Structurally related protein. Medical search. Frequent questions

Although these receptors are structurally similar, they determine specificity for four ligands-GDNF, Neurturin (NRTN), Artemin (ARTN) and Persephin (PSPN). (medsci.org)

The fact that NUDF and LIS1 interact with the same protein domain strengthens the notion that these two proteins are functionally related. (xenbase.org)
Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. (antibodies-online.com)

Other examples of Drosophila gene complexes include the Antennapedia complex (ANTP-C), the bithorax complex (BX-C) and the achaete-scute complex (AS-C). The hallmark of all these gene complexes, including the E(spl)-C is that within any complex the genes are evolutionarily related and jointly regulated. (sdbonline.org)
All genes in the ANTP-C and BX-C code for homeodomain proteins. (sdbonline.org)
Genes of the E(spl)-C and AS-C regulate neurogenesis and related differentiation pathways. (sdbonline.org)
In Drosophila, the majority of Notch target genes known so far is located in the Enhancer of split complex , encoding small basic helix-loop-helix (bHLH) proteins that presumably act as transcriptional repressors. (sdbonline.org)
The five genes described in this paper are arrayed between mbeta and m7 , both coding for bHLH proteins. (sdbonline.org)
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. (genetex.com)
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health. (medsci.org)
8- 10 In attempts to identify new breast and ovarian cancer susceptibility genes, much research has focused on BRCA1 associated proteins. (bmj.com)
It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. (antibodies-online.com)
Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans. (cdc.gov)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

HveA (formerly HVEM) is a member of the tumor necrosis factor receptor family, whereas the poliovirus receptor-related proteins 1 and 2 (PRR1 and PRR2, renamed HveC and HveB) belong to the immunoglobulin superfamily. (nih.gov)
By finding biomarkers, affimers have been applied to cancer studies, where they have been used to target a protein in tumor vessel formation called the VEGF receptor. (news-medical.net)
Similarly, the IL-17 receptor family (IL-17RA-RE) is not related to any of the other known cytokine receptors [ 2 ]. (hindawi.com)
HERZUMA (trastuzumab-pkrb) is a humanized IgG1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, HER2 . (rxlist.com)
19 normal healthy in- receptor protein (CD117) that is structurally dividuals were recruited as a control group. (who.int)
The intact receptor lacks tyrosine kinase activity, but binding of GH and dimerization results in association with JAK2, a member of the Janus kinase family, which results in self-phosphorylation of the JAK2 and a cascade of phosphorylation of cellular proteins. (medscape.com)
IGF binding involves 3 basic types of receptors: the structurally homologous insulin receptor and type 1 IGF receptor and the distinctive type 2 IGF-II/mannose-6-phosphate receptor. (medscape.com)
Parafollicular (PF) cells secrete 5-HT in response to stimulation of a G-protein-coupled Ca 2+ receptor (CaR) by increased extracellular Ca 2+ (↑[Ca 2+ ] e ). (jneurosci.org)
Dulhunty and her colleagues were studying how the ryanodine receptor, a type of protein receptor, functions in muscle cells. (the-scientist.com)
Three years after the initial discovery, they found that another protein structurally related to glutathione transferases, a chloride intracellular ion channel, CLIC-2, could also dampen the activity of the ryanodine receptor in the heart. (the-scientist.com)

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (K i = 109 nM). (tocris.com)
Role of AMP-activated protein kinase in mechanism of MetF. (tocris.com)
The isoform beta 1 has been studied as a possible target for anti-cancer drugs and as an inducer, via diacylglycerol generation, of the translocation of specific protein kinase C (PKC) isozyme to the nucleus. (curehunter.com)
We tested the hypothesis that protein kinase C (PKC) participates in stimulus-secretion coupling. (jneurosci.org)
The ↑[Ca 2+ ] i activates a signaling cascade that involves, sequentially, calcium-calmodulin, nitric oxide synthase, guanylyl cyclase, and protein kinase G. This signal transduction pathway enables Cl − to pass through vesicular channels and act as a counterion for the transport of H + , so that the vesicles of secretogogue-stimulated cells become acidic. (jneurosci.org)
CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. (thermofisher.com)
A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. (bvsalud.org)

