• The most common method for investigating embryonic developmental disorders is to concentrate on a single organ system in the mouse and conduct gene knockout studies. (mpg.de)
  • Developmental biology and organogenesis. (estiv.org)
  • We then discuss recent studies on the role of neural crest and placodes-and their developmental association-in the head of lamprey embryos, and how comparisons with jawed vertebrates can provide insights into the causes and consequences of this event in early vertebrate evolution. (frontiersin.org)
  • Another study in mice, by Johansson et al, indicated "that embryonic thyroid differentiation is an asynchronous process," one that spans "several developmental stages of thyroid organogenesis. (medscape.com)
  • In the last decades, HOX proteins have been extensively studied due to their pivotal role in transcriptional events. (mdpi.com)
  • These findings were confirmed in later studies in which removal of mesenchyme from embryonic day 12 murine thymic lobes impaired thymus growth in vitro ( 8 ). (frontiersin.org)
  • 1977. Metabolism of haloforms to carbon monoxide: I. In vitro studies. (cdc.gov)
  • The organogenesis process can be studied using embryos and organoids. (wikipedia.org)
  • Together with researchers from Berlin, the American team used this method to study the activity of all cells from mouse embryos at the age of 9.5 to 13.5 days. (mpg.de)
  • In the current issue of the journal Nature , the scientists describe how the method has been improved and applied to mouse embryos in order to create an 'atlas' of gene activity during mouse organogenesis. (mpg.de)
  • Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study. (eurekalert.org)
  • A study by López-Márquez et al, utilizing mice, indicated that the Sox9 transcription factor is "likely at the center of an important regulatory network of signals that govern thyroid differentiation both in embryos and in adults. (medscape.com)
  • The researchers carried out this study using 8-12 somite stage mouse embryos. (embl.org)
  • A Ph.D. Candidate in the Garcia lab , Jimmy studies how metabolism affects neurology and behavior in C. elegans . (tamu.edu)
  • worked on organogenesis in C. elegans hermaphrodites. (tamu.edu)
  • High-resolution gene expression maps have been combined with single-cell genomics data to create a new resource for studying how cells adopt different identities during mammalian development. (embl.org)
  • The incentive sensitization theory is a promising model for understanding the mechanisms underlying drug addiction, and has received support in animal and human studies. (researchgate.net)
  • The molecular mechanisms of human embryogenesis and organogenesis are largely unclear," says co-corresponding author Zhen Liu of the Chinese Academy of Sciences (CAS) in Shanghai. (eurekalert.org)
  • Our research projects focus on mechanisms of craniofacial development and kidney organogenesis. (cincinnatichildrens.org)
  • Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
  • Model organisms such as yeast, fruit flies, and worms have advanced the study of genomics, eukaryotic biology, and evolution. (cshlpress.com)
  • It lacks the necessary throughput and resolution to provide a global overview of the dynamic molecular processes that take place in the different and rapidly growing populations and subpopulations of cells during organogenesis. (mpg.de)
  • As with TEC, our understanding of NES has been improved through the phenotypic identification of new subpopulations, such studies on thymic mesenchyme and endothelium have provided new and important insight into their complexity and functional importance. (frontiersin.org)
  • These amount to 10-15 secondary place and methodology in the 4 studies are hospitals and 30-50 primary health care reflected. (who.int)
  • The pig is an increasing important animal model for molecular study and pharmaceutical research. (hindawi.com)
  • Organogenesis occurs at specific locations and involves complex inductive and inhibitory interactions at the cellular and molecular levels to ensure proper structure and function. (cincinnatichildrens.org)
  • Studies using single-cell RNA sequencing (scRNAseq) have provided insights into how the molecular landscape of cells in the mouse embryo changes during early development. (embl.org)
  • This landmark study has already allowed us to pinpoint some of the molecular events that lead to the development of organs in mice. (embl.org)
  • The coelom of the body forms from a split of the mesoderm along the somite axis In plants, organogenesis occurs continuously and only stops when the plant dies. (wikipedia.org)
  • While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
  • The design, conduct, and patient populations of the EU and US studies were comparable. (japmaonline.org)
  • The similar outcomes of the two studies provide robust, consistent evidence of the benefit of Apligraf in treating geographically disparate DFU patient populations. (japmaonline.org)
  • Unfortunately the problems of vulnerable populations who are at risk for adverse health outcomes when routine health care services are disrupted remain inadequately studied or addressed. (cdc.gov)
