Structure for folding. Medical search. Frequent questions

Here, we report the crystal structures of the effector domains from two oomycete RXLR proteins, Phytophthora capsici AVR3a11 and Phytophthora infestans PexRD2. (jic.ac.uk)
The Rossmann fold is a tertiary fold found in proteins that bind nucleotides, such as enzyme cofactors FAD, NAD+, and NADP+. (wikipedia.org)
Rossmann and Rossmannoid fold proteins are extremely common. (wikipedia.org)
They make up 20% of proteins with known structures in the Protein Data Bank, and are found in more than 38% of KEGG metabolic pathways. (wikipedia.org)
N-linked glycosylation is the most prevalent posttranslational modification of plasma membrane and secretory proteins and participates in many important biological roles such as protein folding, intracellular targeting, immune response, cell adhesion, and protease resistance. (jneurosci.org)
Although the structures of rotavirus and other members of the Reoviridae have been extensively studied, little is known about the structures of virus-encoded non-structural proteins that are essential for genome replication and packaging. (nih.gov)
In this work we have studied the folding pathways for four pairs of homologous proteins from thermophilic and mesophilic organisms from two different structural classes (class a, all-alpha proteins and class d, alpha + beta proteins) using Monte Carlo simulations. (nih.gov)
It turns out that the period of successful crossing of the free-energy barrier between unfolded and folded states for 40-45 trajectories (80-90%) makes 10% of the total folding time for four proteins (1tzvA, 1eyvA, 351c, and 1t4aA) and only 0.1% for two proteins (1dd3, 1ctf). (nih.gov)
We have observed that folding pathways of thermophilic and mesophilic proteins may be the same, partly the same, and different. (nih.gov)
And similarity or difference between the folding pathways of thermophilic and mesophilic proteins does not depend on the structural class to which these proteins belong. (nih.gov)
Folding pathways for proteins from both classes correlate with the calculated folding nuclei for these proteins. (nih.gov)
We were unable to identify any other proteins that are closely related in structure to the PilP domain, although the fold appears to be distantly related to the lipocalin family. (kent.ac.uk)
UK-based AI company DeepMind first announced it had developed a method to accurately predict the structure of folded proteins in late 2020, and by the middle of it 2021 it had revealed that it had mapped 98.5 per cent of the proteins used within the human body . (newscientist.com)
Today, the company announced that it is publishing the structures of more than 200 million proteins - nearly all of those catalogued on the globally recognised repository of protein research, UniProt . (newscientist.com)
Most proteins must fold into defined three-dimensional structures to gain functional activity. (nature.com)
But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. (nature.com)
Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
A very small number of natural proteins have folded configurations in which the polypeptide backbone is knotted. (cornell.edu)
Relatively little is known about the folding energy landscapes of such proteins, or how they have evolved. (cornell.edu)
An ultrarapid-mixing continuous-flow method has been developed to study submillisecond folding of chemically denatured proteins. (jascoinc.com)
To seek the most effective definition of residue contacts for template-based protein structure prediction, we evaluated 45 different contact definitions, varying bases of contacts and distance cutoffs, in terms of their ability to identify proteins of the same fold. (biomedcentral.com)
In the case of threading, alignment accuracy strongly influences the fraction of common contacts identified among proteins of the same fold, which eventually affects the fold recognition accuracy. (biomedcentral.com)
The largest deterioration of the fold recognition was observed for β-class proteins when the threading methods were used because the average alignment accuracy was worst for this fold class. (biomedcentral.com)
When results of fold recognition were examined for individual proteins, we found that the effective contact definition depends on the fold of the proteins. (biomedcentral.com)
Residue contacts defined by Cβ−Cβ distance of 7.0 Å work best overall among tested to identify proteins of the same fold. (biomedcentral.com)
The tertiary structure of proteins provides crucial information for understanding molecular mechanisms of biological functions. (biomedcentral.com)
Furthermore, occurrence of this wheat germ agglutinin-neurotoxin domain fold is predicted not only in the snake venom cardiotoxins and cytotoxins with neurotoxin-matched half-cystine sequence positions, but also for two small plant proteins, hevein and ragweed pollen allergen Ra5, on the basis of a nearly exact match of their half-cystine, sequence positions with those of the wheat germ agglutinin domain. (duke.edu)
How proteins fold is a central mystery of the life process that for decades has eluded explanation. (the-scientist.com)
Such knowledge could guide structure-based design of drugs to treat a range of diseases now thought to be caused by misshapen proteins. (the-scientist.com)
This was the first meeting to gather such a critical mass of scientists with shared interests into how membrane proteins attain their native fold. (biophysics.org)
From there, topics covered recent progress on which biophysical forces contribute to stabilizing the native membrane protein fold and how lipid membranes, detergents or surfactants influence the conformational space these important proteins sample. (biophysics.org)
Finally, it was shown how these new insights are exploited for structure prediction and novel design of membrane proteins. (biophysics.org)
Proteins must be folded correctly to fulfill their molecular functions in cells. (mpg.de)
Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. (mpg.de)
Nascent proteins are protected from intermolecular interactions that would hamper their folding by chaperones, molecular folding assistants. (mpg.de)
Therefore, even though proteins can also fold in their absence, chaperones contribute to cellular health by improving the folding efficiency. (mpg.de)
Unlike all previously studied proteins, actin cannot acquire its fold in absence of the chaperonin TRiC. (mpg.de)
Typically, proteins spontaneously find their fold - chaperones just assist them by making the process more effective and keeping the protein away from interactions that would hamper folding. (mpg.de)
In comparison with similar proteins that build the cytoskeleton of bacteria, which are evolutionary older and simpler cells, the researchers found fundamental differences in the protein folding. (mpg.de)
Actin has many more protein interaction partners than the bacterial cytoskeletal proteins, but it has lost the ability to fold independently. (mpg.de)
Bacterial cytoskeletal proteins also require the help of chaperones to effectively reach a folded state. (mpg.de)
The finding of this extreme chaperone-dependency breaks with the dogma that all proteins have an inbuilt potential for folding in their amino acid sequence. (mpg.de)
Simplified lattice-based models provide a means for exploring the basics of the sequence-structure relationship of proteins. (lu.se)
Exploration of AlphaFoldDB, AlphaFold2 prediction of structures of single proteins and small complexes, FoldSeek for finding similar folds in other proteins, structure visualization with PyMol and Mol* Viewer, evaluation of structure reliability. (lu.se)

