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  • doses
  • Results from pharmacokinetic studies indicate that oral doses of 1.25 g/day ascorbic acid produce mean peak plasma vitamin C concentrations of 135 micromol/L, which are about two times higher than those produced by consuming 200-300 mg/day ascorbic acid from vitamin C-rich foods [ 10 ]. (nih.gov)
  • genotoxicity
  • Natural products exerted protective effects against genotoxicity induced by CP in bone marrow cells of mice when these compounds were administrated prior to CP treatment. (hindawi.com)
  • We previously reported that hesperidin, a citrus bioflavonoid, may have antioxidative activity and can reduce the genotoxicity induced by CP in mouse bone marrow cells by decreasing micronucleus formation [ 10 ]. (hindawi.com)
  • The present study assessed the role of Brahmarasayana (BR) on Ethyl methanesulfonate (EMS)-and Methyl methanesulfonate (MMS)-induced genotoxicity and DNA repair in in vivo mouse test system. (biomedcentral.com)
  • etoposide
  • Using four M-phase specific chemotherapeutic agents, Bcl-XL and Bcl-2 provided similar protection against vincristine and vinblastine whereas Bcl-XL afforded as much as 50% greater cell viability than Bcl-2 against etoposide and teniposide-induced cell death. (bloodjournal.org)
  • Placebo-Controlled
  • Data from the randomized, double-blind, placebo-controlled study of 928 patients show that first and subsequent-cycle administration of Neulasta resulted in a 94 percent reduction in the incidence of febrile neutropenia, a 93 percent reduction in the incidence of hospitalization and an 80 percent reduction in the incidence of intravenous anti-infective use in patients previously considered at moderate risk for neutropenic complications. (amgen.com)
  • This is a double-blind, randomized, and placebo-controlled trial study. (tinnitusjournal.com)
  • tissue
  • Immunosuppression and normal tissue injury are the major limitations of chemotherapy [ 2 ], which give rise to numerous side effects [ 3 , 4 ]. (hindawi.com)
  • Oral administration of taurine at a dose of 100mg/kg of body weight for 5 days was found to be highly effective in the prevention of arsenic induced oxidative impairment in the brain tissue of the rats. (alignlife.com)
  • The natural regenerative ability of a type of cardiac tissue resident stem cells in response to heart failure has been highlighted for the first time in a study on rodents by a team of researchers at King's College London. (pubstemcell.com)
  • cycles
  • Demographics, type and number of chemotherapy cycles did not differ between the two groups, recruited between Sept 2015 and Sept 2016. (springer.com)
  • Amgen Inc. (Nasdaq:AMGN), the world's largest biotechnology company, today announced data from a Phase 3 study showing that administration of Neulasta(R) (pegfilgrastim) in the first and subsequent cycles of chemotherapy significantly lowers the rate of infection, as manifested by febrile neutropenia (low white blood cell count with fever), hospitalization and the use of intravenous anti-infectives in breast cancer patients receiving moderately myelosuppressive (strong) chemotherapy. (amgen.com)
  • This study provides compelling evidence that administering Neulasta in the first and subsequent cycles of moderately myelosuppressive chemotherapy can significantly reduce the risk of potentially life-threatening infections that can result in hospitalizations and require IV antibiotics," said Schwartzberg. (amgen.com)
  • lung cancer
  • Patients with lung cancer who plan to receive cisplatin-including chemotherapy will be recruited. (biomedcentral.com)
  • Cisplatin is a key drug in lung cancer chemotherapy. (biomedcentral.com)
  • Cyclacel Pharmaceuticals, Inc. (NASDAQ:CYCC, NASDAQ:CYCCP) announced the publication of a study conducted by Cyclacel scientists showing synergistic activity between its investigational therapy seliciclib and multiple epidermal growth factor receptor (EGFR) inhibitors, including erlotinib (Tarceva(R)) in models of non-small cell lung cancer and the HER2 targeting agent, trastuzumab (Herceptin(R)) in models of breast cancer. (redorbit.com)
  • Seliciclib, Cyclacel's orally available cyclin dependent kinase (CDK) inhibitor, is currently being tested as a single agent in the Phase 2b APPRAISE trial in patients with non-small cell lung cancer and in a Phase 2 study in patients with nasopharyngeal cancer. (redorbit.com)
  • cancers
  • CR also protects against spontaneous cancers and against carcinogen-induced cancers ( 10 - 12 ), raising the possibility that CR and reduced IGF1 may increase stress resistance by similar mechanisms. (pnas.org)
  • humans
  • Although different types of chemotherapy affect the immune system differently, this research suggests that humans undergoing chemotherapy may be able to enhance the function of their leucocytes with taurine. (alignlife.com)
  • Animal studies have suggested that L-carnitine protects the heart from the effects of anthracyclines, however this has not been verified in humans. (clinicaltrials.gov)
  • anorexia
  • To analyze possible involvement of ghrelin in the chemotherapy-induced anorexia and anxiety, gastric ghrelin expression, plasma levels of ghrelin, and ghrelin-reactive IgG were studied in rats treated with methotrexate (MTX). (frontiersin.org)
  • MTX-induced anorexia, weight loss, and anxiety are accompanied by increased ghrelin production and by a decrease of ghrelin-reactive IgG levels and affinity binding properties. (frontiersin.org)
  • While cancer itself may cause anorexia ( 2 , 3 ), anorexia induced by chemotherapy is an independent aggravating problem, which mechanisms need to be better clarified ( 4 ). (frontiersin.org)
  • drug
  • Testing it on the well-studied breast cancer drug tamoxifen helped them refine the approach, which they hope will be useful for understanding future drugs. (asbmb.org)