  • And also provides essential study on the current status of the market, cover market size with respect to valuation as sales volume and providing a precise prediction of the market scenario over the forecast period from 2020 to 2027. (powershow.com)
  • Because animal reproduction studies are not always predictive of human response, Arixtra (fondaparinux sodium) should be used during pregnancy only if clearly needed. (rxlist.com)
  • Compared with other pregnant women, women in the early stages of pregnancy may be at higher risk for adverse pregnancy outcomes because of exposure during organogenesis to toxins or infectious agents. (cdc.gov)
  • Several studies that used mouse models have revealed that Zika virus infection of mice during early pregnancy results in infection of placenta and fetal brain, causing intrauterine growth restrictions, spontaneous abortions, and fetal demise ( 14 - 16 ). (cdc.gov)
  • Our study raises the possibility of an increased risk of gastroschisis due to either antiherpetic medication use during early pregnancy or the underlying genital herpes infection for which it was indicated. (cdc.gov)
  • Until the 2010s, the U.S. Food and Drug Administration (FDA) classified over-the-counter (OTC) and prescription drugs into 5 categories of safety for use during pregnancy (A, B, C, D, X). However, few well-controlled studies of therapeutic drugs have been done in pregnant women. (msdmanuals.com)
  • Most information about drug safety during pregnancy is derived from animal studies, uncontrolled studies, and postmarketing surveillance. (msdmanuals.com)
  • Method: The study was a retrospective review of cases of uterine rupture managed at the ASYBSH between March 2015 and February 2021. (bvsalud.org)
  • During embryonic stages of lung organogenesis, TGF-β1 is pivotal in epithelial-mesenchymal interaction, during alveolarization and for airway branching morphology. (springer.com)
  • A significant number of referrals (234 are also considered of pivotal importance of 974, i.e. around 24% in the Al Hasaa for groups which care for patients with study) were normal and excluded from the congenital heart disease as well as for poli- study. (who.int)
  • The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
  • In addition, they support the need for epidemiologic studies to examine the role of pesticide exposure in the etiology of congenital anomalies. (cdc.gov)
  • We examined the association between antiherpetic medication use and the risk of gastroschisis in the National Birth Defects Prevention Study (NBDPS), which includes the largest sample of gastroschisis cases with maternal exposure information in the US. (cdc.gov)
  • Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
  • Most experimental studies of the predominant results of earlylife do not develop in rats exposed to the carcinogenesis during prenatal life exposure are what would be expect same carcinogen during adult life and infancy have been conducted ed from a higher effective dose to the (Diwan and Rice, 1995 ). (who.int)
  • Other objectives included determining the reproductive outcomes if bilateral tubal ligation was not performed, investigating the alternative forms of contraception provided and to study the demographics of the population requesting bilateral tubal ligation as a form of contraception. (bvsalud.org)
  • The study determined the trends, risk factors, feto-maternal outcomes following uterine rupture as seen at ASYBSH. (bvsalud.org)
  • The aim of this study was to detect the expression of molecules associated with Notch signallng pathway in SHED cultured in specific differentiation medium, namely, KGM. (bvsalud.org)
  • Methods to study organogenesis in decapod crustacean larvae. (awi.de)
  • METHODS: A mixed-methods cross-sectional study was conducted in six South African districts, and data collected through face-to-face interviews with women and focus group discussions (FGDs) with women or male partners. (bvsalud.org)
  • Methods: The study was conducted as a cross-sectional observational study collecting data over a period of 3 months, from June 2019 to August 2019. (bvsalud.org)
  • A primary step in organogenesis for chordates is the development of the notochord, which induces the formation of the neural plate, and ultimately the neural tube in vertebrate development. (wikipedia.org)
  • Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
  • This webinar will summarize insights on how air-liquid interface and airway organoid cultures can be used as experimental virology platforms to study SARS-CoV-2 infectivity and immune responses, and as tools for antiviral drug discovery and development. (corning.com)
  • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. (nature.com)
  • We describe shared and derived patterns of neural crest and placode development in these animals and compare them to well-studied examples from traditional jawed vertebrate model systems. (frontiersin.org)
