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Convergent synthesis of (+/-)-dihydroisocodeine in 11 steps by the tandem radical cyclization strategy. (wikipedia.org)
Hamme, A. T. II "Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation" Synthesis 2006 , 3815-3818. (jsums.edu)
2019 ) A Garratt-Braverman cyclization route towards the synthesis of phenanthridine derivatives and their DNA-binding studies Tetrahedron . (academictree.org)
2018 ) Synthesis of furan-fused 1,4-dihydrocarbazoles via an unusual Garratt-Braverman Cyclization of indolyl propargyl ethers and their antifungal activity Tetrahedron . (academictree.org)
The synthesis of peptides containing both a dehydroalanine and a cysteine residue was carried out using a mixture of solid phase and solution chemistry. (soton.ac.uk)
His graduate studies at the University of Connecticut involved method development and new reaction discovery in the synthesis of natural product-like molecules. (burnslev.com)
His work included phosphine-mediated cycloisomerization of alkynyl hemiketals, the rearrangement of spiroketals, and small library synthesis/SAR studies of desoamine analogs. (burnslev.com)
Recently, significant advances have taken place in the use of SmI 2 for the synthesis of nitrogen heterocycles, enabled in large part by the unique combination of high reducing power of this reagent (E 1/2 of up to −2.8 V) with excellent chemoselectivity of the reductive umpolung cyclizations mediated by SmI 2 . (mdpi.com)
Novel synthetic methodologies for the synthesis of substituted phenanthridines and oxindoles utilizing tandem cyclizations of β-keto radicals were developed. (purdue.edu)
The first chapter introduces the reader to the concept of natural product total synthesis and its importance to chemistry, other sciences, and society. (jyu.fi)
After various challenges, a short and facile formal total synthesis relying on a cascade cyclization was developed. (jyu.fi)
Synthesis and catalytic activity study of Cu(I) complexes with camphor derived ligands. (weebly.com)
Title: FeCl3⋅6H2O-catalyzed intermolecular-cascade cyclization of acetoacetanilide: aldehyde-tuned synthesis to valuable 2-pyridone analogues. (aablocks.com)
Title: Mononuclear Ru(III) Schiff base complexes: synthesis, spectral, redox, catalytic and biological activity studies. (aablocks.com)
Title: Synthesis, spectral, catalytic and antimicrobial studies of PPh3/AsPh3 complexes of Ru(II) with dibasic tridentate O, N, S donor ligands. (aablocks.com)
Title: Synthesis, characterization, and antifungal studies of transition metal complexes of omega-bromoacetoacetanilide isonicotinylhydrazone. (aablocks.com)
Selectfluor as "Fluorine-Free" Functional Reagent Applied to Organic Synthesis under Transition Metal-Free Conditions [J]. Chinese Journal of Organic Chemistry, 2020, 40(9): 2641-2657. (sioc-journal.cn)
Her group has been using directed evolution to explore new-to-nature enzyme chemistry (mainly carbene and nitrene transfer) and enzyme-catalyzed synthesis of noncanonical amino acids. (beyondcchf.org)
Recent studies have focused on asymmetric synthesis of structurally complex amino acids, using what has proved to be a very versatile radical-based methodology and also the use of structurally unusual heterocycles for masking the reactivity of synthetically valuable functional groups. (exeter.ac.uk)
In this area, we have developed a methodology for the incorporation of protected isocyanates into organic molecules and this chemistry is being applied to the synthesis of a diverse set of biologically important, nitrogen-containing heterocycles. (exeter.ac.uk)
My teaching activities cover all aspects of organic chemistry from basic structure and bonding in organic molecules, to complex organic synthesis. (exeter.ac.uk)
The second major area of my group's research has involved studies into the use of structurally 'unusual' heterocycles as protected, reactive functional groups in organic synthesis. (exeter.ac.uk)
In 1990, he won the Nobel Prize in Chemistry "for his development of the theory and methodology of organic synthesis ", specifically retrosynthetic analysis. (kiddle.co)

