AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Anemia, AplasticBone Marrow TransplantationBone MarrowTransplantation, HomologousBone Marrow CellsGraft vs Host DiseaseAnemiaTransplantation, AutologousWhole-Body IrradiationBone and BonesTransplantation ConditioningHematopoietic Stem Cell TransplantationLeukemiaAntilymphocyte SerumTransplantation ChimeraLiver TransplantationTissue DonorsGraft SurvivalHistocompatibility TestingBusulfanHematopoietic Stem CellsBone Marrow DiseasesImmunosuppressive AgentsHistocompatibilityBone Marrow PurgingCyclophosphamidePancytopeniaHematopoiesisTransplantation, IsogeneicKidney TransplantationRecurrenceImmunosuppressionFanconi AnemiaCyclosporineMyelodysplastic SyndromesTreatment OutcomeGraft vs Host ReactionBone Marrow ExaminationCombined Modality TherapyGraft RejectionLeukemia, Myeloid, AcuteMice, Inbred C57BLRadiation ChimeraTime FactorsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveRemission InductionHematologic NeoplasmsLeukemia, MyeloidHLA AntigensColony-Forming Units AssayHemoglobinuria, ParoxysmalPrecursor Cell Lymphoblastic Leukemia-LymphomaHepatic Veno-Occlusive DiseaseBone RemodelingAcute DiseaseBone Marrow NeoplasmsStem Cell TransplantationHematologic DiseasesTransplantation ImmunologySurvival AnalysisRetrospective StudiesT-LymphocytesLymphocyte DepletionLymphoma, Non-HodgkinLeukocyte TransfusionHeart TransplantationLeukocyte CountSevere Combined ImmunodeficiencyChimeraGranulocyte Colony-Stimulating FactorAnemia, HemolyticFollow-Up StudiesAnemia, RefractoryLung TransplantationSurvival RateBlood TransfusionActuarial AnalysisBone DensityBlood Cell CountGranulocytesLymphocyte TransfusionOxymetholoneAntineoplastic Combined Chemotherapy ProtocolsNuclear FamilyCell DifferentiationCarmustineOrgan TransplantationFatal OutcomeGraft vs Tumor EffectDisease-Free SurvivalGraft vs Leukemia EffectFlow CytometryCytarabineCord Blood Stem Cell TransplantationSpleenCytomegalovirus InfectionsCells, CulturedInfectionPrognosisBone Resorption
Autologous Bone Marrow TraImmunosuppressive therapyTransplantsCases of aplastic anemiaSyndromesHepatitis-associated aplastic anaemiaLeukemiaSevere aplastic anaemiaHemolytic AnemiaHematopoietic cell transplantation outcomesDiagnosisMyelodysplasticTreatment of aplastic anemiaHematologicThalassemiaGraft-versus-DonorInternational Bone Marrow Transplant RBiopsyDiseasesPancytopenia and marrow hypoplasiaAllogeneic hemaCyclosporineCongenitalHematologyAutoimmune2021Stem cellsBlood and bone marrowTransplant ResearchDisordersHypoplastic bone marrowRetrospective studyDecided a bone marrow traClinicalProduction of hematopoietic cellsImmuneHaematopoiesisDonorsParoxysmalIncidenceFailureDisease
Autologous Bone Marrow Tra1
Immunosuppressive therapy4
Transplants8
  • 4 Although bone marrow transplants have increased the survival rate of patients with AA, most people do not have access to this therapy, and fatality rates of the disease remain high. (haematologica.org)
  • Mary M. Horowitz is an American oncologist who specializes in blood and marrow transplants. (wikipedia.org)
  • Kaminski E, Hows J, Brookes P, Mackinnon S, Hughes T, Avakian O, Sharrock C, Goldman J, Batchelor JR. Alloreactive cytotoxic T-cell frequency analysis and HLA matching for bone marrow transplants from HLA matched unrelated donors. (anthonynolan.org)
  • In the rhinocerebral or documented that incidence of zygomycosis increased, par- pulmonary forms, patient death rates are reported to be as ticularly in patients with hematologic malignancies or bone high as 60% because of delayed diagnosis or delayed thera- marrow transplants. (cdc.gov)
  • This study will assess the safety and effectiveness of certain cord blood transplants. (nih.gov)
  • The study will help researchers learn the best methods for collecting, storing, and using cord blood in transplants. (nih.gov)
  • Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia. (medscape.com)
  • Dr. Seth Maliske specializes in hematology, oncology and blood and bone marrow transplants. (sanfordhealth.org)
Cases of aplastic anemia3
  • Although the research study centers had a high coverage of health services, the underreporting of cases of aplastic anemia in selected regions can be discussed. (haematologica.org)