Bio-Techne scientist, Anthony Person, Ph.D., discussed novel immunoregulatory pathways that the R&D Systems protein group has uncovered as potential targets for cancer immunotherapy. (rndsystems.com)
The principal objective of our broad, translational research is to determine structural attributes and to develop small-molecule compounds for new, emerging, cancer-related protein-protein interactions in the ubiquitin-proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation pathways. (europa.eu)
Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)

For example, SH2 proteins expressed in mammalian cells are challenging to extract. (news-medical.net)
While fungal and mammalian pepsins are bilobal proteins with structurally related N- and C-termini, retropepsins are half as long as their fungal and mammalian counterparts. (nih.gov)
Structurally, the IL-17 cytokine family members have no sequence similarity to any other known cytokine or other mammalian proteins [ 2 ]. (hindawi.com)

The mutations associated with this condition can affect any part of the DSG4 protein, but these changes typically alter the extracellular domain, which is the region of the protein outside the cell that interacts with other cells. (medlineplus.gov)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
This entry represents the extracellular repeated domains found in cadherins and related proteins. (embl.de)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)

Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC θ , PKA and JAK3. (tocris.com)
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. (thermofisher.com)

We simulate the evolution of a protein-like sequence subject to point mutations, imposing conservation of the ground state, thermodynamic stability and fast folding. (epj.org)
The Adhiron synthetic protein was originally made from the sequence of cystatin, and is very thermally stable. (news-medical.net)
The four conserved cysteines in the C-terminal half of the IL-17F sequence are shown to form a cystine knot structural motif in the crystal structure, and, interestingly, this cystine knot structure is similar to a common structural motif seen in several growth factors, such as bone morphogenic proteins (BMPs), TGF- β , nerve growth factor (NGF), and platelet-derived growth factor (PDGF) [ 9 ]. (hindawi.com)
3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)
Towards in silico CLIP-seq : predicting protein-RNA interaction via sequence-to-signal learning. (ki.si)
NUDF protein, the product of the nudF gene, displays 42% sequence identity with the human protein LIS1 required for neuronal migration. (xenbase.org)
BARD1, unlike BRCA1, also contains a centrally located sequence of three ankyrin repeats 11 that are found in many proteins involved in transcriptional regulation. (bmj.com)
A particularly intriguing piece of information provided in this study, is that the ZNF558 expression is controlled by a non-coding DNA sequence, which is structurally different between humans and chimpanzee. (lu.se)

The class-I and class-II proteins of the Major Histocompatibility Complex play an essential role in immune surveillance, by displaying epitopic peptides derived from the processing of aberrant proteins on the cell surface, where they can be recognized through interactions with specialized receptors on T cells and Natural Killer cells. (upenn.edu)

The human cellular prion protein (PrP C ) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. (mdpi.com)
It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues. (curehunter.com)
Strains were transformed with nudE variants in pAid vector and grown at 43°C. Numbers refer to amino acid residues of NUDE protein expressed by the constructs (see Fig. 3 for detailed amino acid sequences). (xenbase.org)

Efimov VP and Morris NR (2000), The LIS1-related NUDF protein of Aspergillus ni. (xenbase.org)