  • According to the above guidelines, cisplatin is classified as highly emetogenic chemotherapy (HEC), and the standard prophylaxis for CINV is a three-drug combination of a 5-HT3 receptor antagonist, neurokinin-1 receptor antagonist, and dexamethasone. (biomedcentral.com)
  • In the present study, Rg5 was investigated as a novel drug for the chemotherapy of esophageal cancer in in vitro experiments. (spandidos-publications.com)
  • The lymphocyte proliferation and phagocytic activity of peritoneal macrophage and peripheral blood neutrophilic granulocyte and monocyte activity were tested to analyze the effect of taurine on enhancing leucocyte function after the chemotherapy drug was administered. (alignlife.com)
  • In studies using a human lung carcinoma cell line, the combination resulted in greater inhibition of DNA synthesis and loss of clonogenicity than with either drug alone ( 20 ). (aacrjournals.org)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (adventisthealthcare.com)
  • patients
  • This study shows that THC:CBD extract is efficacious for relief of pain in patients with advanced cancer pain not fully relieved by strong opioids. (marijuana.com)
  • INDIANAPOLIS - Indiana University cancer researchers have been awarded $2.9 million to study the debilitating side effects caused by chemotherapy that affect a significant number of cancer patients. (iu.edu)
  • Part of the research includes studying a molecular compound known as APX3330 to see if it will offer cancer patients protection against neuropathy. (iu.edu)
  • Approximately 600,000 chemotherapy patients are at risk for developing neutropenia, which has traditionally been treated reactively. (amgen.com)
  • Doctors usually reserve proactive use of Neulasta for only those patients considered at very high risk of developing chemotherapy-induced neutropenia. (amgen.com)
  • These symptoms sometimes affect patients' quality of life and make continuation of chemotherapy difficult. (biomedcentral.com)
  • Patients who provide written consent will be randomly allocated to receive either TJ-43 (arm A) or placebo (arm B) for one course of chemotherapy (21 or 28 consecutive days). (biomedcentral.com)
  • From November 2014, a total of 60 patients will be recruited, and recruitment for the study is planned to be complete by October 2017. (biomedcentral.com)
  • HOUSTON, TX - February 7, 2018 - The Cancer Prevention and Research Institution of Texas (CPRIT) has awarded Acelerox, LLC, a Fannin Innovation Studio ® company, a $195,665 grant to develop poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCC) antioxidant nanoparticles as a novel therapeutic to protect patients from chemotherapy-associated hearing loss. (newjerseyheadlines.com)
  • Reducing the hearing loss side effects of chemotherapy can truly improve the quality of life for so many patients struggling with the devastation of cancer. (newjerseyheadlines.com)
  • The present study aimed to determine whether the use of oral sertraline can contribute to preserve hearing threshold among the patients who receive cisplatin or not. (tinnitusjournal.com)
  • Recurrent or metastatic breast cancer patients have a median survival of 20 months despite recent advances in chemotherapy ( 1 ). (aacrjournals.org)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (adventisthealthcare.com)
  • The investigators will enroll 144 patients into this study. (clinicaltrials.gov)
  • antioxidant
  • Two other research studies on taurine highlight its ability to act as an important antioxidant that may help protect organs, even during chemotherapy. (alignlife.com)
  • Potential advantages of sertraline may be related to neuroprotective and antioxidant effects (Increased anti-Apoptotic proteins levels), as well as its stimulation in the neurogenesis process (protect neurons against oxidative metabolic effects) [ 10 , 11 ]. (tinnitusjournal.com)
  • CONCLUSION
  • CONCLUSION:Bezafibrate prevents endothelial dysfunction induced by TCchem via TG-dependent and TG-independent mechanisms. (nii.ac.jp)
  • appetite
  • Such changes of ghrelin-reactive IgG may underlie their decreased ghrelin-transporting capacities compromising ghrelin orexigenic and anxiolytic effects and contributing to chemotherapy-induced loss of appetite. (frontiersin.org)
  • commonly
  • Scientific evidence for practical strategies to reduce this distressing and unsightly side effect of one of the most commonly used chemotherapy drugs is long overdue. (springer.com)
  • research
  • In this book, Teicholz covers decades of nutrition research and government policy, and pokes holes in the major studies that have often been used to justify the American Heart Association's policy on dietary fat intake. (chriskresser.com)
  • Data from this study were presented in April 2007 at the Annual Meeting of the American Association for Cancer Research in Los Angeles. (redorbit.com)
  • A modified form of vitamin A has been reported to work synergistically with chemotherapy in test tube research. (adventisthealthcare.com)
  • neurons
  • We hypothesize that APE1 is a critical protein for protecting neurons from cancer therapies and that augmenting its DNA repair activity will prevent and reverse chemotherapy-induced alterations in sensory neuronal function," Dr. Kelley explained. (iu.edu)
  • high
  • People receiving chemotherapy face a high risk for developing infections, and they are less able to fight off infections once they develop. (alignlife.com)
  • supplementation
  • In most well-controlled studies, exercise performance has not been shown to improve following supplementation with vitamin C, unless a deficiency exists, as might occur in athletes with unhealthy or irrational eating patterns. (adventisthealthcare.com)
  • chronic
  • As many as two-thirds of survivors will experience a late effect of chemotherapy or radiation, defined as any chronic or late occurring outcome-physical or psychosocial-that persists or develops beyond five years from the diagnosis of the cancer (Garre et al. (nap.edu)