  • 1 A recent review of the epidemiology of aplastic anemia shows that most cases of aplastic anemia appear to be secondary to the immunological destruction of the hematopoietic cells. (haematologica.org)
  • Because abnormal cytogenetic clones can occur in up to 12% of patients with aplastic anemia, the presence of some clones in otherwise typical cases of aplastic anemia does not necessarily signify a diagnosis of MDS or acute myeloid leukemia (AML) . (medscape.com)
Syndromes13
  • Pretransfusion assessment of HbF levels may help in identifying the cause of aplasia in many cases of inherited bone marrow failure syndromes. (medscape.com)
  • Increased chromosomal breakage in the presence of DNA cross-linking agents such as diepoxybutane or mitomycin C is observed in cases with inherited bone marrow failure syndromes (IBMFS). (medscape.com)
  • The three conditions most commonly included in the differential diagnosis of aplastic anemia are inherited marrow-failure syndromes, paroxysmal nocturnal hemoglobinuria, and myelodysplastic syndrome (MDS). (medscape.com)
  • Bone marrow failure syndromes encompass a number of moderately well described entities, defined largely by clinical presentation rather than results of specific testing, that share the common findings of peripheral blood cytopenia in the setting of marrow hypoplasia. (ashpublications.org)
  • While an increasing number of specific genetic abnormalities have been associated with different congenital marrow failure syndromes over the past few years, only a proportion of patients within each congenital disease category have the mutations described. (ashpublications.org)
  • Nonetheless, the availability of such "genetic testing" has revealed increasing numbers of individuals who by clinical criteria appear to have idiopathic aplastic anemia (AA) and appear phenotypically normal yet have molecular hallmarks of congenital marrow failure syndromes. (ashpublications.org)
  • Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
  • In addition to successfully treating children with a range of cancer diagnoses, the BMT team also has successfully transplanted patients with other conditions such as bone marrow failure syndromes, immunodeficiency, metabolic disorders, genetic disorders and thalassemia. (childrensmercy.org)
  • a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
  • deferasirox efficacy and safety in patients with myelodysplastic syndromes (MDS), aplastic anemia (AA) or other rare anemias. (karger.com)
  • This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes. (sparkcures.com)
  • Studies on the pathogenesis of bone marrow failure syndromes have helped to elucidate the regulation of cellular growth and differentiation in the hematopoietic environment. (medscape.com)
  • This article reviews Fanconi's anemia (FA), the most common of the rare inherited bone marrow failure syndromes, and discusses new insights on the pathophysiology of this disease. (medscape.com)
Hepatitis-associated aplastic anaemia1
  • Gonzalez-Casas R, Garcia-Buey L, Jones EA, Gisbert JP, Moreno-Otero R. Systematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function. (medscape.com)
Leukemia7
Severe aplastic anaemia2
  • Gordon-Smith EC, Fairhead SM, Chipping PM, Hows J, James DC, Dodi A, Batchelor JR. Bone-marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors. (anthonynolan.org)
  • McCormack PL. Eltrombopag: a review of its use in patients with severe aplastic anaemia. (medscape.com)
Hemolytic Anemia4
Hematopoietic cell transplantation outcomes1
Diagnosis12
  • The cases were patients with diagnosis of aplastic anemia confirmed through biopsy or bone marrow aspiration, selected through an active search of clinical laboratories, hematology clinics and medical records. (haematologica.org)
  • Although a biochemical profile has limited value in evaluation of the etiology and differential diagnosis of aplastic anemia, an analysis of kidney function, as well as measurement of transaminase, bilirubin, and lactate dehydrogenase (LDH) levels, can indicate relevant kidney or liver diseases. (medscape.com)