Say goodbye to traditional fixed shelves and embrace the convenience and adaptability of these incredible folding shelf brackets for 2023. (citizenside.com)

A common problem for researchers working with RNA is to determine the three-dimensional structure of the molecule given only a nucleic acid sequence. (wikipedia.org)
However, in the case of RNA much of the final structure is determined by the secondary structure or intra-molecular base pairing interactions of the molecule. (wikipedia.org)
In globular glial tauopathy and PSP, each tau molecule folds into three layers. (alzforum.org)
Next, they zeroed in on tau filaments from people with chronic traumatic encephalopathy, uncovering a C-shaped fold similar to that of AD, but with a mysterious molecule nestled within ( Mar 2019 news ). (alzforum.org)

Most recently, they reported yet another flavor of fold-a quadruple-layered contortion found in three people with corticobasal degeneration ( Feb 2020 news ). (alzforum.org)

The overall tertiary structure of the fold resembles a three-layered sandwich wherein the filling is composed of an extended beta sheet and the two slices of bread are formed by the connecting parallel alpha-helices. (wikipedia.org)
Tertiary structure can be predicted from the sequence, or by comparative modeling (when the structure of a homologous sequence is known). (wikipedia.org)
The protein folds to its native, knotted configuration approximately 20 times more slowly than a control protein, which was designed to have a similar tertiary structure but to be unknotted. (cornell.edu)
A proper encoding of residue contact information is crucial for structure prediction because in principle, a full distance map or a residue contact map has sufficient information for reconstructing the tertiary structure of a protein[ 25 ]. (biomedcentral.com)

