• "These structure-activity relationships provided useful clues for predicting the NO inhibitory activity of triterpenoids and other compounds from durian," ​ said the study team. (nutraingredients.com)
  • Our interest in medicinal chemistry of dicoumarol compounds have been developed by keeping in view the importance of coumarins along with its derivatives in medicinal chemistry. (biomedcentral.com)
  • Elemental analyses, ESI(+,−) MS, 1 H and 13 C{ 1 H}-NMR, infrared spectroscopy and conductance studies were used to characterize the synthesized compounds which revealed the dicoumarol and dichromone structures for the compounds. (biomedcentral.com)
  • Coumarins are naturally occurring organic compounds [ 1 , 2 ] which belong to benzo-α-pyrones group of compounds. (biomedcentral.com)
  • The study aim was to evaluate the cytotoxic activity, using the MTT test [3-(4,5-Dimethilthiazol-2-yl)-2,5-diphenil tetrazolium bromide], from the crude extract of Picrasma crenata (Pau Tenente) and its isolated compounds, quassin and parain, in culture of rat liver tumor cells (HTC). (scielo.br)
  • These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)
  • From the GCMS study, 12 phytocompounds were identified from C. alata flowers, 9 compounds from C. auriculata flowers, 12 compounds from C. fistula flowers and 13 phytocompounds identified from the C. occidentalis flower extract. (scialert.net)
  • The paper shows that the tested coumarins derivatives were new compounds with good UV absorption properties, making them good UV absorbers of commercial potential. (emerald.com)
  • Virtual screening using molecular docking studies of the synthesized compounds was performed by (MOE), the molecular docking results indicate that, some synthesized compounds suitable inhibitor against (COX-2) with further modification. (scirp.org)
  • The phytochemical analysis revealed rich phytochemical composition of the plant and led to the isolation of more than hundred different compounds, such as flavonoids, biophenols, and terpenoids such as iridoids, secoiridoids, triterpenoids, coumarin. (springer.com)
  • The leaf extracts and its derivative compounds have shown potent anticancer effects against different cell lines in different organs. (springer.com)
  • Among others Oleuropein and its derivative compounds (hydroxytyrosol, tyrosol and others) were studied in a several types of cancer cells. (springer.com)
  • Recent studies of anticancer activities conducted on natural products isolated from plants, namely coumarin and related compounds, prove them to be a promising drug candidate in cancer treatments. (antiox.org)
  • Efforts made by the scientists to design and develop novel anti-cancer agents using coumarins as lead compounds and study their effectiveness using Structural Activity Relationship is worth appreciating. (antiox.org)
  • sulfur compounds: dithienyl-(2,2')-5-hydroxy-methyl-5'-(but-3-en-1-inyl) of angelic, butyric and tiglic acids, and derivatives 6-10 . (tramil.net)
  • Pharmacokinetic studies demonstrated that the synthesized albocarbon-based coumarins penetrate the gastrointestinal mucosa very well, and the majority of these compounds penetrate the blood-brain barrier only slightly. (jmchemsci.com)
  • Coumarins constitute an interesting group of compounds. (jmchemsci.com)
  • Coumarins are a class of heterocyclic compounds with a benzopyrone structure. (jmchemsci.com)
  • Study the biological activity of different ferrocenyl derivatives, coumain derivatives, and azo-dyes compounds as antimicrobial and anticancer drugs. (uprrp.edu)
  • Thereafter, we theoretically evaluated the TP recognition performance of these compounds and studied the relationship between their molecular structure and TP performance by means of time-dependent density functional theory and quadratic response theory. (rsc.org)
  • Coumarins and related compounds inhibit vitamin K 1 -2,3 epoxide reductase, preventing vitamin K from being reduced to its active form. (medscape.com)
  • In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. (researchgate.net)
  • Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors. (journals.cz)
  • His research integrates issues of Tertiary amine, Necrosis, Chemical synthesis and Stereochemistry in his study of Apoptosis. (research.com)
  • Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells. (research.com)
  • This study involves the synthesis of eight novel albocarbon-based coumarins, which were confirmed by various spectrophotometers. (jmchemsci.com)
  • The synthesis of ferrocenyl derivatives using esterification, amidation, and F-C acylation reactions. (uprrp.edu)
  • The synthesis and characterization of coumarins derivatives. (uprrp.edu)