  • [ 6 ] The Pediatric Haemato-Oncology Italian Association has issued guidelines on diagnosis and management of acquired aplastic anemia in childhood. (medscape.com)
  • Miano M, Dufour C. The diagnosis and treatment of aplastic anemia: a review. (medscape.com)
  • Guidelines for the diagnosis and management of adult aplastic anaemia. (medscape.com)
  • Diagnosis and management of acquired aplastic anemia in childhood. (medscape.com)
  • While determining the onset, duration, and severity of signs and symptoms related to poor marrow function may be of diminished value in discriminating diagnoses, a sophisticated history at diagnosis and thereafter remains critical to guiding management. (ashpublications.org)
  • Due to the increased susceptibility to the development of cancer in this specific population, it is important for the dentist to know the common oral manifestations and potentially cancerous lesions, in order to make an early diagnosis in individuals with Fanconi Anemia. (bvsalud.org)
  • Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o. (medscimonit.com)
  • The diagnosis, evaluation, and treatment of aplastic anemia varies between institutions. (pedemmorsels.com)
  • The principal studies used to establish the diagnosis of PNH are flow cytometry of peripheral blood and bone marrow analysis. (medscape.com)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Myelodysplastic4
  • Carefully evaluate dysplasia to rule out myelodysplastic syndrome (MDS), although some degree of dysplasia may be present in aplastic anemia. (medscape.com)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • 15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
  • Clinical and prognostic significance of small paroxysmal nocturnal hemoglobinuria clones in myelodysplastic syndrome and aplastic anemia. (cdc.gov)
Treatment of aplastic anemia1
Hematologic5
  • Aplastic anemia (AA) is a hematologic condition characterized by bone marrow hypoplasia or aplasia resulting in pancytopenia. (haematologica.org)
  • Later, Horowitz was honored by the Aplastic Anemia & MDS International Foundation "for the significant impact her work has had on stem cell transplant and hematologic malignancy practice worldwide. (wikipedia.org)
  • Severe or very severe aplastic anemia is a hematologic emergency, and care should be instituted promptly. (medscape.com)
  • The company anticipates submitting a Biologics License Application (BLA) to the FDA in the fourth quarter of this year, based on the results of an international, randomized Phase 3 study of omidubicel that was designed to evaluate the safety and efficacy of omidubicel in patients with hematologic malignancies undergoing a bone marrow transplant compared to patients who received a standard umbilical cord blood transplant. (biospace.com)
  • Relapsed patients who previously met hematologic criteria for severe aplastic anemia do not have to meet these hematologic criteria for severe aplastic anemia at time of relapse to be eligible for transplant. (sparkcures.com)
Thalassemia2
Graft-versus-4
  • Kaminski E, Hows J, Man S, Brookes P, Mackinnon S, Hughes T, Avakian O, Goldman JM, Batchelor JR. Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation. (anthonynolan.org)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex. (unibas.ch)
  • This study will use a medicine called sirolimus instead of the usual medicine, cyclosporine, to prevent graft-versus-host disease. (zhihuiya.com)
Donor9
International Bone Marrow Transplant R1
  • Following her formal education, Horowitz joined the International Bone Marrow Transplant Registry in 1985 and began serving as its Chief Scientific Director in 1991. (wikipedia.org)
Biopsy2
Diseases14
Pancytopenia and marrow hypoplasia2
Allogeneic hema1
  • The company also highlighted progress with omidubicel , an advanced cell therapy with positive Phase 3 clinical data, as a potentially life-saving treatment option for patients in need of an allogeneic hematopoietic stem cell (bone marrow) transplant, and GDA-201 , a natural killer (NK) cell immunotherapy in Phase 1/2 development for patients with non-Hodgkin lymphoma (NHL). (biospace.com)