We hypothesize that the molecular stability provided by this core fold, combined with considerable potential for plasticity, underlies the evolution of effectors that maintain their virulence activities while evading recognition by the plant immune system. (jic.ac.uk)
Both studies suggest that defects in rhodopsin glycosylation are associated with impairment of protein folding or stability. (jneurosci.org)
We combined two types of permanently deforming kirigami elements, working on the basis of either multi-stability or plastic deformation, with an elastic layer to create self-folding basic elements. (materialstoday.com)
Summing the free energy for such interactions should provide an approximation for the stability of a given structure. (wikipedia.org)
Plus, the specially designed X-shaped structure ensures higher stability. (bedbathandbeyond.com)
The unique design allows for easy folding and locking, ensuring stability and safety. (citizenside.com)

A combination of molecular simulation with hydrogendeuterium-exchange mass spectrometry and electron paramagnetic resonance spectroscopy reveal an asymmetry across the membrane: ATP-induced conformational changes in the cytosolic cavity promote unfolded pre-protein structure, while the exterior cavity favours its formation. (elifesciences.org)
To avoid these dangers, cells invest in a complex network of molecular chaperones, which use ingenious mechanisms to prevent aggregation and promote efficient folding. (nature.com)
Hartl, F. U. Molecular chaperones in cellular protein folding. (nature.com)
Led by Michel Goedert and Sjors Scheres of the MRC Laboratory of Molecular Biology, Cambridge, England, U.K., the study describes an array of high-resolution structures of tau protofibrils plucked from postmortem brain samples. (alzforum.org)
Biological systems require precise folding, recognition, and self-assembly behaviors to form complex nanostructures and molecular machines. (confex.com)
Knowledge of the three-dimensional structures of the carbo-hydrate molecules is indispensable for a full understanding of the molecular processes in which carbohydrates are involved, such as protein glycosylation or protein-carbohydrate interactions. (iucr.org)
But actin is different because it absolutely requires the molecular folding help of TRiC. (mpg.de)

Together, the human disease and animal models suggest that glycosylation plays a crucial role in the structure and/or function of rhodopsin. (jneurosci.org)

Bartlett, A. I. & Radford, S. E. An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms. (nature.com)
Skach, W. R. Cellular mechanisms of membrane protein folding. (nature.com)
Effective closure mechanisms ensure that folding cartons remain securely closed during transportation and storage. (metrostarpackaging.com)
The foldable pocket umbrella was invented in 1928 and the folding mechanisms used in most modern umbrellas was introduced in 1969. (cdc.gov)
Naganathan A, Muñoz V, Insights into protein folding mechanisms from large scale analysis of mutational effects, Proc Natl Acad Sci U S A;107(19):8611-6. (lu.se)

Here, we propose a mechanical self-folding technique that only requires global stretching for activation, is applicable to a wide range of materials, allows for sequential self-folding of multi-storey constructs, and can be downscaled to microscale dimensions. (materialstoday.com)
The folding angles of these elements could be controlled using the kirigami cut patterns as well as the dimensions of the elastic layer and be accurately predicted using our computational models. (materialstoday.com)

Syroegin, E. A. , Aleksandrova, E. V. , and Polikanov, Y. S. (2022) Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes . (cornell.edu)

LU-Fold is a Lund University-based facility for helping researchers predict protein structures of interest using the cutting-edge method AlphaFold2 ( Nature Methods method of the year, 2021). (lu.se)

As pretty as a picture, the Fold Pendant Lamp uses origami and repetitive geometry to charm, and to hypnotize. (yankodesign.com)

We conclude that the core α-helical fold enables functional adaptation of these fast evolving effectors through (i) insertion/deletions in loop regions between α-helices, (ii) extensions to the N and C termini, (iii) amino acid replacements in surface residues, (iv) tandem domain duplications, and (v) oligomerization. (jic.ac.uk)
We present here the X-ray structure of the functional octamer of NSP2 determined to a resolution of 2.6 A. The NSP2 monomer has two distinct domains. (nih.gov)
Several self-folding techniques have therefore been developed during the last few years to fabricate such multi-functional devices. (materialstoday.com)
many molecules have several possible three-dimensional structures, so predicting these structures remains out of reach unless obvious sequence and functional similarity to a known class of nucleic acid molecules, such as transfer RNA (tRNA) or microRNA (miRNA), is observed. (wikipedia.org)
In addition, patients with vocal fold cysts often have compounding functional issues that need to be addressed, both preoperatively and postoperatively, with expert speech-language intervention. (medscape.com)

