AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Ambystoma mexicanumRegenerationExtremitiesTurbellariaNotophthalmusAmbystomaNotophthalmus viridescensForelimbSalamandridaeAnimal FinsPlanariansTriturusTailAmputationUrodelaPleurodelesWilms TumorNerve TissueZebrafishIn Situ HybridizationAnaplasiaAmputation StumpsCell DedifferentiationAnimal StructuresPentosan Sulfuric PolyesterWound HealingGene Expression Regulation, DevelopmentalCell DifferentiationMorphogenesisGenes, HomeoboxMesodermZebrafish ProteinsEpidermisDermisCartilageAnimals, Genetically ModifiedFibroblast Growth FactorsTretinoinBody PatterningMSX1 Transcription FactorCellular MicroenvironmentHomeodomain ProteinsLimb BudsChoristomaDenervationXenopus ProteinsPAX7 Transcription FactorXenopus laevisHindlimbMolecular Sequence DataMultipotent Stem CellsTenascinEmbryo, NonmammalianLarvaCell ProliferationAmino Acid SequenceT-Box Domain ProteinsKidney NeoplasmsUreterHedgehog ProteinsStem CellsDNA, ComplementaryImmunohistochemistryGene ExpressionHead
RegenerationMetanephric blastemaDifferentiationProgenitor cellsAmputationTissuesUreteric budProliferationWoundRegenerativeFormationMigrationAdult stemFragmentsMechanismStemLineagesMechanismsOrganCellularDifferentiateDevelopmentBiologySignalsKidneyCycleFateGene expressionPresenceResistantGeneticBloodTypesProcessNormalCancersDivision
Regeneration21
  • In intact leg discs ubiquitously expressed low levels of Wg also leads to blastema formation, regeneration and transdetermination. (washington.edu)
  • Which biological mechanisms guide the mature cells through the regeneration process? (unifr.ch)
  • Regarding extracellular matrix, we characterized the dynamics and regulation of the regeneration of actinotrichia, which are fin-specific skeletal structures. (unifr.ch)
  • We are currently investigating which adhesion mechanisms organize the different cells types during fin regeneration. (unifr.ch)
  • In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
  • The contributors discuss the dramatic molecular and cellular changes that occur when a regeneration program is initiated, the progenitor cells and morphogenic signals involved, the formation of a blastema, the roles of reprogramming and polyploidy, the diversity of cell fates, the integration of new structures with existing body parts, and our current understanding of why some structures are more resistant to regeneration than others. (cshlpress.com)
  • The importance of technologies (e.g., single-cell RNA-seq) that have been instrumental in deciphering various aspects of regeneration in recent years is emphasized throughout. (cshlpress.com)
  • Several chapters are also devoted to regeneration in specific human organs-the skin, retina, heart, lung, pancreas, liver, skeletal muscle, and intestine-and examine possibilities for therapeutically replacing injured or diseased structures and for managing age-related declines in function. (cshlpress.com)
  • This volume is therefore essential reading for molecular, cell, and developmental biologists studying regeneration in animals, as well as for all interested in the development of regenerative therapies for clinical application. (cshlpress.com)
  • Planarians are flatworms with large populations of stem cells capable of dividing to support adult tissue renewal and regeneration. (biomedcentral.com)
  • Our results also reveal novel roles for Akt signaling during regeneration, specifically for the timely localization of cell death near the injury site. (biomedcentral.com)
  • This paucity is likely due to the ubiquitous nature of this signaling pathway and the difficulty of analyzing stem cells in their natural environment during physiological cell turnover and regeneration in conventional animal models [ 15 - 17 ]. (biomedcentral.com)
  • Unidirectional regeneration in the basal chordate Ciona intestinalis involves the proliferation of adult stem cells residing in the branchial sac vasculature and the migration of progenitor cells to the site of distal injury. (biomedcentral.com)
  • However, after the Ciona body is bisected, regeneration occurs in the proximal but not in the distal fragments, even if the latter include a part of the branchial sac with stem cells. (biomedcentral.com)
  • siRNA-mediated gene knockdown showed that hsp70 and dnaJb4, but not bag3, are required for progenitor cell targeting and distal regeneration. (biomedcentral.com)
  • Heat shock treatment of distal body fragments activated hsp70 and dnaJb4 expression indicative of a stress response, induced cell proliferation in branchial sac vasculature cells, and promoted distal regeneration. (biomedcentral.com)
  • The stress response is absent from distal fragments, but can be induced by a heat shock, which activates cell division in the branchial sac vasculature and promotes distal regeneration. (biomedcentral.com)
  • This study demonstrates the importance of a stress response for stem cell activation and regeneration in a basal chordate, which may have implications for understanding the limited regenerative activities in other animals, including vertebrates. (biomedcentral.com)