The Gene Ontology contains a wealth of terms covering immune system processes for the annotation of proteins involved in the functioning of the immune system. (bioontology.org)
The DSG4 gene provides instructions for making a protein called desmoglein 4 (DSG4). (medlineplus.gov)
Other DSG4 gene mutations result in the production of abnormal DSG4 proteins that cannot communicate signals between cells within hair follicles or skin. (medlineplus.gov)
However, it is unclear how mutations in the DSG4 gene are related to the abnormality in the cortex or the beaded appearance of the hair. (medlineplus.gov)
Nerve fibers were assayed structurally by protein gene product 9.5 (PGP9.5) nerve immunostaining. (cdc.gov)
After treatment, rats were euthanized, and tail tissues were chemically fixed for histological analysis of nerves (PGP9.5, neuropeptide Y, calcitonin gene related protein) and mast cells (avidin, Alcian Blue/Safranin O).2 Single sections were doublestained for nerve fibers and mast cells to permit assessment of the degree of physical overlap. (cdc.gov)
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)
Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
The product of the nudE gene isolated in the screen, NUDE, is a homologue of the nuclear distribution protein RO11 of Neurospora crassa. (xenbase.org)
The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)
The protein encoded by this gene lacks the zinc binding activity of other family members. (antibodies-online.com)
Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. (lu.se)
Although the gene knockout results in structurally normal kidneys, we detect higher albumin in urine and lowered ferritin in the blood. (lu.se)

Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)
related to other transmembrane receptors. (who.int)
One of these is CSMD1, a large transmembrane protein deleted in number of tumors but also acting as classical complement inhibitor targeting complement convertases. (lu.se)

Furthermore, the screening process by which binding reagents are identified is more efficient because the target proteins are screened in a folded state. (news-medical.net)
this is because they directly bind to their target proteins and thus control substrate specificity. (europa.eu)

Our lab's principal efforts focus on mechanistic, structural and functional studies of protein complexes, with emphasis on the development of an iterative experimental / computational approach. (upenn.edu)
These annotations allow human TLR proteins, the complexes they form, and the functions they mediate to be classified and related to those of structurally similar TLR proteins from chicken, mouse, and other species. (bioontology.org)

Understanding of the molecular and ionic mechanisms underlying cardiac conduction is essential for the appreciation of the pathogenesis of conduction abnormalities in structurally normal and altered hearts. (medscape.com)

Disruption of plant plasma membrane by Nep1-like proteins in pathogen/plant interactions. (ki.si)

Activation domains influence the way proteins interact with the trancription apparatus of the cell (Dawson, 1995). (sdbonline.org)
The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)
Oximes such as pralidoxime help regenerate the protein enzyme targeted by nerve agents (called "cholinesterase"), but do not interact with nerve agents that have not yet bound a cholinesterase molecule. (cdc.gov)

Structurally related to the TNF superfamily, CTRPs have roles in immunity and metabolism. (rndsystems.com)

Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. (upenn.edu)
Unfortunately, the design of drugs with multiple activities on a selected handful of different protein structures remains a significant experimental and computational challenge ( Konc, 2019 ). (frontiersin.org)

SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
The structural comparison of proteins has become increasingly important as a means to identify protein motifs and fold families. (aaai.org)
In this paper we present a new algorithm for the comparison of proteins based on a hierarchy of structural representations, from the secondary structure level to the atomic level. (aaai.org)

The LIS1 -related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. (xenbase.org)
NUDF protein interacts with the Aspergillus NUDE coiled-coil in a yeast two-hybrid system, while human LIS1 interacts with the human homologue of the NUDE/RO11 coiled-coil and also the Xenopus MP43 coiled-coil. (xenbase.org)
6, 7 BRCA1 interacts with a variety of proteins and is involved in multiple cellular processes including DNA repair, transcription, and checkpoint control. (bmj.com)

The UPS and UBL proteins studied by us are: the oncogenic E3 ligase Mdm2, which regulates levels of p53, the deubiquitinating enzyme (DUB) USP2a, and the UBL protein Hub1, which has been recently shown to control alternative splicing by non-covalent binding to the Snu66 spliceosomal protein. (europa.eu)