The ability to unfold and refold the structures could be useful in biomedical applications. (sciencedaily.com)

Protein synthesis, folding, and tertiary and quaternary structure ultimately determine much of the body's structure and function. (msdmanuals.com)

This article is about the computational prediction of nucleic acid structure. (wikipedia.org)
For experimental methods, see Nucleic acid structure determination . (wikipedia.org)
Nucleic acid structure prediction is a computational method to determine secondary and tertiary nucleic acid structure from its sequence. (wikipedia.org)
Secondary structure can be predicted from one or several nucleic acid sequences. (wikipedia.org)

The vast majority of such approaches are, however, limited to simple folding sequences, specific materials, or large length scales, rendering them inapplicable to microscale (meta)materials and devices with complex geometries, which are often made from materials other than the ones for which these approaches are developed. (materialstoday.com)
Although protein structures have been solved by experiments at an increasing rate, a flood of new sequences have been determined even more rapidly due to the advance of sequencing technologies[ 6 , 7 ]. (biomedcentral.com)

LU-Fold specialises in high-throughput prediction of protein complexes to predict novel protein-protein interactions. (lu.se)

The "Membrane Protein Folding" meeting, organized jointly by the Biophysical Society and the Korean Institute for Advanced Studies, held in Seoul mid-May, provided a vibrant stage for membrane protein folding scientists to exchange ideas and hold stimulating discussions. (biophysics.org)
Ten sessions distributed over four days covered the current state-of-the-art on the fundamentals of membrane protein folding to disease related misfolding. (biophysics.org)
The opening session on "Membrane Protein Folding in the Cell" immediately hit all the right notes, building bridges between biologists and biophysicists. (biophysics.org)

20% sequence identity in their effector domains, they display a conserved core α-helical fold. (jic.ac.uk)
Together, these results indicate that the structure of the rhodopsin N terminus must be maintained by an appropriate amino acid sequence surrounding N2 and may require a carbohydrate moiety at N15. (jneurosci.org)
[6] For longer molecules, the number of possible secondary structures is huge: a sequence of 100 nucleotides has more than 10 25 possible secondary structures. (wikipedia.org)
Finally, the signal sequence is cleaved and the pre-protein is either folded or trafficked onwards. (elifesciences.org)
The findings illustrate a situation where a protein is able to successfully traverse a complex folding energy landscape, though the amino acid sequence of the protein has not been subjected to evolutionary pressure for that ability. (cornell.edu)
So far, it has been believed that the general information on this fold is encoded in the primary protein structure - the sequence of amino acids. (mpg.de)

The amino-terminal domain has a new fold. (nih.gov)
The actin amino acid chain (center) gets folded into the mature 3D-structure inside the cavity of the chaperonin TRiC. (mpg.de)

The scientists also reported structures of two mixed tauopathies-familial British dementia (FBD) and familial Danish dementia (FDD). (alzforum.org)
Using only a drop of water, the scientists have folded flat sheets of silicon nitride into cubes, pyramids, half soccer-ball-shaped bowls and long triangular structures that resemble Toblerone chocolate bars - an omnium-gatherum of geometric objects, which are almost too tiny to see with the naked eye. (sciencedaily.com)
This article gives an overview of the information that can be obtained from individual PDB entries and from statistical analyses of sets of three-dimensional structures, of typical problems that arise during the analysis of carbohydrate three-dimensional structures and of the validation tools that are currently available to scientists to evaluate the quality of these structures. (iucr.org)

Figure 3: Folding in the GroEL-GroES chaperonin cage. (nature.com)
The co-evolution of TRiC and actin has allowed actin to "out-source" the responsibility for protein folding to the chaperonin. (mpg.de)