Cyclosporine2
Congenital3
  • Fanconi Anemia is a recessive and rare genetic disorder, characterized by chromosomal instability that induces congenital alterations in individuals. (bvsalud.org)
  • Fanconi Anemia (FA) is a recessive genetic disorder, in which individuals present congenital alterations associated with consanguinity. (bvsalud.org)
  • Aplastic anaemia can be divided into congenital forms (e.g. (aa-pnh.org)
Hematology1
  • These studies were presented at the American Society of Hematology (ASH) 2022 meeting. (aamds.org)
Autoimmune3
  • Clinical and laboratory observations suggest that acquired aplastic anemia is an autoimmune disease. (medscape.com)
  • It is believed that PNH arises in the setting of autoimmune acquired aplastic anemia and bone marrow failure. (rarediseases.org)
  • Studies have shown that a subtype of lymphocyte in the body's own immune system attacks cells in the bone marrow, and this autoimmune process prevents the development of new blood cells. (aa-pnh.org)
20212
  • The bone marrow market is expected to gain market growth in the forecast period of 2021 to 2028. (powershow.com)
  • In February 2021, the company presented details of the results of the omidubicel Phase 3 study at the Transplantation & Cellular Therapy Meetings of the American Society of Transplantation and Cellular Therapy and Center for International Blood & Marrow Transplant Research. (biospace.com)
Stem cells18
Blood and bone marrow2
Transplant Research1
  • Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
Disorders6
Hypoplastic bone marrow2
Retrospective study1
  • We designed a retrospective study to evaluate the incidence of renal involvement on 120 bone marrow recipients referred to the pediatric nephrology outpatient clinic between 2003 and 2005. (ectrx.org)
Decided a bone marrow tra1
Clinical15
  • While serving in this role, she was also appointed Research Director for the Stem Cell Therapeutic Outcomes Database of the C.W. Bill Young Cell Transplantation Program and Principal Investigator of the Data and Coordinating Center of the National Blood and Marrow Transplant Clinical Trials Network. (wikipedia.org)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • The onset is insidious, and the initial clinical manifestation is frequently related to anemia or bleeding, although fever or infections may be noted at presentation. (medscape.com)
  • The registry will also help connect patients with DBA to research and clinical studies, and possible treatment options. (nih.gov)
  • For example, issues related to pubertal progression appear nowhere on the list of differential diagnoses for marrow failure, are unlikely to appear as part of a "clinical practice guideline," and may not appear to be salient when faced with new onset marrow failure in a child. (ashpublications.org)
  • Acute liver failure and acquired aplastic anaemia in children - life - threatening clinical entities of common etiopathogenesis? (medscimonit.com)
  • The review presents etiopathogenesis, clinical presentation and treatment of acute liver failure and acquired aplastic anemia in children. (medscimonit.com)
  • His clinical interests include multiple myeloma, stem cell transplantation, and myeloproliferative neoplasm. (aamds.org)
  • We also continue to expand our clinical pipeline with plans to submit an IND for our GDA-201 natural killer cell therapy, initiate a multi-center Phase 1/2 clinical study in NHL and continue to advance our R&D activities to pursue the development of genetically modified NAM-enabled NK cells in solid tumors. (biospace.com)
  • Additionally, the study met key secondary endpoints related to the speed of platelet engraftment, decrease in infections and reduction in hospitalizations, all significant clinical measures in bone marrow transplant. (biospace.com)
  • Reports have been limited to antimicrobial susceptibility test results of clinical isolates, usually from reference laboratories, animal studies and case summaries ( 19 , 78 ). (antimicrobe.org)
  • In clinical studies, collection of PBPC was usually begun by day 5 and performed daily until protocol specified targets were achieved. (wikidoc.org)