A novel Fourier transform infrared (FT-IR) microspectrophotometer equipped with differential scanning calorimetry (DSC) was used to investigate the kinetics of intramolecular cyclization of aspartame (APM) sweetener in the solid state under isothermal conditions. (unboundmedicine.com)
The results support that the intramolecular cyclization process in APM proceeded in three steps: the methoxyl group of ester was first thermolyzed to release methanol, then an acyl cation was attacked by the lone pair of electrons available on nitrogen by an S(N)1 pathway, and finally ring-closure occurred. (unboundmedicine.com)
The intramolecular cyclization of APM determined by this microscopic FT-IR/DSC system was found to follow zero-order kinetics after a brief induction period. (unboundmedicine.com)
The total activation energy of the DKP formation via intramolecular cyclization was 261.33 kJ/mol, calculated by the above summation of the bond energy of cleavage, conversion, and formation, which was near to the value determined by the DSC or TGA method. (unboundmedicine.com)
This step results from an intramolecular cyclization reaction in which the carbonyl (C=O) group that was a part of the original isocyanate group (-N=C=O), is effectively extracted to yield perimidone and the amine corresponding to the original isocyanate species. (cdc.gov)

The Journal of Organic Chemistry. (wikipedia.org)
My previous research with Josh along with my enjoyable experiences in my organic chemistry courses my sophomore year at Haverford have shaped my interests in the field into what they are today," he says. (haverford.edu)
He is the recipient of the Boehringer-Ingelheim Doctoral Scholarship for Organic Chemistry (2013) which allowed him to spend six months in Chemical Development and six months in Medicinal Chemistry at Boehringer-Ingelheim. (burnslev.com)
Journal of organic chemistry, 87, 3712-3717 doi:10.1021/acs.joc.1c02647. (irb.hr)
Organic Chemistry Frontiers, 9, 428-435 doi:10.1039/d1qo01684a. (irb.hr)
European journal of organic chemistry, 2021 (28), 3920-3924 doi:10.1002/ejoc.202100400. (irb.hr)
Journal of organic chemistry, 85 (21), 14253-14261 doi:10.1021/acs.joc.0c02225. (irb.hr)
Hypervalent Organoiodine Promoted Dearylation Reaction of N -Aryl Sulfonamides [J]. Chinese Journal of Organic Chemistry, 2020, 40(8): 2433-2441. (sioc-journal.cn)
In 1959, he moved to Harvard University , where he is currently an emeritus professor of organic chemistry with an active Corey Group research program. (kiddle.co)
One of the most widely recognized principles within organic chemistry is Hückel's rule: an aromatic compound possesses 4 n +2 π-electrons while an antiaromatic compound possesses 4 n π-electrons. (compchemhighlights.org)

These substrates can undergo cyclization reactions upon treatment with electrophilic brominating reagents. (uni-wuerzburg.de)
Therefore reactions of vanadium dependent bromoperoxidases (VBPOs) were investigated in the present study as well as transformations using functional models thereof. (uni-wuerzburg.de)
The results from studies related to functional models in non-aqueous media were subsequently compared to data from enzyme-catalyzed reactions. (uni-wuerzburg.de)
Prior to joining Burns & Levinson, Chris was a postdoctoral research scientist with Jack Norton at Columbia University where his research involved replacing tin hydrides in pharmaceutically useful radical cyclization reactions with cobalt and vanadium complexes using hydrogen gas. (burnslev.com)
Recent aspects of the research are the study of enantioselective Michael addition reactions, cyclization reactions, domino processes, and phosphonate and bisphosphonate chemistry. (unl.pt)
Investigation of photoinitiated Bergman cyclisation reactions using high-resolution laser spectroscopy. (exeter.ac.uk)
‌54‌ - ‌60‌ , ‌85‌ ] The mechanism for such reactions has been studied by means of density functional theory (DFT) computation. (thieme.com)