In all cases, our computational models could capture the self-folding behavior of the assemblies and the strains in the connectors of the flexible electronic devices, thereby guiding the rational design of our specimens. (materialstoday.com)
The success of the design strategy--connecting two monomers of an intertwined homodimer into a single protein chain--supports a model for evolution of knotted structures via gene duplication. (cornell.edu)
Th e structure and design of folding cartons play a vital role in attracting consumers, protecting products, and conveying brand messaging. (metrostarpackaging.com)
The structure and design of folding cartons not only provide physical protection but also create an engaging and memorable unboxing experience. (metrostarpackaging.com)
The design of folding cartons provides an excellent opportunity for branding and conveying product information. (metrostarpackaging.com)
Design the carton structure for easy and efficient assembly, reducing production time and costs. (metrostarpackaging.com)
Incorporating sustainable practices in the structure and design of folding cartons is essential for environmental responsibility. (metrostarpackaging.com)
Effortless Folding Design: After you've finished relaxing, you can instantly fold the bench into a compact size measuring just 41.5" x 40" x 8.5" (L x W x Thickness). (bedbathandbeyond.com)
This is not the first time the researchers demonstrated the ability to fold silicon with water droplets, but it is the first time they devised a precise way to control the size of the droplets by pumping water through a channel located beneath the flat design. (sciencedaily.com)
With their innovative design, they allow you to effortlessly fold and unfold shelves whenever required, providing ultimate flexibility. (citizenside.com)
With their easy installation and folding design, they provide convenience and versatility. (citizenside.com)
Foldable rollover protective structures: universal lift-assist design. (cdc.gov)
The design considered can be retrofitted and will not modify or compromise the FROPS structure. (cdc.gov)

Functionally important and polymorphic residues map to the surface of the structures, and PexRD2, but not AVR3a11, oligomerizes in planta. (jic.ac.uk)
Here we describe the expression of a recombinant fragment of PilP, spanning residues 20 to 181, and determination of the solution structure of a folded domain, spanning residues 85 to 163, by NMR. (kent.ac.uk)
Over 40 homologues of PilP have been identified in Gram-negative bacteria and the majority of conserved residues lie within the folded domain. (kent.ac.uk)

The numbers of agricultur al tractor rollover fatalities occurring with foldable rollover protective structures (FROPS) in their lowered position are significant. (cdc.gov)

The domain adopts a simple beta-sandwich type fold, consisting of a three-stranded beta-sheet packed against a four-stranded beta-sheet. (kent.ac.uk)
The authors solved the cryo-EM structure of Myomaker, essential for myoblast fusion, and showed that it adopts a GPCR-like fold. (nature.com)

Tau folds tracked remarkably well with the neuropathological characteristics of each disease. (alzforum.org)
The three-dimensional structures of the snake venom postsynaptic neurotoxins and of the domains in wheat germ agglutinin show a remarkably similar overall folding pattern, consisting of equivalently placed, but variably sized loops which are held together by four similarly positioned disulfide bonds. (duke.edu)

Machines cut each section of the canopy that can neatly fold and unfold when stitched together and attached to the ribs. (cdc.gov)

We then assembled these basic elements in a modular manner to create multiple complex 3D structures ( e.g. , multi-storey origami lattices) in different sizes including some with microscale feature sizes. (materialstoday.com)

Three-dimensional folding dynamics of the Xenopus tropicalis genome. (bvsalud.org)

To predict the folding free energy of a given secondary structure, an empirical nearest-neighbor model is used. (wikipedia.org)

These subunits form a cavity inside which actin gets folded. (mpg.de)

The utility model relates to an it has storage brick system of folding brick device to fold brick device and use, it is including folding the brick device, storing up brick device, first conveyer belt mechanism, wherein fold the brick device include again the left side send brick mechanism, right side to send brick mechanism, meet brick mechanism, if dry -press brick wheel etc. (google.com)
The utility model relates to ceramic tile manufacturing machine field, particularly a kind of folded brick device and storage brick device. (google.com)

