductions associated with renal denervation have been reported to be around 30 mm Hg , with smaller reductions in ambulatory readings. (medpagetoday.com)

Explanations offered for this mismatch include renal denervation obliterating the white coat response, thereby disproportionately reducing clinic pressures, or inadvertent bias arising from the unblinded design and lack of sham control procedure in almost all renal denervation trial designs to date. (wikipedia.org)
The results showed no statistically significant difference between renal denervation and the sham procedure. (wikipedia.org)
Based on our findings, we believe that in patients whose systolic blood pressure is 160 to 200 mm Hg even though they are taking multiple antihypertensive medications, catheter-based renal denervation is a logical next step provided that long-term safety is assured and all the evidence to date shows that this is indeed a safe procedure. (renalandurologynews.com)
During the renal denervation procedure with the Symplicity device used in this trial, a catheter is threaded through arteries to deliver radiofrequency energy that inactivates kidney nerves, interrupting electrical signals to and from the kidney, an organ that performs a major role in regulating blood pressure. (acc.org)
At the EuroPCR meeting in Paris on Wednesday, Medtronic announced positive early results from its proof-of-concept trial comparing renal denervation in patients adhering to their drug prescriptions, to results from a group of patients who also stayed on the drugs but got a "sham" medical procedure that left their renal nerves unaltered. (startribune.com)
The "On-Med" study findings were announced about a year after Medtronic unveiled early results of a similar "Off-Med" study , in which patients were taken off their drugs and then randomized to renal denervation or a sham procedure. (startribune.com)
To participate in this study, you must not have had a catheter ablation procedure to treat atrial fibrillation, had surgery to replace your heart valves, or been treated for sleep apnea. (nih.gov)

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. (medtronic.com)
Previous observational studies, including TROPHY 1 , have shown that denervation of the pulmonary artery improves hemodynamic and exercise capacity in patients with PAH, but its efficacy and safety have not been studied in a randomized trial, he noted. (medscape.com)
The objective of this study was to compare the efficacy and safety of different CA strategies for AF ablation through network meta-analysis (NMA). (biomedcentral.com)
This study provides decision-makers with comprehensive and comparative evidence about the efficacy and safety of different CA strategies. (biomedcentral.com)
The objective of this study was to systematically review the efficacy and safety of all different CA strategies for the treatment of patients with paroxysmal (PAF) and non-paroxysmal AF (non-PAF). (biomedcentral.com)

Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. (medtronic.com)

Radiofrequency facet joint denervation efficiency based on the severity of spondylarthrosis and in osteoporotic vertebral compression fractures. (iasp-pain.org)

Atrial septostomy, Potts anastomosis, and pulmonary artery denervation are interventional procedures serving this purpose. (revespcardiol.org)
The risk of recurrence was significantly decreased compared to pulmonary vein isolation (PVI) alone for PVI with renal denervation (RR: 0.60, CI: 0.38-0.94), PVI with ganglia-plexi ablation (RR: 0.62, CI: 0.41-0.94), PVI with additional ablation lines (RR: 0.8, CI: 0.68-0.95) and PVI in combination with bi-atrial modification (RR: 0.32, CI: 0.11-0.88). (biomedcentral.com)
This is a prospective, case-control study that seeks to learn about the role of genetics in early onset atrial fibrillation (AF) and if genetic testing can be used to improve how the investigators treat atrial fibrillation. (nih.gov)
The study will assess safety of the intervention in a population at increased risk for post-operative atrial fibrillation. (nih.gov)

Symplicity HTN-2 was a randomized, controlled trial that compared 54 control patients with 52 patients who underwent catheter-based renal denervation. (wikipedia.org)

Based on those results , Medtronic has already launched a larger pivotal trial of renal denervation in patients not taking high blood-pressure drugs. (startribune.com)

citation needed] Symplicity HTN-1 looked at outcomes in 153 patients that underwent catheter-based renal denervation. (wikipedia.org)
The Symplicity HTN-1, HTN-2 and HTN-3 trials have demonstrated acceptable safety profiles for catheter based renal denervation. (wikipedia.org)
In the TROPHY study, we did see some decrease in efficacy using an ultrasound-based catheter after 6 months. (medscape.com)
Boston Scientific , a medical device company based in Natick, Mass., is extending its reach into the strategically critical renal denervation market by signing a definitive agreement to acquire Vessix Vascular , a Laguna Hills, Calif.-based held company developing novel RF balloon catheter and bipolar RF generator technology. (centerwatch.com)
In my experience, the system offers ease of use, faster treatment times with decreased patient discomfort and an intuitive approach to renal denervation that leverages the expertise of the interventionalist with balloon catheter technology," said Horst Sievert, M.D., Ph.D., director of the CardioVascular Center Frankfurt, Sankt Katharinen Hospital, in Frankfurt, Germany. (centerwatch.com)

