• In biochemistry, the iron-sulfur cluster biosynthesis describes the components and processes involved in the biosynthesis of iron-sulfur proteins. (wikipedia.org)
  • The Suf system for iron-sulfur cluster biosynthesis is generally similar to the Isc system (and the Nif system). (wikipedia.org)
  • His latest research focused on the enzymes in glycosaminoglycan biosynthesis . (imperial.ac.uk)
  • Briggs DC, Hohenester E, 2018, Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1. (imperial.ac.uk)
  • Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. (medlineplus.gov)
  • The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis. (medlineplus.gov)
  • Two tightly regulated biochemical processes, metallation of porphyrin at the last stage of heme biosynthesis and the generation of iron-sulphur clusters (ISC), take place inside the mitochondrial matrix and utilise around 80% of the iron acquired by organisms. (lu.se)
  • Ferrochelatase catalyses iron insertion into protoporphyrin IX at the terminal step of heme biosynthesis, while IscU assists in the formation of iron-sulphur clusters. (lu.se)
  • The two inhibitors of prostaglandin biosynthesis were isolated from the root of Arnebia euchroma (Boraginaceae). (elsevierpure.com)
  • However, the physiologic significance of prostaglandin production did not unfold until 1971, when Vane, Smith, and Willis discovered that aspirin and indomethacin inhibited prostaglandin biosynthesis. (medscape.com)
  • Biochemistry of lipids, membrane structure, anabolism and catabolism of lipids. (up.ac.za)
  • The gene had a structure consisting of 8 introns and 9 exons, similar to other plant AGPGp genes. (usda.gov)
  • Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps . (cdc.gov)
  • Genes in region A encode enzymes for biosynthesis of the capsular polysaccharide, and genes in regions B and C are implicated in the translocation of the high molecular weight polysaccharides to the cell surface. (cdc.gov)
  • Serogroup-specific capsule biosynthesis genes located in region A have been published for serogroup X, and nucleotide sequences for serogroups E, L, and Z have been submitted to GenBank (accession nos. (cdc.gov)
  • The data provided herein suggest that B. fragilis uses N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo arginine biosynthesis and therefore that this pathway in Bacteroides is different from the canonical arginine biosynthetic pathway of most organisms. (nih.gov)
  • Recently chemical biology findings have highlighted the glycosylphosphatidylinositol (GPI) biosynthesis pathway as a promising novel target pathway to treat life-threatening fungal infections. (nature.com)
  • This review examines pantothenate and the CoA biosynthesis pathway in the human-mosquito-malaria parasite triad and explores possible approaches to leverage the CoA biosynthesis pathway to limit malaria parasite development in both human and mosquito hosts. (mdpi.com)
  • Characterization of a Nitro-Forming Enzyme Involved in Fosfazinomycin Biosynthesis. (acs.org)
  • Bioactive Compounds Biosynthesis, Characterization and Applicatio. (intechopen.com)
  • Nitrogen metabolism, amino acid biosynthesis and catabolism. (up.ac.za)
  • Furthermore, the complexity of linkages and sidechain structures in xylan necessitate a suite of hydrolytic enzymes for the complete breakdown of the polymer, and the production of such enzymes can result in significant economic and metabolic costs. (biomedcentral.com)
  • Both the structure of the PGs and the GAG chains, and the expression of the enzymes involved in their biosynthesis and degradation, vary between normal cells and tumor cells. (lu.se)
  • The chlorophyll molecule consists of a central metal core surrounded by a nitrogen-containing structure, resulting in a porphyrin ring. (microbenotes.com)
  • The structure of chlorophyll a is similar to the basic structure of chlorophyll with a chlorin ring where four nitrogen atoms surround the magnesium ion. (microbenotes.com)
  • tRNASec is a key molecule in Sec biosynthesis and incorporation that participates throughout all steps of whole pathways. (uni-goettingen.de)
  • A family of dinuclear iron cluster-containing oxygenases that catalyze β-hydroxylation tailoring reactions in natural product biosynthesis by nonribosomal peptide synthetase (NRPS) systems was recently described [Makris, T. M., Chakrabarti, M., Münck, E., and Lipscomb, J. D. (2010) Proc. (umn.edu)
  • These findings provide new information on the putative role of succinylated intermediates in arginine biosynthesis and on the evolution of transcarbamylases. (nih.gov)
  • Biosynthesis of glycosylphosphatidylinositol (GPI) is required for anchoring proteins to the plasma membrane, and is essential for the integrity of the fungal cell wall. (nature.com)
  • GPI biosynthesis is a conserved process, required for anchoring proteins to the plasma membrane of fungi and thus essential for the integrity of the fungal cell wall in yeasts and molds 4 . (nature.com)
  • The iron sulfur proteins contain iron-sulfur clusters, some with elaborate structures, that feature iron and sulfide centers. (wikipedia.org)
  • Overexpression of recombinant proteins in order to elucidate their structure and catalytic switch. (weizmann.ac.il)
  • Comparison of the structures of the new protein with those recently reported for N-acetyl-L-ornithine transcarbamylase indicates that amino acid residue 90 (B. fragilis numbering) plays an important role in conferring substrate specificity for N-succinyl-L-ornithine versus N-acetyl-L-ornithine. (nih.gov)
  • Biosynthesis of neurotransmitters, pigments, hormones and nucleotides from amino acids. (up.ac.za)
  • The biosynthesis of chlorophyll a takes place by the reaction between chlorophyllide a and phytyl diphosphate in the presence of the enzyme chlorophyll synthase. (microbenotes.com)
