• This is an 18-week open-label, multicenter study to evaluate the efficacy and tolerability of CEP-701 ( lestaurtinib ) treatment in patients with Polycythemia Vera (PV) and patients with Essential Thrombocytosis (ET). (clinicaltrials.gov)
  • This is an 18-week open-label, multicenter study to evaluate the efficacy and tolerability of CEP-701 (lestaurtinib) treatment at a dosage of 80 mg bid for 18 weeks (126 days) in patients with Polycythemia Vera (PV) who have abnormal baseline neutrophil counts or require hydroxyurea therapy and patients with Essential Thrombocytosis (ET) who require hydroxyurea therapy for disease control. (clinicaltrials.gov)
  • 9 While some diseases, such as hematologic neoplasms, cause neutropenia, it occurs most often as a result of the myelosuppression caused by antineoplastic chemotherapy, especially when such therapy is administered at doses designed to achieve maximum antitumor activity. (nih.gov)
  • Parathyroid hormone (PTH) has become the most widely studied hormone with regard to its administration to various species and their respective skeletal responses. (nih.gov)
  • Ninety patients were excluded from the study because the biopsy target was located within the spine or the target was outside the spine and purely sclerotic. (auntminnie.com)
  • Beyond its affirmative effect in osteoporosis treatment, systemic PTH administration seems to stimulate bone formation in the fracture healing process. (nih.gov)
  • This type of separation must be made with the aid of imaging studies, and should not be done by histology examination only. (wikipedia.org)
  • Abnormalities in bone mineral density (BMD), body composition, and bone metabolism have been reported in children who were treated for acute lymphoblastic leukemia (ALL) during and after completion of therapy. (aappublications.org)
  • Therefore this study is testing whether radium-223 added to sipuleucel-T increases the immune response and anti-tumor effect against prostate cancer. (clinicaltrials.gov)
  • Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival. (ox.ac.uk)
  • However, these studies are cross-sectional, and no longitudinal data are available in a large group of patients after completion of therapy. (aappublications.org)
  • In the present study, 1-year longitudinal changes in BMD, body composition, and bone metabolism were evaluated in children with ALL during the first 3 years after completion of therapy without cranial irradiation. (aappublications.org)
  • These findings suggest a positive effect of long-term completion therapy and increase in physical activity on BMD, body composition, and bone metabolism in patients who have been treated for ALL. (aappublications.org)
  • 5 , 13 Although studies have consistently shown that BMD is reduced in patients after the cure of ALL using cranial irradiation during childhood, 14 - 22 few studies have investigated whether these abnormalities persist after completion of therapy in patients who are treated for ALL without the use of cranial irradiation. (aappublications.org)
  • 23 , 24 However, these studies were cross-sectional, and except for 1 study, in which a limited number of patients showed a tendency to improve BMD and body composition during the first year after completion of treatment, 10 no longitudinal data on BMD, bone metabolism, and body-composition changes are available for patients after completion of therapy. (aappublications.org)
  • The incidence of bone neoplasms in animal studies depends on the dose and duration of treatment. (nih.gov)
  • Curcumin as well as the ashwagandha extract are ingredients from traditional indian medicine and have been shown to be potent anti-cancer compounds in laboratory as well as animal studies. (clinicaltrials.gov)
  • The objectives of the study are: (1) to evaluate the clinical effectiveness of intravenous injections of Rexin-G, a tumor-targeted gene vector, in controlling tumor growth and prolonging life, and (2) to evaluate its over-all safety. (clinicaltrials.gov)
  • 6 - 12 Cytotoxic agents and steroids have been said to affect normal bone mass accumulation and bone turnover, leading to increased risk for osteoporosis and fractures. (aappublications.org)
  • Study record managers: refer to the Data Element Definitions if submitting registration or results information. (clinicaltrials.gov)
  • To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. (clinicaltrials.gov)
  • Moreover, contrary to the studies in which treatment included cranial irradiation, 26 - 28 no long-term side effects on lean and fat body mass were found in these studies. (aappublications.org)