Medtronic, Inc. funded SYMPLICITY HTN-3 and provided research funding to Bhatt for the study. (acc.org)
Medtronic still seems confident about its renal denervation opportunity, but investors have 'mostly given up,' a medtech analyst observes. (mddionline.com)
Investors may have given up on renal denervation, but we're not going to see Medtronic throwing in the towel on the opportunity any time soon. (mddionline.com)
Medtronic previously noted in a regulatory filing with the U.S. Securities Exchange Commission that if the primary endpoint had achieved statistical significance at the time of that interim data analysis in late October, the company would have closed enrollment on the renal denervation study early. (mddionline.com)
Medtronic reported progress in a trial of a treatment for high blood pressure called "renal denervation. (startribune.com)

However, when denervation reaches 50%, a mismatch between time scales of DA dynamics and bursts and pauses in firing patterns arises ( Grace and Bunney, 1984b ). (jneurosci.org)

Selective Thumb Carpometacarpal Joint Denervation for Painful Arthritis: Clinical Outcomes and Cadaveric Study. (umassmed.edu)
Our primary objective was to describe design characteristics and outcomes of studies testing the efficacy of pregabalin in behavioral models of pain. (iasp-pain.org)
The results announced Wednesday summarized six-month outcomes for the first 80 patients randomized in a study of 467 people being treated at hospitals in several countries, including the United States. (startribune.com)
Among the many different therapeutic approaches, including exercise, hormone, nutritional therapy, and/or a combination thereof, no one approach has emerged as superior in animal or human studies, and the great variability in the clinical outcomes of patients treated with these approaches has prevented identification of the most effective therapy ( 7 , 8 ). (frontiersin.org)

Researchers at Columbia University in New York and University of Paris tested the device used in outpatient procedures called ultrasound renal denervation. (upi.com)
Carpal Tunnel Syndrome the number of cases in four of the symptoms studied, while ultrasound reduced the number of cases in only two. (bvsalud.org)

In a study of 41 900 patients with chronic AF, only 70% of patients treated with warfarin remained on this therapy at 1 year, 4 further highlighting difficulties with anticoagulation. (bmj.com)
PURPOSE: Hyperglycemia and abnormal glucose tolerance tests observed in some patients with chronic Chagas' disease suggest the possibility of morphological changes in pancreatic islets and/or denervation. (scielo.br)
The purpose of this study was to describe the morphology and morphometry of pancreatic islets in chronic Chagas' disease. (scielo.br)
METHODS: Morphologic and computerized morphometric studies were performed in fragments of the head, body, and tail regions of the pancreas obtained at necropsies of 8 normal controls and 17 patients with chronic Chagas' disease: 8 with the digestive form (Megas) and 9 with the congestive heart failure form. (scielo.br)
The aim of this study was to evaluate comparatively the inflammatory process in muscular and myenteric plexus of esophagus and colon from chronic chagasic patients with and without mega, with the purpose of ascertaining whether there are similarities between the process in esophagus and colon and between cases with and without evident parasitism in the organ. (hindawi.com)
We studied 50 segments of large intestine and 39 segments of esophagus from chronic chagasic patients obtained by surgery (16 colon and 4 esophagus) or autopsies performed at the Department of Surgical Pathology/Special Pathology from the Hospital of Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil. (hindawi.com)
This article covers the current state of the art in robotic assisted microsurgical procedures in male infertility and urology: microsurgical vasectomy reversal, intra-abdominal vasovasostomy (for patient with prior inguinal hernia related inguinal vasal obstruction), microsurgical subinguinal varicocelectomy, microsurgical testicular sperm extraction (MicroTESE) and targeted microsurgical denervation of the spermatic cord for chronic orchialgia. (medscape.com)