  • Here, we report the 2.6 Å resolution crystal structure of FlvF, which adopts the α-helical fold of a class I terpene synthase. (anl.gov)
  • Prior to the addition of IPTG methionine biosynthesis was suppressed by the addition of lysine threonine phenylalanine leucine isoleucine valine and selenomethionine. (conferencedequebec.org)
  • Here we probe these fundamental questions using peroxisomal compartmentalization of the last steps of lysine and histidine biosynthesis in the fission yeast Schizosaccharomyces japonicus . (biorxiv.org)
  • Syroegin, E. A. , Aleksandrova, E. V. , and Polikanov, Y. S. (2022) Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes . (anl.gov)
  • It covers the major chemistry journals where isolation studies, biosynthesis, new compounds and known compounds from new sources, structure determinations, and new properties are reported. (lu.se)
  • The degradation of the GSH moieties requires the activity of the Cys-Gly carboxypeptidase GliJ, for which we describe the X-ray structure here. (cipsm.de)
  • Thus, modification of xylans or specific xylan structures are of interest to the biomass-processing industry, as success in this area may facilitate fermentation and thereby substantially lower costs for full biomass degradation. (biomedcentral.com)
  • Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C-N Bond-Forming Reaction of Flavunoidine Biosynthesis. (anl.gov)
  • Jasmonate acid (JA) is a vital endogenous hormone that regulates taxol biosynthesis and other biological processes, especially (a)biotic stress tolerance in various plants ( Roberts, 2001 ). (frontiersin.org)
  • These substances are chemical structures that perform specialized functions at the biological level [ 3 ]. (intechopen.com)
  • There are different types of chlorophylls that might differ in their chemical structures as they occur in different living organisms. (microbenotes.com)
  • Bioactive compounds make up a highly heterogeneous set of molecules with different chemical structures and distributions in nature [ 5 ]. (intechopen.com)
  • Taxol biosynthesis is significantly regulated by jasmonate acid (JA), one of the most important endogenous hormones in land plants. (frontiersin.org)
  • Taken together, these structures provide mechanistic insights into CHMO-catalyzed Baeyer−Villiger oxidation. (acs.org)
  • Crystal structures of tRNASec lacking nucleotides 72-76 of the acceptor stem were determined up to 2.0 Å resolution. (uni-goettingen.de)
  • Studying the Biosynthesis process of complex Natural Compounds. (weizmann.ac.il)
  • Such compounds will be valuable tools for the exploration of GAG and PG biosynthesis and a starting point for development of anti-tumor agents. (lu.se)
  • In this review, we discuss the key differences in the structural features of xylans across diverse plant species, how these features affect their interactions with cellulose and lignin, and recent developments in understanding their biosynthesis. (biomedcentral.com)
  • Xylans are defined as carbohydrate polymers consisting of a β-1,4-xylosyl (Xyl p ) backbone, although xylans containing a β-1,3 and mixed linkage β-1,4-1,3 backbone structure have been found in algal species [ 9 ]. (biomedcentral.com)
  • We have determined the crystal structures of Chlorobium tepidum CbiL and CbiL in complex with S-adenosylhomocysteine (the S-demethyl form of S-adenosylmethionine). (rcsb.org)
  • Molecular dynamism of Fe-S cluster biosynthesis implicated by the structure of SufC(2)-SufD(2) complex. (expasy.org)
  • During anaerobic cobalamin (vitamin B12) biosynthesis, CbiL catalyzes methylation at the C-20 position of a cyclic tetrapyrrole ring using S-adenosylmethionine as a methyl group source. (rcsb.org)
  • CmlA catalyzes β-hydroxylation of l-p-aminophenylalanine during chloramphenicol biosynthesis. (umn.edu)
  • The compound targets the catalytic subunit Spt14 (also referred to as Gpi3) of the fungal UDP-glycosyltransferase, the first step in GPI biosynthesis, with good selectivity over the human functional homolog PIG-A. Jawsamycin displays antifungal activity in vitro against several pathogenic fungi including Mucorales, and in vivo in a mouse model of invasive pulmonary mucormycosis due to Rhyzopus delemar infection. (nature.com)
  • MYC2 is one of the key regulators of JA signal transfer and the biosynthesis of various secondary metabolites. (frontiersin.org)
  • beta-1,4-Gatactosyltransferase 7 (beta 4GalT7) is an essential enzyme in the biosynthesis of glycosaminoglycan (GAG) chains of proteoglycans (PGs). (lu.se)
  • We present here the atomic structures of CHMO from an environmental Rhodococcus strain bound with FAD and NADP + in two distinct states, to resolutions of 2.3 and 2.2 Å. (acs.org)
  • Based on enzymatic studies, that is galactosylation and its inhibition, conformational analysis and molecular modeling using the crystal structure, we propose that the binding pocket of beta 4GalT7 is very narrow, with a precise set of important hydrogen bonds. (lu.se)
  • Besides, a number of side chains are attached to the ring structure, of which an important one is, the side chain of a long hydrocarbon, called phytol ring. (microbenotes.com)
  • The biosynthesis of GAG chains is initiated by xylosylation of a serine residue of the core protein, followed by galactosylation by beta 4GalT7. (lu.se)
  • Erhard Hohenester is a structural biologist investigating the assembly, structure, and function of extracellular matrix. (imperial.ac.uk)
  • Nematodes and many other non-chordate animals seem to have only type VI intermediate filaments , fibers that structure the nucleus . (wikipedia.org)
  • Structure and assembly of desmosome junctions: biosynthesis and turnover of the major desmosome components of Madin-Darby canine kidney cells in low calcium medium. (rupress.org)