  • Histological studies focusing on the early cephalic tentacle regeneration in P. canaliculata, have demonstrated that wound closure and blastema formation took place within 24 h post amputation (hpa). (unimore.it)
  • Neural control of growth and size in the axolotl limb regenerate [2] "Upon the completion of the developmental stages of regeneration, when the regenerative organ known as the blastema completes patterning and differentiation, the limb regenerate is proportionally small in size. (edu.au)
  • This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
Metanephric blastema5
  • Alright so during fetal development, first off, you've got this structure called the mesonephric duct which is involved in development of urinary and reproductive organs , and during the 5th week of gestation, a little guy called the ureteric bud starts pushing its way into another structure called the metanephric blastema, and together, these two little embryologic structures go on to develop into a kidney. (osmosis.org)
  • By about 20 weeks, the ureteric bud has formed the ureters , the renal calyces, collecting ducts, and collecting tubules, while the metanephric blastema develops into the nephron itself, which includes the epithelial cells and the podocytes of the Bowman's capsule. (osmosis.org)
  • With renal agenesis , the ureteric bud fails to induce development of the metanephric blastema, and so either one or both kidneys don't develop. (osmosis.org)
  • The ureteric bud grows laterally and invades the center of the metanephric blastema, the primordial renal tissue [4]. (esur2023.com)
  • The metanephric blastema forms glomeruli, proximal and distal tubules. (esur2023.com)
Differentiation4
  • Although not essential for initial WD formation, the later differentiation of this embryological structure relies on androgens derived from the Leydig cells. (esur2023.com)
  • In the presence of a Y chromosome and the SRY gene, müllerian‐inhibiting substance produced by Sertoli cells causes regression of the MD. Meanwhile, testosterone produced by the Leydig cells induces differentiation of the WD into the efferent ducts that communicate with the rete testis, followed by the epididymis, ductus deferens, seminal vesicle, and ejaculatory duct. (esur2023.com)
  • In this research, we generate differentiated kidney cells (DKCs) from mouse pluripotent stem cells (mPSCs) analyzing their morphological, genetic, phenotypic, and spectroscopic characteristics along differentiation, highlighting that there are no reports of the use of Fourier transform infrared (FTIR) spectroscopy to characterize the directed differentiation of mPSCs to DKCs. (biomedcentral.com)
  • Moreover, FTIR spectroscopy resulted in a non-invasive, rapid and precise technic that together with principal component analysis allows to characterize chemical and structurally both kind of cells and also discriminate and determine different stages along the cell differentiation process. (biomedcentral.com)
Progenitor cells2
  • The upregulation of HSP70 chaperone genes was verified and their expression confirmed in BS vasculature cells previously identified as stem and progenitor cells. (biomedcentral.com)
  • This process relies on the formation of a blastema, a pool of progenitor cells that is formed in response to amputation. (lu.se)
Amputation5
  • First, the fin margin is covered by a wound epithelium, and next a proliferative blastema arises by dedifferentiation of stump tissues near the amputation. (unifr.ch)
  • Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
  • However, in response to amputation, levels of cell death were decreased and failed to localize near the injury site. (biomedcentral.com)
  • Interestingly, the neoblast mitotic response was increased around the amputation area but the regenerative blastema failed to form. (biomedcentral.com)
  • After amputation, granular hemocytes infiltrate the blastema of regenerating cephalic tentacles of the freshwater snail Pomacea canaliculata. (unimore.it)
Tissues8
  • The formation of new cells, tissues, and organs enables animals to recover from day-to-day wear and tear, injury, and disease. (cshlpress.com)
  • Muller proposed that cancer cells developed from budding elements (blastema) between normal tissues. (cancer.org)
  • The reduced neoblast numbers largely affected the maintenance of adult tissues including the nervous and excretory systems and ciliated structures in the ventral epithelia, which impaired planarian locomotion. (biomedcentral.com)
  • The neoblasts are the only dividing cells in planarians and constantly proliferate to repair tissues and support systemic cellular turnover [ 21 ]. (biomedcentral.com)
  • Although developing tissues and organisms are known to be more sensitive to toxic compounds, three independent experiments in regenerating worms showed a less pronounced effect of AgNP exposure on the microbiome, possibly because underlying bacterial community changes during development mask the AgNP induced effect. (bvsalud.org)
