The newly broadened Uberon ontology is a unified cross-taxon resource for metazoans (animals) that has been substantially expanded to include a broad diversity of vertebrate anatomical structures, permitting reasoning across anatomical variation in extinct and extant taxa. (biomedcentral.com)
Annotations2
It provides unique identifiers, names and synonyms, list of complex members with their unique identifiers (UniProt, ChEBI, RNAcentral), function, binding and stoichiometry annotations, descriptions of their topology, assembly structure, ligands and associated diseases as well as cross-references to the same complex in other databases (e.g. (stanford.edu)
We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. (biomedcentral.com)
Epigenetic3
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
Specifically, we aim to discover the underlying genetic and epigenetic contributions to developmental, evolutionary, behavioral, and morphological variation. (biomedcentral.com)
Ontologies2
Unfortunately this did not resolve all these issues, as CARO was not designed to provide a large set of terms for specific structures shared across species, but rather to provide an organizational framework for constructing anatomy ontologies. (biomedcentral.com)
Unsupervised clustering of 126,104 distinct HMRs revealed that levels of HMR specificity reflects a developmental hierarchy supported by enrichment of stage-specific transcription factors and gene ontologies. (bvsalud.org)
Stages1
Using a pseudo-time course of development from embryonic stem cells to adult stem and mature hematopoietic cells, we find that most HMRs observed in differentiated cells (~ 60%) are established at early developmental stages and accumulate as development progresses. (bvsalud.org)
Adult1
RESULTS: To understand the significance of non-coding HMRs, we systematically dissected HMR patterns across diverse human cell types and developmental timepoints, including embryonic, fetal, and adult tissues. (bvsalud.org)
Stem2
The control of this transition from epithelial stem cell to differentiated corneocyte, which is abnormal in epidermal cancers, is not well understood. (stanford.edu)
We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
Framework1
GoMiner displays the genes within the framework of the Gene Ontology hierarchy, both as a directed acyclic graph (DAG) and as the equivalent tree structure. (scienceopen.com)
Genes2
developmental language disorders are genetic and is therefore caused (at least in part) by the genes passed on from parents to children. (brookes.ac.uk)
Within each of these categories, we identified clusters of genes associated with particular cellular and developmental functions. (biomedcentral.com)
Anatomy1
We describe the tissue specificity of gene expression at each stage range using selected terms from a controlled vocabulary (CV) for embryo anatomy [ 18 ]. (biomedcentral.com)
Tissue1
Cell and tissue specific gene expression is a defining feature of embryonic development in multi-cellular organisms. (biomedcentral.com)
Early1
the process that governs the early embryonic patterning of the Drosophila body plan is now the best understood example of a complex cascade of transcriptional regulation during development [ 14 , 15 ]. (biomedcentral.com)
Development1
There are several reasons for choosing Drosophila melanogaster as an organism for the global study of gene expression during embryonic development. (biomedcentral.com)
Results1
Primary VUR results from a developmental defect of the ureterovesical junction (UVJ). (nih.gov)
Biological2
Computational toxicology combines data from high-throughput test methods, chemical structure analyses and other biological domains (e.g., genes, proteins, cells, tissues) with the goals of predicting and understanding the underlying mechanistic causes of chemical toxicity and for predicting toxicity of new chemicals and products. (nih.gov)
The target value may be a gene, gene product, anatomic structure, biological process, or other concept, where the effect of the agent on the target is thought to be of therapeutic, diagnostic, or other clinical relevance to a disease process. (nih.gov)
System2
While some medical terminologies are flat lists of terms, also called nomenclatures, others bear some kind of organization (single- inheritance or polyhierarchical structures, multi-axial system) [3]. (nih.gov)
Produced by the Enterprise Vocabulary System (EVS), a project by the NCI Center for Biomedical Informatics and Information Technology. (nih.gov)
Terms1
Medical terminologies provide a controlled set of language labels, or terms, attached to a concept, or meaning, in the biomedical domain. (nih.gov)
Provide1
2. provide an understanding of NLM's controlled vocabulary, MeSH. (nih.gov)
Group4
In one group of participants, TMS was applied to the IFG and MTG, and in a control group, no TMS was applied. (mpi.nl)
Both IFG and MTG stimulation modulated the ambiguity effect for total reading times in the temporarily ambiguous sentence region relative to a control group. (mpi.nl)
The results of the scototaxic trials indicate a significant increase in exploratory behavior in only the allopregnanolone group over the control. (ufl.edu)
Those fish treated with anxiolytics and cortisol presented a similar pattern, but with only allopregnanolone+cortisol demonstrating hippocampal-dependent avoidance behavior on par with the control group by the end of the experiment. (ufl.edu)