Current scientific trials are looking into cyclin-dependent kinase (CDK) inhibitors, such as for example roscovitine, an inhibitor of CDK1, -2, -5, -7, and -9, that lowers viral DNA synthesis, creation of late protein and infectious pathogen particles [4]. (niepokorny.org)
Molecule2
Chances are that a change to its molecular structure would disrupt its interaction with some enzyme molecule or other that is essential to the survival of the cell. (heresy.is)
Ganetespib, a highly potent, small-molecule Heatshock protein 90 inhibitor, has potential efficacy in malignant pleural mesothelioma (MPM) via activity on critical survival pathways and known synergies with antifolates and platinum chemotherapy. (aacrjournals.org)
Putative1
ADOS Proteins kinases are putative goals of brand-new herpesviral drugs because of their important function in the legislation of HCMV replication [3,4,5,6,7,8]. (niepokorny.org)
Cellulose1
western transfer and immunoenzymatic staining with affinity-purified monospecific antiserum was used to detect a 38-kd protein that bound to native and denatured dna cellulose. (liverpool.ac.uk)
Kinases2
CDKs are cyclin-dependent serine-/threonine-specific proteins kinases, the experience of which depends upon cyclin binding. (niepokorny.org)
Its kinase area contains subdomains (SD) I-XI, that are conserved (aa 337C651) within herpesviral and mobile proteins kinases. (niepokorny.org)
Intracellular1
These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. (chemscene.com)
Autophagy1
The localization of autophagy proteins in the asthmatic airways is fixed to structural cells in the airway wall structure and is connected with top features of airway redecorating within a TGF-Cdependent way. (roma2024.com)
Nucleotide1
During nucleotide excision repair, several protein complexes cooperate to recognize damaged DNA and locally separate the DNA helix for a short distance on either side of the site of a DNA damage. (wikipedia.org)
Sequence3
Most of the ERCC1 protein is related at the sequence level to the C-terminus of the XPF protein, but residues in the nuclease domain are not present. (wikipedia.org)
By primary sequence and protein structural similarity, the ERCC1-XPF nuclease is a member of a broader family of structure specific DNA nucleases comprising two subunits. (wikipedia.org)
Developing computational methods to relate receptors by the similarity of their ligands, rather than by protein sequence or structure. (ucsf.edu)
Other proteins may have a lower specific activity when used in the opposite species. (medchemexpress.cn)
Molecular3
The human ERCC1 gene encodes the ERCC1 protein of 297 amino acids with a molecular mass of about 32,500 daltons. (wikipedia.org)
These medicines have been looked at in terms of their detailed chemical structures, their proteomic properties, the molecular biological pathways through which they work, their gene activation and epigenetic properties, their pharmacological properties, etc, This work has generally been of high quality and has resulted in thousands or tens of thousands of research reports, many of them published in highly respected Western journals. (anti-agingfirewalls.com)
Metabolic fitness relies on the functionality of heat shock proteins (HSPs), molecular chaperones that facilitate the correct folding of metabolism enzymes and their assembly in macromolecular structures. (biomedcentral.com)
Viral2
herpes simplex virus glycoproteins gc-1 and gc-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity. (liverpool.ac.uk)
Furthermore to people indirect results on cell routine legislation, the viral proteins kinase pUL97 straight cross-talks with CDKs since it mimics CDKs in phosphorylating partly-identical substrates and evidently possesses commonalities in protein framework and functionality. (niepokorny.org)
Residues1
The forming of pUL97 oligomers and ADOS dimers is dependant on a self-interaction domain, located within proteins 231-280, that facilitates solid autophosphorylation taking place at N-terminal residues [35 generally,36,37]. (niepokorny.org)
Gene5
DNA excision repair protein ERCC-1 is a protein that in humans is encoded by the ERCC1 gene. (wikipedia.org)
Following this, the differentially expressed genes (DEGs) were included in Gene Ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, protein‑protein interaction network and survival analyses. (cancerindex.org)
We show heat shock protein family D member 1 (HSPD1 or HSP60) as a survival gene ubiquitously expressed in NSCLC and associated with poor patients' prognosis. (biomedcentral.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Compounds1
