ReceptorsDendritic cellsAPCsCapture antigenChimeric antigenSurfaceReceptorCD45Rosette formationMoleculesRecognitionModulateImmunological synapseMigrateMoleculeTumorLigandCellsLymphocyteMicePhenotypeGenesCellGeneAffinityHumanInteractionIdentified novelChronicResponsesPresentBloodResponseMemberPredictiveSpecificYearMethodsDevelopmentPatientsMouseRisk
Receptors4
- LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
- NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
- Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
- [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
Dendritic cells5
- Dendritic cells (DCs) can take up an array of different antigens, including microorganisms which they can process and present more effectively than any other antigen presenting cell. (biomedcentral.com)
- Langerhans cells (LCs) are antigen-presenting dendritic cells located in the skin. (transhumanist.ru)
- The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (medscape.com)
- [ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)
- Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
APCs3
- The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
- 5-7 These molecules are important components of the immunological synapse (IS), which enables antigen-dependent communication between T cells and antigen-presenting cells (APCs). (ashpublications.org)
- Adhesion molecule pairs, such as CD2-CD58 and CD11a-CD54, induce a transient adhesion of T cells to APCs, after which the T-cell receptor (TCR) scans the cell surface for antigens presented in the context of human leukocyte antigen (HLA) molecules. (ashpublications.org)
Capture antigen1
- [ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)
Chimeric antigen1
Surface6
- Mouse monoclonal to CD2.This recognizes a 50KDa lymphocyte surface antigen which is expressed on all peripheral blood T lymphocytes,the majority of lymphocytes and malignant cells of T cell origin, including T ALL cells. (angiogenesis-blog.com)
- Normal B lymphocytes, monocytes or granulocytes do not express surface CD2 antigen, neither do common ALL cells. (angiogenesis-blog.com)
- In this study, Pulsipher and colleagues investigated the predictive value of flow cytometry-a technique that interrogates proteins on the cell surface-and next-generation DNA sequencing minimal residual disease (NGS-MRD) monitoring, using blood and bone marrow samples collected from the ELIANA and ENSIGN phase II clinical trials at one, three, six, nine, and 12 months after tisagenlecleucel infusion. (aacr.org)
- We are currently investing this problem by studying the organisation of key molecules, such as CD45, TCR, CD4 and pMHC, on the surface of T cells and antigen presenting cells during the early stages of an immune response. (lu.se)
- TCRs can recognize fragments of antigen attached to MHC on the surface of an APC. (medscape.com)
- T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)
Receptor3
- However, it is unknown whether this synapse is fully assembled and leads to T-cell activation by enabling interaction between the T-cell receptor (TCR) and human leukocyte antigen class II (HLA-II). (ashpublications.org)
- CD2 antigen has been characterised as the receptor for sheep erythrocytes. (angiogenesis-blog.com)
- CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells . (wikidoc.org)
CD451
Rosette formation2
- Intriguingly, the level of CD58 expression correlated with the extent of rosette formation, and CD58 knockout or CD2 blockade reduced both rosette formation and T-cell activation. (ashpublications.org)
- 3,4 Previous studies have described the involvement of several adhesion molecules in HL rosette formation. (ashpublications.org)
Molecules4
- Traditionally, microcirculatory physiologists studied the essential transport functions of lymphatic vessels in removing fluid, molecules, and cells after leaking from blood vessels in the periphery and before returning them to the blood circulation. (jci.org)
- Upon antigen recognition, F-actin polymerization enables stabilization of the mature IS with a central region that contains the TCR-HLA molecules and interacting adhesion molecules in the periphery. (ashpublications.org)
- This is achieved by using artificial cell surfaces, so called supported lipid bilayers (SLBs), and advanced fluorescence microscopy with fluorescence labelling of the studied molecules (see Fig. 1). (lu.se)
- CD2, CD48 and CD58 are structurally similar cell adhesion-molecules forming a subset of the immunoglobulin superfamily (IgSF). (ox.ac.uk)
Recognition2