Research grantee within the Project: "Catalysts for alkynes cyclization", supported by the FCT project PPCDT/QUI/58119/2004. (weebly.com)
Duñach E, Esteves A.P, Medeiros M.J, Pletcher D, Olivero S: The study of nickel(II) and cobalt(II) complexes with a chiral salen derivative as catalysts for the electrochemical cyclisation of unsaturated 2-bromophenyl ethers. (iupac.org)
Duñach E., Esteves A.P., Medeiros M.J., Olivero S.: Electrogenerated Nickel(I) complexes as catalysts for the intramolecular radical cyclisation of unsaturated α-bromoesters. (iupac.org)

Norton, J.R. 'Catalysis of Radical Cyclizations from Alkyl Iodides under H2: Evidence for Electron Transfer from [CpV(CO)3H]-' J. Am. Chem . (burnslev.com)
This ongoing area of research has led to further investigations into the 1,5-hydrogen atom transfer process and in particular, studies into the effectiveness of deuterium as a protecting group for C-H bonds in radical and carbene chemistry. (exeter.ac.uk)
Esteves A.P., Ferreira E.C., Medeiros M.J.: Selective radical cyclisation of propargyl bromoethers to tetrahydrofuran derivatives via electrogenerated nickel(I) tetramethylcyclam. (iupac.org)

Visiting Assistant Professor at Charles University, Faculty of Science, Department of Inorganic Chemistry, Praha. (weebly.com)

Thereafter, she worked as a postdoctoral researcher at both the Department of Chemistry of the University of Saskatchewan (Canada) between 1989 and 1990, and the Department of Chemistry of Queen's University in Kingston (Canada) between 1993 and 1994. (tcd.ie)
During 2009-2012 she served as External Examiner in Organic/Medicinal Chemistry at the School of Chemistry in NUI Maynooth and during 2012-2016 in the Department of Chemistry and Pharmaceutical Chemistry (serving the Schools of Pharmacy and Medicine) at the Royal College of Surgeons in Ireland. (tcd.ie)
Research report / Department of Chemistry. (jyu.fi)
In 2006, John joined the Department of Chemistry at the University of Wisconsin - Madison, where he has established a vibrant research program tackling fundamental problems in coordination chemistry and bonding. (beyondcchf.org)

She worked as a researcher in the Medicinal Chemistry Institute (CSIC) until the year 2000, thereafter joining the School of Chemistry in TCD as a Lecturer. (tcd.ie)
Additionally, she has held positions as Director of the Medicinal Chemistry Moderatorship, member of the Fellowship Central committee, Head of Organic, Medicinal and Biological Chemistry at the School of Chemistry, Director of Postgraduate Teaching and Learning, Director of Research and Director of Global Relationships at the School of Chemistry, Director of Dublin Chemistry postgraduate program, Tutor and served in numerous College committees and selection panels. (tcd.ie)
Moreover, she has served in different scientific committees such as the Irish panel of the ERA-Chemistry panel, the Irish Centre of High-End Computing or the XXIII EFMC-International Symposium in Medicinal Chemistry held in Lisbon in September 2014, and the WATOC Theoretical Chemist conference to be held in Vancouver 2022. (tcd.ie)
besides, she has driven the foundation of the Division of Medicinal and Biological Chemistry within the Institute of Chemistry of Ireland (ICI) and its adherence to the European Federation of Medicinal Chemistry and Chemical Biology (EFMC) in 2022. (tcd.ie)
Between 2019 and 2022 she has been an Editor of the journal Bioorganic and Medicinal Chemistry Letters (Elsevier). (tcd.ie)