Importantly, increasing numbers of novel reports suggest that the GFRα-mediated signaling pathway acts as an oncogenic promoter related to tumor proliferation, invasion, and metastasis as well as treatment resistance. (medsci.org)
We study how these proteins are related to tumor development in breast, prostate and melanoma cancer models. (lu.se)

My research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells. (upenn.edu)

We use nuclear magnetic resonance (NMR) and X-ray crystallography techniques to structurally characterize protein-protein interactions (PPI) and to develop small-molecule inhibitors for these PPIs. (europa.eu)

This protein family describes a large family of such proteins that work by acting as rRNA N-glycosylase (EC 3.2.2.22). (wikipedia.org)
Members of the family include shiga toxins, and type I (e.g. trichosanthin and luffin) and type II (e.g. ricin, agglutinin, and abrin) ribosome inactivating proteins (RIPs). (wikipedia.org)
Only a minority of RIPs are toxic to humans when consumed, and proteins of this family are found in the vast majority of plants used for human consumption, such as Rice, Maize and Barley. (wikipedia.org)
However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. (embl.de)
The IGFBPs are a family of 6 structurally related proteins with a high affinity for binding IGF. (medscape.com)

BARD1 was originally identified through its interaction with BRCA1, with which it has a closely related domain structure. (bmj.com)

Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins. (embl.de)

Antibodies have been the most popular method for studying protein expression and function for the past decades, but have been dogged by lack of validation and the poor cost-effectiveness of constantly generating new antibodies. (news-medical.net)
Affimers stem from the drive to generate alternative methods of studying protein binding and function, which can complement information provided by antibodies. (news-medical.net)

Markers specific for nerve subtypes are required to relate changes to functional alterations. (cdc.gov)
The phenotype of Bard1 null mice was found to be remarkably similar to that of Brca1 nulls, further emphasising the functional relationship between these two proteins. (bmj.com)

The intracellular protein extracts of a fungal strain Pycnoporus sanguineus was used as reducing and stabilizing agents to synthesize AuNPs with various shapes and dimensions, which present good catalyzing ability on the degradation of 4-nitroaniline [ 11 ]. (springer.com)

Complex formation between soluble gD and HveC appears to involve one or two gD molecules for one HveC protein. (nih.gov)
We relate the high variability of the fraction of neutral mutations to the complex energy landscape within a neutral network, arguing that valleys in this landscape are associated to high values of the neutral mutation rate. (epj.org)
Fundamental differences exist between proteins when comparing one complex to another. (sdbonline.org)
It has been known that liquiritin from licorice forms complexation with aconitine and therefore reduces the amount of free aconitine [ 7 ], indicating that interactions between aconitine with other major amphiphilic compounds (i.e., protein) from licorice may facilitate the formation of aconitine complex of such kind, too. (springer.com)
I will describe both our efforts to stabilize the protein and to the recently published crystal structure of a genetically modified version of UapA in complex with xanthine. (lu.se)

The HMW agents that were considered most relevant were flour dusts, enzymes (both plant and animal derived), gums, foods and tobacco, rubber-derived proteins, animal- and insect-derived allergens, and fish/ seafood-derived allergens ( Table 1 ). (cdc.gov)
Enzymes are proteins used as biocatalysts to reduce or replace the use of chemi- cals in a variety of processes.9 As catalysts, enzymes are used in a variety of indus- tries, including cleaning, food processing, animal feed, fuel alcohol, textile, paper, and pharmaceuticals. (cdc.gov)

The stefin A scaffold is engineered from human stefin A protein, whereas Adhiron is synthetic. (news-medical.net)
It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. (genetex.com)
B) Complementation of the nudE deletion and the nudF7 mutant by extra copies of nudE, the nudE NH2-terminal domain, and nudE chimeras carrying coiled-coil regions from human and frog proteins, respectively. (xenbase.org)
In Reactome we have integrated annotations of human TLR molecular functions with those of 6800 other human proteins involved in diverse biological processes to generate a resource suitable for data mining, pathway analysis, and other systems biology approaches. (bioontology.org)
This enabled them to identify a Zinc finger protein (ZNF) specifically expressed in humans and not chimpanzees and demonstrate that the human-specific ZNF (named ZNF558) is crucial for both mitochondrial homeostasis and early human brain development. (lu.se)
Based on comparison with the structurally related human Anion Exchanger 1, it seems likely that UapA uses an elevator mechanism to transport substrate across the membrane. (lu.se)