Bioactive Compound Library Plus, with more powerful screening capability, further complements Bioactive Compound Library (HY-L001) by adding some compounds with low solubility or solution stability (Part B) and some novel, rare or exclusive compounds (Part C) to this library. (chemscene.com)
Pathway1
it was reported that glycoprotein c of hsv-1 (gc-1) mediates the binding of c3b-coated erythrocytes to infected cells and has regulatory (decay-accelerating) activity for the alternative pathway c3 convertase of human complement. (liverpool.ac.uk)
Cells5
Since cells alter their metabolic rewiring during tumorigenesis and along cancer progression, targeting key metabolic players and metabolism-associated proteins represents a valuable approach with a high therapeutic potential. (biomedcentral.com)
Applying these to G-Protein Coupled Receptors (GPCRs), which are the single largest family of signaling receptors in human cells. (ucsf.edu)
PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. (medchemexpress.com)
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase ( eNOS ) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. (medchemexpress.com)
Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. (medchemexpress.cn)
Structural1
Ribosomal proteins (green) serve in structural and auxiliary roles. (heresy.is)
Amino1
Importantly, the amino acid diversity of EMAs is distributed throughout the length of the proteins. (biomedcentral.com)
Therapeutic1
A longstanding effort to do so is by exploiting protein structures to predict new reagents and therapeutic leads (structure-based ligand discovery). (ucsf.edu)
Nuclear3
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. (le.ac.uk)
On the contrary, the activities or levels of immunoglobulin A, complement 3, total antioxidant capacity, glutathione peroxidase (GSH-Px), superoxide dismutase, interleukin-10, and the abundance of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) mRNA were significantly decreased (p (bvsalud.org)
the hnrnp core protein antigens remain associated with the host chromatin, which appears to collapse into internal aggregates and along the nuclear envelope. (liverpool.ac.uk)
Functionality1
Many key cellular metabolic processes are dependent on the functionality of heat shock proteins (HSPs) [ 14 ]. (biomedcentral.com)
Methods2
Tests the new methods in well-controlled systems, determining x-ray crystal structures and measuring binding thermodynamics. (ucsf.edu)
Mouse BAL Defense Cell Lung and Staining.the data complement for whole methods. (roma2024.com)
Human1
One of the unexpected findings of the Human Genome Project was that over 98% of the human genome does not encode for proteins. (pharmaceuticalintelligence.com)
Receptor1
The differences in the characteristics between the murine model and humans are the host receptor and the absence of knob-like structures of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) (Table 2 ) [ 11 ]. (biomedcentral.com)
Complex3
The ERCC1-XPF complex is a structure-specific endonuclease. (wikipedia.org)
Using Argonaute CLIP-seq data, Dr. Rigoutsos and colleagues showed that similar percentages of the two sets of microRNAs were in complex with Argonaute proteins. (pharmaceuticalintelligence.com)
In this study, we confirmed that both GrmH and GrmL, which were shown to constitute a protein complex by a co-purification experiment, were required to catalyze the dehydration, epimerization, and proteolytic cleavage of a precursor peptide GrmA by in vivo experiments. (hokudai.ac.jp)
Enzyme1
If we make some random change to the structure of the enzyme, there is a reasonable chance that the interactions with all of these ligands will remain intact. (heresy.is)
Domain1
A DNA binding "helix-hairpin-helix" domain at the C-terminus of each protein. (wikipedia.org)
Specific2
dna binding of a 38,000-dalton herpes-simplex-virus-2-specific protein. (liverpool.ac.uk)
this protein has previously been shown to be a delayed early herpes simplex virus type-2 specific protein. (liverpool.ac.uk)
Serve1
Or to be more precise, at least some portions of non-protein-coding DNA are thought to serve important biological functions. (pharmaceuticalintelligence.com)
Expression2
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
Case1
In case of proteins for which it is possible to identify the secondary structure, symbols are given in the Stride classification (e.g. (edu.pl)
Levels1
Interestingly, RSV infection decreased the protein levels of caspase-1, cleaved caspase-1, cleaved IL-1β, N terminal of GSDMD and Bcl-2, while andrographolide elevated them. (researchsquare.com)
Correct1
However, if the above scenario for the evolutionary replacement of RNA enzymes by protein enzymes is correct, why did a similar replacement not occur with cosubstrates? (heresy.is)