- 00:14.1 Today, I'm going to talk to you about 00:16.1 the immunological synapse, 00:17.2 Part 1 - antigen recognition. (ibiology.org)
- A subtle role for CD2 in T cell antigen recognition. (ox.ac.uk)
Modulate2
- Furthermore studies had been carried out to judge the restorative ability from the peptide to modulate the immune system response in the collagen-induced joint disease (CIA) mouse model. (bio-biz-navi.com)
- We further examined the power of peptide 6 to modulate antigen-specific immune system response inside a human being RA-relevant pet model through the use of CIA-susceptible HLA-class II transgenic mice. (bio-biz-navi.com)
Immunological synapse1
- Hodgkin tumor cells extensively interact with rosetting CD4 + T cells by immunological synapse formation involving HLA class II and CD58. (ashpublications.org)
Migrate1
- After antigen uptake, DC rapidly migrate to the draining secondary lymphoid organ. (biomedcentral.com)
Molecule1
- The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikidoc.org)
Tumor2
- Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
- His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)
Ligand1
- In humans CD58 is a ligand for CD2 while in mice CD2 binds CD48. (ox.ac.uk)
Cells14
- LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
- Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
- In conclusion, T-cell rosetting in HL is established by formation of the IS, and activation of rosetting T cells critically depends on the interaction of both TCR-HLA-II and CD2-CD58. (ashpublications.org)
- DCs comprise a family of antigen presenting cells that act like 'conductors' of the immune response in their capacity to orchestrate signals derived from the different parts of the immune system [ 2 ]. (biomedcentral.com)
- Our current recommendation to centers giving tisagenlecleucel is to follow B cells in the blood monthly, using a standard test, as a way to predict patients at higher risk of relapse," said Stephan Grupp, MD, PhD , senior author of the study and a professor of pediatrics and the chief of Cell Therapy and Transplant at Children's Hospital of Philadelphia and the University of Pennsylvania. (aacr.org)
- In past studies, researchers have identified a subset of T cells that serve as precursors to exhausted T cells. (acir.org)
- Decreasing the dose of the virus increased IFNγ production by TP cells, suggesting that higher antigen loads led to the generation of TP cells with repressed effector functions. (acir.org)
- An important step is the triggering of T cells to start an immune response, which takes place when a T cell contacts an antigen presenting cell. (lu.se)
- 5 We have also recently developed a method making it possible to measure the binding affinity on single cells making it possible to study binding differences within the cell population. (lu.se)
- (B) White light image showing the contour of two binding T cells (top image), and a fluorescence microscopy images showing accumulation of CD58 underneath the T cells (bright areas in the lower image). (lu.se)
- In another group of Eppendorf pipes Caco-2 cells had been added with 50 μL of FITC-labeled anti-CD58 100 μL of peptide 6 at different concentrations was added and incubated for 30 min at 4 °C. Following the incubation the Birinapant (TL32711) cells had been Birinapant (TL32711) spun down at 720 × g at space temp for 10 min and resuspended in 4-5 mL of PBS. (bio-biz-navi.com)
- The adverse control was Caco-2 cells without FITC-anti-CD58. (bio-biz-navi.com)
- Caco-2 cells concurrently treated using the peptide at different concentrations and with FITC-labeled anti-CD58 had Birinapant (TL32711) been analyzed using movement cytometry. (bio-biz-navi.com)
- Committed stem cells can mature to become antigen-processing cells, with some possessing phagocytic capabilities. (medscape.com)
Lymphocyte1
- Here we have studied the motility and ultrastructure of large granule lymphocyte (LGL) on lipid bilayers containing purified LFA-1, ICAM-1, and the transmembrane and glycophosphatidylinositol isoforms of LFA-3. (ox.ac.uk)
Mice2
- Hind foot pads from db/db and control db/ mice from 5 to 24 weeks of age (encompassing the period of mechanical allodynia development and its abatement) were collected and processed for immunohistochemistry studies. (transhumanist.ru)
- studies recommended a conformationally constrained peptide designed from Compact disc2 could suppress the development of CIA inside a restorative process in DBA/1 mice. (bio-biz-navi.com)
Phenotype1
Genes1