  • By providing a more detailed blueprint for development shared between mammals, this study could help to further advance the possibility of generating cell types in a dish for regenerative medicine. (embl.org)
  • KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
  • At the final analysis of the study, there was not an improvement in OS for patients who received KEYTRUDA plus LENVIMA compared to docetaxel. (streetinsider.com)
  • In both the LEAP-006 and LEAP-008 trials, the safety profiles of the KEYTRUDA plus LENVIMA-based treatment regimens were consistent with that observed in previously reported studies evaluating the combination. (streetinsider.com)
  • Merck and Eisai are studying the KEYTRUDA plus LENVIMA combination through the LEAP (LEnvatinib And Pembrolizumab) clinical program in various tumor types, including but not limited to endometrial carcinoma, hepatocellular carcinoma, RCC, head and neck cancer, gastric cancer and esophageal cancer across multiple clinical trials. (streetinsider.com)
  • The systematic review method involves taking all the relevant studies in a field of interest and synthesising their findings in order to produce a definitive answer. (safermedicines.org)
  • Another systematic review found that only a third of animal study findings agreed with the findings of the corresponding human randomised trials (Hackam and Redelmeier 2006). (safermedicines.org)
  • It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. (cdc.gov)
  • ABSTRACT To provide an overview of the epidemiology of congenital heart disease, the results of epidemiological studies done in 4 regions of Saudi Arabia (August 1988-February 2000) and 2604 individuals with congenital heart disease were evaluated. (who.int)
  • In their study the researchers examined about two million cells, with the RNA of each cell labeled individually with a specially developed method termed sci-RNA-seq. (mpg.de)
  • A study of 72 subjects conducted in the European Union and Australia assessed the safety and efficacy of Apligraf (Organogenesis, Inc, Canton, Massachusetts), a bilayered cell therapy composed of living keratinocytes and living fibroblasts in the treatment of non-infected, diabetic foot ulcers (DFU). (japmaonline.org)
  • The proper methylation status of histones is essential for appropriate cell lineage and organogenesis. (hindawi.com)
  • In this webinar, Dr. Regan will discuss the use of organoid technologies to study organogenesis and cell fate determination in the postnatal mammary gland. (corning.com)
  • This study, published in Nature Biotechnology , combines scRNAseq data with spatially-resolved expression profiles to generate an atlas of gene expression at single-cell resolution across the entire embryo. (embl.org)
  • An on-line lecture series will be set-up to provide background information to the field of animal free safety assessment and also to create an interactive case study where practical skills will be fostered and trained. (estiv.org)
  • Many of the proponents of animal research cite single, selected studies as evidence that animal research 'works' in a particular area, but single studies - which may be flawed or biased - do not constitute sufficient, high quality evidence. (safermedicines.org)
  • However, relatively few systematic reviews of animal studies have been conducted and it is rare for them to explore issues relating to human relevance. (safermedicines.org)
  • An exception is provided by Perel and colleagues (2007), who conducted systematic reviews of animal studies for six different conditions and compared them with systematic reviews of human studies for the same six conditions. (safermedicines.org)
  • They found that the animal and human studies agreed in three cases and disagreed in three cases. (safermedicines.org)
  • They concluded that the lack of agreement may have been due to either the inability of animal models to accurately mimic human diseases, or to the poor quality of the animal studies. (safermedicines.org)
  • So far, the expression pattern and the function of EZH2 have been broadly studied in humans [ 11 ] and mice [ 12 , 13 ]. (hindawi.com)
  • It is unlikely that anyone would follow up the study in twenty years' time to see whether it did actually produce any benefits for humans. (safermedicines.org)
  • 3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis. (duke.edu)
  • Different types of calli produced on benzyladenine (BA) and thidiazuron (TDZ) supplemented Murashige and Skoog (MS) basal medium were selected for shoot induction and somatic embryogenesis studies. (tubitak.gov.tr)
  • However, this approach, which is mostly performed on mice , is limited to the study of individual animals and tissues. (mpg.de)
  • Considering the varieties of EZH2 splicing variant, identifying its transcript in porcine fetal tissues is the foundation to study its function. (hindawi.com)
  • In this study, we identified a transcript variant of EZH2 in porcine fetal tissues by cloning and sequencing. (hindawi.com)
  • I am interested in studying how metabolism affects neural activity and behavior. (tamu.edu)