Results from mechanistic studies have indicated that (schiffbase)vanadium(V) complexes react with tert-butyl hydroperoxide (TBHP) to furnish peroxy complexes (ESI-MS, 51V NMR). (uni-wuerzburg.de)
Title: Spectroscopic, and thermal studies of some new binuclear transition metal(II) complexes with hydrazone ligands containing acetoacetanilide and isoxazole. (aablocks.com)
Title: Metal-induced cyclization of thiosemicarbazones derived from beta-keto amides and beta-keto esters: open-chain and cyclized ligands in zinc(II) complexes. (aablocks.com)
A Comparative Study of the Structures and Fluxionality of the Carbenium Ion Complexes [FvMo2(CO)4(.mu. (mcmaster.ca)
Duñach Elisabet, Paula Esteves Ana, Medeiros Maria J., Olivero Sandra: Electrochemical intramolecular cyclisation of propargyl bromoethers catalysed by nickel complexes. (iupac.org)

Jorgi Mandelbaum graduated from Tulane University with a B.S. (2021) and M.S. (2022) in neuroscience, with undergraduate minors in chemistry and Spanish. (rsc.org)

In the final phase of this investigations it was explored the use of chiral derivatives of the chiral pool molecule citronellal as well as an achiral analogue in an effort to afford novel chiral aldehydes for propargylation and cyclisation. (bl.uk)
The aim of these studies has been to develop a much-needed general synthetic route to amino acids (and other amine derivatives) possessing a quaternary chiral centre alpha -to the nitrogen atom and in particular, alpha , alpha -disubstituted alpha -amino acids. (exeter.ac.uk)

As a result of this work, a previously unreported benzoxazine monomer based on 3,3'-dichloro-4,4'-diaminodiphenylmethane was obtained, characterized by 1H and 13C NMR spectroscopy, and its thermal and rheological properties were studied. (preprints.org)

Duñach E., Esteves A. P., Medeiros M. J., Olivero S.: Reductive cyclisation of propargyloxy and allyloxy α-bromoester derivatives using environmentally friendly electrochemical methodologies. (iupac.org)

The objective of the present study was associated with a development of methods for preparing halogenated cyclic ethers starting from bishomoallylic alcohols. (uni-wuerzburg.de)
The strategy employed is based on the chemistry of vanadium dependent haloperoxidases (VHPOs) that are able to catalyze the oxidation of chloride and bromide using H2O2 as The objective of the present study was associated with a development of methods for preparing halogenated cyclic ethers starting from bishomoallylic alcohols. (uni-wuerzburg.de)

These studies have also revealed intriguing and unexpected physical properties associated with the parent imide heterocycle (particularly in terms of its acidity) and as a result, studies involving related heterocycles are proposed. (exeter.ac.uk)

From 2004 - 2006, he worked with Prof. Karl Wieghardt at the Max Planck Institute for Bioinorganic Chemistry in Mülheim an der Ruhr, Germany, on new electrochemical and photochemical routes to unstable high-valent iron intermediates. (beyondcchf.org)
Duñach E., Medeiros M.J.: Indirect electrochemical cyclization of bromoalkoxylated derivatives mediated by nickel(II) complex in environmental-friendly medium. (iupac.org)

This result is owing to evaporation of water and/or MP molecules following exothermic cyclization reaction. (elsevierpure.com)
His work involves patent prosecution in the Life Sciences, including biotechnology and pharmaceuticals, small molecules, and chemistry. (burnslev.com)
Dr. Abolhasani leads a diverse research group that studies flow chemistry strategies tailored towards accelerated development and manufacturing of advanced functional materials and molecules using autonomous robotic experimentation. (beyondcchf.org)
His graduate work involved synthetic and experimental studies to elucidate the electronic structure and metal-metal bonding in linear trinuclear molecules that serve as models for molecular wires. (beyondcchf.org)

2018 ) Recent advances in Garratt-Braverman cyclization: Mechanistic and synthetic explorations Tetrahedron Letters . (academictree.org)
Erik's postdoctoral work with Prof. John Hartwig at the University of Illinois centered on synthetic and mechanistic studies of transition metal enolates. (beyondcchf.org)
My involvement in this project is from the synthetic angle, and I am currently directing and supervising the preparation of the required enediyne cyclisation precursors. (exeter.ac.uk)

Biomimetic cyclisation studies using the precursor to the B ring of subtilin (2) were found to occur stereospecifically both in solution and in the solid phase. (soton.ac.uk)