- Variations in dozens of genes have been studied as risk factors for rheumatoid arthritis. (medlineplus.gov)
Cell1
- (A) A schematic illustration showing specific binding between the proteins CD2 on a T cell with fluorescently-labelled CD58 in an SLB. (lu.se)
Gene2
- Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. (uchicago.edu)
- In a study of this gene among the Hominoidea two finding unique to humans emerged: (1) an excess of non-synonymous divergence among species that appears to be caused solely by accelerated evolution and (2) the ability of the single GYPC gene to encode both the GPC and GPD proteins. (wikidoc.org)
Affinity1
- The upper limit of the affinity of the rat CD48-CD2 interaction is 4 x 10(5) M-1, lower than the published affinity of human CD2 for CD58. (ox.ac.uk)
Human3
- 04:02.2 So, these are important contributions 04:04.1 that studying the immune system 04:06.3 has made to human health. (ibiology.org)
- Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis (HFLS-RA) provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of rheumatoid arthritis. (cellapplications.com)
- First-in-Human Phase I Study of ABBV-838, an Antibody-Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma. (uchicago.edu)
Interaction1
- The extension of our findings to primary HL tissue by immunohistochemistry and proximity ligation assays showed interaction of CD2 with CD58 and of TCR-associated CD4 with HLA-II. (ashpublications.org)
Identified novel1
- OBJECTIVE: A recent collaborative genome-wide association study replicated a large number of susceptibility loci and identified novel loci. (ox.ac.uk)
Chronic1
- this was found to be the direct result of higher viral loads, and thus higher antigen burden in the chronic infection model. (acir.org)
Responses1
- In the randomized phase II DREAMM-2 study, single-agent belantamab mafodotin demonstrated deep and durable responses and a manageable safety profile in triple-class refractory relapsed/refractory multiple myeloma (RRMM). (bvsalud.org)
Present1
- We present patient-reported outcomes (PROs) from this study for patients treated with the approved dose of belantamab mafodotin (2.5 mg/kg q3w). (bvsalud.org)
Blood3
- In this study, we find >95% nascent blood ASC in culture express Ki-67 but only 6-12% incorporate BrdU after 4h or 24h labeling. (bvsalud.org)
- PHILADELPHIA - In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive, according to a study published in Blood Cancer Discovery , a journal of the American Association for Cancer Research. (aacr.org)
- In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)
Response1
- The antigen was discovered in 1960 when three women who lacked the antigen made anti-Gea in response to pregnancy. (wikidoc.org)
Member1
- He is a member of the GOG Developmental Therapeutics Committee, a national Committee that reviews multi-site concepts/protocols to be implemented at nationwide level by the GOG funded by the NIH and he is Chairman for the entire GOG of multiple Phase II clinical studies testing novel biologic agents in patient harboring gynecologic malignancies. (yale.edu)
Predictive1
- Next, in a modelling study we explored current and potential predictive performance of genetic MS risk models. (ox.ac.uk)
Specific1
- This is the first paper to show an approach that identifies markers of relapse that are very specific, allowing clinicians to add additional therapy prior to relapse that will prevent it," said Michael Pulsipher, MD, lead author of the study and a professor of pediatrics and the division chief of Pediatric Hematology and Oncology at Intermountain Primary Children's Hospital and the Huntsman Cancer Institute of the University of Utah. (aacr.org)
Year1
- [1] The following year a new but related antigen was discovered in a Mrs Yus for whom an antigen in this system is also named. (wikidoc.org)
Methods1
- Methods A prospective observational study was conducted from April 1, 2019, to December 31, 2019, in the Pulmonology department of a tertiary care hospital in Pakistan. (preprints.org)
Development1
- The db/db mouse, a rodent model of PDN, was used to study the roles of LCs in the development of PDN in type 2 diabetes. (transhumanist.ru)
Patients1
- The antigen is named after one of the patients - a Mrs Gerbich. (wikidoc.org)
Mouse1
- activity of a peptide (peptide 6) in regularly studied mouse style of arthritis rheumatoid collagen-induced joint disease (CIA). (bio-biz-navi.com)
Risk1
- In the simulation study we showed that the area under the receiver operating characteristic curve (AUC) for a risk score based on the 6 SNPs was 0.64. (ox.ac.uk)