Our study aimed to find other, effective but indirect indication signs through the retrospective analysis of our patients treated earlier. (iasp-pain.org)
With more than 3,000 patients enrolled, the GLOBAL SYMPLICITY REGISTRY (GSR) is the largest renal denervation (RDN) data set in the world. (medtronic.com)
24 of 29 patients in the steroid injection group and 26 of 27 patients in the denervation group completed the 6-month follow-up. (nih.gov)
A total of 293 patients were screened for the study but those with multi-level disease, prior lumbar surgery and negative discography were excluded. (medpagetoday.com)
In addition, there were no changes in renal function with denervation, even in patients with mild to moderate renal failure. (renalandurologynews.com)
The study began enrolment in January 2013 to evaluate the reduction in systolic blood pressure at six months across all enrolled patients after having renal denervation, and within subgroups with varying degrees of kidney functionality. (cardiovascularnews.com)
Heneka MT. Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients. (umassmed.edu)
They included 31 drug trial with 4,121 patients and 23 renal denervation trials with 720 patients. (medpagetoday.com)
Nearly all patients with heart failure and a preserved ejection fraction (94%) had some type of lung function abnormality, a pilot study published in Heart, Lung, and Circulation showed. (medpagetoday.com)
Study senior author Dr. Steven Wexner, Director of the Digestive Disease Center and Chairman of the Department of Colorectal Surgery at Cleveland Clinic Florida, and a paid consultant for Mederi Therapeutics Inc., commented: 'The results of this study should allow us to help patients with GERD and fecal incontinence, as the regeneration we see here clarifies the mechanism of action of radiofrequency treatment. (massdevice.com)
It's difficult to estimate the market value of a medical-device treatment for high blood pressure, since renal denervation is investigational in the United States and researchers are still working to understand which patients respond best. (startribune.com)
That proof-of-concept study found that after three months, patients in the experimental arm with a continuously worn blood-pressure monitor saw an average systolic pressure decrease of 5.5 millimeters of mercury, compared with a 0.5-point reduction in the control group. (startribune.com)
Many patients in our clinical practice are just like the patients in our study, with uncontrolled blood pressure in the 150s despite some efforts," Dr. Ajay Kirtane, professor of medicine at Columbia University Vagelos College of Physicians and Surgeons and co-leader of the study, said in a statement. (upi.com)
With one study positive and another negative, the panel felt too conflicted on effectiveness and risk versus benefits to patients. (tctmd.com)
The study merges Chinese and Western medicines, the PI says, noting patients were well treated with triple-therapy HF drugs. (tctmd.com)
The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
This clinical trial will have 2 components: a brief dose-ranging study and a randomized comparison of 2 doses of AdKCNH2-G628S with control cardiac surgery patients. (nih.gov)
From studies, as well as our unpublished data and anecdotal experience, there are many patients who do not respond, although many who do. (cardiacrhythmnews.com)
Reviewing the literature, we came across few studies of direct microscopic examination of Trypanosoma cruzi in chronically infected human tissues and we did not find studies evaluating both research on T. cruzi and inflammatory infiltration simultaneously in histological sections of esophagus and colon from chagasic patients with and without mega. (hindawi.com)
Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis. (lww.com)
In the present retrospective case-control study, we included 582 patients with amyotrophic lateral sclerosis and 582 age- and sex-matched healthy controls. (lww.com)
What role do you see for renal denervation in control of blood pressure in your patients? (radcliffecardiology.com)

More recent sham-controlled trials suggest renal denervation can lead to lower systolic blood pressure. (wikipedia.org)
This is the first blinded trial or sham controlled trial in the field of renal denervation. (acc.org)

Thus, Marks and Cahill [ 1 ] examined in an experimental study the effect on eruption after surgical removal of different parts of the follicle. (hindawi.com)
Yet, whether stellate ganglion block is the same as surgical denervation is not clear. (cardiacrhythmnews.com)
The aim of the present study was thus to assess clinically the lack of pulp sensitivity to cold among maxillary canines in infraocclusion submitted to non-surgical orthodontic traction. (bvsalud.org)

2. Other pain conditions, not intended to be treated in this study, that in the opinion of the investigator could interfere with study procedures, accurate pain reporting, and/or confound evaluation of study endpoints. (who.int)

They suggested in their study that the Malassez epithelium may be involved in the maintenance of periodontal space and that sensory innervation might be indirectly associated with it [ 4 ]. (hindawi.com)
Electrodiagnostic studies, however, displayed reduced compound muscle action potentials, normal sensory nerve action potentials, and widespread denervation, consistent with a severe, asymmetric process involving anterior horn cells or motor axons. (cdc.gov)
effect of sensory denervation. (medscape.com)

Although both study groups showed a statistically significant decrease at six months compared with baseline (-14.1 mmHg for renal denervation compared to -11.7 mmHg for the sham treatment control), the difference of -2.29 mmHg in office systolic blood pressure between the two arms was not significant. (acc.org)

Ensayo clínico abierto, en pacientes con síndrome del túnel carpiano leve y moderado, que consultaron del 1 software management, data de octubre 2021 al 30 de mayo 2022. (bvsalud.org)