Effective encoding of residue contact information is crucial for protein structure prediction since it has a unique role to capture long-range residue interactions compared to other commonly used scoring terms. (biomedcentral.com)

Keith Willison at Imperial College London says that AlphaFold has unarguably "changed the world" of biological research, but that there are still problems to be solved in protein folding. (newscientist.com)

DURABLE STRUCTURE & EFFICIENCY】- Constructed of plastic and metal body, this electric drywall sander is durable for long-term use. (blackberryforums.com)
The utility model discloses a ceramic tile process that stacks is perfect harmless, and stores up the brick system and can be used for keeping in and fold the brick pillar of brick device output, and help has improved the production efficiency of enterprise. (google.com)

This fold is composed of alternating beta strands and alpha helical segments where the beta strands are hydrogen bonded to each other forming an extended beta sheet and the alpha helices surround both faces of the sheet to produce a three-layered sandwich. (wikipedia.org)
The classical Rossmann fold contains six beta strands whereas Rossmann-like folds, sometimes referred to as Rossmannoid folds, contain only five strands. (wikipedia.org)
The Rossmann fold is composed of six parallel beta strands that form an extended beta sheet. (wikipedia.org)
The first three strands are connected by α- helices resulting in a beta-alpha-beta-alpha-beta structure. (wikipedia.org)
The fold may contain additional strands joined by short helices or coils. (wikipedia.org)
In vivo , DNA structures are more likely to be duplexes with full complementarity between two strands, while RNA structures are more likely to fold into complex secondary and tertiary structures such as in the ribosome , spliceosome , or transfer RNA . (wikipedia.org)

Figure 1: Competing reactions of protein folding and aggregation. (nature.com)

Folding cartons can be designed in a wide range of shapes to suit product requirements and enhance visual appeal. (metrostarpackaging.com)
So-called solder assembly used the surface tension of melting solder to fold silicon, the electronic industry's standard semiconductor material, into 3-D shapes that more efficiently filled a small space with electrical components. (sciencedaily.com)
The University of Twente team also created silicon-based shapes, but they used a more ubiquitous liquid -- water -- to activate and control the folding. (sciencedaily.com)
Watching through a microscope as the new system folded and unfolded shapes in front of his eyes was an exciting experience, said Legrain. (sciencedaily.com)

The structure prediction methods can follow a completely theoretical approach, or a hybrid one incorporating experimental data. (wikipedia.org)

A larger distance cutoff is often advantageous for capturing spatial arrangement of the secondary structures which are not physically in contact. (biomedcentral.com)

RNALands (Fast and Efficient Sampling of Structures in RNA Folding Landscapes) is a joint collaborative project on RNA kinetics involving the French Inria groups AMIB and BONSAI , the Université Paris-Sud, and the Austrian Institute for Theoretical Biochemistry of the university of Vienna . (inria.fr)

He was the first to deduce the structure of lactate dehydrogenase and characterized the structural motif within this enzyme which would later be called the Rossmann fold. (wikipedia.org)
The N- and C-terminal domains of UgdG share structural features with ancient mitochondrial ribonucleases named MAR. MARs are present in lower eukaryotic microorganisms, have a Rossmannoid-fold and belong to the isochorismatase superfamily. (wikipedia.org)
These structure-based terms are commonly derived from statistics of structural properties observed in representative structures (knowledge-based statistical potentials). (biomedcentral.com)

Biophysical characterization and X-ray crystal structure determination show that the designed protein folds to the intended configuration, tying itself in a knot in the process, and that it folds reversibly. (cornell.edu)

Secondary structure of small RNA molecules is largely determined by strong, local interactions such as hydrogen bonds and base stacking . (wikipedia.org)

Preliminary kinetic experiments suggest a complicated folding mechanism, providing opportunities for further characterization. (cornell.edu)
The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. (mpg.de)

We have obtained 50 trajectories for each protein and followed the free-energy profile and the order of folding of secondary structure elements between the last occurrence of the completely unfolded state and the first occurrence of the completely folded state. (nih.gov)