  • Synthesis of differentially monoprotected alkynyl triol derivatives. (uprrp.edu)
  • Coumarins inhibit hepatic synthesis of the vitamin K ̶ dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S. Vitamin K is a cofactor in the synthesis of these clotting factors. (medscape.com)
  • In summary, herb-warfarin interaction, especially the clinical effects of herbs on warfarin therapy should be further investigated through multicenter studies with larger sample sizes. (hindawi.com)
  • The potency shown in clinical use boosts the studies on the mechanisms of warfarin anticoagulation. (hindawi.com)
  • In absence of good evidence, speculation has taken its place, and poor quality of available information in turn restricts future study of herb-warfarin interaction. (hindawi.com)
  • Azapropazone is primarily bound to the warfarin site, to which also other coumarin derivatives and, e.g., phenytoin and bilirubin are bound. (aspetjournals.org)
  • According to recent studies on drug and herb interactions,GBE should not be used while taking blood thinning medications such as warfarin, heparin coumarin or derivative. (chisuk.org.uk)
  • Additionally, although warfarin is no longer used primarily as a rodenticide, several long-acting coumarin derivatives (the so-called superwarfarin anticoagulants, such as brodifacoum, diphenadione, chlorophacinone, and bromadiolone) are used for this purpose and can produce profound and prolonged anticoagulation. (medscape.com)
  • The 3-carboxamide coumarins (figure 1) are to date the only nonpetidic and selective inhibitors of FXIIa described in literature4. (unamur.be)
  • Atanasova M, Yordanov N, Dimitrov I, Berkov S, Doytchinova I (2015a) Molecular docking study on galantamine derivatives as cholinesterase inhibitors. (journals.cz)
  • Venous thromboembolism (VTE, including deep vein thrombosis [DVT] and pulmonary embolism [PE]) in surgical patients undergoing general anesthesia has been extensively studied. (medscape.com)
  • Coumarin derivatives are widely used in the field of medicines and drugs for many years [ 2 - 7 ] as for example coumarin and its derivatives exhibited pronounced anticancer and antimicrobial activities as revealed from literature. (biomedcentral.com)
  • Ghorab, M.M., Ragab, F.A., Heiba, H.I., Arafa, R.K. and El-Hossary, E.M. (2011) Docking Study, in Vitro Anticancer Screening and Radiosensitizing Evaluation of Some New Fluorine-Containing Quinoline and Pyrimidoquinoline Derivatives Bearing a Sulfonamide Moiety. (scirp.org)
  • There are some examples of coumarin natural products that exert antidiabetic effect [ 1 , 3 ]. (hindawi.com)
  • Osthole, a coumarin derivative, reported as antidiabetic agent, alleviates hyperglycemia in db / db mice [ 3 ]. (hindawi.com)
  • The results indicate that the mechanism by which 6a, 5l and 6b coumarin derivatives inhibit BfD‐LDH by reversible non-competitive inhibition. (chemaxon.com)
  • It is commonly known that oxidative stress caused by free radicals and their derivatives is responsible for disturbing redox homeostasis [ 1 ]. (biomedcentral.com)
  • Tetraterpenes and carotenoids have been shown to possess potent anti-oxidant activity within both in vivo and in vitro studies 6 , however, some valuable carotenoids such as beta-carotene showed prooxidant effects at high concentration and oxygen pressure 7 . (scialert.net)
  • The various areas that Bao-Xiang Zhao examines in his Apoptosis study include Cancer cell, Cancer research, In vitro and Cell biology. (research.com)
  • This review, therefore, focuses on the recent progress in the discovery of coumarin derivatives with potential antitumor activity. (antiox.org)
  • In the study, the use of analytical methods looking into compound bioactivity were applied to durian shells isolating two new triterpenoids, two new phenolics, and seven new glycoside esters. (nutraingredients.com)
  • Subject has consumed medicines or foodstuff that may affect pharmacological or pharmacokinetic properties of chenodeoxycholic acid (for example: Antacids (aluminum containing), Bile acid sequestrants such as (cholestyramine or colestipol), Clofibrate, Coumarin-derivative anticoagulants, Estrogens & oral contraceptive) two weeks before dosing, during the study and two weeks after dosing. (who.int)
  • [ 3 ] Today, coumarin derivatives are used therapeutically as anticoagulants and commercially as rodenticides . (medscape.com)
  • ABSTRACT In this study, a total of 12 coumarin-chalcone derivatives, 6 of which are original were synthesized. (biruni.edu.tr)
  • Abstract Abstract : In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a-l) was synthesized using the tail-approach method. (biruni.edu.tr)