  • One of our research interests is to understand mitochondrial heterogeneity and diversity of structure, function and expression dynamics across different tissues, but also in different disease conditions. (univ-amu.fr)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)
Ureteric bud2
  • Which of the following structures does the ureteric bud give rise to under normal conditions? (osmosis.org)
  • The ureteric bud is a pivotal structure that differentiate into the ureter and the collecting duct system of the kidney. (esur2023.com)
Proliferation4
  • In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation, metabolism, cell growth and cell death. (biomedcentral.com)
  • Functional disruption of Smed-Akt alters the balance between cell proliferation and cell death leading to systemic impairment of adult tissue renewal. (biomedcentral.com)
  • This study defined the role of Smed-Akt in abnormal cell proliferation triggered by the abrogation of the phosphatase PTEN, an upstream component of the Akt signaling pathway, which is highly mutated in human cancers. (biomedcentral.com)
  • In both processes, rapid proliferation gives rise to new tissue, cell fate has to be specified within that tissue, and distinct positional identities have to be established to generate a properly patterned structure. (frontiersin.org)
Wound3
  • After fragmentation wound healing occurs, ectopic wg is induced and a blastema is formed. (washington.edu)
  • We hypothesized that kickstarting a limb-building routine required two components acting at a very early initiating stage of the process: first, an enclosed and permissive microenvironment that enables the wound cells to control the biochemical milieu following injury and, second, an instructive set of signals that specifically trigger a limb-building program. (genengnews.com)
  • Advances in tissue engineering technology have led to the production of novel human skin equivalents and organoids that reproduce cell-cell interactions with tissue-scale tensional homeostasis, and enable us to evaluate skin tissue morphology, functionality, drug response and wound healing. (mdpi.com)
Regenerative5
  • Fragments that fail to both transdetermine and regenerate missing structures will do both when provided with exogenous Wg, demonstrating the necessity of Wg in regenerative processes. (washington.edu)
  • We are currently investigating the regenerative capacity of specific cardiac cell populations and comparing the restorative programs of different fish species. (unifr.ch)
  • This organism is well known for its stem cell-based regenerative capability. (biomedcentral.com)
  • therefore, new researches focused on regenerative medicine have been developed, including the use of stem cells. (biomedcentral.com)
  • Consequently, because of the increased rate of RF in terminal stage and few alternative treatments, new investigations focused on regenerative medicine have been developed, including the use of stem cells (SCs) [ 7 ]. (biomedcentral.com)
Formation3
  • By perturbing BMP activities, we demonstrated that BMP signaling is required for activating the expression of the left-sided genes and the formation of the left-sided structures. (echinobase.org)
  • BMP is required for left-sided structure formation and gene expression in the aboral veg2 descendants.ISH of bmp2/4 and pSmad immunostaining in control and DM-treated embryos at the LG (A, treated from 24 to 48 hpf) or EPL stage (B, treated from 42 to 48 hpf). (echinobase.org)
  • We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
Migration2
  • This property involves activation of the remaining tissue at the site of injury to promote cell division, cell migration and replacement of the missing structures. (unifr.ch)
  • Embryonic GABAB Receptor Blockade Alters Cell Migration, Adult Hypothalamic Structure, and Anxiety- and Depression-Like Behaviors Sex Specifically in Mice. (arnes.si)
Adult stem1
Fragments1
  • In some, but not all fragments, the blastema will replace missing structures and a few cells can become more plastic and transdetermine to structures of other discs. (washington.edu)
Mechanism1
  • One concentrate inside the mechanism of neuronal death in AD would be the aberrant expression of cell cycle related proteins, this kind of as cdc2, cdk4, cyclin B1, and cyclin D, which med iate cell cycle progression, in vulnerable neurons from the AD brain, these molecules perform important roles in neuronal death related with several paradigms of neuronal death. (fgfrinhibitors.com)
Stem5
  • However, the mechanisms by which Akt signaling regulates stem cell behavior in the complexity of the whole body are poorly understood. (biomedcentral.com)
  • Our findings abrogating Smed-Akt with RNA-interference in the planarian Schmidtea mediterranea led to a gradual decrease in stem cell (neoblasts) numbers. (biomedcentral.com)
  • Nonetheless, there is limited understanding of how Akt signaling controls the response of stem cells during cellular turnover and tissue injury in the complexity of the whole organism. (biomedcentral.com)
  • According to their potentiality, embryonic stem cells (ESCs) are classified as totipotent and pluripotent, both of them can differentiate into the three germ lines. (biomedcentral.com)