Structure-activity relationship studies have been conducted to identify the aryl isonitrile group as the key functional group responsible for the observed antibacterial activity. (purdue.edu)

Known obstacles like side interaction with the PCl6- counterion and a tendency of longer chains to undergo crosslinking elongation instead of cyclization are still relevant and ways to overcome them are being discussed. (preprints.org)
Cyclopropanols readily undergo single-electron oxidation and ring opening to give β-keto radicals which underwent cyclization with biaryl isonitriles and acrylamides followed by homolytic aromatic substitution to give ketoalkylated phenanthridines and oxindoles. (purdue.edu)

‌39‌ ] Although the reported cyclizations ultimately furnish the desired organic products complexed to cobalt, this outcome is advantageous as it stabilizes the ligands against isomerization or aromatization and, at the same time, potentially activates them toward hydride abstraction, and further substitution. (thieme.com)

Hassan joined the Busschaert group in 2020 as a post-doctoral researcher responsible for microbiology studies. (rsc.org)

She received the Nobel Prize in Chemistry (2018) for pioneering the directed evolution of enzymes. (beyondcchf.org)

Reilley is working with Professor William Lubell of the chemistry department on the mechanism of cyclization of macrolactams. (haverford.edu)
Despite a significant number of investigations in the field of phosphazene chemistry, the mechanism of this class cyclic compounds formation is still poorly studied. (preprints.org)

Among numerous honors, Corey was awarded the National Medal of Science in 1988, the Nobel Prize in Chemistry in 1990, and the American Chemical Society 's greatest honor, the Priestley Medal, in 2004. (kiddle.co)

In 2019, he received his B.S. in Chemistry from the University of Miami. (rsc.org)
Erik enthusiastically joined the Chemistry Department faculty at UNC Chapel Hill in 2008 and was promoted to Professor of Chemistry in 2019. (beyondcchf.org)

He is the Laboratory Coordinator for the suite of fundamental materials sciences projects funded through the U.S. Department of Energy Office of Science, Basic Energy Sciences, Division of Materials Sciences and Engineering and is the lead investigator for programs dealing with defects in TCO films, growth of hierarchically ordered composite materials, in situ Raman studies of materials under extreme conditions, nonlinear optical materials, and studies of pulsed laser-solid interactions. (pnnl.gov)

Journal of Physical Chemistry C 119, no. 39:22465-22476. (pnnl.gov)

The intensity anomaly can be explained by intracluster cyclization reaction induced by electron transfer from the metal atom and resulting a stable benzene derivative formation. (elsevierpure.com)

Organic & biomolecular chemistry, 21 (16), 3381-3387 doi:10.1039/d3ob00326d. (irb.hr)
Organic & biomolecular chemistry, 20 (18), 3823-3834 doi:10.1039/d2ob00090c. (irb.hr)
Organic & biomolecular chemistry, 19, 4637-4651 doi:10.1039/d1ob00164g. (irb.hr)
Organic and Biomolecular Chemistry. (york.ac.uk)

In this research study, the removal of ammonium ions from aqueous solution by hydroxy-sodalite (HS) was evaluated. (ajgreenchem.com)

Quantum chemistry has contributed significantly to nearly all spectroscopic methods used in chemistry, but comparatively less so for mass spectrometry. (compchemhighlights.org)

After graduation, he immediately joined the Electrochemistry Group in the School of Chemistry in Southampton and has remained there since. (southampton.ac.uk)

Professor Derek Pletcher is Emeritus Professor within Chemistry at the University of Southampton. (southampton.ac.uk)

Postdoctoral researcher within CQB Thematic Line "Chemistry and Biochemistry for a Clean Environment" (MULTI/00612). (weebly.com)

Antisense oligonucleotides (ASO), short single-stranded polymers (based on DNA or RNA chemistries) synthesized in vitro , regulate gene expression by binding in a sequence-specific manner to a RNA target. (preprints.org)