  • Medical research has isolated at least six coumarin derivatives that exert antispasmodic and vasodilatory effects. (net-planet.org)
  • The docking pose of the studied LA1 molecule depends of the protonated state of the nitrogen atom of the piperazine moiety where in the best scored poses, the xanthine moiety of LA1 is bound into the catalytic active site (CAS) of AChE, while the arylpiperazine fragment is placed into the peripheral binding site (PAS). (journals.cz)
  • He has included themes like Ratiometric fluorescence, Protonation, Moiety, Coumarin and High selectivity in his Photochemistry study. (research.com)
  • His primary areas of study are Förster resonance energy transfer, Photochemistry, Hypochlorous acid, Moiety and Acceptor. (research.com)
  • The study incorporates disciplines such as Double bond and Hypochlorite in addition to Moiety. (research.com)
  • Studies in the Photochemistry of Coumarin and Certain Coumarin Derivatives. (caltech.edu)
  • However, the coumarin derivatives extracted did not show NO inhibitory activity. (nutraingredients.com)
  • His studies in Selectivity integrate themes in fields like Fluorescence intensity and Analytical chemistry. (research.com)
  • Moreover, we comprehensively investigated the effect of the benzene-fused position in the coumarin backbone on the transition dipole moment and nonradiative decay channels, explaining the fluorescence near-quenching mechanism of benzo[ f ]coumarin derivative DCCA-4 for the first time. (rsc.org)
  • Gerbera contains naturally occurring coumarin derivatives. (wikipedia.org)
  • His biological study spans a wide range of topics, including Pyrazoline, Inorganic chemistry, Fluorophore, High selectivity and Aqueous solution. (research.com)
  • The CEROC projects include developing new undergraduate experiments and the integration of technology in undergraduate laboratories for organic chemistry and biochemistry, and the study of student performance in traditional vs online lectures, experiments and activities to improve the BS chemistry curriculum and introduce new elective courses. (uprrp.edu)
  • B. fragilis D‐lactate dehydrogenase has been expressed, purified and inhibitory activities of 25 coumarin derivatives previously synthetize for their antioxidant activity were evaluated. (chemaxon.com)
  • In fact, many studies have demonstrated the oleuropein and its derivative have proved pharmacological activity against proliferation of cancer cells and several tumor cell lines by different mechanisms such arrest cell cycle and cause apoptosis in cancerous cells, by modulation of miRNA expression and upregulation and downregulation of several genes. (springer.com)
  • A large number of studies are in progress to find natural sources, which are effective in reducing the intensity of diabetes [ 3 ]. (hindawi.com)
  • The effect of the psoralen derivatives from radix Angelicae dahuricae on retinoid X receptor- α enzymes transcriptional regulation was reported [ 4 ] and this in turn plays key roles in various biological processes including diabetes and obesity. (hindawi.com)
  • This study provides valuable insights into the preventive and therapeutic effects of RC and RP in CHD. (bvsalud.org)
  • Researchers have been focused for decades on studying their crucial biological features and preparing analogues for therapeutic applications. (jmchemsci.com)
  • His study connects Pyrazole and Biochemistry. (research.com)
  • His Pyrazole study combines topics in areas such as Dihedral angle, Carbohydrazide and Ring. (research.com)
  • In the present study, it was shown that tuber and leaf extracts may increase the expression of the ROS SOD-1 inactivating enzyme gene in the fibroblast cell line. (biomedcentral.com)
  • The study suggest that Jerusalem artichoke leaves and tubers extracts affect the cell proliferation and can alter the expression of genes related to oxidative stress. (biomedcentral.com)
  • III experimental: BD + Bacillus cereus + coumarin (BC + CO). Metagenomic analysis of the bacterial profile of the cecum contents showed the prevalence of representatives of Bacteroidetes phylum in the experimental groups (4.5-15.2%) at 14 days of age, and a decrease in the percentage of Firmicutes phylum (5.9-14.8%), the dominance of Bacteroidaceae families was noted. (aimspress.com)
  • Experimental Study of Analgesic Activity of Cajanus cajan Linn Leaves in Mice. (rjstonline.com)
  • The tested coumarins showed good UV absorption properties in the range 280‐380 nm, making them potential candidates for many applications. (emerald.com)
  • AIM OF THE STUDY: The aim of this work is to elucidate the potential effective parts (phthalides) of L. chuanxiong responsible for renal protection and to explore the possible mechanism of renal protection. (bvsalud.org)