  • This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)
Lineages2
  • Regarding vibrational spectroscopy analysis by FTIR, bands related with biomolecules were shown on mPSCs and DKCs spectra, observing distinct differences between cell lineages and maturation stages. (biomedcentral.com)
  • Embryonic or adult SCs by definition are characterized by their self-renewal and potentiality, peculiarities that allow them to give rise to more SCs and differentiate into various cell lineages under appropriate conditions. (biomedcentral.com)
Mechanisms1
  • Nevertheless, the mechanisms by which neuronal degeneration and death happen in AD and no matter whether they may be induced by Ab will not be wholly understood. (fgfrinhibitors.com)
Organ1
  • The kidney is a complex organ composed of several cell types, and it is conformed approximately by 11,000 nephrons. (biomedcentral.com)
Cellular2
  • mitotically active cells of intact segments do not significantly contribute to the blastemal cellular sources. (mdpi.com)
  • On a cellular level, we look at the evolution of epithelia in the most primitive metazoan organisms (sea-water sponges) as an important structure to define organismal and tissue boundaries (in collaboration with Andre le Bivic and Carole Borchiellini). (univ-amu.fr)
Differentiate1
  • ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)
Development1
  • This quantitative study explores the acceptability of Online Learning Action Cell (LAC) practice as a school-based professional development strategy for Tagumpay National High School (TNHS) teachers. (philarchive.org)
Biology1
  • Thus, Akt signaling regulates neoblast biology and mediates in the distribution of injury-mediated cell death during tissue repair in planarians. (biomedcentral.com)
Signals1
  • In (A-G), the arrowheads indicate the bilateral signals in the aboral skeletogenic cells, and the arrows indicate signals in the CPs. (echinobase.org)
Kidney1
  • The structure of the kidney may differ between species depending on the environment, in particular on its aridity. (wikipedia.org)
Cycle3
  • On top of that to cell cycle progres sion molecules, quite a few cell cycle inhibitors, such as p16 and p27, and tumor suppressor proteins such as p53 and BRCA1 are also increased in levels during the AD brain. (fgfrinhibitors.com)
  • Also to your human AD brain, the improved expression levels of cell cycle relevant proteins were also found in transgenic mouse models of AD. (fgfrinhibitors.com)
  • Although it selleckchem is unclear why cell cycle connected proteins show enhanced in ranges within the AD brain and AD mouse models, 1 chance is that DNA harm induced by Ab may possibly improve the levels of or activate these molecules. (fgfrinhibitors.com)
Fate1
  • Our fate mapping experiments demonstrated that the activated mesenchyme of the stump gives rise to the blastema. (unifr.ch)
Gene expression1
Presence1
  • After the injection of clodronate liposomes, a specific computer-assisted image analysis protocol still evidenced the presence of granular hemocytes in the tentacle blastema. (unimore.it)
Resistant1
  • In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
Genetic1
  • Many conditions do not appear to be induced entirely by environmental factors and so genetic profiles have been studied to determine why some individuals are more susceptible to particular diseases. (biomedcentral.com)
Blood1
  • As the blastema and its cells continue to divide, the growing structure flattens and eventually resembles a perfect copy of the lost limb, including nerves and blood vessels buy hack arma 3 are connected to the rest of the body F. Decreased breath sounds, crackles, wheezing, and rhonchi that clears with coughs may be heard in the chest. (stjohnsacademy.org)
Types4
  • An improved ontological representation of dendritic cells as a paradigm for all cell types. (philarchive.org)
  • The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. (philarchive.org)
  • Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. (philarchive.org)
  • Thousands of copies of the circular mtDNA are present in most cell types that are packaged by TFAM into higher-order structures called nucleoids1. (regenerativemedicine.net)
Process1
  • Our objective is to identify the cells and factors that are essential in the engineering process. (lu.se)
Normal1
  • In 1838, German pathologist Johannes Muller demonstrated that cancer is made up of cells and not lymph, but he believed that cancer cells did not come from normal cells. (cancer.org)
Cancers2
  • In the 1860s, German surgeon, Karl Thiersch, showed that cancers metastasize through the spread of malignant cells and not through some unidentified fluid. (cancer.org)
  • 14. Which of the following lymphatic cancers is associated with multinucleated Reed-Sternberg cells and EBV? (mockdocs.org)
Division1
  • Recently, we described that the genome of S. mediterranea contains a single Akt ortholog termed Smed-Akt , which affects cell division and impairs planarian locomotion [ 22 ]. (biomedcentral.com)