  • Most contemporary researchers in the fields of neural crest and placode "evo-devo" have directed their efforts and expertise toward the study of either neural crest or placodes in isolation, the inevitable result of specialization that characterizes modern scientific research. (frontiersin.org)
  • You may need to have studied specific subjects - find full entry requirements and other qualifications we accept at UCAS . (port.ac.uk)
  • Previous studies examining the teratogenic effects of antiherpetic medications have found no associations for birth defects overall but have not examined the risk of specific birth defects. (cdc.gov)
  • Pooling of data was able to be performed because of the similarity and consistency of the two studies. (japmaonline.org)
  • A full evaluation of the data from these studies is ongoing. (streetinsider.com)
  • For this study we needed to process, analyse and integrate a lot of data sets to enable us to map the identities of cells onto a spatial reference," said Shila Ghazanfar, Research Associate at CRUK Cambridge Institute . (embl.org)
  • The 1982 Joint Meeting noted that the higher ADI established by the 1972 Meeting (0.002 mg/kg b.w. as paraquat dichloride) was based on long-term studies conducted by Industrial Bio-Test Laboratories (IBT), for which no replacement studies, validations, or additional data had been submitted. (inchem.org)
  • In addition, it requested submission of full discriptions of the lung lesions seen in the new long-term rat study and of historical control data on all lung lesions in the strain of rats utilized in the study in the laboratory in which it was conducted. (inchem.org)
  • 9 Antiherpetic medications are nucleoside analogues that disrupt DNA replication and pharmacokinetic studies have shown that acyclovir crosses the placenta, 12 , 14 , 15 therefore it is possible that antiherpetic medications could affect embryogenesis, a process that involves rapid mitotic divisions and DNA replication. (cdc.gov)
  • This new approach provides a robust framework for future studies looking at spatial gene expression, both in the mouse and potentially other biological systems. (embl.org)
  • Thus, inhibiting HOX-PBX interaction represents a potential strategy to prevent these malignancies, as demonstrated by the patented peptide HTL001 that is being studied in clinical trials. (mdpi.com)
  • Tissue Engineering Market research report delivers a comprehensive study on production capacity, consumption, import and export for all major regions across the world. (powershow.com)
  • Previous studies have found no evidence for an increased risk of birth defects overall due to antiherpetic medication use. (cdc.gov)
  • There are, however, no adequate and well-controlled studies in pregnant women. (rxlist.com)
  • The study enrolled both treatment-naive patients and heavily pretreated patients with a variety of advanced solid tumors including RET fusion-positive NSCLC, RET -mutant MTC, RET fusion-positive thyroid cancer, and certain other advanced solid tumors with RET alterations. (prnewswire.com)
  • The clinically meaningful responses observed in this study demonstrate that selpercatinib can help fill this need, offering a valuable treatment option to these patients. (prnewswire.com)
  • Stem cells from human exfoliated deciduous teeth (SHED) (ALLCells, Alameda, CA, USA) were employed in the current study. (bvsalud.org)
  • Since identification of EZH2 in the research of protooncogene product Vav [ 3 ], studies have shown that EZH2 is highly expressed in tumorigenesis, which regulates the expression of tumor suppressor genes, such as in breast cancer, prostate cancer, and lung cancer [ 4 - 6 ]. (hindawi.com)
  • The Women's Health Initiative and the Million Women Study have shown that hormone replacement therapy is associated with an increased risk of incident and fatal breast cancer 2 , 3 . (nature.com)
  • The National Birth Defects Prevention Study ascertains population-based cases with birth defects and live-born controls without birth defects in ten states across the United States for the purpose of identifying potential teratogenic risk factors. (cdc.gov)
  • A case-control study of gastrointestinal and urinary tract cancer mortality and drinking water chlorination. (cdc.gov)
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. (duke.edu)
  • The introduction of magnetoencephalography has made it possible to study electromagnetic signaling in deeper, paralimbic cortical structures such as the medial prefrontal/anterior cingulate (ACC) and medial parietal/posterior cingulate (PCC) cortices. (researchgate.net)
  • When studied under a microscope, the embryo-like structures, also called blastoids, were found to have similar morphology to natural blastocysts. (eurekalert.org)
  • Efficacy and safety results remained consistent across studies independent of mean ulcer duration that was significantly longer in the EU study (21 months, compared to 10 months in the US). (japmaonline.org)
  • Genomic studies are likely to contribute significantly to our knowledge in the future. (tonmo.com)
  • Previous studies have shown that brief starvation counteracts age related behavioral decline. (tamu.edu)