The Dublin, Ireland-based company's goal was to present data from the ongoing SPYRAL HTN-ON MED clinical study of its Symplicity Renal Denervation System at the 2021 Transcatheter Cardiovascular Therapeutics Conference (TCT), but that presentation hinged on an interim look at the data by an independent monitoring board. (mddionline.com)

The purpose of this study was to evaluate the safety and efficacy of laparoscopic-based perivascular RDN in a porcine model. (biomedcentral.com)
NORWALK, Conn. - A newly published, pathologist-blinded study in a porcine model, examines the histopathology changes after non-ablative radiofrequency (NARF) to smooth muscle as delivered by Stretta therapy for GERD and Secca therapy for fecal incontinence. (massdevice.com)

I found that progressive denervation may alter DA signaling by three independent mechanisms depending on degree of denervation and macroscopic morphology of the lesion. (jneurosci.org)
Competitive marathon running and regular high intensity distance running in young and middle-aged adults may not produce leg muscle hypertrophy due to insufficient recovery from the damaging running bout, although there have been no studies that have investigated the effects of running on leg muscle morphology in older subjects. (researchgate.net)
Morphology studies yielded similar results. (nature.com)

citation needed] The most widely discussed studies to date are the Symplicity HTN-1, HTN-2 and HTN-3 trials, conducted with Medtronic's Symplicity RDN System. (wikipedia.org)
James Howard, MBBChir , of Imperial College London, and colleagues looked at the discrepancy between office-based and ambulatory readings in trials of antihypertensive agents and renal denervation. (medpagetoday.com)
There aren't any results from randomized, blinded trials for renal denervation yet, but in the unblinded trials, office-based systolic blood pressure drops averaged 27.6 mm Hg versus pretreatment values and 26.6 mm Hg versus untreated controls. (medpagetoday.com)

The primary outcome of change from baseline in 6-minute walk distance increased in both groups at 30 days, with a median change at 6 months of 61 meters with denervation and 18 meters with sham treatment ( P = .04). (medscape.com)
The major adverse event rate of 1.4 percent for renal denervation comfortably met the safety goal of 9.8 percent, compared with 0.3 percent in the sham treatment arm. (acc.org)
Electrodiagnostic studies were performed by neurol- ate treatment and diagnostic testing. (cdc.gov)
Together with references 3 and 4, these large-scale studies analysed the genomes of ∼ 1 million individuals, identifying new BP-associated loci, doubling the number of reported BP-associated genes and helping to identify potential new targets for BP treatment. (nature.com)

We queried MEDLINE, Embase, and BIOSIS to identify all animal studies testing the efficacy of pregabalin published before January 2018 and recorded experimental design elements addressing threats to validity and all necessary data for calculating effect sizes, expressed as the percentage of maximum possible effect. (iasp-pain.org)
Animal experimental studies have generally demonstrated that the tooth follicle plays a major role as the structure that forms the path for the crown through the overlying bone during the eruption process [ 1 - 3 ]. (hindawi.com)
In another experimental study [ 2 ] Wise et al. (hindawi.com)
Accordingly, several experimental studies have been performed that show how the follicle functions in the resorption process that is invoked in the bone tissue during eruption. (hindawi.com)
It has also been evaluated in experimental studies what influence the innervation has on tooth eruption. (hindawi.com)
Thus, it was shown in experimental studies that eruption stopped when the nerve connection to the teeth was interrupted [ 4 ]. (hindawi.com)
The study also demonstrates that there is an increase in complex synaptic interactions that have been implicated in synaptic plasticity in other regions of the CNS after experimental manipulations. (jneurosci.org)
2007). Emerging evidence from both epidemiological and experimental studies indicates the adverse consequences of PM2.5 exposure on diabetes, including worsening of whole-body insulin sensitivity, glucose tolerance impairment, lipid accumulation, and glucose metabolism dysfunction (Hwang et al. (deepdyve.com)
Two study groups were selected: an experimental group, comprising 32 canine teeth with complete root formation that had been submitted to orthodontic traction, and a control group, comprising 32 canine teeth with complete root formation that had never been submitted to any orthodontic movement. (bvsalud.org)

As long as the remaining innervation stays anatomically coherent, denervation reduces phasic variations in extracellular DA, but the DA tone is not changed. (jneurosci.org)

12: Gustafsson P, Jestin P, Gunnarsson U, Lindforss U. Higher frequency of anastomotic leakage with stapled compared to hand-sewn ileocolic anastomosis in a large population-based study. (cancercentrum.se)