The strategy employed is based on the chemistry of vanadium dependent haloperoxidases (VHPOs) that are able to catalyze the oxidation of chloride and bromide using H2O2 as primary oxidant. (uni-wuerzburg.de)

Thermal cyclization of 3 via N -azolium salt to saturated benzazole-azines is also described. (heterocycles.jp)

After a number of years working in industry, he returned to education in 2011 to complete an MPhil degree in chemistry at the University of Southampton (UK) under the supervision of Dr. Martin Grossel. (rsc.org)
In 2014, he joined the group of Dr. Jonathan Watts to pursue a PhD in chemistry at the University of Southampton (UK) and the RNA Therapeutics Institute (USA). (rsc.org)

Molecular modelling and NMR studies were utilised to determine the stereochemistry of the cyclic compounds however, these studies were unsuccessful in establishing the absolute configuration conclusively. (soton.ac.uk)

NHCs constitute a well-established class of new ligands in organometallic chemistry. (journaltocs.ac.uk)
Although initially NHCs were regarded as pure σ-donor ligands, later experimental and theoretical studies established the presence of a significant back donation from the d-orbital of the metal to the π* orbital of the NHC. (journaltocs.ac.uk)

A small aliquot of impinger solution (0.5 ml) is mixed with an equal volume of formic acid (a catalyst for cyclization). (cdc.gov)

New journal of chemistry, 46 (18), 8760-8764 doi:10.1039/d2nj00493c. (irb.hr)
Chemistry : A European Journal. (york.ac.uk)
Journal of Materials Chemistry C 1, no. 30:4527-4535. (pnnl.gov)
Journal of Electroanalytical Chemistry 2008 , 614 , 131. (iupac.org)
Journal of Electroanalytical Chemistry 2007 , 603 , 124. (iupac.org)
Journal of Electroanalytical Chemistry 2004 , 566 , 39. (iupac.org)

A key step is the Grewe cyclization that is analogous to the cyclization of reticuline that occurs in morphine biosynthesis. (wikipedia.org)
Two aspects of the biosynthesis of the non-canonical terpene synthase for 2-methylisoborneol have been studied. (journaltocs.ac.uk)

I am a member of the Biological Chemistry research group . (exeter.ac.uk)

He was promoted to Associate Professor in 2012, full Professor in 2015, and in 2016 John was appointed the Lester R. McNall Professor of Chemistry. (beyondcchf.org)

The bond cleavage energy (259.38 kJ/mol) of thermolysis for the leaving group of -OCH(3), the bond conversion energy (328.88 kJ/mol) for the amide II NH band to DKP NH band, and the CN bond formation energy (326.93 kJ/mol) of cyclization for the DKP in the APM molecule were also calculated from the Arrhenius equation. (unboundmedicine.com)

After completing her BSc (honours) in Chemistry at the Universidad Complutense de Madrid in 1981, and her "Licenciado de grado" degree (similar to a MSc) in 1982, her PhD research was embarked upon at the Instituto de Quimica Medica in the National Council of Research (CSIC) in Madrid, and the degree achieved in 1987 at the Universidad Complutense de Madrid. (tcd.ie)
The internship has already become a highlight of his undergraduate studies so far, as it has given him firsthand experience of life as a graduate student research in an international setting. (haverford.edu)
My internship this summer feels like the capstone of my studies at Haverford," he explains, "both as a taste of what I can look forward to as a Ph.D. student and through the cultural experiences I am having as a part of an international research group in a foreign country. (haverford.edu)
During her studies, she performed undergraduate research in the lab of Dr. Nathalie Busschaert, focusing on PG binding. (rsc.org)
Erik continued his studies at The Scripps Research Institute in the laboratory of Prof. Erik Sorensen, moving to Princeton University before receiving his Ph. (beyondcchf.org)
John then pursued graduate education in chemistry, attending Texas A&M University from 2000 - 2004 where he worked as an NSF Graduate Research Fellow in the research group of Prof. F. Albert Cotton. (beyondcchf.org)

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20192

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20161

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