  • Clinical significance of detecting human leukocyte antigen class I allele-lacking leukocytes in aplastic anemia]. (cdc.gov)
  • Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria. (cdc.gov)
  • The World Health Organization, through its International Clinical Trials Registry Platform, has developed the ICTRP database to provide patients, family members and members of the public current information about clinical research studies. (who.int)
Production of hematopoietic cells1
  • Aplastic Anemia" = tri-lineage peripheral blood cytopenia due to reduced or absent production of hematopoietic cells without cellular infiltration . (pedemmorsels.com)
Immune6
Haematopoiesis1
Donors2
Paroxysmal3
  • Aplastic anemia often occurs together with paroxysmal nocturnal hemoglobinuria (PNH). (medscape.com)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • Some individuals with acquired aplastic anemia also have another disorder at the same time, called paroxysmal nocturnal hemoglobinuria (PNH). (rarediseases.org)
Incidence6
Failure9
  • Paul Ehrlich introduced the concept of aplastic anemia in 1888 when he reported the case of a pregnant woman who died of bone marrow failure. (medscape.com)
  • The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
  • This study will test whether combining two medicines to reduce inflammation of the airway and to keep it open may help prevent respiratory failure in people who have pneumonia. (nih.gov)
  • Hepatitis-associated aplastic anemia presenting as a familial bone marrow failure syndrome. (medscape.com)
  • Guidelines from the Marrow Failure Study Group of the Pediatric Haemato-Oncology Italian Association (AIEOP). (medscape.com)
  • Acquired aplastic anemia is a rare, serious blood disorder, due to failure of the bone marrow failure to produce blood cells. (rarediseases.org)
  • The following sections present some implications of our altered knowledge for management of children with marrow failure. (ashpublications.org)
  • Negative evaluation for inherited bone marrow failure conditions (see below) iv. (sparkcures.com)
  • Hepatitis-associated aplastic anemia is a common syndrome in patients with bone marrow failure. (biomedcentral.com)
Disease11
  • Based on data from several publications indicating that environmental factors play a major role in the development of AA 2 , the fact that the risk factors have not yet been well-described for our context, and because treatment is not widely available in developing countries, this study has been carried out since 2002, 14 with the purpose of providing more information for prevention of the disease. (haematologica.org)
  • Participants in this study must be 3 years or older and have a telomere disease and signs of aplastic anemia, lung disease such as pulmonary fibrosis, or liver disease. (nih.gov)
  • The usefulness of ATGAM has not been demonstrated in patients with aplastic anemia who are suitable candidates for bone marrow transplantation or in patients with aplastic anemia secondary to neoplastic disease, storage disease, myelofibrosis, Fanconi's syndrome, or in patients known to have been exposed to myelotoxic agents or radiation. (pfizermedicalinformation.com)
  • Furthermore, some aplastic anemia that is genetically inherited may, first manifest in adulthood, sometimes without a family history of blood disease. (rarediseases.org)
  • Validation and refinement of the disease risk index for allogeneic stem cell transplantation: a study from the CIBMTR. (stembook.org)
  • Aplastic anaemia is a non- malignant haematological disease. (aa-pnh.org)
  • Aplastic anaemia is therefore a very rare disease. (aa-pnh.org)
  • In most cases, it is not possible to identify the cause of aplastic anaemia, so the origin of the disease is still unknown ( idiopathic ). (aa-pnh.org)
  • Cell production may be reduced during the course of the disease ( hypoplastic ) or completely absent ( aplastic ). (aa-pnh.org)
  • Have problems from the disease that call for stem cell transplantation. (zhihuiya.com)
  • Many studies have shown the impor- tions of their disease. (who.int)