Thus, the ADGAT DKO mice provide a fascinating new model to study the coupling of metabolic energy storage to energy expenditure. (elifesciences.org)
This study introduces a valuable paradigm in the field of adipose tissue biology: blocking triglyceride storage in adipose tissue does not lead to lipodystrophy and impaired glucose homeostasis but instead improves metabolic health. (elifesciences.org)
The evidence supporting these claims is convincing , based on a comprehensive metabolic analysis, although mechanistic studies would strengthen the study and its impact. (elifesciences.org)

Study principal author Dr. Mariana Berho, Director of the Pathology and Laboratory Medicine Center and of the Center for Research at Cleveland Clinic Florida and a paid consultant for Mederi Therapeutics Inc. explained: 'The results of this animal model study are extremely valuable as they may reflect the changes that take place in the human lower esophageal sphincter as well as the internal anal sphincter after the administration of radiofrequency. (massdevice.com)

With 80-99% denervation, a persistent aberrant signal develops in D 2 -regulated pathways caused by random fluctuations in tonic DA release. (jneurosci.org)

However they advocated further research with better designed randomised studies. (wikipedia.org)

Denervation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)

We conclude that the isolated perfused pig intestine is an effective model for studying the pharmacological effects of drugs and their routes of delivery. (annals.edu.sg)

High blood pressure is usually treated medically with drugs, but many people don't take their medications as prescribed, past studies have found. (startribune.com)

Initial study results have demonstrated that the Enlightn renal denervation system is safe and effective in rapidly lowering blood pressure. (cardiovascularnews.com)
Renal denervation failed to achieve the primary efficacy endpoint of a decrease in systolic blood pressure measured in the doctor's office from baseline to six months or the powered secondary efficacy endpoint of decrease in average 24-hour levels by ambulatory blood pressure monitoring, which provides more reliable readings. (acc.org)
An analysis suggests that randomized renal denervation data will show less substantial -- but still important -- reductions in blood pressure compared with unblinded studies. (medpagetoday.com)
Heritability of conventional and ambulatory blood pressures: a study in twins. (nature.com)
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. (nature.com)
Renal denervation has been demonstrated in published clinical studies to significantly reduce systolic blood pressure. (centerwatch.com)
3: Mörner M, Gunnarsson U, Jestin P, Egenvall M. Volume of blood loss during surgery for colon cancer is a risk determinant for future small bowel obstruction caused by recurrence--a population-based epidemiological study. (cancercentrum.se)

Clinical studies of androgen supplementation in age-related diseases and muscle wasting are a focus of emerging interest ( 11 ). (frontiersin.org)
Find studies for diseases and conditions and see if you or a loved one is eligible. (nih.gov)

We predict that as denervation trial designs gradually improve in bias-resistance, office and ambulatory pressure drops will converge," Howard and colleagues wrote. (medpagetoday.com)

This phenomenon appears with moderate denervation (50-80%), and affects mainly signaling by high-affinity DA receptors (e.g., high-affinity D 2 - and D 3 -type receptors). (jneurosci.org)

At six months, BP in the renal denervation group had decreased significantly by 32/12 mm Hg from a mean baseline level of 178/96 mm Hg. (renalandurologynews.com)
In addition, 84% of the renal denervation group had a decrease in systolic pressure of 10 mm Hg or more versus 35% of controls, a significant difference between the groups. (renalandurologynews.com)
Although a particular area of concern was potential renal stenosis, there was only one case in the renal denervation group and none in the sham group. (acc.org)
The EQ group scored higher in nerve conduction studies, compared to vehicle-treated db/db group. (nature.com)

Anatomy58

Organisms6

Diseases19

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Psychiatry and Psychology1

Phenomena and Processes18

Hypertension38

Cardiac sympathetic denervation17

Sympathetic5

Radiofrequency denervation12

Resistant1

Systolic blood pressure redu1

Procedure7

Efficacy and safety5

Antihypertensive medications1

Facet joint1

Atrial4

Randomized Contr1

Pivotal trial1

Catheter5

Medtronic5

Mismatch1

Outcomes4

Ultrasound2

Chronic7

Patients22

Sham-controlled2

Surgical3

Procedures1

Sensory3

Statistically significant1

20221

20211

Porcine model2

Morphology3

Trials3

Treatment4

Experimental9

Innervation1

Anastomosis1

Metabolic3

Pathology1

Persistent1

Designed randomised1

MeSH1

Pharmacological1

Medications1

Blood7

Diseases2

Predict1

Moderate1

Group4