As a type of affinity reagent, affimers are biophysically stable scaffolds of proteins that can be reused. (news-medical.net)

Some of the applications that have been tested using affimers include cell imaging, super resolution microscopy, protein function modulation, magnetic nanoparticle formation, and MRI reagent development. (news-medical.net)
These proteins will meet needs for ex vivo cell culture in cell therapy manufacturing. (rndsystems.com)
11 Both proteins possess an N-terminal RING finger motif and two BRCA1 C-terminal (BRCT) domains present in numerous proteins involved in DNA repair and cell cycle regulation. (bmj.com)
Day 2 will be focused on flow cytometry, including the question of the Cell and Protein Ontologies and of the role of surface protein expression in cell type classification. (bioontology.org)

The identification of similar three-dimensional (3D) amino acid patterns among different proteins might be helpful to explain the polypharmacological profile of many currently used drugs. (frontiersin.org)
Hexokinase I, the pacemaker of glycolysis in brain tissue, is composed of two structurally similar halves connected by an alpha-helix. (rcsb.org)

Whereas AS-C coded proteins are proneural, meaning they initiate neurogenesis or nerve generation, E(spl)-C coded proteins are inhibitory for neurogenesis. (sdbonline.org)
PGP9.5 binds an ubiquitin pathway protein present in all types of nerve fibers, but PGP9.5 levels may change with injury and alter identification consistency. (cdc.gov)
While there is not enough information to suggest a safe level of these agents in breast milk, there is published evidence that organophosphate chemicals, of which nerve agents are structurally related, may be secreted in breast milk. (cdc.gov)

This co-stimulatory protein and modulator of the immune response is a clear immuno-oncology target. (rndsystems.com)

To select an appropriate affimer, screening is done to find suitable reagents for the target protein. (news-medical.net)

Since chemicals that are structurally related can have distinct saliences for an organism [ 3 ], these cues must be identified and differentiated in order to elicit the appropriate behavior. (plos.org)

Since HveA also mediates HSV entry by interacting with gD, we compared both structurally unrelated receptors for their binding to gD. (nih.gov)
This pore-forming toxin has been reported as an important protein that mediates tissue damage promoted by S. aureus . (nature.com)

This difference is reflected in the activation domains of the respective proteins. (sdbonline.org)

Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

This result indicates that changing significantly a protein structure through a biologically acceptable chain of point mutations is a rare, although possible, event. (epj.org)

The monomers are structurally related to one lobe of the pepsin molecule and retropepsins function as homodimers. (nih.gov)

Anatomy23

Organisms17

Diseases1

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes67

Disciplines and Occupations3

Information Science9

Health Care1

Receptors are structurally1

Functionally related2

Genes11

Receptor10

Kinase7

Pathways3

Mammalian3

Extracellular4

Kinases2

Sequence8

Peptides1

Residues3

20001

Gene13

Transmembrane3

Target proteins2

Complexes2

Pathogenesis1

Plasma membrane1

Interact3

Superfamily1

Computational2

Structural4

Interacts3

Enzyme1

Tumor2

Antigens1

Inhibitors1

Family5

Closely related1

Interaction1

Antibodies2

Functional2

Intracellular1

Complex5

ENZYMES2

Human6

Affinity1

Cell4

Similar2

Nerve3

Immune1

Reagents1

Chemicals1

Mediates2

Activation1

Vivo1

Mutations1

Molecule1