Indole derivatives have been mostly reported to demonstrate significant activities such as analgesics, anti-inflammatory agents, antifungals, antiarrhythmic agents, and inhibitors of nitric oxide synthase. (civilica.com)
Various 2-phenyl-1H-indoles and benzimidazole derivatives have been tested for total antioxidant capacity by phosphomolybednum reduction method and 2,2-diphenyl-1-picrylhydrazide free radical scavenging activity. (ijpsonline.com)
The present study was focused on evaluating substituted indole and benzimidazole derivatives ( Table 1 ) for total antioxidant capacity (TAC), free radical scavenging and antimicrobial activity. (ijpsonline.com)
We describe the syntheses and crystal structures of two indole derivatives, namely a second monoclnic polymorph of ethyl 5-chloro-1H-indole-2-carboxylate (I) and ethyl 5-chloro-3-iodo-1H-indole-2-carboxylate (II). (elsevierpure.com)
Various oxepine and azepine fused N-heterocyclic derivatives were synthesized using a new and one-pot reaction of 2,3-dichloro quinoxaline/pyrazine with 2-(1 H -indol-2-yl)phenol/aniline in the presence of 25 mol% FeCl 3 . (rsc.org)
Synthesis of carbazol-4-ones, 3,4-dihydrocyclopental-indol-1-one, and indole derivatives by a Fe/AcOH-mediated intramolecular reductive N-heteroannulation of 3-hydroxy-2-(2-nitrophenyl)enones is demonstrated. (ntnu.edu.tw)
In the current study, twenty-five indole-carbohydrazide derivatives linked to different aryl substitutions were rationally designed and synthesized. (researchgate.net)
The structures of all derivatives were confirmed using different spectroscopic techniques including ¹H-NMR, ¹³C-NMR, Mass spectrometry, and elemental analysis. (researchgate.net)
Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. (bvsalud.org)
Compounds9
Its utility lies in the capability of heterocyclic compounds to mimic the structure of peptides and to bind reversibly to proteins [ 1 - 4 ]. (ijpsonline.com)
It is reported that the compounds bearing O-H bonds behave as antioxidants but along with them, amines having N-H bond functions as the antioxidant, which have attracted much research attention because cyclic amines have always been the central structure in many currently used drugs [ 11 ]. (ijpsonline.com)
Indoles also present in naturally occurring compounds like dimethyltryptamine (hallucinogen), tryptophan (amino acid) and melatonin [ 16 ] (antioxidant as free radical scavenger). (ijpsonline.com)
In their crystal structures, both compounds form inversion dimers linked by pairs of N-H···O hydrogen bonds, which generate R2 2(10) loops. (elsevierpure.com)
While the structure of schiskiniin (1) was established unequivocally by UV, HRFABMS and a series of ID and 2D NMR analyses, all known compounds were readily identified by comparison of their spectroscopic data with literature data. (comu.edu.tr)
These naturally occurring compounds are known for their diverse chemical structures and profound biological activities. (selfgrowth.com)
The structures of all compounds were confirmed by FT‐IR, 1H‐NMR, 13C‐NMR, and CHNOS techniques. (researchgate.net)
In this article, we will delve into the intriguing world of alkaloids, exploring their sources, structures, and attractive medicinal value. (selfgrowth.com)
Alkaloids can be classified into several subclasses based on their chemical structures and origin. (selfgrowth.com)
Note the presence of an indole moiety in the structure of the iboga alkaloids and 5-HT. (erowid.org)
Reversed-phase HPLC analysis of the methanol extract of the seeds of Centaurea schischkinii afforded a novel indole alkaloid, named schischkiniin (1), together with four lignans, arctiin (2), matairesinoside (3), matairesinol (4), and arctigenin (5), and three flavonoids, astragalin (6), afzelin (7) and apigenin (8). (comu.edu.tr)
Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the West African shrub, Tabernanthe iboga. (erowid.org)
One example of a plant-derived compound with potential utility in treating drug addiction is the indole alkaloid, ibogaine (2,3). (erowid.org)
Tryptophan2
Tryptophan synthase (indole-salvaging) (EC 4.2.1.122, tryptophan synthase beta2) is an enzyme with systematic name L-serine hydro-lyase (adding indole, L-tryptophan-forming). (wikipedia.org)
This enzyme catalyses the following chemical reaction L-serine + indole ⇌ {\displaystyle \rightleftharpoons } L-tryptophan + H2O This enzyme salvages the lost indole to L-tryptophan. (wikipedia.org)
Phosphate synthase1
2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability. (expasy.org)
Synthesis9
The work disclosed in this dissertation outlines novel reactions involving indoles and their applications towards the total synthesis of natural products, tronocarpine and dippinine B. (uwo.ca)
The research in this thesis outlines two new methods for the synthesis of further functionalized indole products. (uwo.ca)
High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. (elifesciences.org)
Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA synthesis pathway. (elifesciences.org)
Yet, to fully understand the mechanisms of DNA synthesis all intermediate structures need to be identified. (elifesciences.org)
Together, these structures provide new insight into the mechanism of DNA synthesis and highlight the dynamic nature of the finger subdomain in the enzyme active site. (elifesciences.org)
This structure was confirmed by total synthesis. (erowid.org)
It can be synthesized through a Fischer indole synthesis which was developed by Emil Fischer. (foodcomex.org)