Bioinformatic analyses suggest that the core fold occurs in ∼44% of annotated Phytophthora RXLR effectors, both as a single domain and in tandem repeats of up to 11 units. (jic.ac.uk)

This session solicits theoretical, simulation, and experimental studies that address aspects of both natural and synthetic biomolecule folding and assembly. (confex.com)

2016). Here, we show that ATP enhances this process by modulating secondary structure formation within the translocating protein. (elifesciences.org)
This paper explores how the protein folding process per se may be exploited to drive protein translocation. (elifesciences.org)
The protein must then fold during or after the translocation process. (elifesciences.org)
An auto-bottom folding carton features a pre-glued bottom, simplifying the assembly process. (metrostarpackaging.com)
international market analysis, China domestic market analysis, Macroeconomic environment and economic situation analysis and influence, Fold Garment Board industry policy and plan, Fold Garment Board product specification, manufacturing process, product cost structure etc. (sbwire.com)
If the water-based process is further developed to fold multiple structures at once, it could become cheaper than current self-folding approaches, said Legrain. (sciencedaily.com)
During the actin-folding process, the structure of TRiC changes, too. (mpg.de)
Raising and lowering the FROPS is a time consuming and strenuous process, and operators often leave the FROPS in the folded-down position providing no protection during a rollover. (cdc.gov)

Lower fold recognition accuracy was observed when inaccurate threading alignments were used to identify common residue contacts between protein pairs. (biomedcentral.com)

Abstract: Self-folding of complex origami-inspired structures from flat states allows for the incorporation of a multitude of surface-related functionalities into the final 3D device. (materialstoday.com)

The function of the Rossmann fold in enzymes is to bind nucleotide cofactors. (wikipedia.org)
The researchers solved the protein structure of TRiC to study its function and found that it has a special mode of action for actin folding. (mpg.de)
Structure and relation to Function. (lu.se)
The focus of my research is the evolution of protein function and structure. (lu.se)

The global report on "Folding Display Stand Market " provides an in-depth examination of the key drivers promoting growth, the tactical choices made by market participants, and the chances for expansion based on the dynamics of the market today, both globally and regionally. (menafn.com)
Protein hydration--the perturbation of water structure and dynamics by the protein surface--has been a particularly rich source of controversy and confusion. (lu.se)
and (ii) the perturbation progress within the field of protein hydration has been of the structure and dynamics of bulk water caused by the interaction with the solute. (lu.se)

Huang L, Gromiha M, First insight into the prediction of protein folding rate change upon point mutation, Bioinformatics;26(17):2121-7. (lu.se)
Chaudhary P, Naganathan A, Gromiha M, Folding RaCe: a robust method for predicting changes in protein folding rates upon point mutations, Bioinformatics;31(13):2091-7. (lu.se)

At 2.7Å resolution, the researchers solved the structures of tau filaments from three people with PSP-RS (see image below). (alzforum.org)

Most popular methods for predicting RNA and DNA's secondary structure involve dynamic programming . (wikipedia.org)
[7] [8] One of the early attempts at predicting RNA secondary structure was made by Ruth Nussinov and co-workers who developed a dynamic programming-based algorithm that maximized the length and number of a series of "blocks" (polynucleotide chains). (wikipedia.org)

Proteins44

20231

Molecule4

20201

Tertiary structure4

Stability6

Molecular7

Glycosylation1

Mechanisms5

Dimensions2

Insights1

20211

Geometry1

Functional5

Refold1

Quaternary1

Nucleic acid4

Sequences2

Complexes1

Membrane protein3

Sequence6

Amino2

Scientists3

Chaperonin2

Design13

Residues3

Foldable1

Adopts2

Remarkably2

Unfold1

Modular1

Genome1

Predict1

Cavity1

Relates2

Crucial for protein1

Biological1

EFFICIENCY2

Strands6

Aggregation1

Shapes4

Prediction methods1

Secondary structures1

Landscapes1

Structural3

Determination1

Molecules1

Mechanism2

Occurrence1

Analyses1

Experimental1

Process8

Recognition1

Origami1

Function4

Dynamics3

Bioinformatics2

Researchers solved1

Predicting2