  • The free radical-housing potential was analyzed by testing these coumarins' ability to scavenge DDPT and hydroxyl harmful radicals. (jmchemsci.com)
  • Besides, the assessment of the free radical-housing potential of these synthesized albocarbon-based coumarins also indicated that all of them were less active than the reference. (jmchemsci.com)
  • The aim of the study was to evaluate the effect of coumarin and Bacillus cereus derivatives on the productivity and ecology of the caecum of broilers. (aimspress.com)
  • PRIMARY OBJECTIVE: I. Evaluate the proportion of patients with objective response (OR) to targeted study agent(s) in patients with advanced refractory cancers. (mycancergenome.org)
  • It was found that the enhanced activities are dependent on the coumarin nucleus. (biomedcentral.com)
  • Coumarin derivative and Bacillus cereus change live weight and cecal ecology in broilers[J]. AIMS Agriculture and Food, 2021, 6(1): 360-380. (aimspress.com)
  • The leaf contains coumestans (benzofurano[2,3-c]coumarins): wedelolactone 2 , demethylwedelolactone and derivatives 3 . (tramil.net)
  • The remarkable results on yield, process, development of DHPs, anti‐proliferative activity, structure determination and single crystal study of DHPs discussed in this article. (researchgate.net)
  • According to the research results, the activity of cellular biomasses to suppress quorum sensing (QS) ( Chromobacterium violaceum 026 ) in Bacillus cereus and a coumarin derivative was revealed. (aimspress.com)
  • Study of anti oxidant and anti-inflammatory activity from ethanol fraction of Thuja occidentalis Linn. (rjstonline.com)
  • The Raman and infrared spectral studies suggests the tridentate behavior of the ligand from each tail. (scirp.org)
  • Ibuprofen, flurbiprofen, and naproxen are primarily bound to the diazepam site on the albumin molecule as shown in interaction studies with albumin immobilized in microparticles. (aspetjournals.org)
  • Background papers were written and tables of evidence constructed summarizing the type of study (e.g., randomized controlled trial, case series), the study population and setting, the treatments or other interventions, outcome measures assessed, reported findings, and weaknesses and biases in study design and analysis. (cdc.gov)
  • This phase II trial studies molecular profiling-based assignment of cancer therapy (MPACT) in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). (mycancergenome.org)
  • A study by Hull et al found that initiation of therapy within 8 hours of surgery had the greatest effect. (medscape.com)
  • AIM OF THE STUDY: L. chuanxiong has significant hepatoprotective effects, but its material basis and mechanism of action are still ambiguous. (bvsalud.org)
  • Study the mechanism of action of the new drugs. (uprrp.edu)
  • Physicochemical and Preliminary Phytochemical Studies on the Fruit of Tribulus terrestries Linn. (rjstonline.com)
  • The subject has been participating in any clinical study (e.g. pharmacokinetics, bioavailability and bioequivalence studies) within the last 80 days prior to the present study. (who.int)
  • The researchers believed that these new albocarbon-based coumarins can be applied for the creation of new successful drugs with hypoglycemic and free radical-housing effects which can help in the modulation of much serious pathology. (jmchemsci.com)
  • His study with Apoptosis involves better knowledge in Biochemistry. (research.com)
  • In this study BfD‐LDH has been targeted for structure based drug design. (chemaxon.com)
  • Coumarin based drugs can be designed for the possible treatment of U2OS leukemia. (biomedcentral.com)
  • The antiinflammatory drugs studied have small distribution volumes and low free fractions in plasma, which means that displacement from their binding sites may be of pharmacokinetic significance. (aspetjournals.org)
  • A recent meta-analysis,published in the British Journal of Pharmacology, analyzed the quality of research conducted in over 40 clinical studies investigating Ginkgo Biloba extract in the treatment of cerebral insufficiency. (chisuk.org.uk)
  • No longer an active study drug as of March 2018) After completion of study treatment , patients are followed up for 30 days. (mycancergenome.org)
  • MATERIALS AND METHODS: The hepatoprotective substance basis and mechanism of L. chuanxiong were investigated using network pharmacology, and the active components of L. chuanxiong extract were studied using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) analytical techniques. (bvsalud.org)
  • I. Studies in Isomerism: Permutations, Point Group Symmetries, and Isomer Counting. (caltech.edu)