It can be synthesized through a Fischer indole synthesis which was developed by Emil Fischer.In a 1994 report released by five top cigarette companies, skatole was listed as one of the 599 additives to cigarettes. (foodcomex.org)
Psychoactive1
Many psychoactive plants owe their activity to structures containing an indole nucleus. (erowid.org)
Substituents2
The products generated in this novel methodology create molecular scaffolding that maps nicely onto natural products tronocarpine and dippinine B. The methodology accesses a variety of 1,2-substituted indoles that tolerated all substituents tested. (uwo.ca)
Having indole, methylphenyl, or dichloro-phenyl substituents led to better potency. (nih.gov)
Molecule1
Important as a component of many pharmaceuticals, indole is a biological molecule found throughout the natural world. (uwo.ca)
Pharmacology1
There is no perfect method to categorize hallucinogenic substances because many overlap in structure, pharmacology, and clinical features. (medscape.com)
Hydrogen2
The hydrogen bond increases the cyclopropane's electrophilicity permitting indole nucleophiles to open the ring. (uwo.ca)
Hydrogen bond activation of donor-acceptor cyclopropanes was successful in generating a multitude of functional indole products in high yields. (uwo.ca)
Hallucinogens1
Hallucinogens can be classified and grouped by chemical structure and the compound from which they are derived. (medscape.com)
Ibogaine1
Figure 1 shows the chemical structures of ibogaine, noribogaine, and the neurotransmitter serotonin (5- hydroxytryptamine, 5-HT). (erowid.org)
Mechanism2
High-resolution structures, biophysical and in silico studies have led to tremendous progress in understanding the mechanism of drug transport by these ABC transporters, and several promising therapies, including irradiation-based immune and thermal therapies, and nanomedicine have been used to overcome ABC transporter-mediated cancer chemoresistance. (nature.com)
We suggest that current information regarding the structure, mechanism and regulation of ABC transporters should be used in clinical trials to improve the efficiency of chemotherapeutics for patients with cancer. (nature.com)
Nitrogen1
Indoles and benzimidazoles are very popular nitrogen containing heterocycles. (ijpsonline.com)
Enzyme3
We suggest that these new structures, along with previously solved structures, highlight the dynamic nature of the finger subdomain in the enzyme active site. (elifesciences.org)
Scientist often use a technique called X-ray crystallography to study intermediate structures of frozen polymerase crystals as the enzyme constructs DNA. (elifesciences.org)
This modified method captured different steps in the process and detailed how the enzyme adjusts its structure as it moves along the template strand. (elifesciences.org)
Ligand1
Structure-based drug design coupled with ring opening strategy of the steroids skeleton revealed the potential of indole-based analogs to be synthesized targeting the ligand binding domain of estrogen receptor-α. (elsevierpure.com)
Functional1
Herein we describe the structure-activity relationships elucidated through biochemical and functional assays. (nih.gov)
Organic1
Skatole or 3-methylindole is a mildly toxic white crystalline organic compound belonging to the indole family. (foodcomex.org)
Describe1
Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)
Found1
Psilocybin is the first natural indole derivative found to contain phosphorus. (erowid.org)
Protein2
Protein hydration--the perturbation of water structure and dynamics by the protein surface--has been a particularly rich source of controversy and confusion. (lu.se)
and (ii) the perturbation progress within the field of protein hydration has been of the structure and dynamics of bulk water caused by the interaction with the solute. (lu.se)
Aromatic1
π-Conjugated oligomers consisting of alternating C≡C bonds and aromatic nuclei, commonly, have a rigid, rod-like structure and exhibit high charge carriers' mobility [6] . (beilstein-journals.org)
Molecular1
In this paper, harmonic vibrational frequencies, molecular structure, NBO and HOMO, LUMO analysis and detonation properties of (E)-2-Bromo-1-[2-(2-nitrostyryl)-1-phenylsulfonyl-1H-indol-3-yl] ethanone is calculated. (civilica.com)
Relationship2
The biological significance of benzimidazoles is due to its close relationship to the structure of purines. (ijpsonline.com)
Here, we further characterized the lead RhoA inhibitor, Rhosin/G04, in platelet function and present structure-activity relationship (SAR) analysis. (nih.gov)
Form1
DNA molecules consist of two separate strands that spiral around each other to form a structure called the double helix. (elifesciences.org)
Include1
Indoles of commercial importance include drugs such as indomethacin (antiinflammatory, an antipyretic and an analgesic) and indoxole (an antiinflammatory and antipyretic drug). (ijpsonline.com)
Frequencies1
IR frequencies derived from the computation which produced the structure are shown in the plot below. (nist.gov)
METHOD2
Method one involves radicals to cyclize an additional ring to an indole precursor. (uwo.ca)
Method two functionalizes indoles by reacting them with strained three-membered ring molecules called cyclopropanes. (uwo.ca)
Activity1
Indoles exhibited better antibacterial activity compared to benzimidazoles. (ijpsonline.com)
Evaluation1
NCHS and contract consultants use a structured competency assessment evaluation during visits to evaluate both the quality of the laboratory work and the quality-control procedures. (cdc.gov)